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Q01980

- AADR_RHOPA

UniProt

Q01980 - AADR_RHOPA

Protein

Transcriptional activatory protein AadR

Gene

aadR

Organism
Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    • Comment

    Functioni

    Transcriptional activator of anaerobic gene expression. For aromatic acid degradation. Also required for the anaerobic degradation of benzoate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi27 – 149123cNMPAdd
    BLAST
    DNA bindingi191 – 21020H-T-H motifPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcriptional activatory protein AadR
    Alternative name(s):
    Anaerobic aromatic degradation regulator
    Gene namesi
    Name:aadR
    Ordered Locus Names:RPA4234
    OrganismiRhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
    Taxonomic identifieri258594 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
    ProteomesiUP000001426: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 239239Transcriptional activatory protein AadRPRO_0000100141Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi258594.RPA4234.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01980.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini158 – 23174HTH crp-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
    Contains 1 HTH crp-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0664.
    HOGENOMiHOG000186462.
    KOiK01420.
    OMAiCDADELE.
    OrthoDBiEOG6TBHH3.
    PhylomeDBiQ01980.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProiIPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR012318. HTH_CRP_2.
    IPR014710. RmlC-like_jellyroll.
    IPR001808. Tscrpt_reg_HTH_Crp.
    IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    PF00325. Crp. 1 hit.
    [Graphical view]
    PRINTSiPR00034. HTHCRP.
    SMARTiSM00100. cNMP. 1 hit.
    SM00419. HTH_CRP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
    PS00042. HTH_CRP_1. 1 hit.
    PS51063. HTH_CRP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q01980-1 [UniParc]FASTAAdd to Basket

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    MPHLAYPTTT CEGFRCETHC AVRGLAICGE LGPADHEEFE RLAQHVRYGP    50
    KEALFSEDEV ADSVYSLIEG IARLYKLLPD GRRQIIGFAL PGDFLGMAPG 100
    NRYSFSADSI GGVTVCKFFR GPFLRFIENR PQMLLRMNDF ATRELSLAQD 150
    QMLLLGRRSA EEKVAAFLVG WRDRLARLEG VTKTVSLPMG RQDIADFLGL 200
    TIETVSRTFT KLEREKLIVI VPDGVRVLDP KRFDALAAA 239
    Length:239
    Mass (Da):26,711
    Last modified:July 1, 1993 - v1
    Checksum:i392ED15225566020
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M92426 Genomic DNA. Translation: AAA26090.1.
    BX572606 Genomic DNA. Translation: CAE29675.1.
    PIRiB43334.
    RefSeqiNP_949570.1. NC_005296.1.
    WP_011159769.1. NC_005296.1.

    Genome annotation databases

    EnsemblBacteriaiCAE29675; CAE29675; RPA4234.
    GeneIDi2692622.
    KEGGirpa:RPA4234.
    PATRICi23293059. VBIRhoPal84835_4443.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M92426 Genomic DNA. Translation: AAA26090.1 .
    BX572606 Genomic DNA. Translation: CAE29675.1 .
    PIRi B43334.
    RefSeqi NP_949570.1. NC_005296.1.
    WP_011159769.1. NC_005296.1.

    3D structure databases

    ProteinModelPortali Q01980.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 258594.RPA4234.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE29675 ; CAE29675 ; RPA4234 .
    GeneIDi 2692622.
    KEGGi rpa:RPA4234.
    PATRICi 23293059. VBIRhoPal84835_4443.

    Phylogenomic databases

    eggNOGi COG0664.
    HOGENOMi HOG000186462.
    KOi K01420.
    OMAi CDADELE.
    OrthoDBi EOG6TBHH3.
    PhylomeDBi Q01980.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProi IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR012318. HTH_CRP_2.
    IPR014710. RmlC-like_jellyroll.
    IPR001808. Tscrpt_reg_HTH_Crp.
    IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    PF00325. Crp. 1 hit.
    [Graphical view ]
    PRINTSi PR00034. HTHCRP.
    SMARTi SM00100. cNMP. 1 hit.
    SM00419. HTH_CRP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
    PS00042. HTH_CRP_1. 1 hit.
    PS51063. HTH_CRP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Anaerobic growth of Rhodopseudomonas palustris on 4-hydroxybenzoate is dependent on AadR, a member of the cyclic AMP receptor protein family of transcriptional regulators."
      Dispensa M., Thomas C.T., Kim M.-K., Perrotta J.A., Gibson J., Harwood C.S.
      J. Bacteriol. 174:5803-5813(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC BAA-98 / CGA009.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-98 / CGA009.
    3. "BadR, a new MarR family member, regulates anaerobic benzoate degradation by Rhodopseudomonas palustris in concert with AadR, an Fnr family member."
      Egland P.G., Harwood C.S.
      J. Bacteriol. 181:2102-2109(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.

    Entry informationi

    Entry nameiAADR_RHOPA
    AccessioniPrimary (citable) accession number: Q01980
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Possesses 4 cysteines which may bind a metal ion (possibly iron).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3