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Q01973 (ROR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 144. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase transmembrane receptor ROR1

EC=2.7.10.1
Alternative name(s):
Neurotrophic tyrosine kinase, receptor-related 1
Gene names
Name:ROR1
Synonyms:NTRKR1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length937 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Tyrosine-protein kinase receptor whose role is not yet clear.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.

Developmental stage

Expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.

Contains 1 FZ (frizzled) domain.

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 1 kringle domain.

Contains 1 protein kinase domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

EGFRP005338EBI-6082337,EBI-297353
SRCP129319EBI-6082337,EBI-621482
SrcP054803EBI-6082337,EBI-298680From a different organism.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform Long (identifier: Q01973-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Short (identifier: Q01973-2)

Also known as: T-ROR1;

The sequence of this isoform differs from the canonical sequence as follows:
     1-549: Missing.
Isoform 3 (identifier: Q01973-3)

The sequence of this isoform differs from the canonical sequence as follows:
     392-393: DS → GK
     394-937: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 937908Tyrosine-protein kinase transmembrane receptor ROR1
PRO_0000024458

Regions

Topological domain30 – 406377Extracellular Potential
Transmembrane407 – 42721Helical; Potential
Topological domain428 – 937510Cytoplasmic Potential
Domain42 – 147106Ig-like C2-type
Domain165 – 299135FZ
Domain312 – 39180Kringle
Domain473 – 746274Protein kinase
Nucleotide binding479 – 4879ATP By similarity
Compositional bias753 – 78230Ser/Thr-rich
Compositional bias784 – 85168Pro-rich
Compositional bias853 – 87624Ser/Thr-rich

Sites

Active site6151Proton acceptor By similarity
Binding site5061ATP By similarity

Amino acid modifications

Modified residue6451Phosphotyrosine; by autocatalysis By similarity
Glycosylation471N-linked (GlcNAc...) Potential
Glycosylation661N-linked (GlcNAc...) Potential
Glycosylation1841N-linked (GlcNAc...) Potential
Glycosylation3151N-linked (GlcNAc...) Potential
Disulfide bond79 ↔ 131 By similarity
Disulfide bond170 ↔ 235 By similarity
Disulfide bond178 ↔ 228 By similarity
Disulfide bond219 ↔ 260 By similarity
Disulfide bond248 ↔ 296 By similarity
Disulfide bond252 ↔ 282 By similarity
Disulfide bond313 ↔ 391 By similarity
Disulfide bond334 ↔ 374 By similarity
Disulfide bond362 ↔ 386 By similarity

Natural variations

Alternative sequence1 – 549549Missing in isoform Short.
VSP_005008
Alternative sequence392 – 3932DS → GK in isoform 3.
VSP_043663
Alternative sequence394 – 937544Missing in isoform 3.
VSP_043664
Natural variant1441G → E in a metastatic melanoma sample; somatic mutation. Ref.7
VAR_041779
Natural variant1501F → L in an ovarian mucinous carcinoma sample; somatic mutation. Ref.7
VAR_041780
Natural variant3011I → V in a renal clear cell carcinoma sample; somatic mutation. Ref.7
VAR_041781
Natural variant5181T → M. Ref.1 Ref.7
Corresponds to variant rs7527017 [ dbSNP | Ensembl ].
VAR_041782
Natural variant5621E → D in a breast cancer sample; somatic mutation. Ref.6
VAR_035713
Natural variant5671R → I in a colorectal adenocarcinoma sample; somatic mutation. Ref.7
VAR_041783
Natural variant6241G → R. Ref.7
Corresponds to variant rs55832740 [ dbSNP | Ensembl ].
VAR_041784
Natural variant6461Y → C. Ref.7
Corresponds to variant rs34109134 [ dbSNP | Ensembl ].
VAR_041785
Natural variant7761S → N in a colorectal adenocarcinoma sample; somatic mutation. Ref.7
VAR_041786

Sequences

Sequence LengthMass (Da)Tools
Isoform Long [UniParc].

Last modified November 28, 2006. Version 2.
Checksum: 0EC0E4762A90C6C7

FASTA937104,283
        10         20         30         40         50         60 
MHRPRRRGTR PPLLALLAAL LLAARGAAAQ ETELSVSAEL VPTSSWNISS ELNKDSYLTL 

        70         80         90        100        110        120 
DEPMNNITTS LGQTAELHCK VSGNPPPTIR WFKNDAPVVQ EPRRLSFRST IYGSRLRIRN 

       130        140        150        160        170        180 
LDTTDTGYFQ CVATNGKEVV SSTGVLFVKF GPPPTASPGY SDEYEEDGFC QPYRGIACAR 

       190        200        210        220        230        240 
FIGNRTVYME SLHMQGEIEN QITAAFTMIG TSSHLSDKCS QFAIPSLCHY AFPYCDETSS 

       250        260        270        280        290        300 
VPKPRDLCRD ECEILENVLC QTEYIFARSN PMILMRLKLP NCEDLPQPES PEAANCIRIG 

       310        320        330        340        350        360 
IPMADPINKN HKCYNSTGVD YRGTVSVTKS GRQCQPWNSQ YPHTHTFTAL RFPELNGGHS 

       370        380        390        400        410        420 
YCRNPGNQKE APWCFTLDEN FKSDLCDIPA CDSKDSKEKN KMEILYILVP SVAIPLAIAL 

       430        440        450        460        470        480 
LFFFICVCRN NQKSSSAPVQ RQPKHVRGQN VEMSMLNAYK PKSKAKELPL SAVRFMEELG 

       490        500        510        520        530        540 
ECAFGKIYKG HLYLPGMDHA QLVAIKTLKD YNNPQQWTEF QQEASLMAEL HHPNIVCLLG 

       550        560        570        580        590        600 
AVTQEQPVCM LFEYINQGDL HEFLIMRSPH SDVGCSSDED GTVKSSLDHG DFLHIAIQIA 

       610        620        630        640        650        660 
AGMEYLSSHF FVHKDLAARN ILIGEQLHVK ISDLGLSREI YSADYYRVQS KSLLPIRWMP 

       670        680        690        700        710        720 
PEAIMYGKFS SDSDIWSFGV VLWEIFSFGL QPYYGFSNQE VIEMVRKRQL LPCSEDCPPR 

       730        740        750        760        770        780 
MYSLMTECWN EIPSRRPRFK DIHVRLRSWE GLSSHTSSTT PSGGNATTQT TSLSASPVSN 

       790        800        810        820        830        840 
LSNPRYPNYM FPSQGITPQG QIAGFIGPPI PQNQRFIPIN GYPIPPGYAA FPAAHYQPTG 

       850        860        870        880        890        900 
PPRVIQHCPP PKSRSPSSAS GSTSTGHVTS LPSSGSNQEA NIPLLPHMSI PNHPGGMGIT 

       910        920        930 
VFGNKSQKPY KIDSKQASLL GDANIHGHTE SMISAEL 

« Hide

Isoform Short (T-ROR1) [UniParc].

Checksum: 8DC1D0BA14085BD2
Show »

FASTA38842,833
Isoform 3 [UniParc].

