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Q01980

- AADR_RHOPA

UniProt

Q01980 - AADR_RHOPA

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Protein

Transcriptional activatory protein AadR

Gene

aadR

Organism
Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional activator of anaerobic gene expression. For aromatic acid degradation. Also required for the anaerobic degradation of benzoate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi27 – 149123cNMPAdd
BLAST
DNA bindingi191 – 21020H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activatory protein AadR
Alternative name(s):
Anaerobic aromatic degradation regulator
Gene namesi
Name:aadR
Ordered Locus Names:RPA4234
OrganismiRhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Taxonomic identifieri258594 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
ProteomesiUP000001426: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 239239Transcriptional activatory protein AadRPRO_0000100141Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi258594.RPA4234.

Structurei

3D structure databases

ProteinModelPortaliQ01980.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini158 – 23174HTH crp-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
Contains 1 HTH crp-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000186462.
KOiK01420.
OMAiCDADELE.
OrthoDBiEOG6TBHH3.
PhylomeDBiQ01980.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
[Graphical view]
PRINTSiPR00034. HTHCRP.
SMARTiSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01980-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPHLAYPTTT CEGFRCETHC AVRGLAICGE LGPADHEEFE RLAQHVRYGP
60 70 80 90 100
KEALFSEDEV ADSVYSLIEG IARLYKLLPD GRRQIIGFAL PGDFLGMAPG
110 120 130 140 150
NRYSFSADSI GGVTVCKFFR GPFLRFIENR PQMLLRMNDF ATRELSLAQD
160 170 180 190 200
QMLLLGRRSA EEKVAAFLVG WRDRLARLEG VTKTVSLPMG RQDIADFLGL
210 220 230
TIETVSRTFT KLEREKLIVI VPDGVRVLDP KRFDALAAA
Length:239
Mass (Da):26,711
Last modified:July 1, 1993 - v1
Checksum:i392ED15225566020
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M92426 Genomic DNA. Translation: AAA26090.1.
BX572606 Genomic DNA. Translation: CAE29675.1.
PIRiB43334.
RefSeqiNP_949570.1. NC_005296.1.

Genome annotation databases

EnsemblBacteriaiCAE29675; CAE29675; RPA4234.
GeneIDi2692622.
KEGGirpa:RPA4234.
PATRICi23293059. VBIRhoPal84835_4443.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M92426 Genomic DNA. Translation: AAA26090.1 .
BX572606 Genomic DNA. Translation: CAE29675.1 .
PIRi B43334.
RefSeqi NP_949570.1. NC_005296.1.

3D structure databases

ProteinModelPortali Q01980.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 258594.RPA4234.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE29675 ; CAE29675 ; RPA4234 .
GeneIDi 2692622.
KEGGi rpa:RPA4234.
PATRICi 23293059. VBIRhoPal84835_4443.

Phylogenomic databases

eggNOGi COG0664.
HOGENOMi HOG000186462.
KOi K01420.
OMAi CDADELE.
OrthoDBi EOG6TBHH3.
PhylomeDBi Q01980.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
[Graphical view ]
PRINTSi PR00034. HTHCRP.
SMARTi SM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Anaerobic growth of Rhodopseudomonas palustris on 4-hydroxybenzoate is dependent on AadR, a member of the cyclic AMP receptor protein family of transcriptional regulators."
    Dispensa M., Thomas C.T., Kim M.-K., Perrotta J.A., Gibson J., Harwood C.S.
    J. Bacteriol. 174:5803-5813(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC BAA-98 / CGA009.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-98 / CGA009.
  3. "BadR, a new MarR family member, regulates anaerobic benzoate degradation by Rhodopseudomonas palustris in concert with AadR, an Fnr family member."
    Egland P.G., Harwood C.S.
    J. Bacteriol. 181:2102-2109(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiAADR_RHOPA
AccessioniPrimary (citable) accession number: Q01980
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Possesses 4 cysteines which may bind a metal ion (possibly iron).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3