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Q01973

- ROR1_HUMAN

UniProt

Q01973 - ROR1_HUMAN

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Protein

Tyrosine-protein kinase transmembrane receptor ROR1

Gene

ROR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Tyrosine-protein kinase receptor whose role is not yet clear.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei506 – 5061ATPPROSITE-ProRule annotation
Active sitei615 – 6151Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi479 – 4879ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. transmembrane receptor protein tyrosine kinase activity Source: ProtInc
  3. Wnt-protein binding Source: UniProtKB

GO - Biological processi

  1. peptidyl-tyrosine phosphorylation Source: GOC
  2. transmembrane receptor protein tyrosine kinase signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1. 2681.
ReactomeiREACT_172631. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
SignaLinkiQ01973.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase transmembrane receptor ROR1 (EC:2.7.10.1)
Alternative name(s):
Neurotrophic tyrosine kinase, receptor-related 1
Gene namesi
Name:ROR1
Synonyms:NTRKR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:10256. ROR1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: ProtInc
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: ProtInc
  4. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34628.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 937908Tyrosine-protein kinase transmembrane receptor ROR1PRO_0000024458Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi79 ↔ 131By similarity
Disulfide bondi170 ↔ 235By similarity
Disulfide bondi178 ↔ 228By similarity
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi219 ↔ 260By similarity
Disulfide bondi248 ↔ 296By similarity
Disulfide bondi252 ↔ 282By similarity
Disulfide bondi313 ↔ 391By similarity
Glycosylationi315 – 3151N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi334 ↔ 374By similarity
Disulfide bondi362 ↔ 386By similarity
Modified residuei645 – 6451Phosphotyrosine; by autocatalysisBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ01973.
PaxDbiQ01973.
PRIDEiQ01973.

PTM databases

PhosphoSiteiQ01973.

Expressioni

Tissue specificityi

Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.

Developmental stagei

Expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues.

Gene expression databases

BgeeiQ01973.
CleanExiHS_ROR1.
GenevestigatoriQ01973.

Organism-specific databases

HPAiHPA057016.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EGFRP005338EBI-6082337,EBI-297353
SRCP129319EBI-6082337,EBI-621482
SrcP054803EBI-6082337,EBI-298680From a different organism.

Protein-protein interaction databases

BioGridi110973. 6 interactions.
DIPiDIP-29734N.
DIP-5713N.
IntActiQ01973. 8 interactions.
MINTiMINT-5004457.
STRINGi9606.ENSP00000360120.

Structurei

3D structure databases

ProteinModelPortaliQ01973.
SMRiQ01973. Positions 53-196, 278-393, 464-786.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 406377ExtracellularSequence AnalysisAdd
BLAST
Topological domaini428 – 937510CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei407 – 42721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 147106Ig-like C2-typeAdd
BLAST
Domaini165 – 299135FZPROSITE-ProRule annotationAdd
BLAST
Domaini312 – 39180KringlePROSITE-ProRule annotationAdd
BLAST
Domaini473 – 746274Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi753 – 78230Ser/Thr-richAdd
BLAST
Compositional biasi784 – 85168Pro-richAdd
BLAST
Compositional biasi853 – 87624Ser/Thr-richAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.PROSITE-ProRule annotation
Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation
Contains 1 kringle domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Kringle, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118818.
HOVERGENiHBG017736.
InParanoidiQ01973.
KOiK05122.
OMAiHYQPAGP.
OrthoDBiEOG76739G.
PhylomeDBiQ01973.
TreeFamiTF106465.

