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Q01971 (RAB2A_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ras-related protein Rab-2A
Gene names
Name:RAB2A
Synonyms:RAB2
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length212 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Required for protein transport from the endoplasmic reticulum to the Golgi complex By similarity.

Subunit structure

Interacts with PRKCI By similarity.

Subcellular location

Endoplasmic reticulum-Golgi intermediate compartment membrane; Lipid-anchor. Melanosome By similarity. Endoplasmic reticulum membrane; Lipid-anchor Potential. Golgi apparatus membrane; Lipid-anchor Potential.

Tissue specificity

Brain and parietal cells.

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 212212Ras-related protein Rab-2A
PRO_0000121068

Regions

Nucleotide binding13 – 219GTP By similarity
Nucleotide binding61 – 655GTP By similarity
Nucleotide binding119 – 1224GTP By similarity
Nucleotide binding149 – 1513GTP By similarity
Region1 – 1919Required for interaction with PRKCI By similarity
Motif35 – 439Effector region By similarity

Amino acid modifications

Lipidation2111S-geranylgeranyl cysteine By similarity
Lipidation2121S-geranylgeranyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q01971 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: F8731E3F8B68B9A3

FASTA21223,532
        10         20         30         40         50         60 
MAYAYLFKYI IIGDTGVGKS CLLLQFTDKR FQPVHDLTIG VEFGARMITI DGKQIKLQIW 

        70         80         90        100        110        120 
DTAGQESFRS ITRSYYRGAA GALLVYDITR RDTFNHLTTW LEDARQHSNS NMVIMLIGNK 

       130        140        150        160        170        180 
SDLESRREVK KEEGEAFARE HGLIFMETSA KTASNVEEAF INTAKEIYEK IQEGVFDINN 

       190        200        210 
EANGIKIGPQ HGATNATHAG NQGGQQAGGG CC

« Hide

References

[1]"Identification of rab2 as a tubulovesicle-membrane-associated protein in rabbit gastric parietal cells."
Tang L.H., Stoch S.A., Modlin I.M., Goldenring J.R.
Biochem. J. 285:715-719(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X68071 mRNA. Translation: CAA48208.1.
PIRS23979.
RefSeqNP_001095172.1. NM_001101702.1.
UniGeneOcu.1928.

3D structure databases

ProteinModelPortalQ01971.
SMRQ01971. Positions 2-170.
ModBaseSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000018751.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100009281.

Organism-specific databases

CTD5862.

Phylogenomic databases

eggNOGCOG1100.
HOGENOMHOG000233968.
HOVERGENHBG009351.
OrthoDBEOG41G354.

Family and domain databases

InterProIPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00175. RAB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRAB2A_RABIT
AccessionPrimary (citable) accession number: Q01971
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 3, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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