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Q01MI9

- APX3_ORYSI

UniProt

Q01MI9 - APX3_ORYSI

Protein

Probable L-ascorbate peroxidase 3

Gene

APX3

Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Plays a key role in hydrogen peroxide removal.By similarity

    Catalytic activityi

    2 L-ascorbate + H2O2 + 2 H+ = L-ascorbate + L-dehydroascorbate + 2 H2O.

    Cofactori

    Binds 1 heme B (iron-protoporphyrin IX) group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei37 – 371Transition state stabilizerPROSITE-ProRule annotation
    Active sitei41 – 411Proton acceptorPROSITE-ProRule annotation
    Metal bindingi161 – 1611Iron (heme axial ligand)PROSITE-ProRule annotation
    Metal bindingi162 – 1621Potassium or calciumBy similarity
    Metal bindingi178 – 1781Potassium or calciumBy similarity
    Metal bindingi185 – 1851Potassium or calciumBy similarity

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. L-ascorbate peroxidase activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. hydrogen peroxide catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase, Peroxidase

    Keywords - Biological processi

    Hydrogen peroxide

    Keywords - Ligandi

    Calcium, Heme, Iron, Metal-binding, Potassium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable L-ascorbate peroxidase 3 (EC:1.11.1.11)
    Alternative name(s):
    OsAPx03
    Gene namesi
    Name:APX3
    ORF Names:H0515C11.2, OsI_014375
    OrganismiOryza sativa subsp. indica (Rice)
    Taxonomic identifieri39946 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

    Organism-specific databases

    GrameneiQ01MI9.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 291291Probable L-ascorbate peroxidase 3PRO_0000300258Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ01MI9.
    SMRiQ01MI9. Positions 5-245.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei263 – 28321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0376.
    HOGENOMiHOG000189824.

    Family and domain databases

    InterProiIPR002207. Asc_peroxidase.
    IPR010255. Haem_peroxidase.
    IPR002016. Haem_peroxidase_pln/fun/bac.
    IPR019794. Peroxidases_AS.
    IPR019793. Peroxidases_heam-ligand_BS.
    [Graphical view]
    PfamiPF00141. peroxidase. 1 hit.
    [Graphical view]
    PRINTSiPR00459. ASPEROXIDASE.
    PR00458. PEROXIDASE.
    SUPFAMiSSF48113. SSF48113. 1 hit.
    PROSITEiPS00435. PEROXIDASE_1. 1 hit.
    PS00436. PEROXIDASE_2. 1 hit.
    PS50873. PEROXIDASE_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q01MI9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAAPVVDAE YMAEVERARR DLRALIASKS CAPIMLRLAW HDAGTYDKAT    50
    KTGGPNGSIR FPQEYSHAAN AGIKIAIDLL EPMKQRHPKI TYADLYQLAG 100
    VVAVEVTGGP TIDYVPGRRD SSDSPEEGRL PDAKKGAAHL REVFYRMGLS 150
    DKDIVALSGG HTLGKARPER SGFDGAWTKD PLKFDNSYFI ELLKENSEGL 200
    LKLPTDKALV EDPTFRRYVE LYAKDEDAFF RDYAESHKKL SELGFTPPRS 250
    AFIYKSCQKP KSLLMQTAAG VAVAAAVVAW AYLCESNKRL G 291
    Length:291
    Mass (Da):32,076
    Last modified:November 14, 2006 - v1
    Checksum:i9D2E57C3DBC277F6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY382617 mRNA. Translation: AAQ88105.1.
    CR855043 Genomic DNA. Translation: CAH66026.1.
    CM000129 Genomic DNA. Translation: EAY93142.1.
    UniGeneiOs.4987.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY382617 mRNA. Translation: AAQ88105.1 .
    CR855043 Genomic DNA. Translation: CAH66026.1 .
    CM000129 Genomic DNA. Translation: EAY93142.1 .
    UniGenei Os.4987.

    3D structure databases

    ProteinModelPortali Q01MI9.
    SMRi Q01MI9. Positions 5-245.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    Gramenei Q01MI9.

    Phylogenomic databases

    eggNOGi COG0376.
    HOGENOMi HOG000189824.

    Family and domain databases

    InterProi IPR002207. Asc_peroxidase.
    IPR010255. Haem_peroxidase.
    IPR002016. Haem_peroxidase_pln/fun/bac.
    IPR019794. Peroxidases_AS.
    IPR019793. Peroxidases_heam-ligand_BS.
    [Graphical view ]
    Pfami PF00141. peroxidase. 1 hit.
    [Graphical view ]
    PRINTSi PR00459. ASPEROXIDASE.
    PR00458. PEROXIDASE.
    SUPFAMi SSF48113. SSF48113. 1 hit.
    PROSITEi PS00435. PEROXIDASE_1. 1 hit.
    PS00436. PEROXIDASE_2. 1 hit.
    PS50873. PEROXIDASE_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the molecular evolutionary history of the ascorbate peroxidase gene family: inferences from the rice genome."
      Teixeira F.K., Menezes-Benavente L., Margis R., Margis-Pinheiro M.
      J. Mol. Evol. 59:761-770(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], NOMENCLATURE.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Guang-Lu-Ai No.4.
    3. "The genomes of Oryza sativa: a history of duplications."
      Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
      , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
      PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. 93-11.

    Entry informationi

    Entry nameiAPX3_ORYSI
    AccessioniPrimary (citable) accession number: Q01MI9
    Secondary accession number(s): A2XQN2, Q6TY83, Q7XWZ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Binds one cation per subunit; probably K+, but might also be Ca2+.By similarity

    Caution

    According to PubMed:15599508, it may be peroxisomal. There is however no experimental evidence to prove this.Curated

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3