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Q01988

- UBP11_CANFA

UniProt

Q01988 - UBP11_CANFA

Protein

Ubiquitin carboxyl-terminal hydrolase 11

Gene

USP11

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei362 – 3621NucleophilePROSITE-ProRule annotation
    Active sitei370 – 3701Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: UniProtKB

    GO - Biological processi

    1. protein deubiquitination Source: UniProtKB
    2. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 11 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 11
    Ubiquitin thioesterase 11
    Ubiquitin-specific-processing protease 11
    Gene namesi
    Name:USP11
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Unplaced

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity
    Note: Predominantly nuclear. Associates with chromatin By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 445›445Ubiquitin carboxyl-terminal hydrolase 11PRO_0000080631Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei130 – 1301PhosphoserineBy similarity
    Modified residuei430 – 4301PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Interacts with RANBP9/RANBPM. Interacts with BRCA2, CHUK/IKKA and NFKBIA By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000022125.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01988.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 412412USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5560.
    HOGENOMiHOG000264375.
    HOVERGENiHBG000864.
    InParanoidiQ01988.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q01988-1 [UniParc]FASTAAdd to Basket

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    NSARADLCVA LAKHTGMSPE RMMVADVFSH RFYKIYQLEE SLSSILDRDD    50
    IFIYEVSGRS AIGENSREDV VLPIYLRERT PARDYNNSYY GLMLFGHPLL 100
    VSVPRDRLSW DALYHILLYR LSRYVTRPSS DDEDDGDEKD IEDKDNIPKP 150
    GHVAGASSQD SGAGSGGAQL WSRRRKPAPV DNSPGPSHWP QRARRKHLFT 200
    LQTVNSNGTS DRSTFNEDTH AQPYIAIDWE PEMKKRYYDE VEAEGYVKHD 250
    CVGYVLKKAP VRLQECIELF TTVETLEKEN PWFCPTCKQH QLATKKLDLW 300
    MLPETLIIHL KRFSYTKFSR EKLDTLVEFP IRDLDFSEFV IKPQNESAPE 350
    LYKYDLIAVS NHYGGLRDGH YTTFACNKDS GQSDYFDDNS VSPVTENQIE 400
    SKAAYVLFYQ RQDVARRLQP QPSSSDPPAS PACGSPPNSE FMDVN 445
    Length:445
    Mass (Da):50,892
    Last modified:June 1, 1994 - v1
    Checksum:iFE921DD1EEAF7C9E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L03387 mRNA. Translation: AAA30875.1.
    PIRiPC1174. I46225.
    UniGeneiCfa.3886.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L03387 mRNA. Translation: AAA30875.1 .
    PIRi PC1174. I46225.
    UniGenei Cfa.3886.

    3D structure databases

    ProteinModelPortali Q01988.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000022125.

    Protein family/group databases

    MEROPSi C19.014.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG5560.
    HOGENOMi HOG000264375.
    HOVERGENi HBG000864.
    InParanoidi Q01988.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of the carboxy terminus of a canine tracheobronchial mucin."
      Shankar V., Tan S., Gilmore M.S., Sachdev G.P.
      Biochem. Biophys. Res. Commun. 189:958-964(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Trachea.

    Entry informationi

    Entry nameiUBP11_CANFA
    AccessioniPrimary (citable) accession number: Q01988
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    Was originally thought to be apomucin (also known as mucin core protein; CTM-A).1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3