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Q01970

- PLCB3_HUMAN

UniProt

Q01970 - PLCB3_HUMAN

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Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

Gene

PLCB3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

Cofactori

Calcium.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei332 – 3321PROSITE-ProRule annotation
Active sitei379 – 3791PROSITE-ProRule annotation

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. calmodulin binding Source: BHF-UCL
  3. phosphatidylinositol phospholipase C activity Source: UniProtKB-EC
  4. phospholipase C activity Source: ProtInc
  5. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. inositol phosphate metabolic process Source: Reactome
  2. intracellular signal transduction Source: InterPro
  3. lipid catabolic process Source: UniProtKB-KW
  4. regulation of systemic arterial blood pressure Source: MGI
  5. small molecule metabolic process Source: Reactome
  6. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transducer

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BRENDAi3.1.4.11. 2681.
ReactomeiREACT_150312. Synthesis of IP3 and IP4 in the cytosol.
REACT_15426. PLC beta mediated events.
REACT_172761. Ca2+ pathway.
REACT_18283. G alpha (q) signalling events.
REACT_18405. Acetylcholine regulates insulin secretion.
REACT_19145. G beta:gamma signalling through PLC beta.
REACT_19193. Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion.
REACT_21254. Presynaptic function of Kainate receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC:3.1.4.11)
Alternative name(s):
Phosphoinositide phospholipase C-beta-3
Phospholipase C-beta-3
Short name:
PLC-beta-3
Gene namesi
Name:PLCB3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:9056. PLCB3.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. membrane Source: UniProtKB-KW
  3. nucleus Source: HPA
  4. protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33386.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 123412331-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3PRO_0000088491Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei474 – 4741Phosphoserine1 Publication
Modified residuei537 – 5371Phosphoserine2 Publications
Modified residuei1105 – 11051Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ01970.
PaxDbiQ01970.
PRIDEiQ01970.

PTM databases

PhosphoSiteiQ01970.

Expressioni

Gene expression databases

BgeeiQ01970.
CleanExiHS_PLCB3.
GenevestigatoriQ01970.

Organism-specific databases

HPAiCAB009257.
HPA039279.
HPA043907.

Interactioni

Subunit structurei

Interacts with SHANK2 (By similarity). Interacts with LPAR2.By similarity1 Publication

Protein-protein interaction databases

BioGridi111347. 9 interactions.
DIPiDIP-41928N.
MINTiMINT-4999151.
STRINGi9606.ENSP00000279230.

Structurei

Secondary structure

1
1234
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi20 – 245
Beta strandi26 – 316
Beta strandi40 – 456
Beta strandi51 – 555
Helixi57 – 593
Beta strandi61 – 655
Helixi66 – 683
Beta strandi69 – 746
Turni75 – 773
Helixi84 – 885
Beta strandi103 – 1086
Helixi112 – 1143
Beta strandi116 – 12611
Helixi127 – 14014
Helixi142 – 1454
Helixi149 – 16214
Helixi172 – 1776
Helixi180 – 1823
Helixi183 – 1919
Turni192 – 1943
Helixi205 – 2073
Helixi210 – 22011
Helixi224 – 2329
Helixi243 – 25311
Turni261 – 2633
Helixi269 – 27911
Helixi283 – 2875
Helixi293 – 3008
Helixi310 – 3134
Helixi323 – 3253
Beta strandi326 – 3283
Beta strandi331 – 3333
Beta strandi336 – 3383
Beta strandi340 – 3434
Helixi348 – 3558
Beta strandi360 – 3667
Beta strandi370 – 3723
Beta strandi382 – 3843
Helixi389 – 39911
Beta strandi408 – 4158
Helixi421 – 43313
Helixi434 – 4363
Beta strandi447 – 4504
Turni456 – 4616
Beta strandi463 – 4664
Helixi578 – 5803
Helixi588 – 5914
Helixi605 – 6117
Beta strandi616 – 6216
Helixi622 – 63110
Helixi633 – 64210
Beta strandi645 – 6484
Helixi662 – 6654
Turni666 – 6683
Beta strandi670 – 6723
Helixi681 – 69010
Helixi693 – 6953
Beta strandi697 – 7004
Helixi703 – 7053
Beta strandi726 – 73712
Beta strandi745 – 75410
Turni755 – 7573
Beta strandi771 – 7733
Beta strandi781 – 7877
Helixi789 – 7913
Beta strandi793 – 8008
Turni801 – 8033
Beta strandi804 – 8129
Turni813 – 8153
Beta strandi819 – 8268
Beta strandi832 – 84615
Helixi850 – 8523
Helixi853 – 8608
Helixi862 – 87514
Helixi877 – 8804

