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Protein

pH-response transcription factor pacC/RIM101

Gene

PACC

Organism
Penicillium chrysogenum (Penicillium notatum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including PACC itself) and represses transcription of acid-expressed genes. Specifically recognizes and binds the consensus sequence 5'-GCCARG-3'.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri58 – 8326C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri94 – 11825C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri124 – 14623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
pH-response transcription factor pacC/RIM101
Gene namesi
Name:PACC
OrganismiPenicillium chrysogenum (Penicillium notatum)
Taxonomic identifieri5076 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 643643pH-response transcription factor pacC/RIM101PRO_0000046840Add
BLAST

Post-translational modificationi

Activated by C-terminal proteolytic cleavage by signaling protease (probably palB/RIM13) at neutral to alkaline ambient pH.By similarity

Expressioni

Inductioni

By alkaline conditions.1 Publication

Interactioni

Subunit structurei

Binds to DNA.

Protein-protein interaction databases

STRINGi500485.XP_002561889.1.

Structurei

3D structure databases

ProteinModelPortaliQ01864.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi435 – 4384YPX[LI] motif 1
Motifi625 – 6284YPX[LI] motif 2

Sequence similaritiesi

Belongs to the pacC/RIM101 family.Curated
Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri58 – 8326C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri94 – 11825C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri124 – 14623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01864-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTENHTPSTT QPTLPAPVAE AAPIQANPAP SASVTATAAA ATAAVNNAPS
60 70 80 90 100
MNGAGEQLPC QWVGCTEKSP TAESLYEHVC ERHVGRKSTN NLNLTCQWGT
110 120 130 140 150
CNTTTVKRDH ITSHIRVHVP LKPHKCDFCG KAFKRPQDLK KHVKTHADDS
160 170 180 190 200
EIRSPEPGMK HPDMMFPQNP RGSPAATHYF ESPINGINGQ YSHAPPPQYY
210 220 230 240 250
QPHPPPQAPN PHSYGNLYYA LSQGQEGGHP YDRKRGYDAL NEFFGDLKRR
260 270 280 290 300
QFDPNSYAAV GQRLLGLQAL QLPFLSGPAP EYQQMPAPVA VGGGGGGYGG
310 320 330 340 350
GAPQPPGYHL PPMSNVRTKN DLINIDQFLE QMQNTIYESD ENVAAAGVAQ
360 370 380 390 400
PGAHYVHGGM NHRTTHSPPT HSRQATLLQL PSAPMAAATA HSPSVGTPAL
410 420 430 440 450
TPPSSAQSYT SNRSPISLHS SRVSPPHEEA APGMYPRLPA AICADSMTAG
460 470 480 490 500
YPTASGAAPP STLSGAYDHD DRRRYTGGTL QRARPAERAA TEDRMDISQD
510 520 530 540 550
SKHDGERTPK AMHISASLID PALSGTSSDP EQESAKRTAA TATEVAERDV
560 570 580 590 600
NVAWVEKVRL LENLRRLVSG LLEAGSLTPE YGVQTSSASP TPGLDAMEGV
610 620 630 640
ETASVRAASE QAREEPKSES EGVFYPTLRG VDEDEDGDSK MPE
Length:643
Mass (Da):68,823
Last modified:November 1, 1998 - v2
Checksum:i0BBA037FDE189765
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44726 Genomic DNA. Translation: AAC36492.1.
PIRiJC6017.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44726 Genomic DNA. Translation: AAC36492.1.
PIRiJC6017.

3D structure databases

ProteinModelPortaliQ01864.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi500485.XP_002561889.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of a Penicillium chrysogenum gene encoding a PacC transcription factor and its binding sites in the divergent pcbAB-pcbC promoter of the penicillin biosynthetic cluster."
    Suarez T., Penalva M.A.
    Mol. Microbiol. 20:529-540(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, DNA-BINDING, INDUCTION.
    Strain: ATCC 9480 / CBS 307.48 / NRRL 1951 / GB8 / QM 941.

Entry informationi

Entry nameiPACC_PENCH
AccessioniPrimary (citable) accession number: Q01864
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: November 1, 1998
Last modified: November 11, 2015
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.