Q01970 (PLCB3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
EC=3.1.4.11

Alternative name(s):
Phosphoinositide phospholipase C-beta-3
Phospholipase C-beta-3
Short name=PLC-beta-3

Gene names

Name:

PLCB3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1234 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Catalytic activity	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Cofactor	Calcium.
Subunit structure	Interacts with SHANK2 By similarity. Interacts with LPAR2. Ref.7
Subcellular location	Membrane; Peripheral membrane protein.
Sequence similarities	Contains 1 C2 domain. Contains 1 PI-PLC X-box domain. Contains 1 PI-PLC Y-box domain.
Sequence caution	The sequence AAH32659.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Lipid degradation Lipid metabolism
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	Calcium
Molecular function	Hydrolase Transducer
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of systemic arterial blood pressure Inferred from direct assay PubMed 18468998. Source: MGI synaptic transmission Traceable author statement. Source: Reactome
Cellular_component	cytosol Traceable author statement. Source: Reactome membrane Inferred from electronic annotation. Source: UniProtKB-SubCell protein complex Inferred from direct assay PubMed 18468998. Source: MGI
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro phosphatidylinositol phospholipase C activity Inferred from electronic annotation. Source: EC phospholipase C activity Traceable author statement Ref.2. Source: ProtInc signal transducer activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q01970-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q01970-2)

The sequence of this isoform differs from the canonical sequence as follows:
     33-99: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1234

1234

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

PRO_0000088491

Regions

Domain

318 – 468

151

PI-PLC X-box

Domain

590 – 706

117

PI-PLC Y-box

Domain

713 – 810

98

C2

Region

1231 – 1234

4

Interaction with SHANK2 By similarity

Sites

Active site

332

1

By similarity

Active site

379

1

By similarity

Amino acid modifications

Modified residue

474

1

Phosphoserine Ref.11

Modified residue

537

1

Phosphoserine Ref.9 Ref.11

Modified residue

1105

1

Phosphoserine Ref.11

Natural variations

Alternative sequence

33 – 99

67

Missing in isoform 2.

VSP_046054

Natural variant

483

1

R → H.
Corresponds to variant rs12146487 [ dbSNP | Ensembl ].

VAR_029229

Experimental info

Sequence conflict

845

1

S → L in CAA78903. Ref.6

Sequence conflict

881

1

G → E in CAA85776. Ref.2

Sequence conflict

1089 – 1119

31

REKKE…HKKEA → SWPSWPRSVRSSGRGSPRRS AGACWARCRRG in CAA85776. Ref.2

Secondary structure

1

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1234

Helix Strand Turn

Details...

Helix

20 – 24

5

Beta strand

26 – 31

6

Beta strand

40 – 45

6

Beta strand

51 – 55

5

Helix

57 – 59

3

Beta strand

61 – 65

5

Helix

66 – 68

3

Beta strand

69 – 74

6

Turn

75 – 77

3

Helix

84 – 88

5

Beta strand

103 – 108

6

Helix

112 – 114

3

Beta strand

116 – 126

11

Helix

127 – 140

14

Helix

142 – 145

4

Helix

149 – 162

14

Helix

172 – 177

6

Helix

180 – 182

3

Helix

183 – 191

9

Turn

192 – 194

3

Helix

205 – 207

3

Helix

210 – 220

11

Helix

224 – 232

9

Helix

243 – 253

11

Turn

261 – 263

3

Helix

269 – 279

11

Helix

283 – 287

5

Helix

293 – 300

8

Helix

310 – 313

4

Helix

323 – 325

3

Beta strand

326 – 328

3

Beta strand

331 – 333

3

Beta strand

336 – 338

3

Beta strand

340 – 343

4

Helix

348 – 355

8

Beta strand

360 – 366

7

Beta strand

370 – 372

3

Beta strand

382 – 384

3

Helix

389 – 399

11

Beta strand

408 – 415

8

Helix

421 – 433

13

Helix

434 – 436

3

Beta strand

447 – 450

4

Turn

456 – 461

6

Beta strand

463 – 466

4

Helix

578 – 580

3

Helix

588 – 591

4

Helix

605 – 611

7

Beta strand

616 – 621

6

Helix

622 – 631

10

Helix

633 – 642

10

Beta strand

645 – 648

4

Helix

662 – 665

4

Turn

666 – 668

3

Beta strand

670 – 672

3

Helix

681 – 690

10

Helix

693 – 695

3

Beta strand

697 – 700

4

Helix

703 – 705

3

Beta strand

726 – 737

12

Beta strand

745 – 754

10

Turn

755 – 757

3

Beta strand

771 – 773

3

Beta strand

781 – 787

7

Helix

789 – 791

3

Beta strand

793 – 800

8

Turn

801 – 803

3

Beta strand

804 – 812

9

Turn

813 – 815

3

Beta strand

819 – 826

8

Beta strand

832 – 846

15

Helix

850 – 852

3

Helix

853 – 860

8

Helix

862 – 875

14

Helix

877 – 880

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 1996. Version 2. Checksum: C5106EFBA8037788	FASTA	1,234	138,799
	10 20 30 40 50 60 MAGAQPGVHA LQLEPPTVVE TLRRGSKFIK WDEETSSRNL VTLRVDPNGF FLYWTGPNME 70 80 90 100 110 120 VDTLDISSIR DTRTGRYARL PKDPKIREVL GFGGPDARLE EKLMTVVSGP DPVNTVFLNF 130 140 150 160 170 180 MAVQDDTAKV WSEELFKLAM NILAQNASRN TFLRKAYTKL KLQVNQDGRI PVKNILKMFS 190 200 210 220 230 240 ADKKRVETAL ESCGLKFNRS ESIRPDEFSL EIFERFLNKL CLRPDIDKIL LEIGAKGKPY 250 260 270 280 290 300 LTLEQLMDFI NQKQRDPRLN EVLYPPLRPS QARLLIEKYE PNQQFLERDQ MSMEGFSRYL 310 320 330 340 350 360 GGEENGILPL EALDLSTDMT QPLSAYFINS SHNTYLTAGQ LAGTSSVEMY RQALLWGCRC 370 380 390 400 410 420 VELDVWKGRP PEEEPFITHG FTMTTEVPLR DVLEAIAETA FKTSPYPVIL SFENHVDSAK 430 440 450 460 470 480 QQAKMAEYCR SIFGDALLIE PLDKYPLAPG VPLPSPQDLM GRILVKNKKR HRPSAGGPDS 490 500 510 520 530 540 AGRKRPLEQS NSALSESSAA TEPSSPQLGS PSSDSCPGLS NGEEVGLEKP SLEPQKSLGD 550 560 570 580 590 600 EGLNRGPYVL GPADREDEEE DEEEEEQTDP KKPTTDEGTA SSEVNATEEM STLVNYIEPV 610 620 630 640 650 660 KFKSFEAARK RNKCFEMSSF VETKAMEQLT KSPMEFVEYN KQQLSRIYPK GTRVDSSNYM 670 680 690 700 710 720 PQLFWNVGCQ LVALNFQTLD VAMQLNAGVF EYNGRSGYLL KPEFMRRPDK SFDPFTEVIV 730 740 750 760 770 780 DGIVANALRV KVISGQFLSD RKVGIYVEVD MFGLPVDTRR KYRTRTSQGN SFNPVWDEEP 790 800 810 820 830 840 FDFPKVVLPT LASLRIAAFE EGGKFVGHRI LPVSAIRSGY HYVCLRNEAN QPLCLPALLI 850 860 870 880 890 900 YTEASDYIPD DHQDYAEALI NPIKHVSLMD QRARQLAALI GESEAQAGQE TCQDTQSQQL 910 920 930 940 950 960 GSQPSSNPTP SPLDASPRRP PGPTTSPAST SLSSPGQRDD LIASILSEVA PTPLDELRGH 970 980 990 1000 1010 1020 KALVKLRSRQ ERDLRELRKK HQRKAVTLTR RLLDGLAQAQ AEGRCRLRPG ALGGAADVED 1030 1040 1050 1060 1070 1080 TKEGEDEAKR YQEFQNRQVQ SLLELREAQV DAEAQRRLEH LRQALQRLRE VVLDANTTQF 1090 1100 1110 1120 1130 1140 KRLKEMNERE KKELQKILDR KRHNSISEAK MRDKHKKEAE LTEINRRHIT ESVNSIRRLE 1150 1160 1170 1180 1190 1200 EAQKQRHDRL VAGQQQVLQQ LAEEEPKLLA QLAQECQEQR ARLPQEIRRS LLGEMPEGLG 1210 1220 1230 DGPLVACASN GHAPGSSGHL SGADSESQEE NTQL
	Isoform 2 [UniParc]. Checksum: 597C35D7C25D4773	FASTA	1,167	131,205
