Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

POU domain, class 5, transcription factor 1

Gene

POU5F1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi230 – 289HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • DNA binding Source: HGNC
  • miRNA binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: BHF-UCL
  • sequence-specific DNA binding Source: MGI
  • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding Source: BHF-UCL
  • transcription factor activity, sequence-specific DNA binding Source: HGNC
  • transcription factor binding Source: BHF-UCL
  • transcription regulatory region DNA binding Source: BHF-UCL
  • transcription regulatory region sequence-specific DNA binding Source: BHF-UCL
  • ubiquitin protein ligase binding Source: BHF-UCL

GO - Biological processi

  • anatomical structure morphogenesis Source: ProtInc
  • blastocyst development Source: BHF-UCL
  • BMP signaling pathway involved in heart induction Source: BHF-UCL
  • cardiac cell fate determination Source: BHF-UCL
  • cell fate commitment involved in formation of primary germ layer Source: BHF-UCL
  • endodermal cell fate specification Source: MGI
  • mRNA transcription from RNA polymerase II promoter Source: BHF-UCL
  • negative regulation of gene silencing by miRNA Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • positive regulation of catenin import into nucleus Source: BHF-UCL
  • positive regulation of SMAD protein import into nucleus Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • regulation of asymmetric cell division Source: BHF-UCL
  • regulation of gene expression Source: UniProtKB
  • regulation of heart induction by regulation of canonical Wnt signaling pathway Source: BHF-UCL
  • regulation of methylation-dependent chromatin silencing Source: BHF-UCL
  • regulation of transcription, DNA-templated Source: HGNC
  • response to wounding Source: UniProtKB
  • somatic stem cell population maintenance Source: UniProtKB
  • transcription from RNA polymerase II promoter Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137369-MONOMER.
ReactomeiR-HSA-2892245. POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation.
R-HSA-2892247. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.
R-HSA-452723. Transcriptional regulation of pluripotent stem cells.
SignaLinkiQ01860.
SIGNORiQ01860.

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 5, transcription factor 1
Alternative name(s):
Octamer-binding protein 3
Short name:
Oct-3
Octamer-binding protein 4
Short name:
Oct-4
Octamer-binding transcription factor 3
Short name:
OTF-3
Gene namesi
Name:POU5F1
Synonyms:OCT3, OCT4, OTF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:9221. POU5F1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: UniProtKB
  • nucleoplasm Source: BHF-UCL
  • nucleus Source: UniProtKB
  • transcription factor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Biotechnological usei

POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes.1 Publication

Organism-specific databases

DisGeNETi5460.
OpenTargetsiENSG00000204531.
ENSG00000206454.
ENSG00000229094.
ENSG00000230336.
ENSG00000233911.
ENSG00000235068.
ENSG00000237582.
PharmGKBiPA33545.

Chemistry databases

ChEMBLiCHEMBL3580526.
DrugBankiDB00988. Dopamine.
DB00368. Norepinephrine.

Polymorphism and mutation databases

DMDMi400659.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007471 – 360POU domain, class 5, transcription factor 1Add BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei111Phosphoserine; by MAPK2 Publications1
Cross-linki123Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residuei235Phosphothreonine1 Publication1
Modified residuei236Phosphoserine1 Publication1
Modified residuei289Phosphoserine1 Publication1
Modified residuei290Phosphoserine1 Publication1
Modified residuei355Phosphoserine1 Publication1

Post-translational modificationi

Sumoylation enhances the protein stability, DNA binding and transactivation activity. Sumoylation is required for enhanced YES1 expression (By similarity).By similarity
Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination by WWP2 leading to proteasomal degradation.By similarity
ERK1/2-mediated phosphorylation at Ser-111 promotes nuclear exclusion and proteasomal degradation. Phosphorylation at Thr-235 and Ser-236 decrease DNA-binding and alters ability to activate transcription.2 Publications

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ01860.
MaxQBiQ01860.
PaxDbiQ01860.
PeptideAtlasiQ01860.
PRIDEiQ01860.

PTM databases

iPTMnetiQ01860.
PhosphoSitePlusiQ01860.

Expressioni

Tissue specificityi

Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues.2 Publications

Developmental stagei

Highly expressed in undifferentiated embryonic stem cells and expression decreases gradually after embryoid body (EB) formation.1 Publication

Inductioni

Transcriptional activity is positively regulated by PKM.1 Publication

Gene expression databases

BgeeiENSG00000204531.
ExpressionAtlasiQ01860. baseline and differential.
GenevisibleiQ01860. HS.

