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Protein

Transgelin

Gene

TAGLN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.By similarity

GO - Biological processi

  1. epithelial cell differentiation Source: UniProtKB
  2. muscle organ development Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transgelin
Alternative name(s):
22 kDa actin-binding protein
Protein WS3-10
Smooth muscle protein 22-alpha
Short name:
SM22-alpha
Gene namesi
Name:TAGLN
Synonyms:SM22, WS3-10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:11553. TAGLN.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36324.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 201200TransgelinPRO_0000204781Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei166 – 1661Phosphoserine1 Publication
Modified residuei172 – 1721N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ01995.
PaxDbiQ01995.
PeptideAtlasiQ01995.
PRIDEiQ01995.

2D gel databases

REPRODUCTION-2DPAGEIPI00216138.
UCD-2DPAGEQ01995.

PTM databases

PhosphoSiteiQ01995.

Expressioni

Inductioni

Overexpressed in senescent human fibroblasts.

Gene expression databases

BgeeiQ01995.
CleanExiHS_TAGLN.
ExpressionAtlasiQ01995. baseline and differential.
GenevestigatoriQ01995.

Organism-specific databases

HPAiCAB001447.
HPA019467.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
IGF1RP080692EBI-1054248,EBI-475981

Protein-protein interaction databases

BioGridi112739. 21 interactions.
IntActiQ01995. 2 interactions.
MINTiMINT-2805284.
STRINGi9606.ENSP00000278968.

Structurei

3D structure databases

ProteinModelPortaliQ01995.
SMRiQ01995. Positions 24-154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 137114CHPROSITE-ProRule annotationAdd
BLAST
Repeati175 – 20026Calponin-likeAdd
BLAST

Sequence similaritiesi

Belongs to the calponin family.Curated
Contains 1 calponin-like repeat.PROSITE-ProRule annotation
Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5199.
HOGENOMiHOG000232113.
HOVERGENiHBG005186.
InParanoidiQ01995.
OMAiVEWIVVQ.
OrthoDBiEOG718KD9.
PhylomeDBiQ01995.
TreeFamiTF313921.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
InterProiIPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR003096. SM22_calponin.
IPR029976. TAGLN.
[Graphical view]
PANTHERiPTHR18959:SF40. PTHR18959:SF40. 1 hit.
PfamiPF00402. Calponin. 1 hit.
PF00307. CH. 1 hit.
[Graphical view]
PRINTSiPR00888. SM22CALPONIN.
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS01052. CALPONIN_1. 1 hit.
PS51122. CALPONIN_2. 1 hit.
PS50021. CH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01995-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANKGPSYGM SREVQSKIEK KYDEELEERL VEWIIVQCGP DVGRPDRGRL
60 70 80 90 100
GFQVWLKNGV ILSKLVNSLY PDGSKPVKVP ENPPSMVFKQ MEQVAQFLKA
110 120 130 140 150
AEDYGVIKTD MFQTVDLFEG KDMAAVQRTL MALGSLAVTK NDGHYRGDPN
160 170 180 190 200
WFMKKAQEHK REFTESQLQE GKHVIGLQMG SNRGASQAGM TGYGRPRQII

S
Length:201
Mass (Da):22,611
Last modified:January 23, 2007 - v4
Checksum:i7AE9E7A9A45602C3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti49 – 491R → P in AAA58351. (PubMed:1520290)Curated
Sequence conflicti72 – 721D → E in AAA58375. (PubMed:1872880)Curated
Sequence conflicti104 – 1041Y → C in AAA58375. (PubMed:1872880)Curated
Sequence conflicti104 – 1041Y → S in AAA58351. (PubMed:1520290)Curated
Sequence conflicti179 – 1791M → V in AAA58375. (PubMed:1872880)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti182 – 1821N → S.
Corresponds to variant rs12284316 [ dbSNP | Ensembl ].
VAR_048670

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95787 mRNA. Translation: AAA58351.1.
M83106 mRNA. Translation: AAA58375.1.
AF013711 Genomic DNA. Translation: AAC21582.1.
D17409 mRNA. Translation: BAA21811.1.
D84342 Genomic DNA. Translation: BAA21839.1.
BC004927 mRNA. Translation: AAH04927.1.
BC065829 mRNA. Translation: AAH65829.1.
CCDSiCCDS8381.1.
PIRiJC5577. JS0774.
RefSeqiNP_001001522.1. NM_001001522.1.
NP_003177.2. NM_003186.3.
UniGeneiHs.410977.

Genome annotation databases

EnsembliENST00000278968; ENSP00000278968; ENSG00000149591.
ENST00000392951; ENSP00000376678; ENSG00000149591.
ENST00000525531; ENSP00000432054; ENSG00000149591.
ENST00000530649; ENSP00000431941; ENSG00000149591.
ENST00000532870; ENSP00000432282; ENSG00000149591.
GeneIDi6876.
KEGGihsa:6876.
UCSCiuc001pqm.3. human.

Polymorphism databases

DMDMi3123283.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95787 mRNA. Translation: AAA58351.1.
M83106 mRNA. Translation: AAA58375.1.
AF013711 Genomic DNA. Translation: AAC21582.1.
D17409 mRNA. Translation: BAA21811.1.
D84342 Genomic DNA. Translation: BAA21839.1.
BC004927 mRNA. Translation: AAH04927.1.
BC065829 mRNA. Translation: AAH65829.1.
CCDSiCCDS8381.1.
PIRiJC5577. JS0774.
RefSeqiNP_001001522.1. NM_001001522.1.
NP_003177.2. NM_003186.3.
UniGeneiHs.410977.

3D structure databases

ProteinModelPortaliQ01995.
SMRiQ01995. Positions 24-154.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112739. 21 interactions.
IntActiQ01995. 2 interactions.
MINTiMINT-2805284.
STRINGi9606.ENSP00000278968.

PTM databases

PhosphoSiteiQ01995.

Polymorphism databases

DMDMi3123283.

2D gel databases

REPRODUCTION-2DPAGEIPI00216138.
UCD-2DPAGEQ01995.

Proteomic databases

MaxQBiQ01995.
PaxDbiQ01995.
PeptideAtlasiQ01995.
PRIDEiQ01995.

Protocols and materials databases

DNASUi6876.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278968; ENSP00000278968; ENSG00000149591.
ENST00000392951; ENSP00000376678; ENSG00000149591.
ENST00000525531; ENSP00000432054; ENSG00000149591.
ENST00000530649; ENSP00000431941; ENSG00000149591.
ENST00000532870; ENSP00000432282; ENSG00000149591.
GeneIDi6876.
KEGGihsa:6876.
UCSCiuc001pqm.3. human.

Organism-specific databases

CTDi6876.
GeneCardsiGC11P117070.
HGNCiHGNC:11553. TAGLN.
HPAiCAB001447.
HPA019467.
MIMi600818. gene.
neXtProtiNX_Q01995.
PharmGKBiPA36324.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5199.
HOGENOMiHOG000232113.
HOVERGENiHBG005186.
InParanoidiQ01995.
OMAiVEWIVVQ.
OrthoDBiEOG718KD9.
PhylomeDBiQ01995.
TreeFamiTF313921.

Miscellaneous databases

ChiTaRSiTAGLN. human.
GeneWikiiTAGLN.
GenomeRNAii6876.
NextBioi26849.
PROiQ01995.
SOURCEiSearch...

Gene expression databases

BgeeiQ01995.
CleanExiHS_TAGLN.
ExpressionAtlasiQ01995. baseline and differential.
GenevestigatoriQ01995.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
InterProiIPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR003096. SM22_calponin.
IPR029976. TAGLN.
[Graphical view]
PANTHERiPTHR18959:SF40. PTHR18959:SF40. 1 hit.
PfamiPF00402. Calponin. 1 hit.
PF00307. CH. 1 hit.
[Graphical view]
PRINTSiPR00888. SM22CALPONIN.
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS01052. CALPONIN_1. 1 hit.
PS51122. CALPONIN_2. 1 hit.
PS50021. CH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel gene encoding a smooth muscle protein is overexpressed in senescent human fibroblasts."
    Thweatt R., Lumpkin C.K. Jr., Goldstein S.
    Biochem. Biophys. Res. Commun. 187:1-7(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fibroblast.
  2. "Gene cloning and nucleotide sequence of SM22 alpha from the chicken gizzard smooth muscle."
    Nishida W., Kitami Y., Abe M., Kiwada K.
    Biochem. Int. 23:663-668(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Structure and expression of the human SM22alpha gene, assignment of the gene to chromosome 11, and repression of the promoter activity by cytosine DNA methylation."
    Yamamura H., Masuda H., Ikeda W., Tokuyama T., Takagi M., Shibata N., Tatsuta M., Takahashi K.
    J. Biochem. 122:157-167(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Aorta and Peripheral blood.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTAGL_HUMAN
AccessioniPrimary (citable) accession number: Q01995
Secondary accession number(s): O15542
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: January 7, 2015
This is version 146 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.