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Q01QS5 (Q01QS5_SOLUE) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485
Gene names
Ordered Locus Names:Acid_7082
OrganismSolibacter usitatus (strain Ellin6076) [Complete proteome] [HAMAP]
Taxonomic identifier234267 [NCBI]
Taxonomic lineageBacteria › Acidobacteria › Solibacteres › Solibacterales › Solibacteraceae › Candidatus Solibacter

Protein attributes

Sequence length485 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding11 – 166NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding34 – 363NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding76 – 783NADP By similarity PIRSR PIRSR000109-3
Region130 – 1323Substrate binding By similarity PIRSR PIRSR000109-2
Region188 – 1892Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1851Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1921Proton donor By similarity PIRSR PIRSR000109-1
Binding site1041NADP By similarity PIRSR PIRSR000109-3
Binding site1041Substrate By similarity PIRSR PIRSR000109-2
Binding site1931Substrate By similarity PIRSR PIRSR000109-2
Binding site2631Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2901Substrate By similarity PIRSR PIRSR000109-2
Binding site4481Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4541Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
Q01QS5 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: EE3E3A94B8860412

FASTA48553,378
        10         20         30         40         50         60 
MEQTADIALI GLAVMGQNLI MNMNDHGYTV VAYNRTTSKV DEFLNDAAKG SKVIGAHSIE 

        70         80         90        100        110        120 
EMVKLLKRPR KIMLMVKAGK PVDEFIETLL PYLEPGDLII DGGNSHFPDT IRRTQYLESK 

       130        140        150        160        170        180 
GLLFVGTGVS GGEEGARFGP SMMPGGTPAA WPLVKDIFQA ICAKTPEGEP CCDWVGRDGA 

       190        200        210        220        230        240 
GHFVKMTHNG IEYGDMQLIC EAYQLMKEGL GMSNEEMHEV FAEWNKGELD SYLIEITRDI 

       250        260        270        280        290        300 
LGYKDPATGE QTLDKILDTA GQKGTGKWTS VSSLDLGMPV TLIGEAVYAR CLSAMKDDRV 

       310        320        330        340        350        360 
KASKILTGPK AKFPGDKKAF VEDIRQALLA SKIVSYAQGF MLLAEAAKEY KWDLNYGSIA 

       370        380        390        400        410        420 
MMWREGCIIR SVFLGKIKAA FANNPTLANL LLDSYFRGLL DRCQGSWRHT VSEAVLNGVP 

       430        440        450        460        470        480 
VPAFTTALAF YDGYRSERLP ANLLQAQRDY FGAHTFERVD QPRGKFFHTN WTGKGGNVSA 


GVYTV

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000473 Genomic DNA. Translation: ABJ87995.1.
RefSeqYP_828280.1. NC_008536.1.

3D structure databases

ProteinModelPortalQ01QS5.
SMRQ01QS5. Positions 5-476.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ01QS5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4424873.
GenomeReviewsGene locus Acid_7082 in contig CP000473_GR.
KEGGsus:Acid_7082.
NMPDRfig|234267.9.peg.6712.
PATRIC32016878. VBICanSol30224_7388.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0362.
HOGENOMHBG286913.
OMAMEHNEMA.
PhylomeDBQ01QS5.
ProtClustDBPRK09287.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ01QS5_SOLUE
AccessionPrimary (citable) accession number: Q01QS5
Entry history
Integrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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