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Q01988 (UBP11_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 11

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 11
Ubiquitin thioesterase 11
Ubiquitin-specific-processing protease 11
Gene names
Name:USP11
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length445 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

Interacts with RANBP9/RANBPM. Interacts with BRCA2, CHUK/IKKA and NFKBIA By similarity.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity. Note: Predominantly nuclear. Associates with chromatin By similarity.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Caution

Was originally (Ref.1) thought to be apomucin (also known as mucin core protein; CTM-A).

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 445›445Ubiquitin carboxyl-terminal hydrolase 11
PRO_0000080631

Regions

Domain1 – 412412USP

Sites

Active site3621Nucleophile By similarity
Active site3701Proton acceptor By similarity

Amino acid modifications

Modified residue1301Phosphoserine By similarity
Modified residue4301Phosphoserine By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
Q01988 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: FE921DD1EEAF7C9E

FASTA44550,892
        10         20         30         40         50         60 
NSARADLCVA LAKHTGMSPE RMMVADVFSH RFYKIYQLEE SLSSILDRDD IFIYEVSGRS 

        70         80         90        100        110        120 
AIGENSREDV VLPIYLRERT PARDYNNSYY GLMLFGHPLL VSVPRDRLSW DALYHILLYR 

       130        140        150        160        170        180 
LSRYVTRPSS DDEDDGDEKD IEDKDNIPKP GHVAGASSQD SGAGSGGAQL WSRRRKPAPV 

       190        200        210        220        230        240 
DNSPGPSHWP QRARRKHLFT LQTVNSNGTS DRSTFNEDTH AQPYIAIDWE PEMKKRYYDE 

       250        260        270        280        290        300 
VEAEGYVKHD CVGYVLKKAP VRLQECIELF TTVETLEKEN PWFCPTCKQH QLATKKLDLW 

       310        320        330        340        350        360 
MLPETLIIHL KRFSYTKFSR EKLDTLVEFP IRDLDFSEFV IKPQNESAPE LYKYDLIAVS 

       370        380        390        400        410        420 
NHYGGLRDGH YTTFACNKDS GQSDYFDDNS VSPVTENQIE SKAAYVLFYQ RQDVARRLQP 

       430        440 
QPSSSDPPAS PACGSPPNSE FMDVN 

« Hide

References

[1]"Molecular cloning of the carboxy terminus of a canine tracheobronchial mucin."
Shankar V., Tan S., Gilmore M.S., Sachdev G.P.
Biochem. Biophys. Res. Commun. 189:958-964(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Trachea.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L03387 mRNA. Translation: AAA30875.1.
PIRI46225. PC1174.
UniGeneCfa.3886.

3D structure databases

ProteinModelPortalQ01988.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9615.ENSCAFP00000022125.

Protein family/group databases

MEROPSC19.014.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG5560.
HOGENOMHOG000264375.
HOVERGENHBG000864.
InParanoidQ01988.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBP11_CANFA
AccessionPrimary (citable) accession number: Q01988
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 11, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries