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Protein

Tyrosine-protein kinase transmembrane receptor ROR2

Gene

ROR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (PubMed:17717073). In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443).By similarity2 Publications

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation1 Publication

Cofactori

Mg2+1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei507ATPPROSITE-ProRule annotation1
Active sitei615Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi479 – 487ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway Source: ParkinsonsUK-UCL
  • metal ion binding Source: UniProtKB-KW
  • transmembrane receptor protein tyrosine kinase activity Source: ProtInc
  • Wnt-protein binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Wnt signaling pathway

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS09878-MONOMER.
BRENDAi2.7.10.1. 2681.
ReactomeiR-HSA-4086400. PCP/CE pathway.
R-HSA-5140745. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
SignaLinkiQ01974.
SIGNORiQ01974.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase transmembrane receptor ROR2 (EC:2.7.10.11 Publication)
Alternative name(s):
Neurotrophic tyrosine kinase, receptor-related 2
Gene namesi
Name:ROR2
Synonyms:NTRKR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:10257. ROR2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini34 – 403ExtracellularSequence analysisAdd BLAST370
Transmembranei404 – 424HelicalSequence analysisAdd BLAST21
Topological domaini425 – 943CytoplasmicSequence analysisAdd BLAST519

GO - Cellular componenti

  • clathrin-coated endocytic vesicle membrane Source: Reactome
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Brachydactyly B1 (BDB1)
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of brachydactyly. Brachydactyly defines a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. In brachydactyly type B1 the middle phalanges are short but in addition the terminal phalanges are rudimentary or absent. Both fingers and toes are affected. The thumbs and big toes are usually deformed. Symphalangism is also a feature.
See also OMIM:113000
Robinow syndrome autosomal recessive (RRS)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA recessive form of Robinow syndrome, a disease characterized by short-limb dwarfism, costovertebral segmentation defects and abnormalities of the head, face and external genitalia. The clinical signs are generally far more severe in recessive cases, particularly skeletal abnormalities. All patients with the recessive form suffer from vertebral segmentation abnormalities, resulting in scoliosis and chest deformities. Rib fusions are considered to be characteristic of the autosomal recessive form. Patients can also present brachydactyly, with extensive aplasia/hypoplasia of the phalanges and metacarpals/metatarsals, and brachy-syn-polydactyly of the hands and oligodactyly of the feet.
See also OMIM:268310
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_010911182C → Y in RRS. 1 Publication1
Natural variantiVAR_010768184R → C in RRS. 1 PublicationCorresponds to variant rs121909084dbSNPEnsembl.1
Natural variantiVAR_010769189R → W in RRS. 1 PublicationCorresponds to variant rs199975149dbSNPEnsembl.1
Natural variantiVAR_010770366R → W in RRS. 1 Publication1
Natural variantiVAR_010771620N → K in RRS. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi482D → G: Slight increase in kinase activity. 1 Publication1

Keywords - Diseasei

Disease mutation, Dwarfism

Organism-specific databases

DisGeNETi4920.
MalaCardsiROR2.
MIMi113000. phenotype.
268310. phenotype.
OpenTargetsiENSG00000169071.
Orphaneti1507. Autosomal recessive Robinow syndrome.
93383. Brachydactyly type B.
PharmGKBiPA34629.

Chemistry databases

ChEMBLiCHEMBL2375201.

Polymorphism and mutation databases

BioMutaiROR2.
DMDMi90110767.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000002446034 – 943Tyrosine-protein kinase transmembrane receptor ROR2Add BLAST910

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi70N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi83 ↔ 135By similarity
Disulfide bondi174 ↔ 239By similarity
Disulfide bondi182 ↔ 232By similarity
Glycosylationi188N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi223 ↔ 264By similarity
Disulfide bondi252 ↔ 300By similarity
Disulfide bondi256 ↔ 286By similarity
Disulfide bondi316 ↔ 394By similarity
Glycosylationi318N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi337 ↔ 377By similarity
Disulfide bondi365 ↔ 389By similarity
Modified residuei469Sulfoserine; partial1 Publication1
Modified residuei471Sulfoserine; partial1 Publication1
Modified residuei646Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei785Asymmetric dimethylarginineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation, Phosphoprotein, Sulfation

Proteomic databases

EPDiQ01974.
MaxQBiQ01974.
PaxDbiQ01974.
PeptideAtlasiQ01974.
PRIDEiQ01974.

