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Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

Gene

PLCB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei332PROSITE-ProRule annotation1
Active sitei379PROSITE-ProRule annotation1

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • calcium ion binding Source: InterPro
  • calmodulin binding Source: BHF-UCL
  • phosphatidylinositol phospholipase C activity Source: Reactome
  • phospholipase C activity Source: ProtInc
  • signal transducer activity Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transducer

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:HS07640-MONOMER.
BRENDAi3.1.4.11. 2681.
ReactomeiR-HSA-112043. PLC beta mediated events.
R-HSA-1855204. Synthesis of IP3 and IP4 in the cytosol.
R-HSA-399997. Acetylcholine regulates insulin secretion.
R-HSA-4086398. Ca2+ pathway.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-418217. G beta:gamma signalling through PLC beta.
R-HSA-434316. Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion.
R-HSA-500657. Presynaptic function of Kainate receptors.
SIGNORiQ01970.

Names & Taxonomyi

Protein namesi
Recommended name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC:3.1.4.11)
Alternative name(s):
Phosphoinositide phospholipase C-beta-3
Phospholipase C-beta-3
Short name:
PLC-beta-3
Gene namesi
Name:PLCB3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:9056. PLCB3.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • cytosol Source: Reactome
  • membrane Source: UniProtKB-SubCell
  • nucleoplasm Source: HPA
  • protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5331.
OpenTargetsiENSG00000149782.
PharmGKBiPA33386.

Chemistry databases

ChEMBLiCHEMBL5449.

Polymorphism and mutation databases

BioMutaiPLCB3.
DMDMi1730573.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000884912 – 12341-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3Add BLAST1233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei474PhosphoserineCombined sources1
Modified residuei490PhosphoserineCombined sources1
Modified residuei495PhosphoserineCombined sources1
Modified residuei537PhosphoserineCombined sources1
Modified residuei926PhosphoserineCombined sources1
Modified residuei1105PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ01970.
MaxQBiQ01970.
PaxDbiQ01970.
PeptideAtlasiQ01970.
PRIDEiQ01970.

PTM databases

iPTMnetiQ01970.
PhosphoSitePlusiQ01970.

Expressioni

Gene expression databases

BgeeiENSG00000149782.
CleanExiHS_PLCB3.
GenevisibleiQ01970. HS.

Organism-specific databases

HPAiCAB009257.
HPA039279.
HPA043907.

Interactioni

Subunit structurei

Interacts with SHANK2 (By similarity). Interacts with LPAR2.By similarity1 Publication

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • calmodulin binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi111347. 15 interactors.
DIPiDIP-41928N.
IntActiQ01970. 4 interactors.
MINTiMINT-4999151.
STRINGi9606.ENSP00000279230.

Chemistry databases

BindingDBiQ01970.

