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Q01984

- HNMT_RAT

UniProt

Q01984 - HNMT_RAT

Protein

Histamine N-methyltransferase

Gene

Hnmt

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.

    Catalytic activityi

    S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + N(tau)-methylhistamine.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei28 – 281SubstratePROSITE-ProRule annotation
    Binding sitei60 – 601S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation
    Binding sitei89 – 891S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei94 – 941S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei120 – 1201S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation
    Binding sitei143 – 1431S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation
    Binding sitei284 – 2841SubstratePROSITE-ProRule annotation

    GO - Molecular functioni

    1. histamine N-methyltransferase activity Source: RGD

    GO - Biological processi

    1. brain development Source: RGD
    2. hyperosmotic response Source: RGD
    3. response to amine Source: RGD
    4. response to cocaine Source: RGD
    5. response to glucocorticoid Source: RGD
    6. response to immobilization stress Source: RGD
    7. response to interleukin-1 Source: RGD
    8. response to tumor cell Source: RGD

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-14646.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histamine N-methyltransferase (EC:2.1.1.8)
    Short name:
    HMT
    Gene namesi
    Name:Hnmt
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi71049. Hnmt.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. neuron projection Source: RGD
    3. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 295295Histamine N-methyltransferasePRO_0000084024Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21Blocked amino end (Ala)

    Proteomic databases

    PaxDbiQ01984.
    PRIDEiQ01984.

    Expressioni

    Gene expression databases

    GenevestigatoriQ01984.

    Interactioni

    Subunit structurei

    Monomer.

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000007471.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01984.
    SMRiQ01984. Positions 5-293.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG39680.
    GeneTreeiENSGT00390000002862.
    HOGENOMiHOG000231790.
    HOVERGENiHBG051914.
    InParanoidiQ01984.
    KOiK00546.
    OMAiMDISDCF.
    OrthoDBiEOG7Z69CQ.
    PhylomeDBiQ01984.
    TreeFamiTF331080.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR016673. Histamine_N-methyltransferase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PIRSFiPIRSF016616. HHMT. 1 hit.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51597. SAM_HNMT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q01984-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASFMRSLFS DHSRYVESFR RFLNNSTEHQ CMQEFMDKKL PGIIARIGET    50
    KAEIKILSIG GGAGEIDLQI LSKVQAQYPG ICINNEVVEP NAEQIVKYKE 100
    LVAKTSNMEN IKFAWHKETS SEYQKRVVEE DEEPPKWDFI HMIQMLYYVK 150
    DIPATLKFFH GLLAANAKIL IILVSGTSGW EKLWKKYGFR LPRDDLCQYV 200
    TSSDLAQILD DLGIKYECYD LLSTMDITDC FIDGNENGDL LWDFLTETCN 250
    FIKTAPLDLK EEIMKDLQEP EFSVKKEGKV LFNNNLSFIV VEANV 295
    Length:295
    Mass (Da):33,942
    Last modified:January 23, 2007 - v3
    Checksum:iA54539BA3AE1032E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10693 mRNA. Translation: BAA01535.1.
    AB007834 Genomic DNA. Translation: BAB84319.1.
    BC087635 mRNA. Translation: AAH87635.1.
    PIRiA42851.
    RefSeqiNP_112306.1. NM_031044.3.
    UniGeneiRn.13145.

    Genome annotation databases

    EnsembliENSRNOT00000007471; ENSRNOP00000007471; ENSRNOG00000005223.
    GeneIDi81676.
    KEGGirno:81676.
    UCSCiRGD:71049. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10693 mRNA. Translation: BAA01535.1 .
    AB007834 Genomic DNA. Translation: BAB84319.1 .
    BC087635 mRNA. Translation: AAH87635.1 .
    PIRi A42851.
    RefSeqi NP_112306.1. NM_031044.3.
    UniGenei Rn.13145.

    3D structure databases

    ProteinModelPortali Q01984.
    SMRi Q01984. Positions 5-293.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000007471.

    Chemistry

    BindingDBi Q01984.
    ChEMBLi CHEMBL3241.

    Proteomic databases

    PaxDbi Q01984.
    PRIDEi Q01984.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000007471 ; ENSRNOP00000007471 ; ENSRNOG00000005223 .
    GeneIDi 81676.
    KEGGi rno:81676.
    UCSCi RGD:71049. rat.

    Organism-specific databases

    CTDi 3176.
    RGDi 71049. Hnmt.

    Phylogenomic databases

    eggNOGi NOG39680.
    GeneTreei ENSGT00390000002862.
    HOGENOMi HOG000231790.
    HOVERGENi HBG051914.
    InParanoidi Q01984.
    KOi K00546.
    OMAi MDISDCF.
    OrthoDBi EOG7Z69CQ.
    PhylomeDBi Q01984.
    TreeFami TF331080.

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-14646.

    Miscellaneous databases

    NextBioi 615280.
    PROi Q01984.

    Gene expression databases

    Genevestigatori Q01984.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR016673. Histamine_N-methyltransferase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PIRSFi PIRSF016616. HHMT. 1 hit.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51597. SAM_HNMT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Histamine N-methyltransferase from rat kidney. Cloning, nucleotide sequence, and expression in Escherichia coli cells."
      Takemura M., Tanaka T., Taguchi Y., Imamura I., Mizuguchi H., Kuroda M., Fukui H., Yamatodani A., Wada H.
      J. Biol. Chem. 267:15687-15691(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Tissue: Kidney.
    2. "Genomic structure of the rat and mouse histamine N-methyltransferase gene."
      Kitanaka N., Kitanaka J., Oue T., Tada Y., Tanaka T., Takemura M.
      Jpn. J. Pharmacol. 88:85-92(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Sprague-Dawley.
      Tissue: Liver.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiHNMT_RAT
    AccessioniPrimary (citable) accession number: Q01984
    Secondary accession number(s): Q59JM9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 93 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3