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Q01973

- ROR1_HUMAN

UniProt

Q01973 - ROR1_HUMAN

Protein

Tyrosine-protein kinase transmembrane receptor ROR1

Gene

ROR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 149 (01 Oct 2014)
      Sequence version 2 (28 Nov 2006)
      Previous versions | rss
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    Functioni

    Tyrosine-protein kinase receptor whose role is not yet clear.

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei506 – 5061ATPPROSITE-ProRule annotation
    Active sitei615 – 6151Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi479 – 4879ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. transmembrane receptor protein tyrosine kinase activity Source: ProtInc
    4. Wnt-protein binding Source: UniProtKB

    GO - Biological processi

    1. peptidyl-tyrosine phosphorylation Source: GOC
    2. transmembrane receptor protein tyrosine kinase signaling pathway Source: ProtInc

    Keywords - Molecular functioni

    Kinase, Receptor, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.1. 2681.
    ReactomeiREACT_172631. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
    SignaLinkiQ01973.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase transmembrane receptor ROR1 (EC:2.7.10.1)
    Alternative name(s):
    Neurotrophic tyrosine kinase, receptor-related 1
    Gene namesi
    Name:ROR1
    Synonyms:NTRKR1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:10256. ROR1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: ProtInc
    2. integral component of plasma membrane Source: ProtInc
    3. plasma membrane Source: ProtInc
    4. receptor complex Source: MGI

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34628.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 937908Tyrosine-protein kinase transmembrane receptor ROR1PRO_0000024458Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi79 ↔ 131By similarity
    Disulfide bondi170 ↔ 235By similarity
    Disulfide bondi178 ↔ 228By similarity
    Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi219 ↔ 260By similarity
    Disulfide bondi248 ↔ 296By similarity
    Disulfide bondi252 ↔ 282By similarity
    Disulfide bondi313 ↔ 391By similarity
    Glycosylationi315 – 3151N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi334 ↔ 374By similarity
    Disulfide bondi362 ↔ 386By similarity
    Modified residuei645 – 6451Phosphotyrosine; by autocatalysisBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ01973.
    PaxDbiQ01973.
    PRIDEiQ01973.

    PTM databases

    PhosphoSiteiQ01973.

    Expressioni

    Tissue specificityi

    Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.

    Developmental stagei

    Expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues.

    Gene expression databases

    BgeeiQ01973.
    CleanExiHS_ROR1.
    GenevestigatoriQ01973.

    Organism-specific databases

    HPAiHPA057016.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    EGFRP005338EBI-6082337,EBI-297353
    SRCP129319EBI-6082337,EBI-621482
    SrcP054803EBI-6082337,EBI-298680From a different organism.

    Protein-protein interaction databases

    BioGridi110973. 6 interactions.
    DIPiDIP-29734N.
    DIP-5713N.
    IntActiQ01973. 8 interactions.
    MINTiMINT-5004457.
    STRINGi9606.ENSP00000360120.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01973.
    SMRiQ01973. Positions 34-154, 278-393, 464-786.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini30 – 406377ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini428 – 937510CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei407 – 42721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini42 – 147106Ig-like C2-typeAdd
    BLAST
    Domaini165 – 299135FZPROSITE-ProRule annotationAdd
    BLAST
    Domaini312 – 39180KringlePROSITE-ProRule annotationAdd
    BLAST
    Domaini473 – 746274Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi753 – 78230Ser/Thr-richAdd
    BLAST
    Compositional biasi784 – 85168Pro-richAdd
    BLAST
    Compositional biasi853 – 87624Ser/Thr-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.PROSITE-ProRule annotation
    Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation
    Contains 1 kringle domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Kringle, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    HOVERGENiHBG017736.
    InParanoidiQ01973.
    KOiK05122.
    OMAiHYQPAGP.
    OrthoDBiEOG76739G.
    PhylomeDBiQ01973.
    TreeFamiTF106465.