Family and domain databases

Gene3Di2.40.20.10. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR020067. Frizzled_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016247. Tyr_kinase_rcpt_ROR.
[Graphical view]
PfamiPF01392. Fz. 1 hit.
PF07679. I-set. 1 hit.
PF00051. Kringle. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000624. TyrPK_TMrec_ROR. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00408. IGc2. 1 hit.
SM00130. KR. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
SSF57440. SSF57440. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: Q01973-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHRPRRRGTR PPLLALLAAL LLAARGAAAQ ETELSVSAEL VPTSSWNISS
60 70 80 90 100
ELNKDSYLTL DEPMNNITTS LGQTAELHCK VSGNPPPTIR WFKNDAPVVQ
110 120 130 140 150
EPRRLSFRST IYGSRLRIRN LDTTDTGYFQ CVATNGKEVV SSTGVLFVKF
160 170 180 190 200
GPPPTASPGY SDEYEEDGFC QPYRGIACAR FIGNRTVYME SLHMQGEIEN
210 220 230 240 250
QITAAFTMIG TSSHLSDKCS QFAIPSLCHY AFPYCDETSS VPKPRDLCRD
260 270 280 290 300
ECEILENVLC QTEYIFARSN PMILMRLKLP NCEDLPQPES PEAANCIRIG
310 320 330 340 350
IPMADPINKN HKCYNSTGVD YRGTVSVTKS GRQCQPWNSQ YPHTHTFTAL
360 370 380 390 400
RFPELNGGHS YCRNPGNQKE APWCFTLDEN FKSDLCDIPA CDSKDSKEKN
410 420 430 440 450
KMEILYILVP SVAIPLAIAL LFFFICVCRN NQKSSSAPVQ RQPKHVRGQN
460 470 480 490 500
VEMSMLNAYK PKSKAKELPL SAVRFMEELG ECAFGKIYKG HLYLPGMDHA
510 520 530 540 550
QLVAIKTLKD YNNPQQWTEF QQEASLMAEL HHPNIVCLLG AVTQEQPVCM
560 570 580 590 600
LFEYINQGDL HEFLIMRSPH SDVGCSSDED GTVKSSLDHG DFLHIAIQIA
610 620 630 640 650
AGMEYLSSHF FVHKDLAARN ILIGEQLHVK ISDLGLSREI YSADYYRVQS
660 670 680 690 700
KSLLPIRWMP PEAIMYGKFS SDSDIWSFGV VLWEIFSFGL QPYYGFSNQE
710 720 730 740 750
VIEMVRKRQL LPCSEDCPPR MYSLMTECWN EIPSRRPRFK DIHVRLRSWE
760 770 780 790 800
GLSSHTSSTT PSGGNATTQT TSLSASPVSN LSNPRYPNYM FPSQGITPQG
810 820 830 840 850
QIAGFIGPPI PQNQRFIPIN GYPIPPGYAA FPAAHYQPTG PPRVIQHCPP
860 870 880 890 900
PKSRSPSSAS GSTSTGHVTS LPSSGSNQEA NIPLLPHMSI PNHPGGMGIT
910 920 930
VFGNKSQKPY KIDSKQASLL GDANIHGHTE SMISAEL
Length:937
Mass (Da):104,283
Last modified:November 28, 2006 - v2
Checksum:i0EC0E4762A90C6C7
GO
Isoform Short (identifier: Q01973-2) [UniParc]FASTAAdd to Basket

Also known as: T-ROR1

The sequence of this isoform differs from the canonical sequence as follows:
     1-549: Missing.

Show »
Length:388
Mass (Da):42,833
Checksum:i8DC1D0BA14085BD2
GO
Isoform 3 (identifier: Q01973-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     392-393: DS → GK
     394-937: Missing.

Note: No experimental confirmation available.

Show »
Length:393
Mass (Da):43,826
Checksum:i1F93DCBBBBF53855
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti144 – 1441G → E in a metastatic melanoma sample; somatic mutation. 1 Publication
VAR_041779
Natural varianti150 – 1501F → L in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication
VAR_041780
Natural varianti301 – 3011I → V in a renal clear cell carcinoma sample; somatic mutation. 1 Publication
VAR_041781
Natural varianti518 – 5181T → M.2 Publications
Corresponds to variant rs7527017 [ dbSNP | Ensembl ].
VAR_041782
Natural varianti562 – 5621E → D in a breast cancer sample; somatic mutation. 1 Publication
VAR_035713
Natural varianti567 – 5671R → I in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
VAR_041783
Natural varianti624 – 6241G → R.1 Publication
Corresponds to variant rs55832740 [ dbSNP | Ensembl ].
VAR_041784
Natural varianti646 – 6461Y → C.1 Publication
Corresponds to variant rs34109134 [ dbSNP | Ensembl ].
VAR_041785
Natural varianti776 – 7761S → N in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
VAR_041786

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 549549Missing in isoform Short. 1 PublicationVSP_005008Add
BLAST
Alternative sequencei392 – 3932DS → GK in isoform 3. 1 PublicationVSP_043663
Alternative sequencei394 – 937544Missing in isoform 3. 1 PublicationVSP_043664Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M97675 mRNA. Translation: AAA60275.1.
U38894 mRNA. Translation: AAC50714.1.
AL137859, AL161742, AL445205 Genomic DNA. Translation: CAC17591.2.
AL445205, AL137859, AL161742 Genomic DNA. Translation: CAH71705.1.
AL445205, AL137859, AL161742 Genomic DNA. Translation: CAH71706.1.
AL137859, AL445205, AL161742 Genomic DNA. Translation: CAI21732.1.
AL161742, AL137859, AL445205 Genomic DNA. Translation: CAI21931.1.
AL161742, AL445205, AL137859 Genomic DNA. Translation: CAI21932.1.
AL138793 Genomic DNA. No translation available.
AL353713 Genomic DNA. No translation available.
AL808029 Genomic DNA. No translation available.
AL808030 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX06556.1.
BC080541 mRNA. Translation: AAH80541.1.
CCDSiCCDS41344.1. [Q01973-3]
CCDS626.1. [Q01973-1]
PIRiA45082.
RefSeqiNP_001077061.1. NM_001083592.1. [Q01973-3]
NP_005003.2. NM_005012.3. [Q01973-1]
UniGeneiHs.128753.

