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Q01965 (LY9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
T-lymphocyte surface antigen Ly-9
Alternative name(s):
Cell surface molecule Ly-9
Lymphocyte antigen 9
SLAM family member 3
Short name=SLAMF3
Signaling lymphocytic activation molecule 3
CD_antigen=CD229
Gene names
Name:Ly9
Synonyms:Ly-9
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length654 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Lymphocytes.

Sequence similarities

Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Contains 2 Ig-like V-type (immunoglobulin-like) domains.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainImmunoglobulin domain
Repeat
Signal
Transmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
Phosphoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionreceptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4747 Ref.2
Chain48 – 654607T-lymphocyte surface antigen Ly-9
PRO_0000014852

Regions

Topological domain48 – 453406Extracellular Potential
Transmembrane454 – 47421Helical; Potential
Topological domain475 – 654180Cytoplasmic Potential
Domain48 – 158111Ig-like V-type 1
Domain159 – 24385Ig-like C2-type 1
Domain250 – 362113Ig-like V-type 2
Domain353 – 453101Ig-like C2-type 2

Amino acid modifications

Modified residue4991Phosphothreonine Ref.3
Glycosylation681N-linked (GlcNAc...) Potential
Glycosylation1201N-linked (GlcNAc...) Potential
Glycosylation2311N-linked (GlcNAc...) Potential
Glycosylation2841N-linked (GlcNAc...) Potential
Glycosylation3901N-linked (GlcNAc...) Potential
Glycosylation4121N-linked (GlcNAc...) Potential
Glycosylation4231N-linked (GlcNAc...) Potential
Glycosylation4341N-linked (GlcNAc...) Potential
Disulfide bond172 ↔ 242 Potential
Disulfide bond178 ↔ 222 Potential
Disulfide bond376 ↔ 445 Potential
Disulfide bond382 ↔ 426 Potential

Natural variations

Natural variant101D → G in Ly9-1.
Natural variant141G → S in Ly9-1.
Natural variant791I → T in Ly9-1.
Natural variant911F → S in Ly9-1.
Natural variant1301H → Y in Ly9-1.
Natural variant1391I → T in Ly9-1.
Natural variant3621P → S.
Natural variant3661K → N in Ly9-1.
Natural variant3771E → K in Ly9-1.
Natural variant5501M → I in Ly9-1.
Natural variant5921G → E in Ly9-1.

Experimental info

Sequence conflict2831F → L in AAA39468. Ref.2
Sequence conflict4991T → P in AAA39468. Ref.2
Sequence conflict5601V → L in AAA39468. Ref.2
Sequence conflict647 – 6548TPTYENFT → SPYL in AAA39468. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q01965 [UniParc].

Last modified June 20, 2002. Version 2.
Checksum: 1CBBE99708AE8EE7

FASTA65473,143
        10         20         30         40         50         60 
MADLKRYWCD WALGPLSENP RMSQQQIFSP ILWIPLLFLL MGLGASGKET PPTVISGMLG 

        70         80         90        100        110        120 
GSVTFSLNIS KDAEIEHIIW NCPPKALALV FYKKDITILD KGYNGRLKVS EDGYSLYMSN 

       130        140        150        160        170        180 
LTKSDSGSYH AQINQKNVIL TTNKEFTLHI YEKLQKPQII VESVTPSDTD SCTFTLICTV 

       190        200        210        220        230        240 
KGTKDSVQYS WTREDTHLNT YDGSHTLRVS QSVCDPDLPY TCKAWNPVSQ NSSQPVRIWQ 

       250        260        270        280        290        300 
FCTGASRRKT AAGKTVVGIL GEPVTLPLEF RATRATKNVV WVFNTSVISQ ERRGAATADS 

       310        320        330        340        350        360 
RRKPKGSEER RVRTSDQDQS LKISQLKMED AGPYHAYVCS EASRDPSVRH FTLLVYKRLE 

       370        380        390        400        410        420 
KPSVTKSPVH MMNGICEVVL TCSVDGGGNN VTYTWMPLQN KAVMSQGKSH LNVSWESGEH 

       430        440        450        460        470        480 
LPNFTCTAHN PVSNSSSQFS SGTICSGPER NKRFWLLLLL VLLLLMLIGG YFILRKKKQC 

       490        500        510        520        530        540 
SSLATRYRQA EVPAEIPETP TGHGQFSVLS QRYEKLDMSA KTTRHQPTPT SDTSSESSAT 

       550        560        570        580        590        600 
TEEDDEKTRM HSTANSRNQV YDLVTHQDIA HALAYEGQVE YEAITPYDKV DGSMDEEDMA 

       610        620        630        640        650 
YIQVSLNVQG ETPLPQKKED SNTIYCSVQK PKKTAQTPQQ DAESPETPTY ENFT 

« Hide

References

« Hide 'large scale' references
[1]"Gene structure of the mouse leukocyte cell surface molecule Ly9."
Tovar V., de la Fuente M.A., Pizcueta P., Bosch J., Engel P.
Immunogenetics 51:788-793(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], POLYMORPHISM.
Strain: 129/Sv, BALB/c and C57BL/6.
Tissue: Spleen.
[2]"Isolation and characterization of cDNA clones for mouse Ly-9."
Sandrin M.S., Gumley T.P., Henning M.M., Vaughan H.A., Gonez L.J., Trapani J.A., McKenzie I.F.C.
J. Immunol. 149:1636-1641(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-654, PROTEIN SEQUENCE OF 48-59.
[3]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-499, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF244131 mRNA. Translation: AAG14997.1.
AF244130 mRNA. Translation: AAG14996.1.
AF246701 expand/collapse EMBL AC list , AF245117, AF245506, AF245118, AF245507, AF245508, AF245509, AF245510, AF246699, AF246700 Genomic DNA. Translation: AAG13268.2.
M84412 mRNA. Translation: AAA39468.1.
CCDSCCDS35779.1.
RefSeqNP_001264897.1. NM_001277968.1.
NP_032560.2. NM_008534.3.
UniGeneMm.560.

3D structure databases

ProteinModelPortalQ01965.
SMRQ01965. Positions 55-229, 256-445.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ01965.

Proteomic databases

PaxDbQ01965.
PRIDEQ01965.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000068878; ENSMUSP00000069319; ENSMUSG00000004707.
GeneID17085.
KEGGmmu:17085.
UCSCuc007dou.1. mouse.

Organism-specific databases

CTD4063.
MGIMGI:96885. Ly9.

Phylogenomic databases

eggNOGNOG150167.
GeneTreeENSGT00530000063114.
HOGENOMHOG000013143.
HOVERGENHBG030765.
InParanoidQ01965.
KOK06570.
OMAYHAYVCS.
OrthoDBEOG77HDFC.
PhylomeDBQ01965.
TreeFamTF334964.

Gene expression databases

ArrayExpressQ01965.
BgeeQ01965.
CleanExMM_LY9.
GenevestigatorQ01965.

Family and domain databases

Gene3D2.60.40.10. 3 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015631. SLAM_fam_rcpts.
[Graphical view]
PANTHERPTHR12080. PTHR12080. 1 hit.
SMARTSM00409. IG. 2 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio291220.
PROQ01965.
SOURCESearch...

Entry information

Entry nameLY9_MOUSE
AccessionPrimary (citable) accession number: Q01965
Secondary accession number(s): Q9ES29, Q9ES35, Q9ES36
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 20, 2002
Last modified: July 9, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot