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Q01965

- LY9_MOUSE

UniProt

Q01965 - LY9_MOUSE

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Protein

T-lymphocyte surface antigen Ly-9

Gene
Ly9, Ly-9
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction.

GO - Molecular functioni

  1. receptor activity Source: InterPro

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
T-lymphocyte surface antigen Ly-9
Alternative name(s):
Cell surface molecule Ly-9
Lymphocyte antigen 9
SLAM family member 3
Short name:
SLAMF3
Signaling lymphocytic activation molecule 3
CD_antigen: CD229
Gene namesi
Name:Ly9
Synonyms:Ly-9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:96885. Ly9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini48 – 453406Extracellular Reviewed predictionAdd
BLAST
Transmembranei454 – 47421Helical; Reviewed predictionAdd
BLAST
Topological domaini475 – 654180Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 47471 PublicationAdd
BLAST
Chaini48 – 654607T-lymphocyte surface antigen Ly-9PRO_0000014852Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi68 – 681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi120 – 1201N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi172 ↔ 242 Reviewed prediction
Disulfide bondi178 ↔ 222 Reviewed prediction
Glycosylationi231 – 2311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi284 – 2841N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi376 ↔ 445 Reviewed prediction
Disulfide bondi382 ↔ 426 Reviewed prediction
Glycosylationi390 – 3901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi412 – 4121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi423 – 4231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi434 – 4341N-linked (GlcNAc...) Reviewed prediction
Modified residuei499 – 4991Phosphothreonine1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ01965.
PRIDEiQ01965.

PTM databases

PhosphoSiteiQ01965.

Expressioni

Tissue specificityi

Lymphocytes.

Gene expression databases

ArrayExpressiQ01965.
BgeeiQ01965.
CleanExiMM_LY9.
GenevestigatoriQ01965.

Structurei

3D structure databases

ProteinModelPortaliQ01965.
SMRiQ01965. Positions 55-229, 256-445.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 158111Ig-like V-type 1Add
BLAST
Domaini159 – 24385Ig-like C2-type 1Add
BLAST
Domaini250 – 362113Ig-like V-type 2Add
BLAST
Domaini353 – 453101Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150167.
GeneTreeiENSGT00530000063114.
HOGENOMiHOG000013143.
HOVERGENiHBG030765.
InParanoidiQ01965.
KOiK06570.
OMAiYHAYVCS.
OrthoDBiEOG77HDFC.
PhylomeDBiQ01965.
TreeFamiTF334964.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015631. SLAM_fam_rcpts.
[Graphical view]
PANTHERiPTHR12080. PTHR12080. 1 hit.
SMARTiSM00409. IG. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01965-1 [UniParc]FASTAAdd to Basket

« Hide

MADLKRYWCD WALGPLSENP RMSQQQIFSP ILWIPLLFLL MGLGASGKET    50
PPTVISGMLG GSVTFSLNIS KDAEIEHIIW NCPPKALALV FYKKDITILD 100
KGYNGRLKVS EDGYSLYMSN LTKSDSGSYH AQINQKNVIL TTNKEFTLHI 150
YEKLQKPQII VESVTPSDTD SCTFTLICTV KGTKDSVQYS WTREDTHLNT 200
YDGSHTLRVS QSVCDPDLPY TCKAWNPVSQ NSSQPVRIWQ FCTGASRRKT 250
AAGKTVVGIL GEPVTLPLEF RATRATKNVV WVFNTSVISQ ERRGAATADS 300
RRKPKGSEER RVRTSDQDQS LKISQLKMED AGPYHAYVCS EASRDPSVRH 350
FTLLVYKRLE KPSVTKSPVH MMNGICEVVL TCSVDGGGNN VTYTWMPLQN 400
KAVMSQGKSH LNVSWESGEH LPNFTCTAHN PVSNSSSQFS SGTICSGPER 450
NKRFWLLLLL VLLLLMLIGG YFILRKKKQC SSLATRYRQA EVPAEIPETP 500
TGHGQFSVLS QRYEKLDMSA KTTRHQPTPT SDTSSESSAT TEEDDEKTRM 550
HSTANSRNQV YDLVTHQDIA HALAYEGQVE YEAITPYDKV DGSMDEEDMA 600
YIQVSLNVQG ETPLPQKKED SNTIYCSVQK PKKTAQTPQQ DAESPETPTY 650
ENFT 654
Length:654
Mass (Da):73,143
Last modified:June 20, 2002 - v2
Checksum:i1CBBE99708AE8EE7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101D → G in Ly9-1.
Natural varianti14 – 141G → S in Ly9-1.
Natural varianti79 – 791I → T in Ly9-1.
Natural varianti91 – 911F → S in Ly9-1.
Natural varianti130 – 1301H → Y in Ly9-1.
Natural varianti139 – 1391I → T in Ly9-1.
Natural varianti362 – 3621P → S.
Natural varianti366 – 3661K → N in Ly9-1.
Natural varianti377 – 3771E → K in Ly9-1.
Natural varianti550 – 5501M → I in Ly9-1.
Natural varianti592 – 5921G → E in Ly9-1.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti283 – 2831F → L in AAA39468. 1 Publication
Sequence conflicti499 – 4991T → P in AAA39468. 1 Publication
Sequence conflicti560 – 5601V → L in AAA39468. 1 Publication
Sequence conflicti647 – 6548TPTYENFT → SPYL in AAA39468. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF244131 mRNA. Translation: AAG14997.1.
AF244130 mRNA. Translation: AAG14996.1.
AF246701
, AF245117, AF245506, AF245118, AF245507, AF245508, AF245509, AF245510, AF246699, AF246700 Genomic DNA. Translation: AAG13268.2.
M84412 mRNA. Translation: AAA39468.1.
CCDSiCCDS35779.1.
RefSeqiNP_001264897.1. NM_001277968.1.
NP_032560.2. NM_008534.3.
UniGeneiMm.560.

Genome annotation databases

EnsembliENSMUST00000068878; ENSMUSP00000069319; ENSMUSG00000004707.
GeneIDi17085.
KEGGimmu:17085.
UCSCiuc007dou.1. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF244131 mRNA. Translation: AAG14997.1 .
AF244130 mRNA. Translation: AAG14996.1 .
AF246701
, AF245117 , AF245506 , AF245118 , AF245507 , AF245508 , AF245509 , AF245510 , AF246699 , AF246700 Genomic DNA. Translation: AAG13268.2 .
M84412 mRNA. Translation: AAA39468.1 .
CCDSi CCDS35779.1.
RefSeqi NP_001264897.1. NM_001277968.1.
NP_032560.2. NM_008534.3.
UniGenei Mm.560.

3D structure databases

ProteinModelPortali Q01965.
SMRi Q01965. Positions 55-229, 256-445.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q01965.

Proteomic databases

PaxDbi Q01965.
PRIDEi Q01965.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000068878 ; ENSMUSP00000069319 ; ENSMUSG00000004707 .
GeneIDi 17085.
KEGGi mmu:17085.
UCSCi uc007dou.1. mouse.

Organism-specific databases

CTDi 4063.
MGIi MGI:96885. Ly9.

Phylogenomic databases

eggNOGi NOG150167.
GeneTreei ENSGT00530000063114.
HOGENOMi HOG000013143.
HOVERGENi HBG030765.
InParanoidi Q01965.
KOi K06570.
OMAi YHAYVCS.
OrthoDBi EOG77HDFC.
PhylomeDBi Q01965.
TreeFami TF334964.

Miscellaneous databases

NextBioi 291220.
PROi Q01965.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q01965.
Bgeei Q01965.
CleanExi MM_LY9.
Genevestigatori Q01965.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015631. SLAM_fam_rcpts.
[Graphical view ]
PANTHERi PTHR12080. PTHR12080. 1 hit.
SMARTi SM00409. IG. 2 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Gene structure of the mouse leukocyte cell surface molecule Ly9."
    Tovar V., de la Fuente M.A., Pizcueta P., Bosch J., Engel P.
    Immunogenetics 51:788-793(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], POLYMORPHISM.
    Strain: 129/Sv, BALB/c and C57BL/6.
    Tissue: Spleen.
  2. "Isolation and characterization of cDNA clones for mouse Ly-9."
    Sandrin M.S., Gumley T.P., Henning M.M., Vaughan H.A., Gonez L.J., Trapani J.A., McKenzie I.F.C.
    J. Immunol. 149:1636-1641(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-654, PROTEIN SEQUENCE OF 48-59.
  3. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-499, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiLY9_MOUSE
AccessioniPrimary (citable) accession number: Q01965
Secondary accession number(s): Q9ES29, Q9ES35, Q9ES36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 20, 2002
Last modified: July 9, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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