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Q01C49

- Q01C49_OSTTA

UniProt

Q01C49 - Q01C49_OSTTA

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Protein
Submitted name: Cobalamin-dependent methionine synthase (ISS)
Gene
Ot03g04540
Organism
Ostreococcus tauri
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Cofactori

Binds 1 zinc ion per subunit By similarity.
Cobalamin By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi322 – 3221Zinc By similarityUniRule annotation
Metal bindingi385 – 3851Zinc By similarityUniRule annotation
Metal bindingi386 – 3861Zinc By similarityUniRule annotation
Metal bindingi849 – 8491Cobalt (cobalamin axial ligand) By similarityUniRule annotation
Binding sitei1038 – 10381S-adenosyl-L-methionine By similarity
Binding sitei1232 – 12321S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding sitei1236 – 12361Cobalamin; via carbonyl oxygen By similarity

GO - Molecular functioni

  1. S-adenosylmethionine-homocysteine S-methyltransferase activity Source: InterPro
  2. cobalamin binding Source: UniProtKB-KW
  3. methionine synthase activity Source: InterPro
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. pteridine-containing compound metabolic process Source: InterPro
Complete GO annotation...

Keywords - Ligandi

CobalaminUniRule annotation, Cobalt, Metal-bindingUniRule annotation, S-adenosyl-L-methionineUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Cobalamin-dependent methionine synthase (ISS)Imported
Gene namesi
Ordered Locus Names:Ot03g04540Imported
OrganismiOstreococcus tauriImported
Taxonomic identifieri70448 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeChlorophytaMamiellophyceaeMamiellalesOstreococcus
ProteomesiUP000009170: Chromosome 6

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ01C49.

Interactioni

Protein-protein interaction databases

STRINGi70448.Q01C49.

Structurei

3D structure databases

ProteinModelPortaliQ01C49.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni924 – 9252Cobalamin-binding By similarity
Regioni1287 – 12882S-adenosyl-L-methionine binding By similarity

Phylogenomic databases

eggNOGiCOG1410.
HOGENOMiHOG000251409.
KOiK00548.
OMAiLTEHYAM.

Family and domain databases

Gene3Di1.10.1240.10. 1 hit.
3.10.196.10. 1 hit.
3.20.20.20. 1 hit.
3.20.20.330. 1 hit.
3.40.50.280. 1 hit.
InterProiIPR003759. Cbl-bd_cap.
IPR006158. Cobalamin-bd.
IPR011005. Dihydropteroate_synth-like.
IPR011822. MetH.
IPR000489. Pterin-binding.
IPR003726. S_MeTrfase.
IPR004223. VitB12-dep_Met_synth_activ_dom.
[Graphical view]
PfamiPF02310. B12-binding. 1 hit.
PF02607. B12-binding_2. 1 hit.
PF02965. Met_synt_B12. 1 hit.
PF00809. Pterin_bind. 1 hit.
PF02574. S-methyl_trans. 1 hit.
[Graphical view]
PIRSFiPIRSF000381. MetH. 1 hit.
SMARTiSM01018. B12-binding_2. 1 hit.
[Graphical view]
SUPFAMiSSF47644. SSF47644. 1 hit.
SSF51717. SSF51717. 1 hit.
SSF52242. SSF52242. 1 hit.
SSF56507. SSF56507. 1 hit.
SSF82282. SSF82282. 1 hit.
TIGRFAMsiTIGR02082. metH. 1 hit.
PROSITEiPS50974. ADOMET_ACTIVATION. 1 hit.
PS51332. B12_BINDING. 1 hit.
PS51337. B12_BINDING_NTER. 1 hit.
PS50970. HCY. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q01C49-1 [UniParc]FASTAAdd to Basket

« Hide

XXADATERML EFAATLDPKS KPTQLRRLGA EPPAPKFEAQ PKQNYSSENK     50
IAPKKASELL PVPTYKEFVD PMKKSPAFDV IEGIMAKRVM VIDGAMGTAV 100
QRYKLTEDDF RGERYKEHTH DLKGNNDILV LTRPDVIGEI HEAYLAAGAD 150
IIETNTFSST MIAQADYELD KKNEVRDMNI AAARLAKAAC EKFTKQNPDK 200
PRFAAGAIGP TNRTLSVSPS VENPAFRACT FDEIVDGYYD QIEALVEGGV 250
DMLLVETIFD TLNAKAAIFA IEKFFDAYGT RLPLFVSGTI VDNSGRTLSG 300
QTNEAFWNSV MHAKPMAIGL NCALGAKDMV PYIENLSKCA DCWVFAYPNA 350
GLPNAMGGYD QKGAEMAEDC RVFLEKGLLN GIGGCCGTTD EHIGALADMV 400
APYTPRKKHG IPDIMRLSGL EPFNYSPDEK DYRKTFINLG ERCNVAGSTI 450
FKKAIVDGDF EKALAIALKQ VENGAHVIDI NMDDGLIDGE SAMTRFVNLL 500
VSEPDASKVP FMIDSSKFHV VEAGLKCSQG KCIMNSISLK GGEEEFLKHA 550
RIVKRHGAAV VVMAFDEAGQ AATEAEKIRI CCRAYKLLVE EVGFNPQDII 600
FDPNILTIGT GMEEHNNYAV DFINATREIK RLCPGCKISG GVSNLAFSFR 650
GNEPVRRAFH SAFLYHACKA GMDMGIVNAA QELLEYVEDV LLNRCTNATE 700
RMLEFAATLD PKSKPTELRK KGVAATSKKT AGSGKEWRNQ PAEKRLEYAL 750
IKGIDEFCIA DTEECRIGGK YSSCLEVIEG PLMDGMNIVG DLFGAGKMFL 800
PQVIKSARVM KKAVGHLIPF MDAEKAATGS TEASTAGTFL IATVKGDVHD 850
IGKNIVAVVL GCNNFKVVDI GVMCPCEKIL DAVVEHKADI LGLSGLITPS 900
LDEMVTVAKE MEKRGMKLPL LIGGATTSKM HTAVKLTPNY SGGVIHVLDA 950
SRAVPVAQTL LDDRKNVDFL DDINETYAEM REEFYAGLED RKYLTLEKAR 1000
ATVQPVDFTV APNIPVTPKF CGAKSVEVSI DDVLPYIDWN PFFQVWQLRG 1050
RYPNRGYPKI FNDETVGSEA KKLFNEANAM IQKIKENKRL TLKGIYGFYP 1100
ANSVGDDIVV YTDETRSTPQ HTFFTLRQQA EKDTDEPYMA LSDFIAPKSS 1150
GVKDYLGMFV CSAGFGLDEL TAEYKAANDD YSYIMAEALA DRLAEAFAEL 1200
LHEQVRKDHW GYAKDEAFSC DDLLKVKYQG IRPAPGYPSQ PDHTEKATMW 1250
DLMKVKEEIG VELTETFAML PSASVSGLYF AGACSQYFNV GKITADQVTE 1300
YADRKKMDLS EAQRWLGPNL SYEP 1324
Length:1,324
Mass (Da):145,764
Last modified:November 14, 2006 - v1
Checksum:i5A01F66A6FAB5326
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1324 – 13241Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CAID01000003 Genomic DNA. Translation: CAL53105.1.
RefSeqiXP_003078364.1. XM_003078316.1.

Genome annotation databases

GeneIDi9833122.
KEGGiota:Ot03g04540.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CAID01000003 Genomic DNA. Translation: CAL53105.1 .
RefSeqi XP_003078364.1. XM_003078316.1.

3D structure databases

ProteinModelPortali Q01C49.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 70448.Q01C49.

Proteomic databases

PRIDEi Q01C49.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9833122.
KEGGi ota:Ot03g04540.

Phylogenomic databases

eggNOGi COG1410.
HOGENOMi HOG000251409.
KOi K00548.
OMAi LTEHYAM.

Family and domain databases

Gene3Di 1.10.1240.10. 1 hit.
3.10.196.10. 1 hit.
3.20.20.20. 1 hit.
3.20.20.330. 1 hit.
3.40.50.280. 1 hit.
InterProi IPR003759. Cbl-bd_cap.
IPR006158. Cobalamin-bd.
IPR011005. Dihydropteroate_synth-like.
IPR011822. MetH.
IPR000489. Pterin-binding.
IPR003726. S_MeTrfase.
IPR004223. VitB12-dep_Met_synth_activ_dom.
[Graphical view ]
Pfami PF02310. B12-binding. 1 hit.
PF02607. B12-binding_2. 1 hit.
PF02965. Met_synt_B12. 1 hit.
PF00809. Pterin_bind. 1 hit.
PF02574. S-methyl_trans. 1 hit.
[Graphical view ]
PIRSFi PIRSF000381. MetH. 1 hit.
SMARTi SM01018. B12-binding_2. 1 hit.
[Graphical view ]
SUPFAMi SSF47644. SSF47644. 1 hit.
SSF51717. SSF51717. 1 hit.
SSF52242. SSF52242. 1 hit.
SSF56507. SSF56507. 1 hit.
SSF82282. SSF82282. 1 hit.
TIGRFAMsi TIGR02082. metH. 1 hit.
PROSITEi PS50974. ADOMET_ACTIVATION. 1 hit.
PS51332. B12_BINDING. 1 hit.
PS51337. B12_BINDING_NTER. 1 hit.
PS50970. HCY. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OTTH0595.

Entry informationi

Entry nameiQ01C49_OSTTA
AccessioniPrimary (citable) accession number: Q01C49
Entry historyi
Integrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: July 9, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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