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Q01U81

- SYL_SOLUE

UniProt

Q01U81 - SYL_SOLUE

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Protein

Leucine--tRNA ligase

Gene
leuS, Acid_5844
Organism
Solibacter usitatus (strain Ellin6076)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei581 – 5811ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSUSI234267:GHSK-5887-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Acid_5844
OrganismiSolibacter usitatus (strain Ellin6076)
Taxonomic identifieri234267 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaSolibacteresSolibacteralesSolibacteraceaeCandidatus Solibacter
ProteomesiUP000000671: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 810810Leucine--tRNA ligaseUniRule annotationPRO_0000334821Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi234267.Acid_5844.

Structurei

3D structure databases

ProteinModelPortaliQ01U81.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionUniRule annotationAdd
BLAST
Motifi578 – 5825"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01U81-1 [UniParc]FASTAAdd to Basket

« Hide

MPEKPYDHIA IELKWHERWQ DAQFYKAEEN SAKPKFYVLE MLPYPSGTLH    50
IGHIRNYSIG DALARYKWMR GFNVLHPMGW DAFGLPAENA AIANKVPPRQ 100
WTLQNIAAMK KTHRRFAFSY DWDREVSTCE PEYYRWNQWF FLRMLERGLA 150
YRKRALVNWC PKCATVLANE QVVDGCCWRH EGTPVEQRAL DQWFLKITDY 200
ADQLLDEMAR LEGGWPERVL TMQRNWIGRS EGAEIDFTLA GAGTPIRVFT 250
TRVDTIYGAT SVILAPEHPL NETLLDSEKK AKAKAMVDSR AGRDPGDIDK 300
EGFFTGHYAV NPYNGEQVPI WIANFVLMGY GTGAIMAVPA HDERDFEFCT 350
KYGIPITPVI RPVDQPAGEP VALPYGEYGI LENSGEWSGL ASAEARRQMS 400
AYAEQHGFGK SAITFRIKDW GISRQRYWGT PIPVIHCPSC GVVPVPDDQL 450
PVVLPDRIEI TGAGRSPLEN VPEFVNVACP KCGEPARRET DTMDTFVDSS 500
WYFYRYCDPH NSERPFDPAK IAYWFEIDQY IGGIEHAILH LIYSRFFTKV 550
MRDIGLISNN EPARRLFTQG MVIAEGAKMS KSKGNVVGAD LLADKFGADT 600
ARMFVLSNVP PEKEVDWREE GAEGTYRFLG RVYRFTTRNV PAQQRSGDAD 650
RKVVRKLHQT LKKITEDFET RWHFNTCIAS IMELVNLLYA EEQNISAAVM 700
PQILESLALM LAPFAPYLSQ EMWEEIGKEG PVFRQAWPAF DPELAKEEGA 750
EIVVQVNGKV RTRITAPFGT AKEELESRSL AHEKVKPFID GKQVMKIITV 800
PDKLVNIVVK 810
Length:810
Mass (Da):92,187
Last modified:November 14, 2006 - v1
Checksum:iD643646F29FD9F70
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000473 Genomic DNA. Translation: ABJ86789.1.
RefSeqiYP_827074.1. NC_008536.1.

Genome annotation databases

EnsemblBacteriaiABJ86789; ABJ86789; Acid_5844.
GeneIDi4425957.
KEGGisus:Acid_5844.
PATRICi32014317. VBICanSol30224_6116.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000473 Genomic DNA. Translation: ABJ86789.1 .
RefSeqi YP_827074.1. NC_008536.1.

3D structure databases

ProteinModelPortali Q01U81.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 234267.Acid_5844.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ86789 ; ABJ86789 ; Acid_5844 .
GeneIDi 4425957.
KEGGi sus:Acid_5844.
PATRICi 32014317. VBICanSol30224_6116.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SUSI234267:GHSK-5887-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ellin6076.

Entry informationi

Entry nameiSYL_SOLUE
AccessioniPrimary (citable) accession number: Q01U81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 14, 2006
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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