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Q01C49

- Q01C49_OSTTA

UniProt

Q01C49 - Q01C49_OSTTA

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Protein
Submitted name:

Cobalamin-dependent methionine synthase (ISS)

Gene

Ot03g04540

Organism
Ostreococcus tauri
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Cofactori

Binds 1 zinc ion per subunit.UniRule annotation
Cobalamin.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi322 – 3221ZincUniRule annotation
Metal bindingi385 – 3851ZincUniRule annotation
Metal bindingi386 – 3861ZincUniRule annotation
Metal bindingi849 – 8491Cobalt (cobalamin axial ligand)UniRule annotation
Binding sitei1038 – 10381S-adenosyl-L-methionineUniRule annotation
Binding sitei1232 – 12321S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Binding sitei1236 – 12361Cobalamin; via carbonyl oxygenUniRule annotation

GO - Molecular functioni

  1. cobalamin binding Source: UniProtKB-KW
  2. methionine synthase activity Source: InterPro
  3. S-adenosylmethionine-homocysteine S-methyltransferase activity Source: InterPro
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. pteridine-containing compound metabolic process Source: InterPro
Complete GO annotation...

Keywords - Ligandi

CobalaminUniRule annotation, Cobalt, Metal-bindingUniRule annotation, S-adenosyl-L-methionineUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Cobalamin-dependent methionine synthase (ISS)Imported
Gene namesi
Ordered Locus Names:Ot03g04540Imported
OrganismiOstreococcus tauriImported
Taxonomic identifieri70448 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeChlorophytaprasinophytesMamiellophyceaeMamiellalesBathycoccaceaeOstreococcus
ProteomesiUP000009170: Chromosome 19

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ01C49.

Interactioni

Protein-protein interaction databases

STRINGi70448.Q01C49.

Structurei

3D structure databases

ProteinModelPortaliQ01C49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni924 – 9252Cobalamin-bindingUniRule annotation
Regioni1287 – 12882S-adenosyl-L-methionine bindingUniRule annotation

Phylogenomic databases

eggNOGiCOG1410.
HOGENOMiHOG000251409.
InParanoidiQ01C49.
KOiK00548.
OMAiLTEHYAM.

Family and domain databases

Gene3Di1.10.1240.10. 1 hit.
3.10.196.10. 1 hit.
3.20.20.20. 1 hit.
3.20.20.330. 1 hit.
3.40.50.280. 1 hit.
InterProiIPR003759. Cbl-bd_cap.
IPR006158. Cobalamin-bd.
IPR011005. Dihydropteroate_synth-like.
IPR011822. MetH.
IPR000489. Pterin-binding.
IPR003726. S_MeTrfase.
IPR004223. VitB12-dep_Met_synth_activ_dom.
[Graphical view]
PfamiPF02310. B12-binding. 1 hit.
PF02607. B12-binding_2. 1 hit.
PF02965. Met_synt_B12. 1 hit.
PF00809. Pterin_bind. 1 hit.
PF02574. S-methyl_trans. 1 hit.
[Graphical view]
PIRSFiPIRSF000381. MetH. 1 hit.
SMARTiSM01018. B12-binding_2. 1 hit.
[Graphical view]
SUPFAMiSSF47644. SSF47644. 1 hit.
SSF51717. SSF51717. 1 hit.
SSF52242. SSF52242. 1 hit.
SSF56507. SSF56507. 1 hit.
SSF82282. SSF82282. 1 hit.
TIGRFAMsiTIGR02082. metH. 1 hit.
PROSITEiPS50974. ADOMET_ACTIVATION. 1 hit.
PS51332. B12_BINDING. 1 hit.
PS51337. B12_BINDING_NTER. 1 hit.
PS50970. HCY. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q01C49-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
XXADATERML EFAATLDPKS KPTQLRRLGA EPPAPKFEAQ PKQNYSSENK
60 70 80 90 100
IAPKKASELL PVPTYKEFVD PMKKSPAFDV IEGIMAKRVM VIDGAMGTAV
110 120 130 140 150
QRYKLTEDDF RGERYKEHTH DLKGNNDILV LTRPDVIGEI HEAYLAAGAD
160 170 180 190 200
IIETNTFSST MIAQADYELD KKNEVRDMNI AAARLAKAAC EKFTKQNPDK
210 220 230 240 250
PRFAAGAIGP TNRTLSVSPS VENPAFRACT FDEIVDGYYD QIEALVEGGV
260 270 280 290 300
DMLLVETIFD TLNAKAAIFA IEKFFDAYGT RLPLFVSGTI VDNSGRTLSG
310 320 330 340 350
QTNEAFWNSV MHAKPMAIGL NCALGAKDMV PYIENLSKCA DCWVFAYPNA
360 370 380 390 400
GLPNAMGGYD QKGAEMAEDC RVFLEKGLLN GIGGCCGTTD EHIGALADMV
410 420 430 440 450
APYTPRKKHG IPDIMRLSGL EPFNYSPDEK DYRKTFINLG ERCNVAGSTI
460 470 480 490 500
FKKAIVDGDF EKALAIALKQ VENGAHVIDI NMDDGLIDGE SAMTRFVNLL
510 520 530 540 550
VSEPDASKVP FMIDSSKFHV VEAGLKCSQG KCIMNSISLK GGEEEFLKHA
560 570 580 590 600
RIVKRHGAAV VVMAFDEAGQ AATEAEKIRI CCRAYKLLVE EVGFNPQDII
610 620 630 640 650
FDPNILTIGT GMEEHNNYAV DFINATREIK RLCPGCKISG GVSNLAFSFR
660 670 680 690 700
GNEPVRRAFH SAFLYHACKA GMDMGIVNAA QELLEYVEDV LLNRCTNATE
710 720 730 740 750
RMLEFAATLD PKSKPTELRK KGVAATSKKT AGSGKEWRNQ PAEKRLEYAL
760 770 780 790 800
IKGIDEFCIA DTEECRIGGK YSSCLEVIEG PLMDGMNIVG DLFGAGKMFL
810 820 830 840 850
PQVIKSARVM KKAVGHLIPF MDAEKAATGS TEASTAGTFL IATVKGDVHD
860 870 880 890 900
IGKNIVAVVL GCNNFKVVDI GVMCPCEKIL DAVVEHKADI LGLSGLITPS
910 920 930 940 950
LDEMVTVAKE MEKRGMKLPL LIGGATTSKM HTAVKLTPNY SGGVIHVLDA
960 970 980 990 1000
SRAVPVAQTL LDDRKNVDFL DDINETYAEM REEFYAGLED RKYLTLEKAR
1010 1020 1030 1040 1050
ATVQPVDFTV APNIPVTPKF CGAKSVEVSI DDVLPYIDWN PFFQVWQLRG
1060 1070 1080 1090 1100
RYPNRGYPKI FNDETVGSEA KKLFNEANAM IQKIKENKRL TLKGIYGFYP
1110 1120 1130 1140 1150
ANSVGDDIVV YTDETRSTPQ HTFFTLRQQA EKDTDEPYMA LSDFIAPKSS
1160 1170 1180 1190 1200
GVKDYLGMFV CSAGFGLDEL TAEYKAANDD YSYIMAEALA DRLAEAFAEL
1210 1220 1230 1240 1250
LHEQVRKDHW GYAKDEAFSC DDLLKVKYQG IRPAPGYPSQ PDHTEKATMW
1260 1270 1280 1290 1300
DLMKVKEEIG VELTETFAML PSASVSGLYF AGACSQYFNV GKITADQVTE
1310 1320
YADRKKMDLS EAQRWLGPNL SYEP
Length:1,324
Mass (Da):145,764
Last modified:November 14, 2006 - v1
Checksum:i5A01F66A6FAB5326
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1324 – 13241Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CAID01000003 Genomic DNA. Translation: CAL53105.1.
RefSeqiXP_003078364.1. XM_003078316.1.

Genome annotation databases

GeneIDi9833122.
KEGGiota:Ot03g04540.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CAID01000003 Genomic DNA. Translation: CAL53105.1 .
RefSeqi XP_003078364.1. XM_003078316.1.

3D structure databases

ProteinModelPortali Q01C49.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 70448.Q01C49.

Proteomic databases

PRIDEi Q01C49.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9833122.
KEGGi ota:Ot03g04540.

Phylogenomic databases

eggNOGi COG1410.
HOGENOMi HOG000251409.
InParanoidi Q01C49.
KOi K00548.
OMAi LTEHYAM.

Family and domain databases

Gene3Di 1.10.1240.10. 1 hit.
3.10.196.10. 1 hit.
3.20.20.20. 1 hit.
3.20.20.330. 1 hit.
3.40.50.280. 1 hit.
InterProi IPR003759. Cbl-bd_cap.
IPR006158. Cobalamin-bd.
IPR011005. Dihydropteroate_synth-like.
IPR011822. MetH.
IPR000489. Pterin-binding.
IPR003726. S_MeTrfase.
IPR004223. VitB12-dep_Met_synth_activ_dom.
[Graphical view ]
Pfami PF02310. B12-binding. 1 hit.
PF02607. B12-binding_2. 1 hit.
PF02965. Met_synt_B12. 1 hit.
PF00809. Pterin_bind. 1 hit.
PF02574. S-methyl_trans. 1 hit.
[Graphical view ]
PIRSFi PIRSF000381. MetH. 1 hit.
SMARTi SM01018. B12-binding_2. 1 hit.
[Graphical view ]
SUPFAMi SSF47644. SSF47644. 1 hit.
SSF51717. SSF51717. 1 hit.
SSF52242. SSF52242. 1 hit.
SSF56507. SSF56507. 1 hit.
SSF82282. SSF82282. 1 hit.
TIGRFAMsi TIGR02082. metH. 1 hit.
PROSITEi PS50974. ADOMET_ACTIVATION. 1 hit.
PS51332. B12_BINDING. 1 hit.
PS51337. B12_BINDING_NTER. 1 hit.
PS50970. HCY. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OTTH0595Imported.

Entry informationi

Entry nameiQ01C49_OSTTA
AccessioniPrimary (citable) accession number: Q01C49
Entry historyi
Integrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: October 29, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3