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Q01984

- HNMT_RAT

UniProt

Q01984 - HNMT_RAT

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Protein

Histamine N-methyltransferase

Gene

Hnmt

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.

Catalytic activityi

S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + N(tau)-methylhistamine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei28 – 281SubstratePROSITE-ProRule annotation
Binding sitei60 – 601S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation
Binding sitei89 – 891S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei94 – 941S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei120 – 1201S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation
Binding sitei143 – 1431S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation
Binding sitei284 – 2841SubstratePROSITE-ProRule annotation

GO - Molecular functioni

  1. histamine N-methyltransferase activity Source: RGD

GO - Biological processi

  1. brain development Source: RGD
  2. hyperosmotic response Source: RGD
  3. response to amine Source: RGD
  4. response to cocaine Source: RGD
  5. response to glucocorticoid Source: RGD
  6. response to immobilization stress Source: RGD
  7. response to interleukin-1 Source: RGD
  8. response to tumor cell Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14646.

Names & Taxonomyi

Protein namesi
Recommended name:
Histamine N-methyltransferase (EC:2.1.1.8)
Short name:
HMT
Gene namesi
Name:Hnmt
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi71049. Hnmt.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: Ensembl
  3. neuron projection Source: RGD
  4. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Histamine N-methyltransferasePRO_0000084024Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21Blocked amino end (Ala)

Proteomic databases

PaxDbiQ01984.
PRIDEiQ01984.

Expressioni

Gene expression databases

GenevestigatoriQ01984.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007471.

Structurei

3D structure databases

ProteinModelPortaliQ01984.
SMRiQ01984. Positions 5-293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG39680.
GeneTreeiENSGT00390000002862.
HOGENOMiHOG000231790.
HOVERGENiHBG051914.
InParanoidiQ01984.
KOiK00546.
OMAiMDISDCF.
OrthoDBiEOG7Z69CQ.
PhylomeDBiQ01984.
TreeFamiTF331080.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR016673. Histamine_N-methyltransferase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PIRSFiPIRSF016616. HHMT. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51597. SAM_HNMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01984-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASFMRSLFS DHSRYVESFR RFLNNSTEHQ CMQEFMDKKL PGIIARIGET
60 70 80 90 100
KAEIKILSIG GGAGEIDLQI LSKVQAQYPG ICINNEVVEP NAEQIVKYKE
110 120 130 140 150
LVAKTSNMEN IKFAWHKETS SEYQKRVVEE DEEPPKWDFI HMIQMLYYVK
160 170 180 190 200
DIPATLKFFH GLLAANAKIL IILVSGTSGW EKLWKKYGFR LPRDDLCQYV
210 220 230 240 250
TSSDLAQILD DLGIKYECYD LLSTMDITDC FIDGNENGDL LWDFLTETCN
260 270 280 290
FIKTAPLDLK EEIMKDLQEP EFSVKKEGKV LFNNNLSFIV VEANV
Length:295
Mass (Da):33,942
Last modified:January 23, 2007 - v3
Checksum:iA54539BA3AE1032E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10693 mRNA. Translation: BAA01535.1.
AB007834 Genomic DNA. Translation: BAB84319.1.
BC087635 mRNA. Translation: AAH87635.1.
PIRiA42851.
RefSeqiNP_112306.1. NM_031044.3.
UniGeneiRn.13145.

Genome annotation databases

EnsembliENSRNOT00000007471; ENSRNOP00000007471; ENSRNOG00000005223.
GeneIDi81676.
KEGGirno:81676.
UCSCiRGD:71049. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10693 mRNA. Translation: BAA01535.1 .
AB007834 Genomic DNA. Translation: BAB84319.1 .
BC087635 mRNA. Translation: AAH87635.1 .
PIRi A42851.
RefSeqi NP_112306.1. NM_031044.3.
UniGenei Rn.13145.

3D structure databases

ProteinModelPortali Q01984.
SMRi Q01984. Positions 5-293.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000007471.

Chemistry

BindingDBi Q01984.
ChEMBLi CHEMBL3241.

Proteomic databases

PaxDbi Q01984.
PRIDEi Q01984.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000007471 ; ENSRNOP00000007471 ; ENSRNOG00000005223 .
GeneIDi 81676.
KEGGi rno:81676.
UCSCi RGD:71049. rat.

Organism-specific databases

CTDi 3176.
RGDi 71049. Hnmt.

Phylogenomic databases

eggNOGi NOG39680.
GeneTreei ENSGT00390000002862.
HOGENOMi HOG000231790.
HOVERGENi HBG051914.
InParanoidi Q01984.
KOi K00546.
OMAi MDISDCF.
OrthoDBi EOG7Z69CQ.
PhylomeDBi Q01984.
TreeFami TF331080.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-14646.

Miscellaneous databases

NextBioi 615280.
PROi Q01984.

Gene expression databases

Genevestigatori Q01984.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR016673. Histamine_N-methyltransferase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PIRSFi PIRSF016616. HHMT. 1 hit.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51597. SAM_HNMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Histamine N-methyltransferase from rat kidney. Cloning, nucleotide sequence, and expression in Escherichia coli cells."
    Takemura M., Tanaka T., Taguchi Y., Imamura I., Mizuguchi H., Kuroda M., Fukui H., Yamatodani A., Wada H.
    J. Biol. Chem. 267:15687-15691(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Kidney.
  2. "Genomic structure of the rat and mouse histamine N-methyltransferase gene."
    Kitanaka N., Kitanaka J., Oue T., Tada Y., Tanaka T., Takemura M.
    Jpn. J. Pharmacol. 88:85-92(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiHNMT_RAT
AccessioniPrimary (citable) accession number: Q01984
Secondary accession number(s): Q59JM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 94 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3