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Protein

Graves disease carrier protein

Gene

SLC25A16

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for the accumulation of coenzyme A in the mitochondrial matrix.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.29.12.1 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Graves disease carrier protein
Short name:
GDC
Alternative name(s):
Mitochondrial solute carrier protein homolog
Solute carrier family 25 member 16
Gene namesi
Name:SLC25A16
Synonyms:GDA, GDC
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 52Helical; Name=1Sequence analysisAdd BLAST20
Transmembranei95 – 112Helical; Name=2Sequence analysisAdd BLAST18
Transmembranei132 – 149Helical; Name=3Sequence analysisAdd BLAST18
Transmembranei189 – 209Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei242 – 262Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei297 – 317Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906151 – 330Graves disease carrier proteinAdd BLAST330

Proteomic databases

PaxDbiQ01888
PRIDEiQ01888

Expressioni

Tissue specificityi

Mostly in thyroid, liver, lung, kidney and to a lesser extent in heart and skeletal muscle.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000031299

Structurei

3D structure databases

ProteinModelPortaliQ01888
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati32 – 118Solcar 1Add BLAST87
Repeati126 – 214Solcar 2Add BLAST89
Repeati236 – 326Solcar 3Add BLAST91

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0752 Eukaryota
ENOG410ZRF1 LUCA
HOGENOMiHOG000165726
HOVERGENiHBG104402
InParanoidiQ01888
KOiK15084

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002167 Graves_DC
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00928 GRAVESDC
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q01888-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAAALAA TEPPPAMPQA AGAGGPAARR DFYWLRSFLA GGIAGCCAKT
60 70 80 90 100
TVAPLDRVKV LLQAHNHHYR HLGVFSTLRA VPKKEGYLGL YKGNGAMMIR
110 120 130 140 150
IFPYGAIQFM AFEHYKTLIT TKLGVSGHVH RLMAGSMAGM TAVICTYPLD
160 170 180 190 200
MVRVRLAFQV KGEHTYTGII HAFKTIYAKE GGFLGFYRGL MPTILGMAPY
210 220 230 240 250
AGVSFFTFGT LKSVGLSYAP TLLGRPSSDN PNVLVLKTHI NLLCGGVAGA
260 270 280 290 300
IAQTISYPFD VTRRRMQLGA VLPEFEKCLT MRETMKYVYG HHGIRKGLYR
310 320 330
GLSLNYIRCV PSQAVAFTTY ELMKQFFHLN
Length:330
Mass (Da):36,085
Last modified:April 1, 1993 - v1
Checksum:i4C614701D2B8DEA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66035 mRNA Translation: CAA46834.1
PIRiS26596
RefSeqiNP_777097.1, NM_174672.2
UniGeneiBt.179

Genome annotation databases

GeneIDi282524
KEGGibta:282524

Similar proteinsi

Entry informationi

Entry nameiGDC_BOVIN
AccessioniPrimary (citable) accession number: Q01888
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 25, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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