    Family and domain databases

    Gene3Di2.40.20.10. 1 hit.
    2.60.40.10. 1 hit.
    InterProiIPR020067. Frizzled_dom.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR011009. Kinase-like_dom.
    IPR000001. Kringle.
    IPR013806. Kringle-like.
    IPR018056. Kringle_CS.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016247. Tyr_kinase_rcpt_ROR.
    [Graphical view]
    PfamiPF01392. Fz. 1 hit.
    PF07679. I-set. 1 hit.
    PF00051. Kringle. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000624. TyrPK_TMrec_ROR. 1 hit.
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00408. IGc2. 1 hit.
    SM00130. KR. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    SSF57440. SSF57440. 1 hit.
    PROSITEiPS50038. FZ. 1 hit.
    PS50835. IG_LIKE. 1 hit.
    PS00021. KRINGLE_1. 1 hit.
    PS50070. KRINGLE_2. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform Long (identifier: Q01973-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MHRPRRRGTR PPLLALLAAL LLAARGAAAQ ETELSVSAEL VPTSSWNISS    50
    ELNKDSYLTL DEPMNNITTS LGQTAELHCK VSGNPPPTIR WFKNDAPVVQ 100
    EPRRLSFRST IYGSRLRIRN LDTTDTGYFQ CVATNGKEVV SSTGVLFVKF 150
    GPPPTASPGY SDEYEEDGFC QPYRGIACAR FIGNRTVYME SLHMQGEIEN 200
    QITAAFTMIG TSSHLSDKCS QFAIPSLCHY AFPYCDETSS VPKPRDLCRD 250
    ECEILENVLC QTEYIFARSN PMILMRLKLP NCEDLPQPES PEAANCIRIG 300
    IPMADPINKN HKCYNSTGVD YRGTVSVTKS GRQCQPWNSQ YPHTHTFTAL 350
    RFPELNGGHS YCRNPGNQKE APWCFTLDEN FKSDLCDIPA CDSKDSKEKN 400
    KMEILYILVP SVAIPLAIAL LFFFICVCRN NQKSSSAPVQ RQPKHVRGQN 450
    VEMSMLNAYK PKSKAKELPL SAVRFMEELG ECAFGKIYKG HLYLPGMDHA 500
    QLVAIKTLKD YNNPQQWTEF QQEASLMAEL HHPNIVCLLG AVTQEQPVCM 550
    LFEYINQGDL HEFLIMRSPH SDVGCSSDED GTVKSSLDHG DFLHIAIQIA 600
    AGMEYLSSHF FVHKDLAARN ILIGEQLHVK ISDLGLSREI YSADYYRVQS 650
    KSLLPIRWMP PEAIMYGKFS SDSDIWSFGV VLWEIFSFGL QPYYGFSNQE 700
    VIEMVRKRQL LPCSEDCPPR MYSLMTECWN EIPSRRPRFK DIHVRLRSWE 750
    GLSSHTSSTT PSGGNATTQT TSLSASPVSN LSNPRYPNYM FPSQGITPQG 800
    QIAGFIGPPI PQNQRFIPIN GYPIPPGYAA FPAAHYQPTG PPRVIQHCPP 850
    PKSRSPSSAS GSTSTGHVTS LPSSGSNQEA NIPLLPHMSI PNHPGGMGIT 900
    VFGNKSQKPY KIDSKQASLL GDANIHGHTE SMISAEL 937
    Length:937
    Mass (Da):104,283
    Last modified:November 28, 2006 - v2
    Checksum:i0EC0E4762A90C6C7
    GO
    Isoform Short (identifier: Q01973-2) [UniParc]FASTAAdd to Basket

    Also known as: T-ROR1

    The sequence of this isoform differs from the canonical sequence as follows:
         1-549: Missing.

    Show »
    Length:388
    Mass (Da):42,833
    Checksum:i8DC1D0BA14085BD2
    GO
    Isoform 3 (identifier: Q01973-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         392-393: DS → GK
         394-937: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:393
    Mass (Da):43,826
    Checksum:i1F93DCBBBBF53855
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti144 – 1441G → E in a metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_041779
    Natural varianti150 – 1501F → L in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication
    VAR_041780
    Natural varianti301 – 3011I → V in a renal clear cell carcinoma sample; somatic mutation. 1 Publication
    VAR_041781
    Natural varianti518 – 5181T → M.2 Publications
    Corresponds to variant rs7527017 [ dbSNP | Ensembl ].
    VAR_041782
    Natural varianti562 – 5621E → D in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035713
    Natural varianti567 – 5671R → I in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_041783
    Natural varianti624 – 6241G → R.1 Publication
    Corresponds to variant rs55832740 [ dbSNP | Ensembl ].
    VAR_041784
    Natural varianti646 – 6461Y → C.1 Publication
    Corresponds to variant rs34109134 [ dbSNP | Ensembl ].
    VAR_041785
    Natural varianti776 – 7761S → N in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_041786

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 549549Missing in isoform Short. 1 PublicationVSP_005008Add
    BLAST
    Alternative sequencei392 – 3932DS → GK in isoform 3. 1 PublicationVSP_043663
    Alternative sequencei394 – 937544Missing in isoform 3. 1 PublicationVSP_043664Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M97675 mRNA. Translation: AAA60275.1.
    U38894 mRNA. Translation: AAC50714.1.
    AL137859, AL161742, AL445205 Genomic DNA. Translation: CAC17591.2.
    AL445205, AL137859, AL161742 Genomic DNA. Translation: CAH71705.1.
    AL445205, AL137859, AL161742 Genomic DNA. Translation: CAH71706.1.
    AL137859, AL445205, AL161742 Genomic DNA. Translation: CAI21732.1.
    AL161742, AL137859, AL445205 Genomic DNA. Translation: CAI21931.1.
    AL161742, AL445205, AL137859 Genomic DNA. Translation: CAI21932.1.
    AL138793 Genomic DNA. No translation available.
    AL353713 Genomic DNA. No translation available.
    AL808029 Genomic DNA. No translation available.
    AL808030 Genomic DNA. No translation available.
    CH471059 Genomic DNA. Translation: EAX06556.1.
    BC080541 mRNA. Translation: AAH80541.1.
    CCDSiCCDS41344.1. [Q01973-3]
    CCDS626.1. [Q01973-1]
    PIRiA45082.
    RefSeqiNP_001077061.1. NM_001083592.1. [Q01973-3]
    NP_005003.2. NM_005012.3. [Q01973-1]
    UniGeneiHs.128753.

    Genome annotation databases

    EnsembliENST00000371079; ENSP00000360120; ENSG00000185483. [Q01973-1]
    ENST00000371080; ENSP00000360121; ENSG00000185483. [Q01973-3]
    ENST00000545203; ENSP00000441637; ENSG00000185483. [Q01973-2]
    GeneIDi4919.
    KEGGihsa:4919.
    UCSCiuc001dbi.4. human. [Q01973-3]
    uc001dbj.3. human. [Q01973-1]

    Polymorphism databases

    DMDMi118572711.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M97675 mRNA. Translation: AAA60275.1 .
    U38894 mRNA. Translation: AAC50714.1 .
    AL137859 , AL161742 , AL445205 Genomic DNA. Translation: CAC17591.2 .
    AL445205 , AL137859 , AL161742 Genomic DNA. Translation: CAH71705.1 .
    AL445205 , AL137859 , AL161742 Genomic DNA. Translation: CAH71706.1 .
    AL137859 , AL445205 , AL161742 Genomic DNA. Translation: CAI21732.1 .
    AL161742 , AL137859 , AL445205 Genomic DNA. Translation: CAI21931.1 .
    AL161742 , AL445205 , AL137859 Genomic DNA. Translation: CAI21932.1 .
    AL138793 Genomic DNA. No translation available.
    AL353713 Genomic DNA. No translation available.
    AL808029 Genomic DNA. No translation available.
    AL808030 Genomic DNA. No translation available.
    CH471059 Genomic DNA. Translation: EAX06556.1 .
    BC080541 mRNA. Translation: AAH80541.1 .
    CCDSi CCDS41344.1. [Q01973-3 ]
    CCDS626.1. [Q01973-1 ]
    PIRi A45082.
    RefSeqi NP_001077061.1. NM_001083592.1. [Q01973-3 ]
    NP_005003.2. NM_005012.3. [Q01973-1 ]
    UniGenei Hs.128753.

