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Q01U81 (SYL_SOLUE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:Acid_5844
OrganismSolibacter usitatus (strain Ellin6076) [Complete proteome] [HAMAP]
Taxonomic identifier234267 [NCBI]
Taxonomic lineageBacteriaAcidobacteriaSolibacteresSolibacteralesSolibacteraceaeCandidatus Solibacter

Protein attributes

Sequence length810 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 810810Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000334821

Regions

Motif43 – 5311"HIGH" region HAMAP-Rule MF_00049
Motif578 – 5825"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site5811ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q01U81 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: D643646F29FD9F70

FASTA81092,187
        10         20         30         40         50         60 
MPEKPYDHIA IELKWHERWQ DAQFYKAEEN SAKPKFYVLE MLPYPSGTLH IGHIRNYSIG 

        70         80         90        100        110        120 
DALARYKWMR GFNVLHPMGW DAFGLPAENA AIANKVPPRQ WTLQNIAAMK KTHRRFAFSY 

       130        140        150        160        170        180 
DWDREVSTCE PEYYRWNQWF FLRMLERGLA YRKRALVNWC PKCATVLANE QVVDGCCWRH 

       190        200        210        220        230        240 
EGTPVEQRAL DQWFLKITDY ADQLLDEMAR LEGGWPERVL TMQRNWIGRS EGAEIDFTLA 

       250        260        270        280        290        300 
GAGTPIRVFT TRVDTIYGAT SVILAPEHPL NETLLDSEKK AKAKAMVDSR AGRDPGDIDK 

       310        320        330        340        350        360 
EGFFTGHYAV NPYNGEQVPI WIANFVLMGY GTGAIMAVPA HDERDFEFCT KYGIPITPVI 

       370        380        390        400        410        420 
RPVDQPAGEP VALPYGEYGI LENSGEWSGL ASAEARRQMS AYAEQHGFGK SAITFRIKDW 

       430        440        450        460        470        480 
GISRQRYWGT PIPVIHCPSC GVVPVPDDQL PVVLPDRIEI TGAGRSPLEN VPEFVNVACP 

       490        500        510        520        530        540 
KCGEPARRET DTMDTFVDSS WYFYRYCDPH NSERPFDPAK IAYWFEIDQY IGGIEHAILH 

       550        560        570        580        590        600 
LIYSRFFTKV MRDIGLISNN EPARRLFTQG MVIAEGAKMS KSKGNVVGAD LLADKFGADT 

       610        620        630        640        650        660 
ARMFVLSNVP PEKEVDWREE GAEGTYRFLG RVYRFTTRNV PAQQRSGDAD RKVVRKLHQT 

       670        680        690        700        710        720 
LKKITEDFET RWHFNTCIAS IMELVNLLYA EEQNISAAVM PQILESLALM LAPFAPYLSQ 

       730        740        750        760        770        780 
EMWEEIGKEG PVFRQAWPAF DPELAKEEGA EIVVQVNGKV RTRITAPFGT AKEELESRSL 

       790        800        810 
AHEKVKPFID GKQVMKIITV PDKLVNIVVK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000473 Genomic DNA. Translation: ABJ86789.1.
RefSeqYP_827074.1. NC_008536.1.

3D structure databases

ProteinModelPortalQ01U81.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING234267.Acid_5844.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ86789; ABJ86789; Acid_5844.
GeneID4425957.
KEGGsus:Acid_5844.
PATRIC32014317. VBICanSol30224_6116.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAHISHELW.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycSUSI234267:GHSK-5887-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_SOLUE
AccessionPrimary (citable) accession number: Q01U81
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 14, 2006
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries