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Q01MI9

- APX3_ORYSI

UniProt

Q01MI9 - APX3_ORYSI

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Protein

Probable L-ascorbate peroxidase 3

Gene

APX3

Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Plays a key role in hydrogen peroxide removal.By similarity

Catalytic activityi

2 L-ascorbate + H2O2 + 2 H+ = L-ascorbate + L-dehydroascorbate + 2 H2O.

Cofactori

Binds 1 heme B (iron-protoporphyrin IX) group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei37 – 371Transition state stabilizerPROSITE-ProRule annotation
Active sitei41 – 411Proton acceptorPROSITE-ProRule annotation
Metal bindingi161 – 1611Iron (heme axial ligand)PROSITE-ProRule annotation
Metal bindingi162 – 1621Potassium or calciumBy similarity
Metal bindingi178 – 1781Potassium or calciumBy similarity
Metal bindingi185 – 1851Potassium or calciumBy similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. L-ascorbate peroxidase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. hydrogen peroxide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Calcium, Heme, Iron, Metal-binding, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Probable L-ascorbate peroxidase 3 (EC:1.11.1.11)
Alternative name(s):
OsAPx03
Gene namesi
Name:APX3
ORF Names:H0515C11.2, OsI_014375
OrganismiOryza sativa subsp. indica (Rice)
Taxonomic identifieri39946 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Organism-specific databases

GrameneiQ01MI9.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 291291Probable L-ascorbate peroxidase 3PRO_0000300258Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ01MI9.
SMRiQ01MI9. Positions 5-245.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei263 – 28321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0376.
HOGENOMiHOG000189824.

Family and domain databases

InterProiIPR002207. Asc_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00459. ASPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01MI9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAAPVVDAE YMAEVERARR DLRALIASKS CAPIMLRLAW HDAGTYDKAT
60 70 80 90 100
KTGGPNGSIR FPQEYSHAAN AGIKIAIDLL EPMKQRHPKI TYADLYQLAG
110 120 130 140 150
VVAVEVTGGP TIDYVPGRRD SSDSPEEGRL PDAKKGAAHL REVFYRMGLS
160 170 180 190 200
DKDIVALSGG HTLGKARPER SGFDGAWTKD PLKFDNSYFI ELLKENSEGL
210 220 230 240 250
LKLPTDKALV EDPTFRRYVE LYAKDEDAFF RDYAESHKKL SELGFTPPRS
260 270 280 290
AFIYKSCQKP KSLLMQTAAG VAVAAAVVAW AYLCESNKRL G
Length:291
Mass (Da):32,076
Last modified:November 14, 2006 - v1
Checksum:i9D2E57C3DBC277F6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY382617 mRNA. Translation: AAQ88105.1.
CR855043 Genomic DNA. Translation: CAH66026.1.
CM000129 Genomic DNA. Translation: EAY93142.1.
UniGeneiOs.4987.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY382617 mRNA. Translation: AAQ88105.1 .
CR855043 Genomic DNA. Translation: CAH66026.1 .
CM000129 Genomic DNA. Translation: EAY93142.1 .
UniGenei Os.4987.

3D structure databases

ProteinModelPortali Q01MI9.
SMRi Q01MI9. Positions 5-245.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Gramenei Q01MI9.

Phylogenomic databases

eggNOGi COG0376.
HOGENOMi HOG000189824.

Family and domain databases

InterProi IPR002207. Asc_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view ]
Pfami PF00141. peroxidase. 1 hit.
[Graphical view ]
PRINTSi PR00459. ASPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMi SSF48113. SSF48113. 1 hit.
PROSITEi PS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the molecular evolutionary history of the ascorbate peroxidase gene family: inferences from the rice genome."
    Teixeira F.K., Menezes-Benavente L., Margis R., Margis-Pinheiro M.
    J. Mol. Evol. 59:761-770(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], NOMENCLATURE.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Guang-Lu-Ai No.4.
  3. "The genomes of Oryza sativa: a history of duplications."
    Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
    , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
    PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. 93-11.

Entry informationi

Entry nameiAPX3_ORYSI
AccessioniPrimary (citable) accession number: Q01MI9
Secondary accession number(s): A2XQN2, Q6TY83, Q7XWZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 14, 2006
Last modified: October 1, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds one cation per subunit; probably K+, but might also be Ca2+.By similarity

Caution

According to PubMed:15599508, it may be peroxisomal. There is however no experimental evidence to prove this.Curated

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3