PTM databases

iPTMnetiQ01974.
PhosphoSitePlusiQ01974.

Expressioni

Developmental stagei

Expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues.

Gene expression databases

BgeeiENSG00000169071.
CleanExiHS_ROR2.
ExpressionAtlasiQ01974. baseline and differential.
GenevisibleiQ01974. HS.

Organism-specific databases

HPAiHPA021868.

Interactioni

Subunit structurei

Homodimer; promotes osteogenesis. Binds YWHAB (PubMed:17717073). Interacts with WTIP (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
HSP90AB1P082382EBI-6422642,EBI-352572
PRR20CP864794EBI-6422642,EBI-10172814

GO - Molecular functioni

  • Wnt-protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi110974. 18 interactors.
IntActiQ01974. 12 interactors.
STRINGi9606.ENSP00000364860.

Structurei

Secondary structure

1943
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi470 – 472Combined sources3
Beta strandi473 – 481Combined sources9
Beta strandi486 – 492Combined sources7
Beta strandi502 – 508Combined sources7
Helixi518 – 530Combined sources13
Beta strandi539 – 543Combined sources5
Beta strandi545 – 548Combined sources4
Beta strandi550 – 554Combined sources5
Helixi561 – 566Combined sources6
Helixi589 – 608Combined sources20
Helixi618 – 620Combined sources3
Beta strandi621 – 623Combined sources3
Helixi625 – 627Combined sources3
Beta strandi629 – 631Combined sources3
Helixi639 – 644Combined sources6
Beta strandi648 – 652Combined sources5
Helixi656 – 658Combined sources3
Helixi661 – 666Combined sources6
Helixi671 – 686Combined sources16
Turni687 – 689Combined sources3
Turni692 – 695Combined sources4
Helixi698 – 706Combined sources9
Helixi719 – 728Combined sources10
Helixi733 – 735Combined sources3
Helixi739 – 747Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZZWX-ray2.90A/B464-751[»]
4GT4X-ray2.41A/B452-753[»]
ProteinModelPortaliQ01974.
SMRiQ01974.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 145Ig-like C2-typeAdd BLAST91
Domaini169 – 303FZPROSITE-ProRule annotationAdd BLAST135
Domaini316 – 394KringlePROSITE-ProRule annotationAdd BLAST79
Domaini473 – 746Protein kinasePROSITE-ProRule annotationAdd BLAST274

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi753 – 782Ser/Thr-richAdd BLAST30
Compositional biasi784 – 857Pro-richAdd BLAST74
Compositional biasi859 – 882Ser/Thr-richAdd BLAST24

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.PROSITE-ProRule annotation
Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation
Contains 1 kringle domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Kringle, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1026. Eukaryota.
ENOG410YGKQ. LUCA.
GeneTreeiENSGT00760000118818.
HOGENOMiHOG000049104.
HOVERGENiHBG017736.
InParanoidiQ01974.
KOiK05123.
OMAiFIPMKGQ.
OrthoDBiEOG091G02W3.
PhylomeDBiQ01974.
TreeFamiTF106465.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR020067. Frizzled_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR016247. Tyr_kinase_rcpt_ROR.
[Graphical view]
PfamiPF01392. Fz. 1 hit.
PF07679. I-set. 1 hit.
PF00051. Kringle. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000624. TyrPK_TMrec_ROR. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00130. KR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF57440. SSF57440. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01974-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGSALPRR PLLCIPAVWA AAALLLSVSR TSGEVEVLDP NDPLGPLDGQ
60 70 80 90 100
DGPIPTLKGY FLNFLEPVNN ITIVQGQTAI LHCKVAGNPP PNVRWLKNDA
110 120 130 140 150
PVVQEPRRII IRKTEYGSRL RIQDLDTTDT GYYQCVATNG MKTITATGVL
160 170 180 190 200
FVRLGPTHSP NHNFQDDYHE DGFCQPYRGI ACARFIGNRT IYVDSLQMQG
210 220 230 240 250
EIENRITAAF TMIGTSTHLS DQCSQFAIPS FCHFVFPLCD ARSRTPKPRE
260 270 280 290 300
LCRDECEVLE SDLCRQEYTI ARSNPLILMR LQLPKCEALP MPESPDAANC
310 320 330 340 350
MRIGIPAERL GRYHQCYNGS GMDYRGTAST TKSGHQCQPW ALQHPHSHHL
360 370 380 390 400
SSTDFPELGG GHAYCRNPGG QMEGPWCFTQ NKNVRMELCD VPSCSPRDSS
410 420 430 440 450
KMGILYILVP SIAIPLVIAC LFFLVCMCRN KQKASASTPQ RRQLMASPSQ
460 470 480 490 500
DMEMPLINQH KQAKLKEISL SAVRFMEELG EDRFGKVYKG HLFGPAPGEQ
510 520 530 540 550
TQAVAIKTLK DKAEGPLREE FRHEAMLRAR LQHPNVVCLL GVVTKDQPLS
560 570 580 590 600
MIFSYCSHGD LHEFLVMRSP HSDVGSTDDD RTVKSALEPP DFVHLVAQIA
610 620 630 640 650
AGMEYLSSHH VVHKDLATRN VLVYDKLNVK ISDLGLFREV YAADYYKLLG
660 670 680 690 700
NSLLPIRWMA PEAIMYGKFS IDSDIWSYGV VLWEVFSYGL QPYCGYSNQD
710 720 730 740 750
VVEMIRNRQV LPCPDDCPAW VYALMIECWN EFPSRRPRFK DIHSRLRAWG
760 770 780 790 800
NLSNYNSSAQ TSGASNTTQT SSLSTSPVSN VSNARYVGPK QKAPPFPQPQ
810 820 830 840 850
FIPMKGQIRP MVPPPQLYVP VNGYQPVPAY GAYLPNFYPV QIPMQMAPQQ
860 870 880 890 900
VPPQMVPKPS SHHSGSGSTS TGYVTTAPSN TSMADRAALL SEGADDTQNA
910 920 930 940
PEDGAQSTVQ EAEEEEEGSV PETELLGDCD TLQVDEAQVQ LEA
Length:943
Mass (Da):104,757
Last modified:March 7, 2006 - v2
Checksum:iF926FB681A8312FE
GO

