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Q01995

- TAGL_HUMAN

UniProt

Q01995 - TAGL_HUMAN

Protein

Transgelin

Gene

TAGLN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 144 (01 Oct 2014)
      Sequence version 4 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Actin cross-linking/gelling protein By similarity. Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. epithelial cell differentiation Source: UniProt
    2. muscle organ development Source: ProtInc

    Keywords - Molecular functioni

    Muscle protein

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transgelin
    Alternative name(s):
    22 kDa actin-binding protein
    Protein WS3-10
    Smooth muscle protein 22-alpha
    Short name:
    SM22-alpha
    Gene namesi
    Name:TAGLN
    Synonyms:SM22, WS3-10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:11553. TAGLN.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36324.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 201200TransgelinPRO_0000204781Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei166 – 1661Phosphoserine1 Publication
    Modified residuei172 – 1721N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ01995.
    PaxDbiQ01995.
    PeptideAtlasiQ01995.
    PRIDEiQ01995.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00216138.
    UCD-2DPAGEQ01995.

    PTM databases

    PhosphoSiteiQ01995.

    Expressioni

    Inductioni

    Overexpressed in senescent human fibroblasts.

    Gene expression databases

    ArrayExpressiQ01995.
    BgeeiQ01995.
    CleanExiHS_TAGLN.
    GenevestigatoriQ01995.

    Organism-specific databases

    HPAiCAB001447.
    HPA019467.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    IGF1RP080692EBI-1054248,EBI-475981

    Protein-protein interaction databases

    BioGridi112739. 21 interactions.
    IntActiQ01995. 2 interactions.
    MINTiMINT-2805284.
    STRINGi9606.ENSP00000278968.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01995.
    SMRiQ01995. Positions 24-154.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 137114CHPROSITE-ProRule annotationAdd
    BLAST
    Repeati175 – 20026Calponin-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the calponin family.Curated
    Contains 1 calponin-like repeat.PROSITE-ProRule annotation
    Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5199.
    HOGENOMiHOG000232113.
    HOVERGENiHBG005186.
    InParanoidiQ01995.
    OMAiVEWIVVQ.
    OrthoDBiEOG718KD9.
    PhylomeDBiQ01995.
    TreeFamiTF313921.

    Family and domain databases

    Gene3Di1.10.418.10. 1 hit.
    InterProiIPR000557. Calponin_repeat.
    IPR001715. CH-domain.
    IPR003096. SM22_calponin.
    [Graphical view]
    PfamiPF00402. Calponin. 1 hit.
    PF00307. CH. 1 hit.
    [Graphical view]
    PRINTSiPR00888. SM22CALPONIN.
    SMARTiSM00033. CH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47576. SSF47576. 1 hit.
    PROSITEiPS01052. CALPONIN_1. 1 hit.
    PS51122. CALPONIN_2. 1 hit.
    PS50021. CH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q01995-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANKGPSYGM SREVQSKIEK KYDEELEERL VEWIIVQCGP DVGRPDRGRL    50
    GFQVWLKNGV ILSKLVNSLY PDGSKPVKVP ENPPSMVFKQ MEQVAQFLKA 100
    AEDYGVIKTD MFQTVDLFEG KDMAAVQRTL MALGSLAVTK NDGHYRGDPN 150
    WFMKKAQEHK REFTESQLQE GKHVIGLQMG SNRGASQAGM TGYGRPRQII 200
    S 201
    Length:201
    Mass (Da):22,611
    Last modified:January 23, 2007 - v4
    Checksum:i7AE9E7A9A45602C3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti49 – 491R → P in AAA58351. (PubMed:1520290)Curated
    Sequence conflicti72 – 721D → E in AAA58375. (PubMed:1872880)Curated
    Sequence conflicti104 – 1041Y → C in AAA58375. (PubMed:1872880)Curated
    Sequence conflicti104 – 1041Y → S in AAA58351. (PubMed:1520290)Curated
    Sequence conflicti179 – 1791M → V in AAA58375. (PubMed:1872880)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti182 – 1821N → S.
    Corresponds to variant rs12284316 [ dbSNP | Ensembl ].
    VAR_048670

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M95787 mRNA. Translation: AAA58351.1.
    M83106 mRNA. Translation: AAA58375.1.
    AF013711 Genomic DNA. Translation: AAC21582.1.
    D17409 mRNA. Translation: BAA21811.1.
    D84342 Genomic DNA. Translation: BAA21839.1.
    BC004927 mRNA. Translation: AAH04927.1.
    BC065829 mRNA. Translation: AAH65829.1.
    CCDSiCCDS8381.1.
    PIRiJC5577. JS0774.
    RefSeqiNP_001001522.1. NM_001001522.1.
    NP_003177.2. NM_003186.3.
    UniGeneiHs.410977.

