Q01988 (UBP11_CANFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin carboxyl-terminal hydrolase 11
EC=3.4.19.12

Alternative name(s):
Deubiquitinating enzyme 11
Ubiquitin thioesterase 11
Ubiquitin-specific-processing protease 11

Gene names

Name:

USP11

Organism

Canis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › Canis lupus

Protein attributes

Sequence length	445 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks By similarity.
Catalytic activity	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Subunit structure	Interacts with RANBP9/RANBPM. Interacts with BRCA2, CHUK/IKKA and NFKBIA By similarity.
Subcellular location	Nucleus By similarity. Cytoplasm By similarity. Note: Predominantly nuclear. Associates with chromatin By similarity.
Sequence similarities	Belongs to the peptidase C19 family.
Caution	Was originally (Ref.1) thought to be apomucin (also known as mucin core protein; CTM-A).

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Cellular component	Cytoplasm Nucleus
Molecular function	Hydrolase Protease Thiol protease
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein deubiquitination Inferred from sequence or structural similarity. Source: UniProtKB ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	ubiquitin thiolesterase activity Inferred from electronic annotation. Source: InterPro ubiquitin-specific protease activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 445	›445	Ubiquitin carboxyl-terminal hydrolase 11		PRO_0000080631
Sites
	Active site	362	1	Nucleophile By similarity
	Active site	370	1	Proton acceptor By similarity
Amino acid modifications
	Modified residue	130	1	Phosphoserine By similarity
	Modified residue	430	1	Phosphoserine By similarity
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q01988 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: FE921DD1EEAF7C9E	FASTA	445	50,892
	10 20 30 40 50 60 NSARADLCVA LAKHTGMSPE RMMVADVFSH RFYKIYQLEE SLSSILDRDD IFIYEVSGRS 70 80 90 100 110 120 AIGENSREDV VLPIYLRERT PARDYNNSYY GLMLFGHPLL VSVPRDRLSW DALYHILLYR 130 140 150 160 170 180 LSRYVTRPSS DDEDDGDEKD IEDKDNIPKP GHVAGASSQD SGAGSGGAQL WSRRRKPAPV 190 200 210 220 230 240 DNSPGPSHWP QRARRKHLFT LQTVNSNGTS DRSTFNEDTH AQPYIAIDWE PEMKKRYYDE 250 260 270 280 290 300 VEAEGYVKHD CVGYVLKKAP VRLQECIELF TTVETLEKEN PWFCPTCKQH QLATKKLDLW 310 320 330 340 350 360 MLPETLIIHL KRFSYTKFSR EKLDTLVEFP IRDLDFSEFV IKPQNESAPE LYKYDLIAVS 370 380 390 400 410 420 NHYGGLRDGH YTTFACNKDS GQSDYFDDNS VSPVTENQIE SKAAYVLFYQ RQDVARRLQP 430 440 QPSSSDPPAS PACGSPPNSE FMDVN

References

[1]	"Molecular cloning of the carboxy terminus of a canine tracheobronchial mucin." Shankar V., Tan S., Gilmore M.S., Sachdev G.P. Biochem. Biophys. Res. Commun. 189:958-964(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Trachea.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L03387 mRNA. Translation: AAA30875.1.
PIR	I46225. PC1174.
UniGene	Cfa.3886.
3D structure databases
ProteinModelPortal	Q01988.
ModBase	Search...
Protein family/group databases
MEROPS	C19.014.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	COG5560.
HOGENOM	HOG000264375.
HOVERGEN	HBG000864.
InParanoid	Q01988.
OrthoDB	EOG4QRH3H.
Family and domain databases
InterPro	IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. [Graphical view]
Pfam	PF00443. UCH. 1 hit. [Graphical view]
PROSITE	PS00972. UCH_2_1. Partial match. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBP11_CANFA

Accession

Primary (citable) accession number: Q01988

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	April 3, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program