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Q01956

- KCNC3_RAT

UniProt

Q01956 - KCNC3_RAT

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Protein

Potassium voltage-gated channel subfamily C member 3

Gene

Kcnc3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: RefGenome

GO - Biological processi

  1. protein homooligomerization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily C member 3
Alternative name(s):
KSHIIID
Voltage-gated potassium channel subunit Kv3.3
Gene namesi
Name:Kcnc3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621358. Kcnc3.

Subcellular locationi

GO - Cellular componenti

  1. voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 889889Potassium voltage-gated channel subfamily C member 3PRO_0000054057Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ01956.
PRIDEiQ01956.

Expressioni

Gene expression databases

GenevestigatoriQ01956.

Interactioni

Subunit structurei

Heterotetramer of potassium channel proteins.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ01956.
SMRiQ01956. Positions 91-195.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 291291CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini372 – 3809CytoplasmicSequence Analysis
Topological domaini436 – 44813CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini541 – 889349CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei292 – 31019Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Transmembranei352 – 37120Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Transmembranei381 – 39919Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Transmembranei413 – 43523Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
BLAST
Transmembranei449 – 47022Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Transmembranei519 – 54022Helical; Name=Segment S6Sequence AnalysisAdd
BLAST

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi504 – 5096Selectivity filterBy similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG280627.
HOGENOMiHOG000231012.
HOVERGENiHBG105862.
InParanoidiQ01956.
PhylomeDBiQ01956.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003974. K_chnl_volt-dep_Kv3.
IPR005404. K_chnl_volt-dep_Kv3.3.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01582. KV33CHANNEL.
PR01491. KVCHANNEL.
PR01498. SHAWCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform KSHIIID.1 (identifier: Q01956-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSSVCVWSF SGRQGTRKQH SQPAPTPQPP ESSPPPLLPP PQQQCAQPGT
60 70 80 90 100
AASPAGAPLS CGPGGRRAEP CSGLPAVAMG RHGGGGGDSG KIVINVGGVR
110 120 130 140 150
HETYRSTLRT LPGTRLAGLT EPEAAARFDY DPGTDEFFFD RHPGVFAYVL
160 170 180 190 200
NYYRTGKLHC PADVCGPLFE EELGFWGIDE TDVEACCWMT YRQHRDAEEA
210 220 230 240 250
LDSFEAPDSS GNANANAGGA HDAGLDDEAG AGGGGLDGAG GELKRLCFQD
260 270 280 290 300
AGGGAGGPAG GPGGAGGTWW RRWQPRVWAL FEDPYSSRAA RYVAFASLFF
310 320 330 340 350
ILISITTFCL ETHEGFIHIS NKTVTQASPI PGAPPENITN VEVETEPFLT
360 370 380 390 400
YVEGVCVVWF TFEFLMRVTF CPDKVEFLKS SLNIIDCVAI LPFYLEVGLS
410 420 430 440 450
GLSSKAAKDV LGFLRVVRFV RILRIFKLTR HFVGLRVLGH TLRASTNEFL
460 470 480 490 500
LLIIFLALGV LIFATMIYYA ERIGADPDDI LGSNHTYFKN IPIGFWWAVV
510 520 530 540 550
TMTTLGYGDM YPKTWSGMLV GALCALAGVL TIAMPVPVIV NNFGMYYSLA
560 570 580 590 600
MAKQKLPKKK NKHIPRPPQP GSPNYCKPDP PPPPPPHPHH GSGGISPPPP
610 620 630 640 650
ITPPSMGVTV AGAYPPGPHT HPGLLRGGAG GLGIMGLPPL PAPGEPCPLA
660 670 680 690 700
QEEVIETNRA GNDLGVLEEG DPRPNGDPAA AALAHEDCPA IDQPAMSPED
710 720 730 740 750
KSPITPGSRG RYSRDRACFL VTDYAPSPDG SIRKATGAPP LPPHAGVSQA
760 770 780 790 800
PPASCPTSTP TQQPGYPPSG RAPSPPQATP EAPAIFDVWL PPFHRSHQPP
810 820 830 840 850
GKHQRGGRHP GVSPSPQQRA CVGEPPSASH PQSLTLCISV PSSCHRLRPR
860 870 880
ETLGFPLSLP PRLATGNGGR ECPRDPGLPF PSRHSSPAV
Length:889
Mass (Da):94,393
Last modified:November 1, 1996 - v1
Checksum:i51424C047B4FC367
GO
Isoform KSHIIID.2 (identifier: Q01956-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     662-679: NDLGVLEEGDPRPNGDPA → EAGARTGGVGRPGGWGSG
     680-889: Missing.

Show »
Length:679
Mass (Da):72,170
Checksum:i077D2D9EE373D0F8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei662 – 67918NDLGV…NGDPA → EAGARTGGVGRPGGWGSG in isoform KSHIIID.2. 1 PublicationVSP_001022Add
BLAST
Alternative sequencei680 – 889210Missing in isoform KSHIIID.2. 1 PublicationVSP_001023Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M84210 mRNA. Translation: AAA73182.1.
M84211 mRNA. Translation: AAA41470.1.
UniGeneiRn.9885.

Genome annotation databases

UCSCiRGD:621358. rat. [Q01956-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M84210 mRNA. Translation: AAA73182.1 .
M84211 mRNA. Translation: AAA41470.1 .
UniGenei Rn.9885.

3D structure databases

ProteinModelPortali Q01956.
SMRi Q01956. Positions 91-195.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 550.

Proteomic databases

PaxDbi Q01956.
PRIDEi Q01956.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:621358. rat. [Q01956-1 ]

Organism-specific databases

RGDi 621358. Kcnc3.

Phylogenomic databases

eggNOGi NOG280627.
HOGENOMi HOG000231012.
HOVERGENi HBG105862.
InParanoidi Q01956.
PhylomeDBi Q01956.

Miscellaneous databases

PROi Q01956.

Gene expression databases

Genevestigatori Q01956.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003974. K_chnl_volt-dep_Kv3.
IPR005404. K_chnl_volt-dep_Kv3.3.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
Pfami PF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01582. KV33CHANNEL.
PR01491. KVCHANNEL.
PR01498. SHAWCHANNEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning of ShIII (Shaw-like) cDNAs encoding a novel high-voltage-activating, TEA-sensitive, type-A K+ channel."
    de Miera E.V.-S., Moreno H., Fruhling D., Kentros C., Rudy B.
    Proc. R. Soc. B 248:9-18(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS KSHIIID.1 AND KSHIIID.2).
    Tissue: Brain.

Entry informationi

Entry nameiKCNC3_RAT
AccessioniPrimary (citable) accession number: Q01956
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3