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Q01956 (KCNC3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily C member 3
Alternative name(s):
KSHIIID
Voltage-gated potassium channel subunit Kv3.3
Gene names
Name:Kcnc3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length889 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Subunit structure

Heterotetramer of potassium channel proteins By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

Sequence similarities

Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.3/KCNC3 sub-subfamily. [View classification]

Ontologies

Keywords
   Biological processIon transport
Potassium transport
Transport
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   LigandPotassium
   Molecular functionIon channel
Potassium channel
Voltage-gated channel
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein homooligomerization

Inferred from electronic annotation. Source: InterPro

   Cellular_componentvoltage-gated potassium channel complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functiondelayed rectifier potassium channel activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform KSHIIID.1 (identifier: Q01956-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform KSHIIID.2 (identifier: Q01956-2)

The sequence of this isoform differs from the canonical sequence as follows:
     662-679: NDLGVLEEGDPRPNGDPA → EAGARTGGVGRPGGWGSG
     680-889: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 889889Potassium voltage-gated channel subfamily C member 3
PRO_0000054057

Regions

Topological domain1 – 291291Cytoplasmic Potential
Transmembrane292 – 31019Helical; Name=Segment S1; Potential
Transmembrane352 – 37120Helical; Name=Segment S2; Potential
Topological domain372 – 3809Cytoplasmic Potential
Transmembrane381 – 39919Helical; Name=Segment S3; Potential
Transmembrane413 – 43523Helical; Voltage-sensor; Name=Segment S4; Potential
Topological domain436 – 44813Cytoplasmic Potential
Transmembrane449 – 47022Helical; Name=Segment S5; Potential
Transmembrane519 – 54022Helical; Name=Segment S6; Potential
Topological domain541 – 889349Cytoplasmic Potential
Motif504 – 5096Selectivity filter By similarity

Amino acid modifications

Glycosylation3211N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence662 – 67918NDLGV…NGDPA → EAGARTGGVGRPGGWGSG in isoform KSHIIID.2.
VSP_001022
Alternative sequence680 – 889210Missing in isoform KSHIIID.2.
VSP_001023

Sequences

Sequence LengthMass (Da)Tools
Isoform KSHIIID.1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 51424C047B4FC367

FASTA88994,393
        10         20         30         40         50         60 
MLSSVCVWSF SGRQGTRKQH SQPAPTPQPP ESSPPPLLPP PQQQCAQPGT AASPAGAPLS 

        70         80         90        100        110        120 
CGPGGRRAEP CSGLPAVAMG RHGGGGGDSG KIVINVGGVR HETYRSTLRT LPGTRLAGLT 

       130        140        150        160        170        180 
EPEAAARFDY DPGTDEFFFD RHPGVFAYVL NYYRTGKLHC PADVCGPLFE EELGFWGIDE 

       190        200        210        220        230        240 
TDVEACCWMT YRQHRDAEEA LDSFEAPDSS GNANANAGGA HDAGLDDEAG AGGGGLDGAG 

       250        260        270        280        290        300 
GELKRLCFQD AGGGAGGPAG GPGGAGGTWW RRWQPRVWAL FEDPYSSRAA RYVAFASLFF 

       310        320        330        340        350        360 
ILISITTFCL ETHEGFIHIS NKTVTQASPI PGAPPENITN VEVETEPFLT YVEGVCVVWF 

       370        380        390        400        410        420 
TFEFLMRVTF CPDKVEFLKS SLNIIDCVAI LPFYLEVGLS GLSSKAAKDV LGFLRVVRFV 

       430        440        450        460        470        480 
RILRIFKLTR HFVGLRVLGH TLRASTNEFL LLIIFLALGV LIFATMIYYA ERIGADPDDI 

       490        500        510        520        530        540 
LGSNHTYFKN IPIGFWWAVV TMTTLGYGDM YPKTWSGMLV GALCALAGVL TIAMPVPVIV 

       550        560        570        580        590        600 
NNFGMYYSLA MAKQKLPKKK NKHIPRPPQP GSPNYCKPDP PPPPPPHPHH GSGGISPPPP 

       610        620        630        640        650        660 
ITPPSMGVTV AGAYPPGPHT HPGLLRGGAG GLGIMGLPPL PAPGEPCPLA QEEVIETNRA 

       670        680        690        700        710        720 
GNDLGVLEEG DPRPNGDPAA AALAHEDCPA IDQPAMSPED KSPITPGSRG RYSRDRACFL 

       730        740        750        760        770        780 
VTDYAPSPDG SIRKATGAPP LPPHAGVSQA PPASCPTSTP TQQPGYPPSG RAPSPPQATP 

       790        800        810        820        830        840 
EAPAIFDVWL PPFHRSHQPP GKHQRGGRHP GVSPSPQQRA CVGEPPSASH PQSLTLCISV 

       850        860        870        880 
PSSCHRLRPR ETLGFPLSLP PRLATGNGGR ECPRDPGLPF PSRHSSPAV 

« Hide

Isoform KSHIIID.2 [UniParc].

Checksum: 077D2D9EE373D0F8
Show »

FASTA67972,170

References

[1]"Cloning of ShIII (Shaw-like) cDNAs encoding a novel high-voltage-activating, TEA-sensitive, type-A K+ channel."
de Miera E.V.-S., Moreno H., Fruhling D., Kentros C., Rudy B.
Proc. R. Soc. B 248:9-18(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS KSHIIID.1 AND KSHIIID.2).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M84210 mRNA. Translation: AAA73182.1.
M84211 mRNA. Translation: AAA41470.1.
UniGeneRn.9885.

3D structure databases

ProteinModelPortalQ01956.
SMRQ01956. Positions 91-195.
ModBaseSearch...
MobiDBSearch...

Chemistry

GuidetoPHARMACOLOGY550.

Proteomic databases

PaxDbQ01956.
PRIDEQ01956.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:621358. rat. [Q01956-1]

Organism-specific databases

RGD621358. Kcnc3.

Phylogenomic databases

eggNOGNOG280627.
HOGENOMHOG000231012.
HOVERGENHBG105862.
InParanoidQ01956.
PhylomeDBQ01956.

Gene expression databases

GenevestigatorQ01956.

Family and domain databases

Gene3D1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003974. K_chnl_volt-dep_Kv3.
IPR005404. K_chnl_volt-dep_Kv3.3.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PfamPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01582. KV33CHANNEL.
PR01491. KVCHANNEL.
PR01498. SHAWCHANNEL.
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
ProtoNetSearch...

Other

PROQ01956.

Entry information

Entry nameKCNC3_RAT
AccessionPrimary (citable) accession number: Q01956
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families