Organism-specific databases

HPAiCAB025600.
CAB026380.

Interactioni

Subunit structurei

Interacts with UBE2I and ZSCAN10 (By similarity). Interacts with PKM. Interacts with WWP2. Interacts with PCGF1 (PubMed:26687479).By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
P032592EBI-475687,EBI-6947456From a different organism.
E1AQ8JSK42EBI-475687,EBI-7453955From a different organism.
FOXD3Q9UJU52EBI-475687,EBI-475674
Hmgb1P631583EBI-475687,EBI-6665811From a different organism.
WWP2O003084EBI-475687,EBI-743923

GO - Molecular functioni

  • transcription factor binding Source: BHF-UCL
  • ubiquitin protein ligase binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi111456. 317 interactors.
DIPiDIP-33440N.
IntActiQ01860. 12 interactors.
MINTiMINT-87567.
STRINGi9606.ENSP00000259915.

Structurei

3D structure databases

ProteinModelPortaliQ01860.
SMRiQ01860.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini138 – 212POU-specificPROSITE-ProRule annotationAdd BLAST75

Domaini

The POU-specific domain mediates interaction with PKM.1 Publication

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG3802. Eukaryota.
ENOG410XQ7X. LUCA.
GeneTreeiENSGT00760000118935.
HOVERGENiHBG057998.
InParanoidiQ01860.
KOiK09367.
OMAiLENMFLQ.
OrthoDBiEOG091G0U0S.
PhylomeDBiQ01860.
TreeFamiTF316413.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_dom.
IPR015585. POU_dom_5.
[Graphical view]
PANTHERiPTHR11636:SF86. PTHR11636:SF86. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: Q01860-1) [UniParc]FASTAAdd to basket
Also known as: Oct-3A, Oct3A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGHLASDFA FSPPPGGGGD GPGGPEPGWV DPRTWLSFQG PPGGPGIGPG
60 70 80 90 100
VGPGSEVWGI PPCPPPYEFC GGMAYCGPQV GVGLVPQGGL ETSQPEGEAG
110 120 130 140 150
VGVESNSDGA SPEPCTVTPG AVKLEKEKLE QNPEESQDIK ALQKELEQFA
160 170 180 190 200
KLLKQKRITL GYTQADVGLT LGVLFGKVFS QTTICRFEAL QLSFKNMCKL
210 220 230 240 250
RPLLQKWVEE ADNNENLQEI CKAETLVQAR KRKRTSIENR VRGNLENLFL
260 270 280 290 300
QCPKPTLQQI SHIAQQLGLE KDVVRVWFCN RRQKGKRSSS DYAQREDFEA
310 320 330 340 350
AGSPFSGGPV SFPLAPGPHF GTPGYGSPHF TALYSSVPFP EGEAFPPVSV
360
TTLGSPMHSN
Length:360
Mass (Da):38,571
Last modified:July 1, 1993 - v1
Checksum:i934C58DAEA0C535B
GO
Isoform B (identifier: Q01860-2) [UniParc]FASTAAdd to basket
Also known as: Oct-3B, Oct3B

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: MAGHLASDFA...KEKLEQNPEE → MHFYRLFLGA...LTSLLPFKIQ

Show »
Length:265
Mass (Da):30,085
Checksum:i41C21E136EFBCBB2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti189A → G in CAA79974 (PubMed:7908264).Curated1
Sequence conflicti220I → T in CAA79974 (PubMed:7908264).Curated1
Sequence conflicti227V → L in CAA79974 (PubMed:7908264).Curated1
Sequence conflicti230R → G in CAA79975 (PubMed:7908264).Curated1
Sequence conflicti240R → Q in CAA79975 (PubMed:7908264).Curated1
Sequence conflicti251Q → R in CAA79975 (PubMed:7908264).Curated1
Sequence conflicti272D → DVVR in AAB35990 (PubMed:8567814).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046203226L → F.Corresponds to variant rs1150767dbSNPEnsembl.1
Natural variantiVAR_003774322T → A.1 Publication1
Natural variantiVAR_046204351T → I.Corresponds to variant rs1061120dbSNPEnsembl.1
Natural variantiVAR_003775357M → L.1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0023331 – 135MAGHL…QNPEE → MHFYRLFLGATRRFLNPEWK GEIDNWCVYVLTSLLPFKIQ in isoform B. 1 PublicationAdd BLAST135