Sequence cautioni

The sequence BAD92391 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_010911182C → Y in RRS. 1 Publication1
Natural variantiVAR_010768184R → C in RRS. 1 PublicationCorresponds to variant rs121909084dbSNPEnsembl.1
Natural variantiVAR_010769189R → W in RRS. 1 PublicationCorresponds to variant rs199975149dbSNPEnsembl.1
Natural variantiVAR_041787244R → Q.1 PublicationCorresponds to variant rs55737262dbSNPEnsembl.1
Natural variantiVAR_010912245T → A.5 PublicationsCorresponds to variant rs10820900dbSNPEnsembl.1
Natural variantiVAR_041788349H → D.1 PublicationCorresponds to variant rs55983376dbSNPEnsembl.1
Natural variantiVAR_010770366R → W in RRS. 1 Publication1
Natural variantiVAR_041789490G → A.1 PublicationCorresponds to variant rs56197744dbSNPEnsembl.1
Natural variantiVAR_041790530R → Q.1 PublicationCorresponds to variant rs35852786dbSNPEnsembl.1
Natural variantiVAR_041791542V → M in a colorectal adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant rs140213020dbSNPEnsembl.1
Natural variantiVAR_041792548P → S.1 PublicationCorresponds to variant rs35764413dbSNPEnsembl.1
Natural variantiVAR_041793557S → L.1 PublicationCorresponds to variant rs56099091dbSNPEnsembl.1
Natural variantiVAR_010771620N → K in RRS. 1 Publication1
Natural variantiVAR_041794644D → N.1 PublicationCorresponds to variant rs55798732dbSNPEnsembl.1
Natural variantiVAR_041795672D → N.1 PublicationCorresponds to variant rs55651110dbSNPEnsembl.1
Natural variantiVAR_041796695G → R.1 PublicationCorresponds to variant rs34431454dbSNPEnsembl.1
Natural variantiVAR_041797738R → C.1 PublicationCorresponds to variant rs56231927dbSNPEnsembl.1
Natural variantiVAR_041798762S → L.1 PublicationCorresponds to variant rs34491822dbSNPEnsembl.1
Natural variantiVAR_010913819V → I.3 PublicationsCorresponds to variant rs10761129dbSNPEnsembl.1
Natural variantiVAR_041799935D → E.1 PublicationCorresponds to variant rs41277835dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97639 mRNA. Translation: AAA60276.1.
AL391219, AL928802, AL583841 Genomic DNA. Translation: CAH70208.1.
AL928802, AL391219, AL583841 Genomic DNA. Translation: CAI17303.1.
AL583841, AL391219, AL928802 Genomic DNA. Translation: CAI15694.1.
AB209154 mRNA. Translation: BAD92391.1. Different initiation.
AH009681 Genomic DNA. Translation: AAG01184.2.
AH010002 Genomic DNA. Translation: AAG33132.1.
CCDSiCCDS6691.1.
PIRiB45082.
RefSeqiNP_001305133.1. NM_001318204.1.
NP_004551.2. NM_004560.3.
UniGeneiHs.644776.
Hs.98255.

