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Protein

Cell division control protein 2 homolog

Gene

CRK

Organism
Crithidia fasciculata
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Probably involved in the control of the cell cycle.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Enzyme regulationi

Phosphorylation at Thr-17 or Tyr-18 inactivates the enzyme.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36ATPPROSITE-ProRule annotation1
Active sitei131Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 21ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22. 1365.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 2 homolog (EC:2.7.11.22, EC:2.7.11.23)
Gene namesi
Name:CRK
OrganismiCrithidia fasciculata
Taxonomic identifieri5656 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeCrithidia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000857371 – 474Cell division control protein 2 homologAdd BLAST474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17PhosphothreonineBy similarity1
Modified residuei18PhosphotyrosineBy similarity1
Modified residuei230PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ01917.

Interactioni

Subunit structurei

Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ01917.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 446Protein kinasePROSITE-ProRule annotationAdd BLAST440

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 2 hits.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 3 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01917-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTLGRYRHV VKLGEGTYGM VYKGTEIQTG RVVAFKRMVV TSDDEGIPGA
60 70 80 90 100
AIREICLLKE LRHNNVVELF EVLFDPPKIT MIFELCDCDL KRYMESRPQR
110 120 130 140 150
LLDANTEMRP ILKQIFLGLE YLHGRCVVHR DMKPQNIFVN VRGPDFAAMT
160 170 180 190 200
ALPSSPQQSM RVPHAGGTNG EAGRASANGN EHAPRPTAAE GSVSPWEEAA
210 220 230 240 250
NTKDAPNQLI IKIGDFGLAR VEEIPVKKYS HEVVTLWYRS PDVLMSSALY
260 270 280 290 300
SYPVDIWSMG AIFFEMATSK VLFSGRNEDE QLLRMFWLLG SPTKETWPSM
310 320 330 340 350
MTYTGTMERL ERSSRAAAER QDLTVNGDVY VQQQQLQAQQ QQPQQGSSPS
360 370 380 390 400
HSSSRAPDLL TQLAHKRFYH SESAMQQRRE SASSAANSYR LPVELWFDRP
410 420 430 440 450
LFKEYMAATR CDVSVSPEGI DLLRRCLMYE PNQRITAAEA VHHPYLERVP
460 470
VPTAGSLDVL ISSLMQTMET IHLL
Length:474
Mass (Da):53,473
Last modified:July 1, 1993 - v1
Checksum:i57CA1361E3651A9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z12149 Genomic DNA. Translation: CAA78133.1.
PIRiS26381.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z12149 Genomic DNA. Translation: CAA78133.1.
PIRiS26381.

3D structure databases

ProteinModelPortaliQ01917.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ01917.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi2.7.11.22. 1365.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 2 hits.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 3 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDC2H_CRIFA
AccessioniPrimary (citable) accession number: Q01917
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 5, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.