Structurei

Secondary structure

11234
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi20 – 24Combined sources5
Beta strandi26 – 31Combined sources6
Beta strandi33 – 35Combined sources3
Beta strandi40 – 45Combined sources6
Beta strandi51 – 55Combined sources5
Helixi57 – 59Combined sources3
Beta strandi61 – 65Combined sources5
Helixi66 – 68Combined sources3
Beta strandi69 – 74Combined sources6
Turni75 – 77Combined sources3
Helixi84 – 88Combined sources5
Helixi97 – 101Combined sources5
Beta strandi103 – 108Combined sources6
Helixi112 – 114Combined sources3
Beta strandi116 – 126Combined sources11
Helixi127 – 140Combined sources14
Helixi142 – 145Combined sources4
Helixi149 – 162Combined sources14
Helixi172 – 177Combined sources6
Helixi180 – 182Combined sources3
Helixi183 – 191Combined sources9
Turni192 – 194Combined sources3
Helixi205 – 207Combined sources3
Helixi210 – 220Combined sources11
Helixi224 – 232Combined sources9
Helixi243 – 253Combined sources11
Turni261 – 263Combined sources3
Helixi269 – 279Combined sources11
Helixi283 – 287Combined sources5
Helixi293 – 300Combined sources8
Beta strandi302 – 305Combined sources4
Helixi310 – 313Combined sources4
Helixi323 – 325Combined sources3
Beta strandi326 – 328Combined sources3
Beta strandi331 – 333Combined sources3
Beta strandi336 – 338Combined sources3
Beta strandi340 – 343Combined sources4
Helixi348 – 355Combined sources8
Beta strandi360 – 366Combined sources7
Beta strandi370 – 372Combined sources3
Beta strandi382 – 384Combined sources3
Helixi389 – 399Combined sources11
Turni400 – 402Combined sources3
Beta strandi408 – 415Combined sources8
Helixi421 – 433Combined sources13
Helixi434 – 436Combined sources3
Beta strandi443 – 445Combined sources3
Beta strandi447 – 450Combined sources4
Turni456 – 461Combined sources6
Beta strandi463 – 466Combined sources4
Helixi578 – 580Combined sources3
Helixi588 – 591Combined sources4
Beta strandi596 – 599Combined sources4
Helixi605 – 611Combined sources7
Beta strandi616 – 621Combined sources6
Helixi622 – 631Combined sources10
Helixi633 – 642Combined sources10
Beta strandi645 – 648Combined sources4
Helixi662 – 665Combined sources4
Turni666 – 668Combined sources3
Beta strandi670 – 672Combined sources3
Helixi681 – 690Combined sources10
Helixi693 – 695Combined sources3
Beta strandi697 – 700Combined sources4
Helixi703 – 705Combined sources3
Beta strandi726 – 737Combined sources12
Beta strandi740 – 742Combined sources3
Beta strandi745 – 754Combined sources10
Turni755 – 757Combined sources3
Beta strandi759 – 763Combined sources5
Beta strandi771 – 773Combined sources3
Beta strandi781 – 787Combined sources7
Helixi789 – 791Combined sources3
Beta strandi793 – 800Combined sources8
Turni801 – 803Combined sources3
Beta strandi804 – 812Combined sources9
Turni813 – 815Combined sources3
Beta strandi819 – 826Combined sources8
Beta strandi832 – 846Combined sources15
Helixi850 – 852Combined sources3
Helixi853 – 860Combined sources8
Helixi862 – 875Combined sources14
Helixi877 – 880Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3OHMX-ray2.70B10-886[»]
4GNKX-ray4.00B/D10-1234[»]
E934-1192[»]
4QJ3X-ray3.00B10-891[»]
4QJ4X-ray3.30B10-891[»]
4QJ5X-ray3.41B10-891[»]
ProteinModelPortaliQ01970.
SMRiQ01970.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini318 – 468PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST151
Domaini590 – 706PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST117
Domaini713 – 810C2PROSITE-ProRule annotationAdd BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1231 – 1234Interaction with SHANK2By similarity4

Sequence similaritiesi

Contains 1 C2 domain.PROSITE-ProRule annotation
Contains 1 PI-PLC X-box domain.PROSITE-ProRule annotation
Contains 1 PI-PLC Y-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0169. Eukaryota.
ENOG410XPSW. LUCA.
GeneTreeiENSGT00760000118936.
HOGENOMiHOG000232046.
HOVERGENiHBG053609.
InParanoidiQ01970.
KOiK05858.
OMAiVDSNGFF.
OrthoDBiEOG091G00XL.
PhylomeDBiQ01970.
TreeFamiTF313216.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR011993. PH_dom-like.
IPR001192. PI-PLC_fam.
IPR016280. PLC-beta.
IPR028390. PLC-beta3.
IPR014815. PLC-beta_C.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLC_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF11. PTHR10336:SF11. 1 hit.
PfamiPF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF08703. PLC-beta_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000956. PLC-beta. 1 hit.
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF51695. SSF51695. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q01970-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGAQPGVHA LQLEPPTVVE TLRRGSKFIK WDEETSSRNL VTLRVDPNGF
60 70 80 90 100
FLYWTGPNME VDTLDISSIR DTRTGRYARL PKDPKIREVL GFGGPDARLE
110 120 130 140 150
EKLMTVVSGP DPVNTVFLNF MAVQDDTAKV WSEELFKLAM NILAQNASRN
160 170 180 190 200
TFLRKAYTKL KLQVNQDGRI PVKNILKMFS ADKKRVETAL ESCGLKFNRS
210 220 230 240 250
ESIRPDEFSL EIFERFLNKL CLRPDIDKIL LEIGAKGKPY LTLEQLMDFI
260 270 280 290 300
NQKQRDPRLN EVLYPPLRPS QARLLIEKYE PNQQFLERDQ MSMEGFSRYL
310 320 330 340 350
GGEENGILPL EALDLSTDMT QPLSAYFINS SHNTYLTAGQ LAGTSSVEMY
360 370 380 390 400
RQALLWGCRC VELDVWKGRP PEEEPFITHG FTMTTEVPLR DVLEAIAETA
410 420 430 440 450
FKTSPYPVIL SFENHVDSAK QQAKMAEYCR SIFGDALLIE PLDKYPLAPG
460 470 480 490 500
VPLPSPQDLM GRILVKNKKR HRPSAGGPDS AGRKRPLEQS NSALSESSAA
510 520 530 540 550
TEPSSPQLGS PSSDSCPGLS NGEEVGLEKP SLEPQKSLGD EGLNRGPYVL
560 570 580 590 600
GPADREDEEE DEEEEEQTDP KKPTTDEGTA SSEVNATEEM STLVNYIEPV
610 620 630 640 650
KFKSFEAARK RNKCFEMSSF VETKAMEQLT KSPMEFVEYN KQQLSRIYPK
660 670 680 690 700
GTRVDSSNYM PQLFWNVGCQ LVALNFQTLD VAMQLNAGVF EYNGRSGYLL
710 720 730 740 750
KPEFMRRPDK SFDPFTEVIV DGIVANALRV KVISGQFLSD RKVGIYVEVD
760 770 780 790 800
MFGLPVDTRR KYRTRTSQGN SFNPVWDEEP FDFPKVVLPT LASLRIAAFE
810 820 830 840 850
EGGKFVGHRI LPVSAIRSGY HYVCLRNEAN QPLCLPALLI YTEASDYIPD
860 870 880 890 900
DHQDYAEALI NPIKHVSLMD QRARQLAALI GESEAQAGQE TCQDTQSQQL
910 920 930 940 950
GSQPSSNPTP SPLDASPRRP PGPTTSPAST SLSSPGQRDD LIASILSEVA
960 970 980 990 1000
PTPLDELRGH KALVKLRSRQ ERDLRELRKK HQRKAVTLTR RLLDGLAQAQ
1010 1020 1030 1040 1050
AEGRCRLRPG ALGGAADVED TKEGEDEAKR YQEFQNRQVQ SLLELREAQV
1060 1070 1080 1090 1100
DAEAQRRLEH LRQALQRLRE VVLDANTTQF KRLKEMNERE KKELQKILDR
1110 1120 1130 1140 1150
KRHNSISEAK MRDKHKKEAE LTEINRRHIT ESVNSIRRLE EAQKQRHDRL
1160 1170 1180 1190 1200
VAGQQQVLQQ LAEEEPKLLA QLAQECQEQR ARLPQEIRRS LLGEMPEGLG
1210 1220 1230
DGPLVACASN GHAPGSSGHL SGADSESQEE NTQL
Length:1,234
Mass (Da):138,799
Last modified:October 1, 1996 - v2
Checksum:iC5106EFBA8037788
GO
Isoform 2 (identifier: Q01970-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     33-99: Missing.

