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Q01988

- UBP11_CANFA

UniProt

Q01988 - UBP11_CANFA

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Protein

Ubiquitin carboxyl-terminal hydrolase 11

Gene

USP11

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei362 – 3621NucleophilePROSITE-ProRule annotation
Active sitei370 – 3701Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. protein deubiquitination Source: UniProtKB
  2. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.014.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 11 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 11
Ubiquitin thioesterase 11
Ubiquitin-specific-processing protease 11
Gene namesi
Name:USP11
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Unplaced

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity
Note: Predominantly nuclear. Associates with chromatin (By similarity).By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 445›445Ubiquitin carboxyl-terminal hydrolase 11PRO_0000080631Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei130 – 1301PhosphoserineBy similarity
Modified residuei430 – 4301PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with RANBP9/RANBPM. Interacts with BRCA2, CHUK/IKKA and NFKBIA (By similarity).By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000022125.

Structurei

3D structure databases

ProteinModelPortaliQ01988.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 412412USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiCOG5560.
HOGENOMiHOG000264375.
HOVERGENiHBG000864.
InParanoidiQ01988.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q01988-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
NSARADLCVA LAKHTGMSPE RMMVADVFSH RFYKIYQLEE SLSSILDRDD
60 70 80 90 100
IFIYEVSGRS AIGENSREDV VLPIYLRERT PARDYNNSYY GLMLFGHPLL
110 120 130 140 150
VSVPRDRLSW DALYHILLYR LSRYVTRPSS DDEDDGDEKD IEDKDNIPKP
160 170 180 190 200
GHVAGASSQD SGAGSGGAQL WSRRRKPAPV DNSPGPSHWP QRARRKHLFT
210 220 230 240 250
LQTVNSNGTS DRSTFNEDTH AQPYIAIDWE PEMKKRYYDE VEAEGYVKHD
260 270 280 290 300
CVGYVLKKAP VRLQECIELF TTVETLEKEN PWFCPTCKQH QLATKKLDLW
310 320 330 340 350
MLPETLIIHL KRFSYTKFSR EKLDTLVEFP IRDLDFSEFV IKPQNESAPE
360 370 380 390 400
LYKYDLIAVS NHYGGLRDGH YTTFACNKDS GQSDYFDDNS VSPVTENQIE
410 420 430 440
SKAAYVLFYQ RQDVARRLQP QPSSSDPPAS PACGSPPNSE FMDVN
Length:445
Mass (Da):50,892
Last modified:June 1, 1994 - v1
Checksum:iFE921DD1EEAF7C9E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L03387 mRNA. Translation: AAA30875.1.
PIRiPC1174. I46225.
UniGeneiCfa.3886.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L03387 mRNA. Translation: AAA30875.1 .
PIRi PC1174. I46225.
UniGenei Cfa.3886.

3D structure databases

ProteinModelPortali Q01988.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000022125.

Protein family/group databases

MEROPSi C19.014.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG5560.
HOGENOMi HOG000264375.
HOVERGENi HBG000864.
InParanoidi Q01988.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of the carboxy terminus of a canine tracheobronchial mucin."
    Shankar V., Tan S., Gilmore M.S., Sachdev G.P.
    Biochem. Biophys. Res. Commun. 189:958-964(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Trachea.

Entry informationi

Entry nameiUBP11_CANFA
AccessioniPrimary (citable) accession number: Q01988
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 29, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to be apomucin (also known as mucin core protein; CTM-A).1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3