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Q01956

- KCNC3_RAT

UniProt

Q01956 - KCNC3_RAT

Protein

Potassium voltage-gated channel subfamily C member 3

Gene

Kcnc3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: RefGenome

    GO - Biological processi

    1. protein homooligomerization Source: InterPro

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily C member 3
    Alternative name(s):
    KSHIIID
    Voltage-gated potassium channel subunit Kv3.3
    Gene namesi
    Name:Kcnc3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi621358. Kcnc3.

    Subcellular locationi

    GO - Cellular componenti

    1. voltage-gated potassium channel complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 889889Potassium voltage-gated channel subfamily C member 3PRO_0000054057Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ01956.
    PRIDEiQ01956.

    Expressioni

    Gene expression databases

    GenevestigatoriQ01956.

    Interactioni

    Subunit structurei

    Heterotetramer of potassium channel proteins.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ01956.
    SMRiQ01956. Positions 91-195.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 291291CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini372 – 3809CytoplasmicSequence Analysis
    Topological domaini436 – 44813CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini541 – 889349CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei292 – 31019Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei352 – 37120Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei381 – 39919Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei413 – 43523Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei449 – 47022Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei519 – 54022Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi504 – 5096Selectivity filterBy similarity

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
    The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG280627.
    HOGENOMiHOG000231012.
    HOVERGENiHBG105862.
    InParanoidiQ01956.
    PhylomeDBiQ01956.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003974. K_chnl_volt-dep_Kv3.
    IPR005404. K_chnl_volt-dep_Kv3.3.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PfamiPF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01582. KV33CHANNEL.
    PR01491. KVCHANNEL.
    PR01498. SHAWCHANNEL.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform KSHIIID.1 (identifier: Q01956-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MLSSVCVWSF SGRQGTRKQH SQPAPTPQPP ESSPPPLLPP PQQQCAQPGT    50
    AASPAGAPLS CGPGGRRAEP CSGLPAVAMG RHGGGGGDSG KIVINVGGVR 100
    HETYRSTLRT LPGTRLAGLT EPEAAARFDY DPGTDEFFFD RHPGVFAYVL 150
    NYYRTGKLHC PADVCGPLFE EELGFWGIDE TDVEACCWMT YRQHRDAEEA 200
    LDSFEAPDSS GNANANAGGA HDAGLDDEAG AGGGGLDGAG GELKRLCFQD 250
    AGGGAGGPAG GPGGAGGTWW RRWQPRVWAL FEDPYSSRAA RYVAFASLFF 300
    ILISITTFCL ETHEGFIHIS NKTVTQASPI PGAPPENITN VEVETEPFLT 350
    YVEGVCVVWF TFEFLMRVTF CPDKVEFLKS SLNIIDCVAI LPFYLEVGLS 400
    GLSSKAAKDV LGFLRVVRFV RILRIFKLTR HFVGLRVLGH TLRASTNEFL 450
    LLIIFLALGV LIFATMIYYA ERIGADPDDI LGSNHTYFKN IPIGFWWAVV 500
    TMTTLGYGDM YPKTWSGMLV GALCALAGVL TIAMPVPVIV NNFGMYYSLA 550
    MAKQKLPKKK NKHIPRPPQP GSPNYCKPDP PPPPPPHPHH GSGGISPPPP 600
    ITPPSMGVTV AGAYPPGPHT HPGLLRGGAG GLGIMGLPPL PAPGEPCPLA 650
    QEEVIETNRA GNDLGVLEEG DPRPNGDPAA AALAHEDCPA IDQPAMSPED 700
    KSPITPGSRG RYSRDRACFL VTDYAPSPDG SIRKATGAPP LPPHAGVSQA 750
    PPASCPTSTP TQQPGYPPSG RAPSPPQATP EAPAIFDVWL PPFHRSHQPP 800
    GKHQRGGRHP GVSPSPQQRA CVGEPPSASH PQSLTLCISV PSSCHRLRPR 850
    ETLGFPLSLP PRLATGNGGR ECPRDPGLPF PSRHSSPAV 889
    Length:889
    Mass (Da):94,393
    Last modified:November 1, 1996 - v1
    Checksum:i51424C047B4FC367
    GO
    Isoform KSHIIID.2 (identifier: Q01956-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         662-679: NDLGVLEEGDPRPNGDPA → EAGARTGGVGRPGGWGSG
         680-889: Missing.

    Show »
    Length:679
    Mass (Da):72,170
    Checksum:i077D2D9EE373D0F8
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei662 – 67918NDLGV…NGDPA → EAGARTGGVGRPGGWGSG in isoform KSHIIID.2. 1 PublicationVSP_001022Add
    BLAST
    Alternative sequencei680 – 889210Missing in isoform KSHIIID.2. 1 PublicationVSP_001023Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M84210 mRNA. Translation: AAA73182.1.
    M84211 mRNA. Translation: AAA41470.1.
    UniGeneiRn.9885.

    Genome annotation databases

    UCSCiRGD:621358. rat. [Q01956-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M84210 mRNA. Translation: AAA73182.1 .
    M84211 mRNA. Translation: AAA41470.1 .
    UniGenei Rn.9885.

    3D structure databases

    ProteinModelPortali Q01956.
    SMRi Q01956. Positions 91-195.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 550.

    Proteomic databases

    PaxDbi Q01956.
    PRIDEi Q01956.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:621358. rat. [Q01956-1 ]

    Organism-specific databases

    RGDi 621358. Kcnc3.

    Phylogenomic databases

    eggNOGi NOG280627.
    HOGENOMi HOG000231012.
    HOVERGENi HBG105862.
    InParanoidi Q01956.
    PhylomeDBi Q01956.

    Miscellaneous databases

    PROi Q01956.

    Gene expression databases

    Genevestigatori Q01956.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003974. K_chnl_volt-dep_Kv3.
    IPR005404. K_chnl_volt-dep_Kv3.3.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    Pfami PF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01582. KV33CHANNEL.
    PR01491. KVCHANNEL.
    PR01498. SHAWCHANNEL.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of ShIII (Shaw-like) cDNAs encoding a novel high-voltage-activating, TEA-sensitive, type-A K+ channel."
      de Miera E.V.-S., Moreno H., Fruhling D., Kentros C., Rudy B.
      Proc. R. Soc. B 248:9-18(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS KSHIIID.1 AND KSHIIID.2).
      Tissue: Brain.

    Entry informationi

    Entry nameiKCNC3_RAT
    AccessioniPrimary (citable) accession number: Q01956
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3