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Q01970

- PLCB3_HUMAN

UniProt

Q01970 - PLCB3_HUMAN

Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

Gene

PLCB3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 146 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

    Catalytic activityi

    1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

    Cofactori

    Calcium.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei332 – 3321PROSITE-ProRule annotation
    Active sitei379 – 3791PROSITE-ProRule annotation

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. calmodulin binding Source: BHF-UCL
    3. phosphatidylinositol phospholipase C activity Source: UniProtKB-EC
    4. phospholipase C activity Source: ProtInc
    5. signal transducer activity Source: UniProtKB-KW

    GO - Biological processi

    1. inositol phosphate metabolic process Source: Reactome
    2. intracellular signal transduction Source: InterPro
    3. lipid catabolic process Source: UniProtKB-KW
    4. regulation of systemic arterial blood pressure Source: MGI
    5. small molecule metabolic process Source: Reactome
    6. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Hydrolase, Transducer

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    BRENDAi3.1.4.11. 2681.
    ReactomeiREACT_150312. Synthesis of IP3 and IP4 in the cytosol.
    REACT_15426. PLC beta mediated events.
    REACT_172761. Ca2+ pathway.
    REACT_18283. G alpha (q) signalling events.
    REACT_18405. Acetylcholine regulates insulin secretion.
    REACT_19145. G beta:gamma signalling through PLC beta.
    REACT_19193. Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion.
    REACT_21254. Presynaptic function of Kainate receptors.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC:3.1.4.11)
    Alternative name(s):
    Phosphoinositide phospholipase C-beta-3
    Phospholipase C-beta-3
    Short name:
    PLC-beta-3
    Gene namesi
    Name:PLCB3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:9056. PLCB3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. membrane Source: UniProtKB-SubCell
    3. nucleus Source: HPA
    4. protein complex Source: MGI

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33386.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 123412331-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3PRO_0000088491Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei474 – 4741Phosphoserine1 Publication
    Modified residuei537 – 5371Phosphoserine2 Publications
    Modified residuei1105 – 11051Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ01970.
    PaxDbiQ01970.
    PRIDEiQ01970.

    PTM databases

    PhosphoSiteiQ01970.

    Expressioni

    Gene expression databases

    BgeeiQ01970.
    CleanExiHS_PLCB3.
    GenevestigatoriQ01970.

    Organism-specific databases

    HPAiCAB009257.
    HPA039279.
    HPA043907.

    Interactioni

    Subunit structurei

    Interacts with SHANK2 By similarity. Interacts with LPAR2.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi111347. 9 interactions.
    DIPiDIP-41928N.
    MINTiMINT-4999151.
    STRINGi9606.ENSP00000279230.

    Structurei

    Secondary structure

    1
    1234
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi20 – 245
    Beta strandi26 – 316
    Beta strandi40 – 456
    Beta strandi51 – 555
    Helixi57 – 593
    Beta strandi61 – 655
    Helixi66 – 683
    Beta strandi69 – 746
    Turni75 – 773
    Helixi84 – 885
    Beta strandi103 – 1086
    Helixi112 – 1143
    Beta strandi116 – 12611
    Helixi127 – 14014
    Helixi142 – 1454
    Helixi149 – 16214
    Helixi172 – 1776
    Helixi180 – 1823
    Helixi183 – 1919
    Turni192 – 1943
    Helixi205 – 2073
    Helixi210 – 22011
    Helixi224 – 2329
    Helixi243 – 25311
    Turni261 – 2633
    Helixi269 – 27911
    Helixi283 – 2875
    Helixi293 – 3008
    Helixi310 – 3134
    Helixi323 – 3253
    Beta strandi326 – 3283
    Beta strandi331 – 3333
    Beta strandi336 – 3383
    Beta strandi340 – 3434
    Helixi348 – 3558
    Beta strandi360 – 3667
    Beta strandi370 – 3723
    Beta strandi382 – 3843
    Helixi389 – 39911
    Beta strandi408 – 4158
    Helixi421 – 43313
    Helixi434 – 4363
    Beta strandi447 – 4504
    Turni456 – 4616
    Beta strandi463 – 4664
    Helixi578 – 5803
    Helixi588 – 5914
    Helixi605 – 6117
    Beta strandi616 – 6216
    Helixi622 – 63110
    Helixi633 – 64210
    Beta strandi645 – 6484
    Helixi662 – 6654
    Turni666 – 6683
    Beta strandi670 – 6723
    Helixi681 – 69010
    Helixi693 – 6953
    Beta strandi697 – 7004
    Helixi703 – 7053
    Beta strandi726 – 73712
    Beta strandi745 – 75410
    Turni755 – 7573
    Beta strandi771 – 7733
    Beta strandi781 – 7877
    Helixi789 – 7913
    Beta strandi793 – 8008
    Turni801 – 8033
    Beta strandi804 – 8129
    Turni813 – 8153
    Beta strandi819 – 8268
    Beta strandi832 – 84615
    Helixi850 – 8523
    Helixi853 – 8608
    Helixi862 – 87514
    Helixi877 – 8804

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3OHMX-ray2.70B10-886[»]
    4GNKX-ray4.00B/D10-1234[»]
    E934-1192[»]
    ProteinModelPortaliQ01970.
    SMRiQ01970. Positions 10-505, 527-881, 934-1192.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini318 – 468151PI-PLC X-boxPROSITE-ProRule annotationAdd
    BLAST
    Domaini590 – 706117PI-PLC Y-boxPROSITE-ProRule annotationAdd
    BLAST
    Domaini713 – 81098C2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1231 – 12344Interaction with SHANK2By similarity

    Sequence similaritiesi

    Contains 1 C2 domain.PROSITE-ProRule annotation
    Contains 1 PI-PLC X-box domain.PROSITE-ProRule annotation
    Contains 1 PI-PLC Y-box domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG149692.
    HOGENOMiHOG000232046.
    HOVERGENiHBG053609.
    InParanoidiQ01970.
    KOiK05858.
    OMAiEFQNRQV.
    OrthoDBiEOG7WDN1N.
    PhylomeDBiQ01970.
    TreeFamiTF313216.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    2.30.29.30. 1 hit.
    2.60.40.150. 1 hit.
    3.20.20.190. 2 hits.
    InterProiIPR000008. C2_dom.
    IPR011992. EF-hand-dom_pair.
    IPR011993. PH_like_dom.
    IPR001192. PI-PLC_fam.
    IPR016280. PLC-beta.
    IPR028390. PLC-beta3.
    IPR014815. PLC-beta_C.
    IPR009535. PLC-beta_CS.
    IPR017946. PLC-like_Pdiesterase_TIM-brl.
    IPR015359. PLipase_C_EF-hand-like.
    IPR000909. PLipase_C_PInositol-sp_X_dom.
    IPR001711. PLipase_C_Pinositol-sp_Y.
    [Graphical view]
    PANTHERiPTHR10336. PTHR10336. 1 hit.
    PTHR10336:SF11. PTHR10336:SF11. 1 hit.
    PfamiPF00168. C2. 1 hit.
    PF06631. DUF1154. 1 hit.
    PF09279. EF-hand_like. 1 hit.
    PF00388. PI-PLC-X. 1 hit.
    PF00387. PI-PLC-Y. 1 hit.
    PF08703. PLC-beta_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000956. PLC-beta. 1 hit.
    PRINTSiPR00390. PHPHLIPASEC.
    SMARTiSM00239. C2. 1 hit.
    SM00148. PLCXc. 1 hit.
    SM00149. PLCYc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 1 hit.
    SSF51695. SSF51695. 2 hits.
    PROSITEiPS50004. C2. 1 hit.
    PS50007. PIPLC_X_DOMAIN. 1 hit.
    PS50008. PIPLC_Y_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q01970-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGAQPGVHA LQLEPPTVVE TLRRGSKFIK WDEETSSRNL VTLRVDPNGF     50
    FLYWTGPNME VDTLDISSIR DTRTGRYARL PKDPKIREVL GFGGPDARLE 100
    EKLMTVVSGP DPVNTVFLNF MAVQDDTAKV WSEELFKLAM NILAQNASRN 150
    TFLRKAYTKL KLQVNQDGRI PVKNILKMFS ADKKRVETAL ESCGLKFNRS 200
    ESIRPDEFSL EIFERFLNKL CLRPDIDKIL LEIGAKGKPY LTLEQLMDFI 250
    NQKQRDPRLN EVLYPPLRPS QARLLIEKYE PNQQFLERDQ MSMEGFSRYL 300
    GGEENGILPL EALDLSTDMT QPLSAYFINS SHNTYLTAGQ LAGTSSVEMY 350
    RQALLWGCRC VELDVWKGRP PEEEPFITHG FTMTTEVPLR DVLEAIAETA 400
    FKTSPYPVIL SFENHVDSAK QQAKMAEYCR SIFGDALLIE PLDKYPLAPG 450
    VPLPSPQDLM GRILVKNKKR HRPSAGGPDS AGRKRPLEQS NSALSESSAA 500
    TEPSSPQLGS PSSDSCPGLS NGEEVGLEKP SLEPQKSLGD EGLNRGPYVL 550
    GPADREDEEE DEEEEEQTDP KKPTTDEGTA SSEVNATEEM STLVNYIEPV 600
    KFKSFEAARK RNKCFEMSSF VETKAMEQLT KSPMEFVEYN KQQLSRIYPK 650
    GTRVDSSNYM PQLFWNVGCQ LVALNFQTLD VAMQLNAGVF EYNGRSGYLL 700
    KPEFMRRPDK SFDPFTEVIV DGIVANALRV KVISGQFLSD RKVGIYVEVD 750
    MFGLPVDTRR KYRTRTSQGN SFNPVWDEEP FDFPKVVLPT LASLRIAAFE 800
    EGGKFVGHRI LPVSAIRSGY HYVCLRNEAN QPLCLPALLI YTEASDYIPD 850
    DHQDYAEALI NPIKHVSLMD QRARQLAALI GESEAQAGQE TCQDTQSQQL 900
    GSQPSSNPTP SPLDASPRRP PGPTTSPAST SLSSPGQRDD LIASILSEVA 950
    PTPLDELRGH KALVKLRSRQ ERDLRELRKK HQRKAVTLTR RLLDGLAQAQ 1000
    AEGRCRLRPG ALGGAADVED TKEGEDEAKR YQEFQNRQVQ SLLELREAQV 1050
    DAEAQRRLEH LRQALQRLRE VVLDANTTQF KRLKEMNERE KKELQKILDR 1100
    KRHNSISEAK MRDKHKKEAE LTEINRRHIT ESVNSIRRLE EAQKQRHDRL 1150
    VAGQQQVLQQ LAEEEPKLLA QLAQECQEQR ARLPQEIRRS LLGEMPEGLG 1200
    DGPLVACASN GHAPGSSGHL SGADSESQEE NTQL 1234
    Length:1,234
    Mass (Da):138,799
    Last modified:October 1, 1996 - v2
    Checksum:iC5106EFBA8037788
    GO
    Isoform 2 (identifier: Q01970-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         33-99: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,167
    Mass (Da):131,205
    Checksum:i597C35D7C25D4773
    GO

    Sequence cautioni

    The sequence AAH32659.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti845 – 8451S → L in CAA78903. (PubMed:1333955)Curated
    Sequence conflicti881 – 8811G → E in CAA85776. (PubMed:7607669)Curated
    Sequence conflicti1089 – 111931REKKE…HKKEA → SWPSWPRSVRSSGRGSPRRS AGACWARCRRG in CAA85776. (PubMed:7607669)CuratedAdd
    BLAST

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti483 – 4831R → H.
    Corresponds to variant rs12146487 [ dbSNP | Ensembl ].
    VAR_029229

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei33 – 9967Missing in isoform 2. 1 PublicationVSP_046054Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U26425 Genomic DNA. Translation: AAA77683.1.
    Z37544
    , Z37545, Z37546, Z37547, Z37548, Z37549, Z37550, Z37551, Z37552, Z37553, Z37554, Z37555, Z37556, Z37557, Z37558, Z37559, Z37560, Z37561, Z37562, Z37564, Z37565, Z37566, Z37567, Z37568, Z37569, Z37570, Z37571, Z37572, Z37573, Z37574 Genomic DNA. Translation: CAA85776.1.
    AP001453 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW74230.1.
    CH471076 Genomic DNA. Translation: EAW74231.1.
    BC032659 mRNA. Translation: AAH32659.1. Different initiation.
    BC142681 mRNA. Translation: AAI42682.1.
    Z16411 mRNA. Translation: CAA78903.1.
    CCDSiCCDS53654.1. [Q01970-2]
    CCDS8064.1. [Q01970-1]
    PIRiI38994.
    S27002.
    S52099.
    RefSeqiNP_000923.1. NM_000932.2. [Q01970-1]
    NP_001171812.1. NM_001184883.1. [Q01970-2]
    XP_005274109.1. XM_005274052.2. [Q01970-1]
    UniGeneiHs.523761.

    Genome annotation databases

    EnsembliENST00000279230; ENSP00000279230; ENSG00000149782. [Q01970-1]
    ENST00000325234; ENSP00000324660; ENSG00000149782. [Q01970-2]
    ENST00000540288; ENSP00000443631; ENSG00000149782. [Q01970-1]
    GeneIDi5331.
    KEGGihsa:5331.
    UCSCiuc009ypg.2. human. [Q01970-1]
    uc009yph.2. human.

    Polymorphism databases

    DMDMi1730573.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U26425 Genomic DNA. Translation: AAA77683.1 .
    Z37544
    , Z37545 , Z37546 , Z37547 , Z37548 , Z37549 , Z37550 , Z37551 , Z37552 , Z37553 , Z37554 , Z37555 , Z37556 , Z37557 , Z37558 , Z37559 , Z37560 , Z37561 , Z37562 , Z37564 , Z37565 , Z37566 , Z37567 , Z37568 , Z37569 , Z37570 , Z37571 , Z37572 , Z37573 , Z37574 Genomic DNA. Translation: CAA85776.1 .
    AP001453 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW74230.1 .
    CH471076 Genomic DNA. Translation: EAW74231.1 .
    BC032659 mRNA. Translation: AAH32659.1 . Different initiation.
    BC142681 mRNA. Translation: AAI42682.1 .
    Z16411 mRNA. Translation: CAA78903.1 .
    CCDSi CCDS53654.1. [Q01970-2 ]
    CCDS8064.1. [Q01970-1 ]
    PIRi I38994.
    S27002.
    S52099.
    RefSeqi NP_000923.1. NM_000932.2. [Q01970-1 ]
    NP_001171812.1. NM_001184883.1. [Q01970-2 ]
    XP_005274109.1. XM_005274052.2. [Q01970-1 ]
    UniGenei Hs.523761.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3OHM X-ray 2.70 B 10-886 [» ]
    4GNK X-ray 4.00 B/D 10-1234 [» ]
    E 934-1192 [» ]
    ProteinModelPortali Q01970.
    SMRi Q01970. Positions 10-505, 527-881, 934-1192.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111347. 9 interactions.
    DIPi DIP-41928N.
    MINTi MINT-4999151.
    STRINGi 9606.ENSP00000279230.

    Chemistry

    BindingDBi Q01970.

    PTM databases

    PhosphoSitei Q01970.

    Polymorphism databases

    DMDMi 1730573.

    Proteomic databases

    MaxQBi Q01970.
    PaxDbi Q01970.
    PRIDEi Q01970.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000279230 ; ENSP00000279230 ; ENSG00000149782 . [Q01970-1 ]
    ENST00000325234 ; ENSP00000324660 ; ENSG00000149782 . [Q01970-2 ]
    ENST00000540288 ; ENSP00000443631 ; ENSG00000149782 . [Q01970-1 ]
    GeneIDi 5331.
    KEGGi hsa:5331.
    UCSCi uc009ypg.2. human. [Q01970-1 ]
    uc009yph.2. human.

    Organism-specific databases

    CTDi 5331.
    GeneCardsi GC11P064019.
    HGNCi HGNC:9056. PLCB3.
    HPAi CAB009257.
    HPA039279.
    HPA043907.
    MIMi 600230. gene.
    neXtProti NX_Q01970.
    PharmGKBi PA33386.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG149692.
    HOGENOMi HOG000232046.
    HOVERGENi HBG053609.
    InParanoidi Q01970.
    KOi K05858.
    OMAi EFQNRQV.
    OrthoDBi EOG7WDN1N.
    PhylomeDBi Q01970.
    TreeFami TF313216.

    Enzyme and pathway databases

    BRENDAi 3.1.4.11. 2681.
    Reactomei REACT_150312. Synthesis of IP3 and IP4 in the cytosol.
    REACT_15426. PLC beta mediated events.
    REACT_172761. Ca2+ pathway.
    REACT_18283. G alpha (q) signalling events.
    REACT_18405. Acetylcholine regulates insulin secretion.
    REACT_19145. G beta:gamma signalling through PLC beta.
    REACT_19193. Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion.
    REACT_21254. Presynaptic function of Kainate receptors.

    Miscellaneous databases

    GeneWikii PLCB3.
    GenomeRNAii 5331.
    NextBioi 20644.
    PROi Q01970.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q01970.
    CleanExi HS_PLCB3.
    Genevestigatori Q01970.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    2.30.29.30. 1 hit.
    2.60.40.150. 1 hit.
    3.20.20.190. 2 hits.
    InterProi IPR000008. C2_dom.
    IPR011992. EF-hand-dom_pair.
    IPR011993. PH_like_dom.
    IPR001192. PI-PLC_fam.
    IPR016280. PLC-beta.
    IPR028390. PLC-beta3.
    IPR014815. PLC-beta_C.
    IPR009535. PLC-beta_CS.
    IPR017946. PLC-like_Pdiesterase_TIM-brl.
    IPR015359. PLipase_C_EF-hand-like.
    IPR000909. PLipase_C_PInositol-sp_X_dom.
    IPR001711. PLipase_C_Pinositol-sp_Y.
    [Graphical view ]
    PANTHERi PTHR10336. PTHR10336. 1 hit.
    PTHR10336:SF11. PTHR10336:SF11. 1 hit.
    Pfami PF00168. C2. 1 hit.
    PF06631. DUF1154. 1 hit.
    PF09279. EF-hand_like. 1 hit.
    PF00388. PI-PLC-X. 1 hit.
    PF00387. PI-PLC-Y. 1 hit.
    PF08703. PLC-beta_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000956. PLC-beta. 1 hit.
    PRINTSi PR00390. PHPHLIPASEC.
    SMARTi SM00239. C2. 1 hit.
    SM00148. PLCXc. 1 hit.
    SM00149. PLCYc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 1 hit.
    SSF51695. SSF51695. 2 hits.
    PROSITEi PS50004. C2. 1 hit.
    PS50007. PIPLC_X_DOMAIN. 1 hit.
    PS50008. PIPLC_Y_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural organization and expression of the human phosphatidylinositol-specific phospholipase C beta-3 gene."
      Mazuruk K., Schoen T.J., Chader G.J., Rodriguez I.R.
      Biochem. Biophys. Res. Commun. 212:190-195(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Genomic organization and complete cDNA sequence of the human phosphoinositide-specific phospholipase C beta 3 gene (PLCB3)."
      Lagercrantz J., Carson E., Phelan C., Grimmond S., Rosen A., Dare E., Nordenskjoeld M., Hayward N.K., Larsson C., Weber G.
      Genomics 26:467-472(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Uterus.
    6. "Identification, purification and characterization of a novel phosphatidylinositol-specific phospholipase C, a third member of the beta subfamily."
      Carozzi A.J., Kriz R.W., Webster C., Parker P.J.
      Eur. J. Biochem. 210:521-529(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 184-1234 (ISOFORM 1/2).
    7. "NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation."
      Oh Y.-S., Jo N.W., Choi J.W., Kim H.S., Seo S.-W., Kang K.-O., Hwang J.-I., Heo K., Kim S.-H., Kim Y.-H., Kim I.-H., Kim J.H., Banno Y., Ryu S.H., Suh P.-G.
      Mol. Cell. Biol. 24:5069-5079(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH LPAR2.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-537, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-474; SER-537 AND SER-1105, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPLCB3_HUMAN
    AccessioniPrimary (citable) accession number: Q01970
    Secondary accession number(s): A5PKZ6, G5E960, Q8N1A4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 146 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3