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Protein

Sodium transport ATPase 2

Gene

ENA2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of sodium or lithiums ions to allow salt tolerance.2 Publications

Catalytic activityi

ATP + H2O + Na+(In) = ADP + phosphate + Na+(Out).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3694-aspartylphosphate intermediateBy similarity1

GO - Molecular functioni

  • ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Source: SGD
  • ATP binding Source: UniProtKB-KW
  • metal ion binding Source: InterPro
  • potassium-transporting ATPase activity Source: SGD
  • sodium-exporting ATPase activity, phosphorylative mechanism Source: SGD

GO - Biological processi

  • potassium ion transport Source: SGD
  • sodium ion transport Source: SGD
  • transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Nucleotide-binding, Sodium

Enzyme and pathway databases

BioCyciYEAST:G3O-29653-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium transport ATPase 2 (EC:3.6.3.7)
Gene namesi
Name:ENA2
Synonyms:PMR2B
Ordered Locus Names:YDR039C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR039C.
SGDiS000002446. ENA2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 63CytoplasmicSequence analysisAdd BLAST63
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Topological domaini85 – 90ExtracellularSequence analysis6
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Topological domaini112 – 282CytoplasmicSequence analysisAdd BLAST171
Transmembranei283 – 303HelicalSequence analysisAdd BLAST21
Topological domaini304 – 312ExtracellularSequence analysis9
Transmembranei313 – 333HelicalSequence analysisAdd BLAST21
Topological domaini334 – 815CytoplasmicSequence analysisAdd BLAST482
Transmembranei816 – 836HelicalSequence analysisAdd BLAST21
Topological domaini837 – 848ExtracellularSequence analysisAdd BLAST12
Transmembranei849 – 869HelicalSequence analysisAdd BLAST21
Topological domaini870 – 885CytoplasmicSequence analysisAdd BLAST16
Transmembranei886 – 906HelicalSequence analysisAdd BLAST21
Topological domaini907 – 943ExtracellularSequence analysisAdd BLAST37
Transmembranei944 – 964HelicalSequence analysisAdd BLAST21
Topological domaini965 – 991CytoplasmicSequence analysisAdd BLAST27
Transmembranei992 – 1012HelicalSequence analysisAdd BLAST21
Topological domaini1013 – 1021ExtracellularSequence analysis9
Transmembranei1022 – 1042HelicalSequence analysisAdd BLAST21
Topological domaini1043 – 1091CytoplasmicSequence analysisAdd BLAST49

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000462431 – 1091Sodium transport ATPase 2Add BLAST1091

Proteomic databases

MaxQBiQ01896.
PRIDEiQ01896.

Interactioni

Protein-protein interaction databases

BioGridi32094. 18 interactors.
DIPiDIP-7915N.
IntActiQ01896. 5 interactors.
MINTiMINT-1359939.

