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Q01965

- LY9_MOUSE

UniProt

Q01965 - LY9_MOUSE

Protein

T-lymphocyte surface antigen Ly-9

Gene

Ly9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (20 Jun 2002)
      Previous versions | rss
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    Functioni

    May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction.

    GO - Molecular functioni

    1. receptor activity Source: InterPro

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-lymphocyte surface antigen Ly-9
    Alternative name(s):
    Cell surface molecule Ly-9
    Lymphocyte antigen 9
    SLAM family member 3
    Short name:
    SLAMF3
    Signaling lymphocytic activation molecule 3
    CD_antigen: CD229
    Gene namesi
    Name:Ly9
    Synonyms:Ly-9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:96885. Ly9.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 47471 PublicationAdd
    BLAST
    Chaini48 – 654607T-lymphocyte surface antigen Ly-9PRO_0000014852Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi172 ↔ 242PROSITE-ProRule annotation
    Disulfide bondi178 ↔ 222PROSITE-ProRule annotation
    Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi284 – 2841N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi376 ↔ 445PROSITE-ProRule annotation
    Disulfide bondi382 ↔ 426PROSITE-ProRule annotation
    Glycosylationi390 – 3901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi412 – 4121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi423 – 4231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi434 – 4341N-linked (GlcNAc...)Sequence Analysis
    Modified residuei499 – 4991Phosphothreonine1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ01965.
    PRIDEiQ01965.

    PTM databases

    PhosphoSiteiQ01965.

    Expressioni

    Tissue specificityi

    Lymphocytes.

    Gene expression databases

    ArrayExpressiQ01965.
    BgeeiQ01965.
    CleanExiMM_LY9.
    GenevestigatoriQ01965.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01965.
    SMRiQ01965. Positions 55-229, 256-445.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini48 – 453406ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini475 – 654180CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei454 – 47421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini48 – 158111Ig-like V-type 1Add
    BLAST
    Domaini159 – 24385Ig-like C2-type 1Add
    BLAST
    Domaini250 – 362113Ig-like V-type 2Add
    BLAST
    Domaini353 – 453101Ig-like C2-type 2Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150167.
    GeneTreeiENSGT00530000063114.
    HOGENOMiHOG000013143.
    HOVERGENiHBG030765.
    InParanoidiQ01965.
    KOiK06570.
    OMAiYHAYVCS.
    OrthoDBiEOG77HDFC.
    PhylomeDBiQ01965.
    TreeFamiTF334964.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR015631. SLAM_fam_rcpts.
    [Graphical view]
    PANTHERiPTHR12080. PTHR12080. 1 hit.
    SMARTiSM00409. IG. 2 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q01965-1 [UniParc]FASTAAdd to Basket

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    MADLKRYWCD WALGPLSENP RMSQQQIFSP ILWIPLLFLL MGLGASGKET    50
    PPTVISGMLG GSVTFSLNIS KDAEIEHIIW NCPPKALALV FYKKDITILD 100
    KGYNGRLKVS EDGYSLYMSN LTKSDSGSYH AQINQKNVIL TTNKEFTLHI 150
    YEKLQKPQII VESVTPSDTD SCTFTLICTV KGTKDSVQYS WTREDTHLNT 200
    YDGSHTLRVS QSVCDPDLPY TCKAWNPVSQ NSSQPVRIWQ FCTGASRRKT 250
    AAGKTVVGIL GEPVTLPLEF RATRATKNVV WVFNTSVISQ ERRGAATADS 300
    RRKPKGSEER RVRTSDQDQS LKISQLKMED AGPYHAYVCS EASRDPSVRH 350
    FTLLVYKRLE KPSVTKSPVH MMNGICEVVL TCSVDGGGNN VTYTWMPLQN 400
    KAVMSQGKSH LNVSWESGEH LPNFTCTAHN PVSNSSSQFS SGTICSGPER 450
    NKRFWLLLLL VLLLLMLIGG YFILRKKKQC SSLATRYRQA EVPAEIPETP 500
    TGHGQFSVLS QRYEKLDMSA KTTRHQPTPT SDTSSESSAT TEEDDEKTRM 550
    HSTANSRNQV YDLVTHQDIA HALAYEGQVE YEAITPYDKV DGSMDEEDMA 600
    YIQVSLNVQG ETPLPQKKED SNTIYCSVQK PKKTAQTPQQ DAESPETPTY 650
    ENFT 654
    Length:654
    Mass (Da):73,143
    Last modified:June 20, 2002 - v2
    Checksum:i1CBBE99708AE8EE7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti283 – 2831F → L in AAA39468. (PubMed:1506686)Curated
    Sequence conflicti499 – 4991T → P in AAA39468. (PubMed:1506686)Curated
    Sequence conflicti560 – 5601V → L in AAA39468. (PubMed:1506686)Curated
    Sequence conflicti647 – 6548TPTYENFT → SPYL in AAA39468. (PubMed:1506686)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti10 – 101D → G in Ly9-1.
    Natural varianti14 – 141G → S in Ly9-1.
    Natural varianti79 – 791I → T in Ly9-1.
    Natural varianti91 – 911F → S in Ly9-1.
    Natural varianti130 – 1301H → Y in Ly9-1.
    Natural varianti139 – 1391I → T in Ly9-1.
    Natural varianti362 – 3621P → S.
    Natural varianti366 – 3661K → N in Ly9-1.
    Natural varianti377 – 3771E → K in Ly9-1.
    Natural varianti550 – 5501M → I in Ly9-1.
    Natural varianti592 – 5921G → E in Ly9-1.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF244131 mRNA. Translation: AAG14997.1.
    AF244130 mRNA. Translation: AAG14996.1.
    AF246701
    , AF245117, AF245506, AF245118, AF245507, AF245508, AF245509, AF245510, AF246699, AF246700 Genomic DNA. Translation: AAG13268.2.
    M84412 mRNA. Translation: AAA39468.1.
    CCDSiCCDS35779.1.
    RefSeqiNP_001264897.1. NM_001277968.1.
    NP_032560.2. NM_008534.3.
    UniGeneiMm.560.

    Genome annotation databases

    EnsembliENSMUST00000068878; ENSMUSP00000069319; ENSMUSG00000004707.
    GeneIDi17085.
    KEGGimmu:17085.
    UCSCiuc007dou.1. mouse.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF244131 mRNA. Translation: AAG14997.1 .
    AF244130 mRNA. Translation: AAG14996.1 .
    AF246701
    , AF245117 , AF245506 , AF245118 , AF245507 , AF245508 , AF245509 , AF245510 , AF246699 , AF246700 Genomic DNA. Translation: AAG13268.2 .
    M84412 mRNA. Translation: AAA39468.1 .
    CCDSi CCDS35779.1.
    RefSeqi NP_001264897.1. NM_001277968.1.
    NP_032560.2. NM_008534.3.
    UniGenei Mm.560.

    3D structure databases

    ProteinModelPortali Q01965.
    SMRi Q01965. Positions 55-229, 256-445.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q01965.

    Proteomic databases

    PaxDbi Q01965.
    PRIDEi Q01965.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000068878 ; ENSMUSP00000069319 ; ENSMUSG00000004707 .
    GeneIDi 17085.
    KEGGi mmu:17085.
    UCSCi uc007dou.1. mouse.

    Organism-specific databases

    CTDi 4063.
    MGIi MGI:96885. Ly9.

    Phylogenomic databases

    eggNOGi NOG150167.
    GeneTreei ENSGT00530000063114.
    HOGENOMi HOG000013143.
    HOVERGENi HBG030765.
    InParanoidi Q01965.
    KOi K06570.
    OMAi YHAYVCS.
    OrthoDBi EOG77HDFC.
    PhylomeDBi Q01965.
    TreeFami TF334964.

    Miscellaneous databases

    NextBioi 291220.
    PROi Q01965.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q01965.
    Bgeei Q01965.
    CleanExi MM_LY9.
    Genevestigatori Q01965.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR015631. SLAM_fam_rcpts.
    [Graphical view ]
    PANTHERi PTHR12080. PTHR12080. 1 hit.
    SMARTi SM00409. IG. 2 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gene structure of the mouse leukocyte cell surface molecule Ly9."
      Tovar V., de la Fuente M.A., Pizcueta P., Bosch J., Engel P.
      Immunogenetics 51:788-793(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], POLYMORPHISM.
      Strain: 129/Sv, BALB/c and C57BL/6.
      Tissue: Spleen.
    2. "Isolation and characterization of cDNA clones for mouse Ly-9."
      Sandrin M.S., Gumley T.P., Henning M.M., Vaughan H.A., Gonez L.J., Trapani J.A., McKenzie I.F.C.
      J. Immunol. 149:1636-1641(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-654, PROTEIN SEQUENCE OF 48-59.
    3. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-499, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiLY9_MOUSE
    AccessioniPrimary (citable) accession number: Q01965
    Secondary accession number(s): Q9ES29, Q9ES35, Q9ES36
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 20, 2002
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3