Note: No experimental confirmation available.
Show »
Length:1,167
Mass (Da):131,205
Checksum:i597C35D7C25D4773
GO

Sequence cautioni

The sequence AAH32659 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti845S → L in CAA78903 (PubMed:1333955).Curated1
Sequence conflicti881G → E in CAA85776 (PubMed:7607669).Curated1
Sequence conflicti1089 – 1119REKKE…HKKEA → SWPSWPRSVRSSGRGSPRRS AGACWARCRRG in CAA85776 (PubMed:7607669).CuratedAdd BLAST31

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029229483R → H.Corresponds to variant rs12146487dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04605433 – 99Missing in isoform 2. 1 PublicationAdd BLAST67

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26425 Genomic DNA. Translation: AAA77683.1.
Z37544
, Z37545, Z37546, Z37547, Z37548, Z37549, Z37550, Z37551, Z37552, Z37553, Z37554, Z37555, Z37556, Z37557, Z37558, Z37559, Z37560, Z37561, Z37562, Z37564, Z37565, Z37566, Z37567, Z37568, Z37569, Z37570, Z37571, Z37572, Z37573, Z37574 Genomic DNA. Translation: CAA85776.1.
AP001453 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74230.1.
CH471076 Genomic DNA. Translation: EAW74231.1.
BC032659 mRNA. Translation: AAH32659.1. Different initiation.
BC142681 mRNA. Translation: AAI42682.1.
Z16411 mRNA. Translation: CAA78903.1.
CCDSiCCDS53654.1. [Q01970-2]
CCDS8064.1. [Q01970-1]
PIRiI38994.
S27002.
S52099.
RefSeqiNP_000923.1. NM_000932.2. [Q01970-1]
NP_001171812.1. NM_001184883.1. [Q01970-2]
NP_001303243.1. NM_001316314.1. [Q01970-1]
UniGeneiHs.523761.

