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Q01917 (CDC2H_CRIFA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cell division control protein 2 homolog

EC=2.7.11.22
EC=2.7.11.23
Gene names
Name:CRK
OrganismCrithidia fasciculata
Taxonomic identifier5656 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeCrithidia

Protein attributes

Sequence length474 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Probably involved in the control of the cell cycle.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Enzyme regulation

Phosphorylation at Thr-17 or Tyr-18 inactivates the enzyme By similarity.

Subunit structure

Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 474474Cell division control protein 2 homolog
PRO_0000085737

Regions

Domain7 – 446440Protein kinase
Nucleotide binding13 – 219ATP By similarity

Sites

Active site1311Proton acceptor By similarity
Binding site361ATP By similarity

Amino acid modifications

Modified residue171Phosphothreonine By similarity
Modified residue181Phosphotyrosine By similarity
Modified residue2301Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q01917 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 57CA1361E3651A9D

FASTA47453,473
        10         20         30         40         50         60 
MSTLGRYRHV VKLGEGTYGM VYKGTEIQTG RVVAFKRMVV TSDDEGIPGA AIREICLLKE 

        70         80         90        100        110        120 
LRHNNVVELF EVLFDPPKIT MIFELCDCDL KRYMESRPQR LLDANTEMRP ILKQIFLGLE 

       130        140        150        160        170        180 
YLHGRCVVHR DMKPQNIFVN VRGPDFAAMT ALPSSPQQSM RVPHAGGTNG EAGRASANGN 

       190        200        210        220        230        240 
EHAPRPTAAE GSVSPWEEAA NTKDAPNQLI IKIGDFGLAR VEEIPVKKYS HEVVTLWYRS 

       250        260        270        280        290        300 
PDVLMSSALY SYPVDIWSMG AIFFEMATSK VLFSGRNEDE QLLRMFWLLG SPTKETWPSM 

       310        320        330        340        350        360 
MTYTGTMERL ERSSRAAAER QDLTVNGDVY VQQQQLQAQQ QQPQQGSSPS HSSSRAPDLL 

       370        380        390        400        410        420 
TQLAHKRFYH SESAMQQRRE SASSAANSYR LPVELWFDRP LFKEYMAATR CDVSVSPEGI 

       430        440        450        460        470 
DLLRRCLMYE PNQRITAAEA VHHPYLERVP VPTAGSLDVL ISSLMQTMET IHLL 

« Hide

References

[1]"The Crithidia fasciculata CRK gene encodes a novel cdc2-related protein containing large inserts between highly conserved domains."
Brown L.M., Hines J.C., Ray D.S.
Nucleic Acids Res. 20:5451-5456(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z12149 Genomic DNA. Translation: CAA78133.1.
PIRS26381.

3D structure databases

ProteinModelPortalQ01917.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA2.7.11.22. 1365.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 3 hits.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDC2H_CRIFA
AccessionPrimary (citable) accession number: Q01917
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: February 19, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families