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Protein

Ubiquitin carboxyl-terminal hydrolase 11

Gene

USP11

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks.By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei362NucleophilePROSITE-ProRule annotation1
Active sitei370Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.014.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 11 (EC:3.4.19.12By similarity)
Alternative name(s):
Deubiquitinating enzyme 11
Ubiquitin thioesterase 11
Ubiquitin-specific-processing protease 11
Gene namesi
Name:USP11
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: Predominantly nuclear (By similarity). Associates with chromatin (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000080631‹1 – 445Ubiquitin carboxyl-terminal hydrolase 11Add BLAST›445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei130PhosphoserineBy similarity1
Modified residuei430PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Monomer. Interacts with RANBP9/RANBPM. Interacts with BRCA2. Interacts with CHUK/IKKA. Interacts with NFKBIA.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ01988.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 412USPAdd BLAST412

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

HOGENOMiHOG000264375.
HOVERGENiHBG000864.
InParanoidiQ01988.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q01988-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
NSARADLCVA LAKHTGMSPE RMMVADVFSH RFYKIYQLEE SLSSILDRDD
60 70 80 90 100
IFIYEVSGRS AIGENSREDV VLPIYLRERT PARDYNNSYY GLMLFGHPLL
110 120 130 140 150
VSVPRDRLSW DALYHILLYR LSRYVTRPSS DDEDDGDEKD IEDKDNIPKP
160 170 180 190 200
GHVAGASSQD SGAGSGGAQL WSRRRKPAPV DNSPGPSHWP QRARRKHLFT
210 220 230 240 250
LQTVNSNGTS DRSTFNEDTH AQPYIAIDWE PEMKKRYYDE VEAEGYVKHD
260 270 280 290 300
CVGYVLKKAP VRLQECIELF TTVETLEKEN PWFCPTCKQH QLATKKLDLW
310 320 330 340 350
MLPETLIIHL KRFSYTKFSR EKLDTLVEFP IRDLDFSEFV IKPQNESAPE
360 370 380 390 400
LYKYDLIAVS NHYGGLRDGH YTTFACNKDS GQSDYFDDNS VSPVTENQIE
410 420 430 440
SKAAYVLFYQ RQDVARRLQP QPSSSDPPAS PACGSPPNSE FMDVN
Length:445
Mass (Da):50,892
Last modified:June 1, 1994 - v1
Checksum:iFE921DD1EEAF7C9E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L03387 mRNA. Translation: AAA30875.1.
PIRiPC1174. I46225.
UniGeneiCfa.3886.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L03387 mRNA. Translation: AAA30875.1.
PIRiPC1174. I46225.
UniGeneiCfa.3886.

3D structure databases

ProteinModelPortaliQ01988.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiC19.014.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOGENOMiHOG000264375.
HOVERGENiHBG000864.
InParanoidiQ01988.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBP11_CANLF
AccessioniPrimary (citable) accession number: Q01988
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 13, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to be apomucin (also known as mucin core protein; CTM-A).1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.