    3D structure databases

    ProteinModelPortali Q01973.
    SMRi Q01973. Positions 34-154, 278-393, 464-786.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110973. 6 interactions.
    DIPi DIP-29734N.
    DIP-5713N.
    IntActi Q01973. 8 interactions.
    MINTi MINT-5004457.
    STRINGi 9606.ENSP00000360120.

    PTM databases

    PhosphoSitei Q01973.

    Polymorphism databases

    DMDMi 118572711.

    Proteomic databases

    MaxQBi Q01973.
    PaxDbi Q01973.
    PRIDEi Q01973.

    Protocols and materials databases

    DNASUi 4919.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000371079 ; ENSP00000360120 ; ENSG00000185483 . [Q01973-1 ]
    ENST00000371080 ; ENSP00000360121 ; ENSG00000185483 . [Q01973-3 ]
    ENST00000545203 ; ENSP00000441637 ; ENSG00000185483 . [Q01973-2 ]
    GeneIDi 4919.
    KEGGi hsa:4919.
    UCSCi uc001dbi.4. human. [Q01973-3 ]
    uc001dbj.3. human. [Q01973-1 ]

    Organism-specific databases

    CTDi 4919.
    GeneCardsi GC01P064239.
    HGNCi HGNC:10256. ROR1.
    HPAi HPA057016.
    MIMi 602336. gene.
    neXtProti NX_Q01973.
    PharmGKBi PA34628.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOVERGENi HBG017736.
    InParanoidi Q01973.
    KOi K05122.
    OMAi HYQPAGP.
    OrthoDBi EOG76739G.
    PhylomeDBi Q01973.
    TreeFami TF106465.

    Enzyme and pathway databases

    BRENDAi 2.7.10.1. 2681.
    Reactomei REACT_172631. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
    SignaLinki Q01973.

    Miscellaneous databases

    ChiTaRSi ROR1. human.
    GeneWikii ROR1.
    GenomeRNAii 4919.
    NextBioi 18939.
    PROi Q01973.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q01973.
    CleanExi HS_ROR1.
    Genevestigatori Q01973.

    Family and domain databases

    Gene3Di 2.40.20.10. 1 hit.
    2.60.40.10. 1 hit.
    InterProi IPR020067. Frizzled_dom.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR011009. Kinase-like_dom.
    IPR000001. Kringle.
    IPR013806. Kringle-like.
    IPR018056. Kringle_CS.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016247. Tyr_kinase_rcpt_ROR.
    [Graphical view ]
    Pfami PF01392. Fz. 1 hit.
    PF07679. I-set. 1 hit.
    PF00051. Kringle. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000624. TyrPK_TMrec_ROR. 1 hit.
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00408. IGc2. 1 hit.
    SM00130. KR. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    SSF57440. SSF57440. 1 hit.
    PROSITEi PS50038. FZ. 1 hit.
    PS50835. IG_LIKE. 1 hit.
    PS00021. KRINGLE_1. 1 hit.
    PS50070. KRINGLE_2. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel family of cell surface receptors with tyrosine kinase-like domain."
      Masiakowski P., Carroll R.D.
      J. Biol. Chem. 267:26181-26190(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), VARIANT MET-518.
    2. "Human neural tissues express a truncated Ror1 receptor tyrosine kinase, lacking both extracellular and transmembrane domains."
      Reddy U.R., Phatak S., Pleasure D.
      Oncogene 13:1555-1559(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Brain.
    6. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-562.
    7. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLU-144; LEU-150; VAL-301; MET-518; ILE-567; ARG-624; CYS-646 AND ASN-776.

    Entry informationi

    Entry nameiROR1_HUMAN
    AccessioniPrimary (citable) accession number: Q01973
    Secondary accession number(s): Q5VVX6, Q66K77, Q92776
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: November 28, 2006
    Last modified: October 1, 2014
    This is version 149 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3