Structurei

3D structure databases

ProteinModelPortaliQ01896.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00840000130975.
HOGENOMiHOG000265621.
InParanoidiQ01896.
KOiK01536.
OrthoDBiEOG092C0DMA.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 2 hits.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006414. P-type_ATPase_IID.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 2 hits.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 2 hits.
TIGRFAMsiTIGR01523. ATPase-IID_K-Na. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01896-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEGTVKENN NEEFNAYHTL TTEEAAEFIG TSLTEGLTQD ESLRRLKAVG
60 70 80 90 100
ENTLGDDTKI DYKAMVLHQV CNAMIMVLVI SMAISFAVRD WITGGVISFV
110 120 130 140 150
IAVNVLIGLV QEYKATKTMN SLKNLSSPNA HVIRNGKSET INSKDVVPGD
160 170 180 190 200
ICLVKVGDTI PADLRLIETK NFDTDESLLT GESLPVSKDA NLVFGKEEET
210 220 230 240 250
SVGDRLNLAF SSSAVVKGRA KGIVIKTALN SEIGKIAKSL QGDSGLISRD
260 270 280 290 300
PSKSWLQNTW ISTKKVTGAF LGTNVGTPLH RKLSKLAVLL FWIAVLFAII
310 320 330 340 350
VMASQKFDVD KRVAIYAICV ALSMIPSSLV VVLTITMSVG AAVMVSRNVI
360 370 380 390 400
VRKLDSLEAL GAVNDICSDK TGTLTQGKML ARQIWIPRFG TITISNSDDP
410 420 430 440 450
FNPNEGNVSL IPRFSPYEYS HNEDGDVGIL QNFKDRLYEK DLPEDIDMDL
460 470 480 490 500
FQKWLETATL ANIATVFKDD ATDCWKAHGD PTEIAIQVFA TKMDLPHNAL
510 520 530 540 550
TGEKSTNQSN ENDQSSLSQH NEKPGSAQFE HIAEFPFDST VKRMSSVYYN
560 570 580 590 600
NHNETYNIYG KGAFESIISC CSSWYGKDGV KITPLTDCDV ETIRKNVYSL
610 620 630 640 650
SNEGLRVLGF ASKSFTKDQV NDDQLKNITS NRATAESDLV FLGLIGIYDP
660 670 680 690 700
PRNETAGAVK KFHQAGINVH MLTGDFVGTA KAIAQEVGIL PTNLYHYSQE
710 720 730 740 750
IVDSMVMTGS QFDGLSEEEV DDLPVLPLVI ARCSPQTKVR MIEALHRRKK
760 770 780 790 800
FCAMTGDGVN DSPSLKMANV GIAMGINGSD VSKEASDIVL SDDNFASILN
810 820 830 840 850
AVEEGRRMTD NIQKFVLQLL AENVAQALYL IIGLVFRDEN GKSVFPLSPV
860 870 880 890 900
EVLWIIVVTS CFPAMGLGLE KAAPDLMDRP PHDSEVGIFT WEVIIDTFAY
910 920 930 940 950
GIIMTGSCMA SFTGSLYGIN SGRLGHDCDG TYNSSCRDVY RSRSAAFATM
960 970 980 990 1000
TWCALILAWE VVDMRRSFFR MHPDTDSPVK EFFRSIWGNQ FLFWSIIFGF
1010 1020 1030 1040 1050
VSAFPVVYIP VINDKVFLHK PIGAEWGLAI AFTIAFWIGA ELYKCGKRRY
1060 1070 1080 1090
FKTQRAHNPE NDLESNNKRD PFEAYSTSTT IHTEVNIGIK Q
Length:1,091
Mass (Da):120,317
Last modified:October 1, 1993 - v1
Checksum:i03683999B2019226
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67136 Genomic DNA. Translation: CAA47615.1.
U24069 Genomic DNA. Translation: AAA65601.1.
Z74335 Genomic DNA. Translation: CAA98866.1.
Z54075 Genomic DNA. Translation: CAA90778.1.
BK006938 Genomic DNA. Translation: DAA11887.1.
PIRiS25007.
RefSeqiNP_010324.3. NM_001180347.3.

Genome annotation databases

EnsemblFungiiYDR039C; YDR039C; YDR039C.
GeneIDi851609.
KEGGisce:YDR039C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67136 Genomic DNA. Translation: CAA47615.1.
U24069 Genomic DNA. Translation: AAA65601.1.
Z74335 Genomic DNA. Translation: CAA98866.1.
Z54075 Genomic DNA. Translation: CAA90778.1.
BK006938 Genomic DNA. Translation: DAA11887.1.
PIRiS25007.
RefSeqiNP_010324.3. NM_001180347.3.

3D structure databases

ProteinModelPortaliQ01896.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32094. 18 interactors.
DIPiDIP-7915N.
IntActiQ01896. 5 interactors.
MINTiMINT-1359939.

Proteomic databases

MaxQBiQ01896.
PRIDEiQ01896.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR039C; YDR039C; YDR039C.
GeneIDi851609.
KEGGisce:YDR039C.

Organism-specific databases

EuPathDBiFungiDB:YDR039C.
SGDiS000002446. ENA2.

Phylogenomic databases

GeneTreeiENSGT00840000130975.
HOGENOMiHOG000265621.
InParanoidiQ01896.
KOiK01536.
OrthoDBiEOG092C0DMA.

Enzyme and pathway databases

BioCyciYEAST:G3O-29653-MONOMER.

Miscellaneous databases

PROiQ01896.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 2 hits.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006414. P-type_ATPase_IID.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 2 hits.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 2 hits.
TIGRFAMsiTIGR01523. ATPase-IID_K-Na. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATN2_YEAST
AccessioniPrimary (citable) accession number: Q01896
Secondary accession number(s): D6VS27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 30, 2016
This is version 153 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 639 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.