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Protein

Riboflavin synthase

Gene

ribE

Organism
Photobacterium leiognathi
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.By similarity

Catalytic activityi

2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.

Pathwayi: riboflavin biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 6,7-dimethyl-8-ribityllumazine synthase (ribH), 6,7-dimethyl-8-ribityllumazine synthase (ribH), 6,7-dimethyl-8-ribityllumazine synthase (ribH), 6,7-dimethyl-8-ribityllumazine synthase (ribH), 6,7-dimethyl-8-ribityllumazine synthase (ribH)
  2. Riboflavin synthase (ribE)
This subpathway is part of the pathway riboflavin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil, the pathway riboflavin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei136Lumazine 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processRiboflavin biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00275; UER00405.

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin synthase (EC:2.5.1.9)
Short name:
RS
Gene namesi
Name:ribE
Synonyms:ribB
OrganismiPhotobacterium leiognathi
Taxonomic identifieri553611 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000681701 – 218Riboflavin synthaseAdd BLAST218

Proteomic databases

PRIDEiQ01993.

Interactioni

Subunit structurei

Homotrimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ01993.
SMRiQ01993.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1 – 97Lumazine-binding 1Add BLAST97
Repeati98 – 194Lumazine-binding 2Add BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni4 – 6Lumazine 1 bindingBy similarity3
Regioni48 – 50Lumazine 2 binding; shared with one trimeric partnerBy similarity3
Regioni62 – 67Lumazine 2 binding; shared with one trimeric partnerBy similarity6
Regioni101 – 103Lumazine 2 binding; shared with one trimeric partnerBy similarity3
Regioni145 – 147Lumazine 1 bindingBy similarity3
Regioni159 – 164Lumazine 1 bindingBy similarity6

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di2.40.30.20. 2 hits.
InterProiView protein in InterPro
IPR023366. ATP_synth_asu-like.
IPR001783. Lumazine-bd.
IPR026017. Lumazine-bd_dom.
IPR017938. Riboflavin_synthase-like_b-brl.
PANTHERiPTHR21098. PTHR21098. 1 hit.
PfamiView protein in Pfam
PF00677. Lum_binding. 2 hits.
PIRSFiPIRSF000498. Riboflavin_syn_A. 1 hit.
SUPFAMiSSF63380. SSF63380. 2 hits.
TIGRFAMsiTIGR00187. ribE. 1 hit.
PROSITEiView protein in PROSITE
PS51177. LUMAZINE_BIND. 2 hits.

Sequencei

Sequence statusi: Complete.

Q01993-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTGIIESIG NIGAIIRHNE DLSIVVNTNN LDISDVNIGD SIATNGVCLT
60 70 80 90 100
VSKLLPSGYT ADLSLETYKR TAFHSYRIGQ EVNLEKAMLP TTRLGGHLVS
110 120 130 140 150
GHVDGVGEVI EFKRNGRAIN IWVAVPVQLK KYLSEKGSVT IDGISLTINA
160 170 180 190 200
VYQNVIKLTI VPHTLAETNL VNINIDKKVN VEIDMMARYL EKLIKVDRYE
210
SEKTSNVSMD LERYGFIS
Length:218
Mass (Da):24,095
Last modified:July 1, 1993 - v1
Checksum:iDD0F8996FCC6173E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90094 Genomic DNA. Translation: AAA73228.1.
PIRiJC1187.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90094 Genomic DNA. Translation: AAA73228.1.
PIRiJC1187.

3D structure databases

ProteinModelPortaliQ01993.
SMRiQ01993.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ01993.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00275; UER00405.

Family and domain databases

Gene3Di2.40.30.20. 2 hits.
InterProiView protein in InterPro
IPR023366. ATP_synth_asu-like.
IPR001783. Lumazine-bd.
IPR026017. Lumazine-bd_dom.
IPR017938. Riboflavin_synthase-like_b-brl.
PANTHERiPTHR21098. PTHR21098. 1 hit.
PfamiView protein in Pfam
PF00677. Lum_binding. 2 hits.
PIRSFiPIRSF000498. Riboflavin_syn_A. 1 hit.
SUPFAMiSSF63380. SSF63380. 2 hits.
TIGRFAMsiTIGR00187. ribE. 1 hit.
PROSITEiView protein in PROSITE
PS51177. LUMAZINE_BIND. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiRISA_PHOLE
AccessioniPrimary (citable) accession number: Q01993
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 10, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.