Genome annotation databases

EnsembliENST00000279230; ENSP00000279230; ENSG00000149782. [Q01970-1]
ENST00000325234; ENSP00000324660; ENSG00000149782. [Q01970-2]
ENST00000540288; ENSP00000443631; ENSG00000149782. [Q01970-1]
GeneIDi5331.
KEGGihsa:5331.
UCSCiuc009ypg.3. human. [Q01970-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26425 Genomic DNA. Translation: AAA77683.1.
Z37544
, Z37545, Z37546, Z37547, Z37548, Z37549, Z37550, Z37551, Z37552, Z37553, Z37554, Z37555, Z37556, Z37557, Z37558, Z37559, Z37560, Z37561, Z37562, Z37564, Z37565, Z37566, Z37567, Z37568, Z37569, Z37570, Z37571, Z37572, Z37573, Z37574 Genomic DNA. Translation: CAA85776.1.
AP001453 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74230.1.
CH471076 Genomic DNA. Translation: EAW74231.1.
BC032659 mRNA. Translation: AAH32659.1. Different initiation.
BC142681 mRNA. Translation: AAI42682.1.
Z16411 mRNA. Translation: CAA78903.1.
CCDSiCCDS53654.1. [Q01970-2]
CCDS8064.1. [Q01970-1]
PIRiI38994.
S27002.
S52099.
RefSeqiNP_000923.1. NM_000932.2. [Q01970-1]
NP_001171812.1. NM_001184883.1. [Q01970-2]
NP_001303243.1. NM_001316314.1. [Q01970-1]
UniGeneiHs.523761.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3OHMX-ray2.70B10-886[»]
4GNKX-ray4.00B/D10-1234[»]
E934-1192[»]
4QJ3X-ray3.00B10-891[»]
4QJ4X-ray3.30B10-891[»]
4QJ5X-ray3.41B10-891[»]
ProteinModelPortaliQ01970.
SMRiQ01970.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111347. 15 interactors.
DIPiDIP-41928N.
IntActiQ01970. 4 interactors.
MINTiMINT-4999151.
STRINGi9606.ENSP00000279230.

Chemistry databases

BindingDBiQ01970.
ChEMBLiCHEMBL5449.

PTM databases

iPTMnetiQ01970.
PhosphoSitePlusiQ01970.

Polymorphism and mutation databases

BioMutaiPLCB3.
DMDMi1730573.

Proteomic databases

EPDiQ01970.
MaxQBiQ01970.
PaxDbiQ01970.
PeptideAtlasiQ01970.
PRIDEiQ01970.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000279230; ENSP00000279230; ENSG00000149782. [Q01970-1]
ENST00000325234; ENSP00000324660; ENSG00000149782. [Q01970-2]
ENST00000540288; ENSP00000443631; ENSG00000149782. [Q01970-1]
GeneIDi5331.
KEGGihsa:5331.
UCSCiuc009ypg.3. human. [Q01970-1]

Organism-specific databases

CTDi5331.
DisGeNETi5331.
GeneCardsiPLCB3.
HGNCiHGNC:9056. PLCB3.
HPAiCAB009257.
HPA039279.
HPA043907.
MIMi600230. gene.
neXtProtiNX_Q01970.
OpenTargetsiENSG00000149782.
PharmGKBiPA33386.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0169. Eukaryota.
ENOG410XPSW. LUCA.
GeneTreeiENSGT00760000118936.
HOGENOMiHOG000232046.
HOVERGENiHBG053609.
InParanoidiQ01970.
KOiK05858.
OMAiVDSNGFF.
OrthoDBiEOG091G00XL.
PhylomeDBiQ01970.
TreeFamiTF313216.

Enzyme and pathway databases

BioCyciZFISH:HS07640-MONOMER.
BRENDAi3.1.4.11. 2681.
ReactomeiR-HSA-112043. PLC beta mediated events.
R-HSA-1855204. Synthesis of IP3 and IP4 in the cytosol.
R-HSA-399997. Acetylcholine regulates insulin secretion.
R-HSA-4086398. Ca2+ pathway.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-418217. G beta:gamma signalling through PLC beta.
R-HSA-434316. Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion.
R-HSA-500657. Presynaptic function of Kainate receptors.
SIGNORiQ01970.

Miscellaneous databases

ChiTaRSiPLCB3. human.
GeneWikiiPLCB3.
GenomeRNAii5331.
PROiQ01970.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000149782.
CleanExiHS_PLCB3.
GenevisibleiQ01970. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR011993. PH_dom-like.
IPR001192. PI-PLC_fam.
IPR016280. PLC-beta.
IPR028390. PLC-beta3.
IPR014815. PLC-beta_C.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLC_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF11. PTHR10336:SF11. 1 hit.
PfamiPF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF08703. PLC-beta_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000956. PLC-beta. 1 hit.
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF51695. SSF51695. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLCB3_HUMAN
AccessioniPrimary (citable) accession number: Q01970
Secondary accession number(s): A5PKZ6, G5E960, Q8N1A4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 170 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.