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3OHMX-ray2.70B10-886[»]
4GNKX-ray4.00B/D10-1234[»]
E934-1192[»]
ProteinModelPortaliQ01970.
SMRiQ01970. Positions 10-505, 527-881, 934-1192.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini318 – 468151PI-PLC X-boxPROSITE-ProRule annotationAdd
BLAST
Domaini590 – 706117PI-PLC Y-boxPROSITE-ProRule annotationAdd
BLAST
Domaini713 – 81098C2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1231 – 12344Interaction with SHANK2By similarity

Sequence similaritiesi

Contains 1 C2 domain.PROSITE-ProRule annotation
Contains 1 PI-PLC X-box domain.PROSITE-ProRule annotation
Contains 1 PI-PLC Y-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG149692.
GeneTreeiENSGT00760000118936.
HOGENOMiHOG000232046.
HOVERGENiHBG053609.
InParanoidiQ01970.
KOiK05858.
OMAiEFQNRQV.
OrthoDBiEOG7WDN1N.
PhylomeDBiQ01970.
TreeFamiTF313216.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR011993. PH_like_dom.
IPR001192. PI-PLC_fam.
IPR016280. PLC-beta.
IPR028390. PLC-beta3.
IPR014815. PLC-beta_C.
IPR009535. PLC-beta_CS.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF11. PTHR10336:SF11. 1 hit.
PfamiPF00168. C2. 1 hit.
PF06631. DUF1154. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF08703. PLC-beta_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000956. PLC-beta. 1 hit.
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q01970-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGAQPGVHA LQLEPPTVVE TLRRGSKFIK WDEETSSRNL VTLRVDPNGF
60 70 80 90 100
FLYWTGPNME VDTLDISSIR DTRTGRYARL PKDPKIREVL GFGGPDARLE
110 120 130 140 150
EKLMTVVSGP DPVNTVFLNF MAVQDDTAKV WSEELFKLAM NILAQNASRN
160 170 180 190 200
TFLRKAYTKL KLQVNQDGRI PVKNILKMFS ADKKRVETAL ESCGLKFNRS
210 220 230 240 250
ESIRPDEFSL EIFERFLNKL CLRPDIDKIL LEIGAKGKPY LTLEQLMDFI
260 270 280 290 300
NQKQRDPRLN EVLYPPLRPS QARLLIEKYE PNQQFLERDQ MSMEGFSRYL
310 320 330 340 350
GGEENGILPL EALDLSTDMT QPLSAYFINS SHNTYLTAGQ LAGTSSVEMY
360 370 380 390 400
RQALLWGCRC VELDVWKGRP PEEEPFITHG FTMTTEVPLR DVLEAIAETA
410 420 430 440 450
FKTSPYPVIL SFENHVDSAK QQAKMAEYCR SIFGDALLIE PLDKYPLAPG
460 470 480 490 500
VPLPSPQDLM GRILVKNKKR HRPSAGGPDS AGRKRPLEQS NSALSESSAA
510 520 530 540 550
TEPSSPQLGS PSSDSCPGLS NGEEVGLEKP SLEPQKSLGD EGLNRGPYVL
560 570 580 590 600
GPADREDEEE DEEEEEQTDP KKPTTDEGTA SSEVNATEEM STLVNYIEPV
610 620 630 640 650
KFKSFEAARK RNKCFEMSSF VETKAMEQLT KSPMEFVEYN KQQLSRIYPK
660 670 680 690 700
GTRVDSSNYM PQLFWNVGCQ LVALNFQTLD VAMQLNAGVF EYNGRSGYLL
710 720 730 740 750
KPEFMRRPDK SFDPFTEVIV DGIVANALRV KVISGQFLSD RKVGIYVEVD
760 770 780 790 800
MFGLPVDTRR KYRTRTSQGN SFNPVWDEEP FDFPKVVLPT LASLRIAAFE
810 820 830 840 850
EGGKFVGHRI LPVSAIRSGY HYVCLRNEAN QPLCLPALLI YTEASDYIPD
860 870 880 890 900
DHQDYAEALI NPIKHVSLMD QRARQLAALI GESEAQAGQE TCQDTQSQQL
910 920 930 940 950
GSQPSSNPTP SPLDASPRRP PGPTTSPAST SLSSPGQRDD LIASILSEVA
960 970 980 990 1000
PTPLDELRGH KALVKLRSRQ ERDLRELRKK HQRKAVTLTR RLLDGLAQAQ
1010 1020 1030 1040 1050
AEGRCRLRPG ALGGAADVED TKEGEDEAKR YQEFQNRQVQ SLLELREAQV
1060 1070 1080 1090 1100
DAEAQRRLEH LRQALQRLRE VVLDANTTQF KRLKEMNERE KKELQKILDR
1110 1120 1130 1140 1150
KRHNSISEAK MRDKHKKEAE LTEINRRHIT ESVNSIRRLE EAQKQRHDRL
1160 1170 1180 1190 1200
VAGQQQVLQQ LAEEEPKLLA QLAQECQEQR ARLPQEIRRS LLGEMPEGLG
1210 1220 1230
DGPLVACASN GHAPGSSGHL SGADSESQEE NTQL
Length:1,234
Mass (Da):138,799
Last modified:October 1, 1996 - v2
Checksum:iC5106EFBA8037788
GO
Isoform 2 (identifier: Q01970-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     33-99: Missing.