Genome annotation databases

EnsembliENST00000371079; ENSP00000360120; ENSG00000185483. [Q01973-1]
ENST00000371080; ENSP00000360121; ENSG00000185483. [Q01973-3]
GeneIDi4919.
KEGGihsa:4919.
UCSCiuc001dbi.4. human. [Q01973-3]
uc001dbj.3. human. [Q01973-1]

Polymorphism databases

DMDMi118572711.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M97675 mRNA. Translation: AAA60275.1 .
U38894 mRNA. Translation: AAC50714.1 .
AL137859 , AL161742 , AL445205 Genomic DNA. Translation: CAC17591.2 .
AL445205 , AL137859 , AL161742 Genomic DNA. Translation: CAH71705.1 .
AL445205 , AL137859 , AL161742 Genomic DNA. Translation: CAH71706.1 .
AL137859 , AL445205 , AL161742 Genomic DNA. Translation: CAI21732.1 .
AL161742 , AL137859 , AL445205 Genomic DNA. Translation: CAI21931.1 .
AL161742 , AL445205 , AL137859 Genomic DNA. Translation: CAI21932.1 .
AL138793 Genomic DNA. No translation available.
AL353713 Genomic DNA. No translation available.
AL808029 Genomic DNA. No translation available.
AL808030 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX06556.1 .
BC080541 mRNA. Translation: AAH80541.1 .
CCDSi CCDS41344.1. [Q01973-3 ]
CCDS626.1. [Q01973-1 ]
PIRi A45082.
RefSeqi NP_001077061.1. NM_001083592.1. [Q01973-3 ]
NP_005003.2. NM_005012.3. [Q01973-1 ]
UniGenei Hs.128753.

3D structure databases

ProteinModelPortali Q01973.
SMRi Q01973. Positions 53-196, 278-393, 464-786.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110973. 6 interactions.
DIPi DIP-29734N.
DIP-5713N.
IntActi Q01973. 8 interactions.
MINTi MINT-5004457.
STRINGi 9606.ENSP00000360120.

PTM databases

PhosphoSitei Q01973.

Polymorphism databases

DMDMi 118572711.

Proteomic databases

MaxQBi Q01973.
PaxDbi Q01973.
PRIDEi Q01973.

Protocols and materials databases

DNASUi 4919.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000371079 ; ENSP00000360120 ; ENSG00000185483 . [Q01973-1 ]
ENST00000371080 ; ENSP00000360121 ; ENSG00000185483 . [Q01973-3 ]
GeneIDi 4919.
KEGGi hsa:4919.
UCSCi uc001dbi.4. human. [Q01973-3 ]
uc001dbj.3. human. [Q01973-1 ]

Organism-specific databases

CTDi 4919.
GeneCardsi GC01P064239.
HGNCi HGNC:10256. ROR1.
HPAi HPA057016.
MIMi 602336. gene.
neXtProti NX_Q01973.
PharmGKBi PA34628.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118818.
HOVERGENi HBG017736.
InParanoidi Q01973.
KOi K05122.
OMAi HYQPAGP.
OrthoDBi EOG76739G.
PhylomeDBi Q01973.
TreeFami TF106465.

Enzyme and pathway databases

BRENDAi 2.7.10.1. 2681.
Reactomei REACT_172631. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
SignaLinki Q01973.

Miscellaneous databases

ChiTaRSi ROR1. human.
GeneWikii ROR1.
GenomeRNAii 4919.
NextBioi 18939.
PROi Q01973.
SOURCEi Search...

Gene expression databases

Bgeei Q01973.
CleanExi HS_ROR1.
Genevestigatori Q01973.

Family and domain databases

Gene3Di 2.40.20.10. 1 hit.
2.60.40.10. 1 hit.
InterProi IPR020067. Frizzled_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016247. Tyr_kinase_rcpt_ROR.
[Graphical view ]
Pfami PF01392. Fz. 1 hit.
PF07679. I-set. 1 hit.
PF00051. Kringle. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000624. TyrPK_TMrec_ROR. 1 hit.
PRINTSi PR00109. TYRKINASE.
SMARTi SM00408. IGc2. 1 hit.
SM00130. KR. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
SSF57440. SSF57440. 1 hit.
PROSITEi PS50038. FZ. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel family of cell surface receptors with tyrosine kinase-like domain."
    Masiakowski P., Carroll R.D.
    J. Biol. Chem. 267:26181-26190(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), VARIANT MET-518.
  2. "Human neural tissues express a truncated Ror1 receptor tyrosine kinase, lacking both extracellular and transmembrane domains."
    Reddy U.R., Phatak S., Pleasure D.
    Oncogene 13:1555-1559(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-562.
  7. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLU-144; LEU-150; VAL-301; MET-518; ILE-567; ARG-624; CYS-646 AND ASN-776.

Entry informationi

Entry nameiROR1_HUMAN
AccessioniPrimary (citable) accession number: Q01973
Secondary accession number(s): Q5VVX6, Q66K77, Q92776
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 28, 2006
Last modified: October 29, 2014
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3