	10 20 30 40 50 60 MAGAQPGVHA LQLEPPTVVE TLRRGSKFIK WDEEKLMTVV SGPDPVNTVF LNFMAVQDDT 70 80 90 100 110 120 AKVWSEELFK LAMNILAQNA SRNTFLRKAY TKLKLQVNQD GRIPVKNILK MFSADKKRVE 130 140 150 160 170 180 TALESCGLKF NRSESIRPDE FSLEIFERFL NKLCLRPDID KILLEIGAKG KPYLTLEQLM 190 200 210 220 230 240 DFINQKQRDP RLNEVLYPPL RPSQARLLIE KYEPNQQFLE RDQMSMEGFS RYLGGEENGI 250 260 270 280 290 300 LPLEALDLST DMTQPLSAYF INSSHNTYLT AGQLAGTSSV EMYRQALLWG CRCVELDVWK 310 320 330 340 350 360 GRPPEEEPFI THGFTMTTEV PLRDVLEAIA ETAFKTSPYP VILSFENHVD SAKQQAKMAE 370 380 390 400 410 420 YCRSIFGDAL LIEPLDKYPL APGVPLPSPQ DLMGRILVKN KKRHRPSAGG PDSAGRKRPL 430 440 450 460 470 480 EQSNSALSES SAATEPSSPQ LGSPSSDSCP GLSNGEEVGL EKPSLEPQKS LGDEGLNRGP 490 500 510 520 530 540 YVLGPADRED EEEDEEEEEQ TDPKKPTTDE GTASSEVNAT EEMSTLVNYI EPVKFKSFEA 550 560 570 580 590 600 ARKRNKCFEM SSFVETKAME QLTKSPMEFV EYNKQQLSRI YPKGTRVDSS NYMPQLFWNV 610 620 630 640 650 660 GCQLVALNFQ TLDVAMQLNA GVFEYNGRSG YLLKPEFMRR PDKSFDPFTE VIVDGIVANA 670 680 690 700 710 720 LRVKVISGQF LSDRKVGIYV EVDMFGLPVD TRRKYRTRTS QGNSFNPVWD EEPFDFPKVV 730 740 750 760 770 780 LPTLASLRIA AFEEGGKFVG HRILPVSAIR SGYHYVCLRN EANQPLCLPA LLIYTEASDY 790 800 810 820 830 840 IPDDHQDYAE ALINPIKHVS LMDQRARQLA ALIGESEAQA GQETCQDTQS QQLGSQPSSN 850 860 870 880 890 900 PTPSPLDASP RRPPGPTTSP ASTSLSSPGQ RDDLIASILS EVAPTPLDEL RGHKALVKLR 910 920 930 940 950 960 SRQERDLREL RKKHQRKAVT LTRRLLDGLA QAQAEGRCRL RPGALGGAAD VEDTKEGEDE 970 980 990 1000 1010 1020 AKRYQEFQNR QVQSLLELRE AQVDAEAQRR LEHLRQALQR LREVVLDANT TQFKRLKEMN 1030 1040 1050 1060 1070 1080 EREKKELQKI LDRKRHNSIS EAKMRDKHKK EAELTEINRR HITESVNSIR RLEEAQKQRH 1090 1100 1110 1120 1130 1140 DRLVAGQQQV LQQLAEEEPK LLAQLAQECQ EQRARLPQEI RRSLLGEMPE GLGDGPLVAC 1150 1160 ASNGHAPGSS GHLSGADSES QEENTQL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structural organization and expression of the human phosphatidylinositol-specific phospholipase C beta-3 gene." Mazuruk K., Schoen T.J., Chader G.J., Rodriguez I.R. Biochem. Biophys. Res. Commun. 212:190-195(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Genomic organization and complete cDNA sequence of the human phosphoinositide-specific phospholipase C beta 3 gene (PLCB3)." Lagercrantz J., Carson E., Phelan C., Grimmond S., Rosen A., Dare E., Nordenskjoeld M., Hayward N.K., Larsson C., Weber G. Genomics 26:467-472(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Uterus.
[6]	"Identification, purification and characterization of a novel phosphatidylinositol-specific phospholipase C, a third member of the beta subfamily." Carozzi A.J., Kriz R.W., Webster C., Parker P.J. Eur. J. Biochem. 210:521-529(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 184-1234 (ISOFORM 1/2).
[7]	"NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation." Oh Y.-S., Jo N.W., Choi J.W., Kim H.S., Seo S.-W., Kang K.-O., Hwang J.-I., Heo K., Kim S.-H., Kim Y.-H., Kim I.-H., Kim J.H., Banno Y., Ryu S.H., Suh P.-G. Mol. Cell. Biol. 24:5069-5079(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH LPAR2.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[9]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-537, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-474; SER-537 AND SER-1105, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U26425 Genomic DNA. Translation: AAA77683.1.
Z37544 , Z37545, Z37546, Z37547, Z37548, Z37549, Z37550, Z37551, Z37552, Z37553, Z37554, Z37555, Z37556, Z37557, Z37558, Z37559, Z37560, Z37561, Z37562, Z37564, Z37565, Z37566, Z37567, Z37568, Z37569, Z37570, Z37571, Z37572, Z37573, Z37574 Genomic DNA. Translation: CAA85776.1.
AP001453 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74230.1.
CH471076 Genomic DNA. Translation: EAW74231.1.
BC032659 mRNA. Translation: AAH32659.1. Different initiation.
BC142681 mRNA. Translation: AAI42682.1.
Z16411 mRNA. Translation: CAA78903.1.

IPI

IPI00010400.
IPI00181283.

PIR

I38994.
S27002.
S52099.

RefSeq

NP_000923.1. NM_000932.2.
NP_001171812.1. NM_001184883.1.

UniGene

Hs.523761.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3OHM	X-ray	2.70	B	10-886	[»]
4GNK	X-ray	4.00	B/D	10-1234	[»]
			E	934-1192	[»]

ProteinModelPortal

Q01970.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-41928N.

MINT

MINT-4999151.

STRING

9606.ENSP00000279230.

PTM databases

PhosphoSite

Q01970.

Polymorphism databases

DMDM

1730573.

Proteomic databases

PaxDb

Q01970.

PRIDE

Q01970.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000279230; ENSP00000279230; ENSG00000149782.
ENST00000325234; ENSP00000324660; ENSG00000149782.
ENST00000540288; ENSP00000443631; ENSG00000149782.

GeneID

5331.

KEGG

hsa:5331.

UCSC

uc009ypg.2. human.

Organism-specific databases

CTD

5331.

GeneCards

GC11P064019.

HGNC

HGNC:9056. PLCB3.

HPA

CAB009257.

MIM

600230. gene.

neXtProt

NX_Q01970.

PharmGKB

PA33386.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG149692.

HOGENOM

HOG000232046.

HOVERGEN

HBG053609.

InParanoid

Q01970.

KO

K05858.

OMA

EFQNRQV.

PhylomeDB

Q01970.

Enzyme and pathway databases

BRENDA

3.1.4.11. 2681.

Pathway_Interaction_DB

lysophospholipid_pathway. LPA receptor mediated events.

Reactome

REACT_111102. Signal Transduction.
REACT_111217. Metabolism.
REACT_13685. Neuronal System.

Gene expression databases

ArrayExpress

Q01970.

Bgee

Q01970.

CleanEx

HS_PLCB3.

Genevestigator

Q01970.

GermOnline

ENSG00000149782. Homo sapiens.

Family and domain databases

Gene3D

1.10.238.10. 1 hit.
2.30.29.30. 1 hit.
3.20.20.190. 2 hits.

InterPro

IPR000008. C2_Ca-dep.
IPR008973. C2_Ca/lipid-bd_dom_CaLB.
IPR018029. C2_membr_targeting.
IPR011992. EF-hand-like_dom.
IPR011993. PH_like_dom.
IPR001192. Pinositol_PLipase_C.
IPR016280. PLC-beta.
IPR014815. PLC-beta_C.
IPR009535. PLC-beta_CS.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]

PANTHER

PTHR10336. PTHR10336. 1 hit.

Pfam

PF00168. C2. 1 hit.
PF06631. DUF1154. 1 hit.
PF09279. efhand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF08703. PLC-beta_C. 1 hit.
[Graphical view]

PIRSF

PIRSF000956. PLC-beta. 1 hit.

PRINTS

PR00390. PHPHLIPASEC.

SMART

SM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]

SUPFAM

SSF49562. C2_CaLB. 1 hit.
SSF51695. PLC-like_Pdiesterase_TIM-brl. 1 hit.

PROSITE

PS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

Q01970.

ChEMBL

CHEMBL5449.

GenomeRNAi

5331.

NextBio

20644.

SOURCE

Search...

Entry information

Entry name

PLCB3_HUMAN

Accession

Primary (citable) accession number: Q01970
Secondary accession number(s): A5PKZ6, G5E960, Q8N1A4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 131 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.