    Genome annotation databases

    EnsembliENST00000278968; ENSP00000278968; ENSG00000149591.
    ENST00000392951; ENSP00000376678; ENSG00000149591.
    ENST00000525531; ENSP00000432054; ENSG00000149591.
    ENST00000530649; ENSP00000431941; ENSG00000149591.
    ENST00000532870; ENSP00000432282; ENSG00000149591.
    GeneIDi6876.
    KEGGihsa:6876.
    UCSCiuc001pqm.3. human.

    Polymorphism databases

    DMDMi3123283.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M95787 mRNA. Translation: AAA58351.1 .
    M83106 mRNA. Translation: AAA58375.1 .
    AF013711 Genomic DNA. Translation: AAC21582.1 .
    D17409 mRNA. Translation: BAA21811.1 .
    D84342 Genomic DNA. Translation: BAA21839.1 .
    BC004927 mRNA. Translation: AAH04927.1 .
    BC065829 mRNA. Translation: AAH65829.1 .
    CCDSi CCDS8381.1.
    PIRi JC5577. JS0774.
    RefSeqi NP_001001522.1. NM_001001522.1.
    NP_003177.2. NM_003186.3.
    UniGenei Hs.410977.

    3D structure databases

    ProteinModelPortali Q01995.
    SMRi Q01995. Positions 24-154.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112739. 21 interactions.
    IntActi Q01995. 2 interactions.
    MINTi MINT-2805284.
    STRINGi 9606.ENSP00000278968.

    PTM databases

    PhosphoSitei Q01995.

    Polymorphism databases

    DMDMi 3123283.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00216138.
    UCD-2DPAGE Q01995.

    Proteomic databases

    MaxQBi Q01995.
    PaxDbi Q01995.
    PeptideAtlasi Q01995.
    PRIDEi Q01995.

    Protocols and materials databases

    DNASUi 6876.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000278968 ; ENSP00000278968 ; ENSG00000149591 .
    ENST00000392951 ; ENSP00000376678 ; ENSG00000149591 .
    ENST00000525531 ; ENSP00000432054 ; ENSG00000149591 .
    ENST00000530649 ; ENSP00000431941 ; ENSG00000149591 .
    ENST00000532870 ; ENSP00000432282 ; ENSG00000149591 .
    GeneIDi 6876.
    KEGGi hsa:6876.
    UCSCi uc001pqm.3. human.

    Organism-specific databases

    CTDi 6876.
    GeneCardsi GC11P117070.
    HGNCi HGNC:11553. TAGLN.
    HPAi CAB001447.
    HPA019467.
    MIMi 600818. gene.
    neXtProti NX_Q01995.
    PharmGKBi PA36324.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5199.
    HOGENOMi HOG000232113.
    HOVERGENi HBG005186.
    InParanoidi Q01995.
    OMAi VEWIVVQ.
    OrthoDBi EOG718KD9.
    PhylomeDBi Q01995.
    TreeFami TF313921.

    Miscellaneous databases

    ChiTaRSi TAGLN. human.
    GeneWikii TAGLN.
    GenomeRNAii 6876.
    NextBioi 26849.
    PROi Q01995.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q01995.
    Bgeei Q01995.
    CleanExi HS_TAGLN.
    Genevestigatori Q01995.

    Family and domain databases

    Gene3Di 1.10.418.10. 1 hit.
    InterProi IPR000557. Calponin_repeat.
    IPR001715. CH-domain.
    IPR003096. SM22_calponin.
    [Graphical view ]
    Pfami PF00402. Calponin. 1 hit.
    PF00307. CH. 1 hit.
    [Graphical view ]
    PRINTSi PR00888. SM22CALPONIN.
    SMARTi SM00033. CH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47576. SSF47576. 1 hit.
    PROSITEi PS01052. CALPONIN_1. 1 hit.
    PS51122. CALPONIN_2. 1 hit.
    PS50021. CH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel gene encoding a smooth muscle protein is overexpressed in senescent human fibroblasts."
      Thweatt R., Lumpkin C.K. Jr., Goldstein S.
      Biochem. Biophys. Res. Commun. 187:1-7(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fibroblast.
    2. "Gene cloning and nucleotide sequence of SM22 alpha from the chicken gizzard smooth muscle."
      Nishida W., Kitami Y., Abe M., Kiwada K.
      Biochem. Int. 23:663-668(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Structure and expression of the human SM22alpha gene, assignment of the gene to chromosome 11, and repression of the promoter activity by cytosine DNA methylation."
      Yamamura H., Masuda H., Ikeda W., Tokuyama T., Takagi M., Shibata N., Tatsuta M., Takahashi K.
      J. Biochem. 122:157-167(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Tissue: Aorta and Peripheral blood.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTAGL_HUMAN
    AccessioniPrimary (citable) accession number: Q01995
    Secondary accession number(s): O15542
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 144 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3