Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q01980 (AADR_RHOPA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcriptional activatory protein AadR
Alternative name(s):
Anaerobic aromatic degradation regulator
Gene names
Name:aadR
Ordered Locus Names:RPA4234
OrganismRhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) [Complete proteome] [HAMAP]
Taxonomic identifier258594 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas

Protein attributes

Sequence length239 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional activator of anaerobic gene expression. For aromatic acid degradation. Also required for the anaerobic degradation of benzoate.

Miscellaneous

Possesses 4 cysteines which may bind a metal ion (possibly iron).

Sequence similarities

Contains 1 cyclic nucleotide-binding domain.

Contains 1 HTH crp-type DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   LigandDNA-binding
   Molecular functionActivator
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintracellular

Inferred from electronic annotation. Source: InterPro

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 239239Transcriptional activatory protein AadR
PRO_0000100141

Regions

Domain158 – 23174HTH crp-type
Nucleotide binding27 – 149123cNMP
DNA binding191 – 21020H-T-H motif By similarity

Sequences

Sequence LengthMass (Da)Tools
Q01980 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 392ED15225566020

FASTA23926,711
        10         20         30         40         50         60 
MPHLAYPTTT CEGFRCETHC AVRGLAICGE LGPADHEEFE RLAQHVRYGP KEALFSEDEV 

        70         80         90        100        110        120 
ADSVYSLIEG IARLYKLLPD GRRQIIGFAL PGDFLGMAPG NRYSFSADSI GGVTVCKFFR 

       130        140        150        160        170        180 
GPFLRFIENR PQMLLRMNDF ATRELSLAQD QMLLLGRRSA EEKVAAFLVG WRDRLARLEG 

       190        200        210        220        230 
VTKTVSLPMG RQDIADFLGL TIETVSRTFT KLEREKLIVI VPDGVRVLDP KRFDALAAA 

« Hide

References

« Hide 'large scale' references
[1]"Anaerobic growth of Rhodopseudomonas palustris on 4-hydroxybenzoate is dependent on AadR, a member of the cyclic AMP receptor protein family of transcriptional regulators."
Dispensa M., Thomas C.T., Kim M.-K., Perrotta J.A., Gibson J., Harwood C.S.
J. Bacteriol. 174:5803-5813(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC BAA-98 / CGA009.
[2]"Complete genome sequence of the metabolically versatile photosynthetic bacterium Rhodopseudomonas palustris."
Larimer F.W., Chain P., Hauser L., Lamerdin J.E., Malfatti S., Do L., Land M.L., Pelletier D.A., Beatty J.T., Lang A.S., Tabita F.R., Gibson J.L., Hanson T.E., Bobst C., Torres y Torres J.L., Peres C., Harrison F.H., Gibson J., Harwood C.S.
Nat. Biotechnol. 22:55-61(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-98 / CGA009.
[3]"BadR, a new MarR family member, regulates anaerobic benzoate degradation by Rhodopseudomonas palustris in concert with AadR, an Fnr family member."
Egland P.G., Harwood C.S.
J. Bacteriol. 181:2102-2109(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M92426 Genomic DNA. Translation: AAA26090.1.
BX572606 Genomic DNA. Translation: CAE29675.1.
PIRB43334.
RefSeqNP_949570.1. NC_005296.1.

3D structure databases

ProteinModelPortalQ01980.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING258594.RPA4234.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE29675; CAE29675; RPA4234.
GeneID2692622.
KEGGrpa:RPA4234.
PATRIC23293059. VBIRhoPal84835_4443.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0664.
HOGENOMHOG000186462.
KOK01420.
OMACDADELE.
OrthoDBEOG6TBHH3.
PhylomeDBQ01980.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
[Graphical view]
PRINTSPR00034. HTHCRP.
SMARTSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAADR_RHOPA
AccessionPrimary (citable) accession number: Q01980
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families