Checksum: 1F93DCBBBBF53855
Show »

FASTA39343,826

References

« Hide 'large scale' references
[1]"A novel family of cell surface receptors with tyrosine kinase-like domain."
Masiakowski P., Carroll R.D.
J. Biol. Chem. 267:26181-26190(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), VARIANT MET-518.
[2]"Human neural tissues express a truncated Ror1 receptor tyrosine kinase, lacking both extracellular and transmembrane domains."
Reddy U.R., Phatak S., Pleasure D.
Oncogene 13:1555-1559(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Brain.
[6]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-562.
[7]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLU-144; LEU-150; VAL-301; MET-518; ILE-567; ARG-624; CYS-646 AND ASN-776.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M97675 mRNA. Translation: AAA60275.1.
U38894 mRNA. Translation: AAC50714.1.
AL137859, AL161742, AL445205 Genomic DNA. Translation: CAC17591.2.
AL445205, AL137859, AL161742 Genomic DNA. Translation: CAH71705.1.
AL445205, AL137859, AL161742 Genomic DNA. Translation: CAH71706.1.
AL137859, AL445205, AL161742 Genomic DNA. Translation: CAI21732.1.
AL161742, AL137859, AL445205 Genomic DNA. Translation: CAI21931.1.
AL161742, AL445205, AL137859 Genomic DNA. Translation: CAI21932.1.
AL138793 Genomic DNA. No translation available.
AL353713 Genomic DNA. No translation available.
AL808029 Genomic DNA. No translation available.
AL808030 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX06556.1.
BC080541 mRNA. Translation: AAH80541.1.
PIRA45082.
RefSeqNP_001077061.1. NM_001083592.1.
NP_005003.2. NM_005012.3.
UniGeneHs.128753.

3D structure databases

ProteinModelPortalQ01973.
SMRQ01973. Positions 34-154, 278-393, 405-786.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110973. 6 interactions.
DIPDIP-29734N.
DIP-5713N.
IntActQ01973. 8 interactions.
MINTMINT-5004457.
STRING9606.ENSP00000360120.

PTM databases

PhosphoSiteQ01973.

Polymorphism databases

DMDM118572711.

Proteomic databases

PaxDbQ01973.
PRIDEQ01973.

Protocols and materials databases

DNASU4919.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000371079; ENSP00000360120; ENSG00000185483. [Q01973-1]
ENST00000371080; ENSP00000360121; ENSG00000185483. [Q01973-3]
ENST00000545203; ENSP00000441637; ENSG00000185483. [Q01973-2]
GeneID4919.
KEGGhsa:4919.
UCSCuc001dbi.4. human. [Q01973-3]
uc001dbj.3. human. [Q01973-1]

Organism-specific databases

CTD4919.
GeneCardsGC01P064239.
HGNCHGNC:10256. ROR1.
HPAHPA057016.
MIM602336. gene.
neXtProtNX_Q01973.
PharmGKBPA34628.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0515.
HOVERGENHBG017736.
InParanoidQ01973.
KOK05122.
OMAHYQPAGP.
OrthoDBEOG76739G.
PhylomeDBQ01973.
TreeFamTF106465.

Enzyme and pathway databases

BRENDA2.7.10.1. 2681.
ReactomeREACT_111102. Signal Transduction.
SignaLinkQ01973.

Gene expression databases

BgeeQ01973.
CleanExHS_ROR1.
GenevestigatorQ01973.

Family and domain databases

Gene3D2.40.20.10. 1 hit.
2.60.40.10. 1 hit.
InterProIPR020067. Frizzled_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016247. Tyr_kinase_rcpt_ROR.
[Graphical view]
PfamPF01392. Fz. 1 hit.
PF07679. I-set. 1 hit.
PF00051. Kringle. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFPIRSF000624. TyrPK_TMrec_ROR. 1 hit.
PRINTSPR00109. TYRKINASE.
SMARTSM00408. IGc2. 1 hit.
SM00130. KR. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
SSF57440. SSF57440. 1 hit.
PROSITEPS50038. FZ. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSROR1. human.
GeneWikiROR1.
GenomeRNAi4919.
NextBio18939.
PROQ01973.
SOURCESearch...

Entry information

Entry nameROR1_HUMAN
AccessionPrimary (citable) accession number: Q01973
Secondary accession number(s): Q5VVX6, Q66K77, Q92776
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 28, 2006
Last modified: April 16, 2014
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM