Q01999 (TRPC_LACLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	LL1467
ORF Names:	L0051

Organism

Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis) [Reference proteome] [HAMAP]

Taxonomic identifier

272623 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Lactococcus › Lactococcus lactis › Lactococcus lactis subsp. lactis

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP-Rule MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP-Rule MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	tryptophan biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	Indole-3-glycerol phosphate synthase HAMAP-Rule MF_00134_B		PRO_0000154225

Sequences

	Sequence		Length	Mass (Da)
	Q01999 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: E7096EE9FA662535	FASTA	264	29,732
	10 20 30 40 50 60 MNIKKGKFLE TILAEKRLEI AKMPEEQVGK VRQTYNFYDY LKEHSDQLQV IAEVKKASPS 70 80 90 100 110 120 LGDINLEVDI VDQAKNYEQA GAAMISVLTD PVFFKGNIEY LCEISENVQI PTLNKDFIID 130 140 150 160 170 180 KKQINRAVNA GATVILLIVA VFENQYPKLQ NLYNYALSLG LEVLVETHNK AELEIAHQLG 190 200 210 220 230 240 AKIIGVNNRN LKTFEVILQN SVDLTPYFKE DSIYISESGI FSANEAQKVS DTFNGILVGT 250 260 ALMQSENLEK SLKDLKVKRK TNEN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Tryptophan biosynthesis genes in Lactococcus lactis subsp. lactis." Bardowski J., Ehrlich S.D., Chopin A. J. Bacteriol. 174:6563-6570(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: IL1403.
[2]	"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403." Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A. Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IL1403.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M87483 Genomic DNA. Translation: AAA25226.1. AE005176 Genomic DNA. Translation: AAK05565.1.
PIR	S35127.
RefSeq	NP_267623.1. NC_002662.1.
3D structure databases
ProteinModelPortal	Q01999.
ModBase	Search...
Protein-protein interaction databases
STRING	272623.L0051.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAK05565; AAK05565; L0051.
GeneID	1115124.
KEGG	lla:L0051.
PATRIC	22295340. VBILacLac136773_1577.
Phylogenomic databases
eggNOG	COG0134.
KO	K01609.
OMA	EKHGAAC.
ProtClustDB	PRK00278.
Enzyme and pathway databases
BioCyc	LLAC272623:GHSH-1604-MONOMER.
UniPathway	UPA00035; UER00043.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
HAMAP	MF_00134_B. IGPS_B.
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_LACLA

Accession

Primary (citable) accession number: Q01999

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program