Reviewed, UniProtKB/Swiss-Prot Q01988 (UBP11_CANFA)

Names and origin

Protein names

Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 11
    EC=3.1.2.15
Alternative name(s):
    Ubiquitin thioesterase 11
    Ubiquitin-specific-processing protease 11
    Deubiquitinating enzyme 11

Gene names

Name:

USP11

Organism

Canis familiaris (Dog)

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis

Protein attributes

Sequence length	445 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol.
Sequence similarities	Belongs to the peptidase C19 family.
Caution	Was originally (Ref.1) thought to be apomucin (also known as mucin core protein; CTM-A).

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Molecular function	Hydrolase Protease Thiol protease
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin thiolesterase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 445	›445	Ubiquitin carboxyl-terminal hydrolase 11		PRO_0000080631
Sites
	Active site	362	1	By similarity
	Active site	370	1	By similarity
Amino acid modifications
	Modified residue	430	1	Phosphoserine By similarity
	Modified residue	435	1	Phosphoserine By similarity
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q01988-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: FE921DD1EEAF7C9E	FASTA	445	50,892
	10 20 30 40 50 60 NSARADLCVA LAKHTGMSPE RMMVADVFSH RFYKIYQLEE SLSSILDRDD IFIYEVSGRS 70 80 90 100 110 120 AIGENSREDV VLPIYLRERT PARDYNNSYY GLMLFGHPLL VSVPRDRLSW DALYHILLYR 130 140 150 160 170 180 LSRYVTRPSS DDEDDGDEKD IEDKDNIPKP GHVAGASSQD SGAGSGGAQL WSRRRKPAPV 190 200 210 220 230 240 DNSPGPSHWP QRARRKHLFT LQTVNSNGTS DRSTFNEDTH AQPYIAIDWE PEMKKRYYDE 250 260 270 280 290 300 VEAEGYVKHD CVGYVLKKAP VRLQECIELF TTVETLEKEN PWFCPTCKQH QLATKKLDLW 310 320 330 340 350 360 MLPETLIIHL KRFSYTKFSR EKLDTLVEFP IRDLDFSEFV IKPQNESAPE LYKYDLIAVS 370 380 390 400 410 420 NHYGGLRDGH YTTFACNKDS GQSDYFDDNS VSPVTENQIE SKAAYVLFYQ RQDVARRLQP 430 440 QPSSSDPPAS PACGSPPNSE FMDVN

References

[1]	"Molecular cloning of the carboxy terminus of a canine tracheobronchial mucin." Shankar V., Tan S., Gilmore M.S., Sachdev G.P. Biochem. Biophys. Res. Commun. 189:958-964(1992) [PubMed: 1282002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Trachea.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L03387 mRNA. Translation: AAA30875.1.
PIR	I46225. PC1174.
UniGene	Cfa.3886
3D structure databases
HSSP	HSSP built from PDB template 1NB8 based on UniProtKB Q93009.
ModBase	Search...
Protein family/group databases
MEROPS	C19.014.
Genome annotation databases
Ensembl	ENSCAFT00000023833; ENSCAFP00000022125; ENSCAFG00000015021; Canis familiaris. [Genome view]
Phylogenomic databases
HOVERGEN	Q01988.
Enzyme and pathway databases
BRENDA	3.1.2.15. 463.
Family and domain databases
InterPro	IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. [Graphical view]
Pfam	PF00443. UCH. 1 hit. [Graphical view]
PROSITE	PS00972. UCH_2_1. Partial match. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBP11_CANFA

Accession

Primary (citable) accession number: Q01988

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	July 28, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)