Note: No experimental confirmation available.

Show »
Length:1,167
Mass (Da):131,205
Checksum:i597C35D7C25D4773
GO

Sequence cautioni

The sequence AAH32659.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti845 – 8451S → L in CAA78903. (PubMed:1333955)Curated
Sequence conflicti881 – 8811G → E in CAA85776. (PubMed:7607669)Curated
Sequence conflicti1089 – 111931REKKE…HKKEA → SWPSWPRSVRSSGRGSPRRS AGACWARCRRG in CAA85776. (PubMed:7607669)CuratedAdd
BLAST

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti483 – 4831R → H.
Corresponds to variant rs12146487 [ dbSNP | Ensembl ].
VAR_029229

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei33 – 9967Missing in isoform 2. 1 PublicationVSP_046054Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U26425 Genomic DNA. Translation: AAA77683.1.
Z37544
, Z37545, Z37546, Z37547, Z37548, Z37549, Z37550, Z37551, Z37552, Z37553, Z37554, Z37555, Z37556, Z37557, Z37558, Z37559, Z37560, Z37561, Z37562, Z37564, Z37565, Z37566, Z37567, Z37568, Z37569, Z37570, Z37571, Z37572, Z37573, Z37574 Genomic DNA. Translation: CAA85776.1.
AP001453 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74230.1.
CH471076 Genomic DNA. Translation: EAW74231.1.
BC032659 mRNA. Translation: AAH32659.1. Different initiation.
BC142681 mRNA. Translation: AAI42682.1.
Z16411 mRNA. Translation: CAA78903.1.
CCDSiCCDS53654.1. [Q01970-2]
CCDS8064.1. [Q01970-1]
PIRiI38994.
S27002.
S52099.
RefSeqiNP_000923.1. NM_000932.2. [Q01970-1]
NP_001171812.1. NM_001184883.1. [Q01970-2]
XP_005274109.1. XM_005274052.2. [Q01970-1]
UniGeneiHs.523761.

Genome annotation databases

EnsembliENST00000279230; ENSP00000279230; ENSG00000149782. [Q01970-1]
ENST00000325234; ENSP00000324660; ENSG00000149782. [Q01970-2]
ENST00000540288; ENSP00000443631; ENSG00000149782. [Q01970-1]
GeneIDi5331.
KEGGihsa:5331.
UCSCiuc009ypg.2. human. [Q01970-1]
uc009yph.2. human.

Polymorphism databases

DMDMi1730573.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U26425 Genomic DNA. Translation: AAA77683.1 .
Z37544
, Z37545 , Z37546 , Z37547 , Z37548 , Z37549 , Z37550 , Z37551 , Z37552 , Z37553 , Z37554 , Z37555 , Z37556 , Z37557 , Z37558 , Z37559 , Z37560 , Z37561 , Z37562 , Z37564 , Z37565 , Z37566 , Z37567 , Z37568 , Z37569 , Z37570 , Z37571 , Z37572 , Z37573 , Z37574 Genomic DNA. Translation: CAA85776.1 .
AP001453 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74230.1 .
CH471076 Genomic DNA. Translation: EAW74231.1 .
BC032659 mRNA. Translation: AAH32659.1 . Different initiation.
BC142681 mRNA. Translation: AAI42682.1 .
Z16411 mRNA. Translation: CAA78903.1 .
CCDSi CCDS53654.1. [Q01970-2 ]
CCDS8064.1. [Q01970-1 ]
PIRi I38994.
S27002.
S52099.
RefSeqi NP_000923.1. NM_000932.2. [Q01970-1 ]
NP_001171812.1. NM_001184883.1. [Q01970-2 ]
XP_005274109.1. XM_005274052.2. [Q01970-1 ]
UniGenei Hs.523761.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3OHM X-ray 2.70 B 10-886 [» ]
4GNK X-ray 4.00 B/D 10-1234 [» ]
E 934-1192 [» ]
ProteinModelPortali Q01970.
SMRi Q01970. Positions 10-505, 527-881, 934-1192.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111347. 9 interactions.
DIPi DIP-41928N.
MINTi MINT-4999151.
STRINGi 9606.ENSP00000279230.

Chemistry

BindingDBi Q01970.

PTM databases

PhosphoSitei Q01970.

Polymorphism databases

DMDMi 1730573.

Proteomic databases

MaxQBi Q01970.
PaxDbi Q01970.
PRIDEi Q01970.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000279230 ; ENSP00000279230 ; ENSG00000149782 . [Q01970-1 ]
ENST00000325234 ; ENSP00000324660 ; ENSG00000149782 . [Q01970-2 ]
ENST00000540288 ; ENSP00000443631 ; ENSG00000149782 . [Q01970-1 ]
GeneIDi 5331.
KEGGi hsa:5331.
UCSCi uc009ypg.2. human. [Q01970-1 ]
uc009yph.2. human.

Organism-specific databases

CTDi 5331.
GeneCardsi GC11P064019.
HGNCi HGNC:9056. PLCB3.
HPAi CAB009257.
HPA039279.
HPA043907.
MIMi 600230. gene.
neXtProti NX_Q01970.
PharmGKBi PA33386.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG149692.
GeneTreei ENSGT00760000118936.
HOGENOMi HOG000232046.
HOVERGENi HBG053609.
InParanoidi Q01970.
KOi K05858.
OMAi EFQNRQV.
OrthoDBi EOG7WDN1N.
PhylomeDBi Q01970.
TreeFami TF313216.

Enzyme and pathway databases

BRENDAi 3.1.4.11. 2681.
Reactomei REACT_150312. Synthesis of IP3 and IP4 in the cytosol.
REACT_15426. PLC beta mediated events.
REACT_172761. Ca2+ pathway.
REACT_18283. G alpha (q) signalling events.
REACT_18405. Acetylcholine regulates insulin secretion.
REACT_19145. G beta:gamma signalling through PLC beta.
REACT_19193. Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion.
REACT_21254. Presynaptic function of Kainate receptors.

Miscellaneous databases

GeneWikii PLCB3.
GenomeRNAii 5331.
NextBioi 20644.
PROi Q01970.
SOURCEi Search...

Gene expression databases

Bgeei Q01970.
CleanExi HS_PLCB3.
Genevestigatori Q01970.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProi IPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR011993. PH_like_dom.
IPR001192. PI-PLC_fam.
IPR016280. PLC-beta.
IPR028390. PLC-beta3.
IPR014815. PLC-beta_C.
IPR009535. PLC-beta_CS.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view ]
PANTHERi PTHR10336. PTHR10336. 1 hit.
PTHR10336:SF11. PTHR10336:SF11. 1 hit.
Pfami PF00168. C2. 1 hit.
PF06631. DUF1154. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF08703. PLC-beta_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF000956. PLC-beta. 1 hit.
PRINTSi PR00390. PHPHLIPASEC.
SMARTi SM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 2 hits.
PROSITEi PS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural organization and expression of the human phosphatidylinositol-specific phospholipase C beta-3 gene."
    Mazuruk K., Schoen T.J., Chader G.J., Rodriguez I.R.
    Biochem. Biophys. Res. Commun. 212:190-195(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Genomic organization and complete cDNA sequence of the human phosphoinositide-specific phospholipase C beta 3 gene (PLCB3)."
    Lagercrantz J., Carson E., Phelan C., Grimmond S., Rosen A., Dare E., Nordenskjoeld M., Hayward N.K., Larsson C., Weber G.
    Genomics 26:467-472(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Uterus.
  6. "Identification, purification and characterization of a novel phosphatidylinositol-specific phospholipase C, a third member of the beta subfamily."
    Carozzi A.J., Kriz R.W., Webster C., Parker P.J.
    Eur. J. Biochem. 210:521-529(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 184-1234 (ISOFORM 1/2).
  7. "NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation."
    Oh Y.-S., Jo N.W., Choi J.W., Kim H.S., Seo S.-W., Kang K.-O., Hwang J.-I., Heo K., Kim S.-H., Kim Y.-H., Kim I.-H., Kim J.H., Banno Y., Ryu S.H., Suh P.-G.
    Mol. Cell. Biol. 24:5069-5079(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LPAR2.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-537, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-474; SER-537 AND SER-1105, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPLCB3_HUMAN
AccessioniPrimary (citable) accession number: Q01970
Secondary accession number(s): A5PKZ6, G5E960, Q8N1A4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3