Genome annotation databases

EnsembliENST00000375708; ENSP00000364860; ENSG00000169071.
GeneIDi4920.
KEGGihsa:4920.
UCSCiuc004arj.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97639 mRNA. Translation: AAA60276.1.
AL391219, AL928802, AL583841 Genomic DNA. Translation: CAH70208.1.
AL928802, AL391219, AL583841 Genomic DNA. Translation: CAI17303.1.
AL583841, AL391219, AL928802 Genomic DNA. Translation: CAI15694.1.
AB209154 mRNA. Translation: BAD92391.1. Different initiation.
AH009681 Genomic DNA. Translation: AAG01184.2.
AH010002 Genomic DNA. Translation: AAG33132.1.
CCDSiCCDS6691.1.
PIRiB45082.
RefSeqiNP_001305133.1. NM_001318204.1.
NP_004551.2. NM_004560.3.
UniGeneiHs.644776.
Hs.98255.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZZWX-ray2.90A/B464-751[»]
4GT4X-ray2.41A/B452-753[»]
ProteinModelPortaliQ01974.
SMRiQ01974.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110974. 18 interactors.
IntActiQ01974. 12 interactors.
STRINGi9606.ENSP00000364860.

Chemistry databases

ChEMBLiCHEMBL2375201.

PTM databases

iPTMnetiQ01974.
PhosphoSitePlusiQ01974.

Polymorphism and mutation databases

BioMutaiROR2.
DMDMi90110767.

Proteomic databases

EPDiQ01974.
MaxQBiQ01974.
PaxDbiQ01974.
PeptideAtlasiQ01974.
PRIDEiQ01974.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375708; ENSP00000364860; ENSG00000169071.
GeneIDi4920.
KEGGihsa:4920.
UCSCiuc004arj.3. human.

Organism-specific databases

CTDi4920.
DisGeNETi4920.
GeneCardsiROR2.
GeneReviewsiROR2.
H-InvDBHIX0034840.
HGNCiHGNC:10257. ROR2.
HPAiHPA021868.
MalaCardsiROR2.
MIMi113000. phenotype.
268310. phenotype.
602337. gene.
neXtProtiNX_Q01974.
OpenTargetsiENSG00000169071.
Orphaneti1507. Autosomal recessive Robinow syndrome.
93383. Brachydactyly type B.
PharmGKBiPA34629.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1026. Eukaryota.
ENOG410YGKQ. LUCA.
GeneTreeiENSGT00760000118818.
HOGENOMiHOG000049104.
HOVERGENiHBG017736.
InParanoidiQ01974.
KOiK05123.
OMAiFIPMKGQ.
OrthoDBiEOG091G02W3.
PhylomeDBiQ01974.
TreeFamiTF106465.

Enzyme and pathway databases

BioCyciZFISH:HS09878-MONOMER.
BRENDAi2.7.10.1. 2681.
ReactomeiR-HSA-4086400. PCP/CE pathway.
R-HSA-5140745. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
SignaLinkiQ01974.
SIGNORiQ01974.

Miscellaneous databases

GeneWikiiROR2.
GenomeRNAii4920.
PROiQ01974.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169071.
CleanExiHS_ROR2.
ExpressionAtlasiQ01974. baseline and differential.
GenevisibleiQ01974. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR020067. Frizzled_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR016247. Tyr_kinase_rcpt_ROR.
[Graphical view]
PfamiPF01392. Fz. 1 hit.
PF07679. I-set. 1 hit.
PF00051. Kringle. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000624. TyrPK_TMrec_ROR. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00130. KR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF57440. SSF57440. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiROR2_HUMAN
AccessioniPrimary (citable) accession number: Q01974
Secondary accession number(s): Q59GF5
, Q5SPI5, Q9HAY7, Q9HB61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 7, 2006
Last modified: November 30, 2016
This is version 184 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The catalytic activity of the kinase domain is controversial.2 Publications

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.