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11898 mRNA. Translation: CAA77951.1.
Z11899 mRNA. Translation: CAA77952.1.
GQ472773 Genomic DNA. Translation: ACZ95700.1.
AB088113 Genomic DNA. Translation: BAC54946.1.
AB202105 Genomic DNA. Translation: BAE78630.1.
AB103619 Genomic DNA. Translation: BAF31281.1.
BA000025 Genomic DNA. Translation: BAB63311.1.
AL662833 Genomic DNA. Translation: CAI17407.1.
AL662833 Genomic DNA. Translation: CAI17408.1.
AL662844 Genomic DNA. Translation: CAI18331.1.
AL773544 Genomic DNA. Translation: CAI18485.1.
AL773544 Genomic DNA. Translation: CAI18486.1.
BX088580 Genomic DNA. Translation: CAI18708.1.
BX088580 Genomic DNA. Translation: CAI18709.1.
CR759815 Genomic DNA. Translation: CAQ07092.1.
CR759815 Genomic DNA. Translation: CAQ07093.1.
CR388229 Genomic DNA. Translation: CAQ09226.1.
CR388229 Genomic DNA. Translation: CAQ09227.1.
CR847794 Genomic DNA. Translation: CAQ10780.1.
CR847794 Genomic DNA. Translation: CAQ10781.1.
CH471081 Genomic DNA. Translation: EAX03367.1.
CH471081 Genomic DNA. Translation: EAX03368.1.
BC117435 mRNA. Translation: AAI17436.1.
BC117437 mRNA. Translation: AAI17438.1.
Z21963 mRNA. Translation: CAA79974.1.
Z21964 mRNA. Translation: CAA79975.1.
S81255 mRNA. Translation: AAB35990.1.
CCDSiCCDS34391.1. [Q01860-1]
PIRiS25561.
S32652.
RefSeqiNP_001272916.1. NM_001285987.1. [Q01860-2]
NP_002692.2. NM_002701.5. [Q01860-1]
UniGeneiHs.249184.
Hs.632482.
Hs.646545.

Genome annotation databases

EnsembliENST00000259915; ENSP00000259915; ENSG00000204531. [Q01860-1]
ENST00000376243; ENSP00000365419; ENSG00000206454. [Q01860-2]
ENST00000383524; ENSP00000373016; ENSG00000206454. [Q01860-1]
ENST00000412166; ENSP00000387646; ENSG00000229094. [Q01860-2]
ENST00000419095; ENSP00000413622; ENSG00000235068. [Q01860-2]
ENST00000429314; ENSP00000387619; ENSG00000237582. [Q01860-2]
ENST00000429603; ENSP00000392877; ENSG00000233911. [Q01860-1]
ENST00000433063; ENSP00000405041; ENSG00000235068. [Q01860-1]
ENST00000433348; ENSP00000412665; ENSG00000230336. [Q01860-2]
ENST00000434616; ENSP00000388842; ENSG00000229094. [Q01860-1]
ENST00000437747; ENSP00000391681; ENSG00000237582. [Q01860-1]
ENST00000451077; ENSP00000391507; ENSG00000233911. [Q01860-2]
ENST00000454714; ENSP00000400047; ENSG00000230336. [Q01860-1]
GeneIDi5460.
KEGGihsa:5460.
UCSCiuc003nsv.4. human. [Q01860-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Oct-4 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11898 mRNA. Translation: CAA77951.1.
Z11899 mRNA. Translation: CAA77952.1.
GQ472773 Genomic DNA. Translation: ACZ95700.1.
AB088113 Genomic DNA. Translation: BAC54946.1.
AB202105 Genomic DNA. Translation: BAE78630.1.
AB103619 Genomic DNA. Translation: BAF31281.1.
BA000025 Genomic DNA. Translation: BAB63311.1.
AL662833 Genomic DNA. Translation: CAI17407.1.
AL662833 Genomic DNA. Translation: CAI17408.1.
AL662844 Genomic DNA. Translation: CAI18331.1.
AL773544 Genomic DNA. Translation: CAI18485.1.
AL773544 Genomic DNA. Translation: CAI18486.1.
BX088580 Genomic DNA. Translation: CAI18708.1.
BX088580 Genomic DNA. Translation: CAI18709.1.
CR759815 Genomic DNA. Translation: CAQ07092.1.
CR759815 Genomic DNA. Translation: CAQ07093.1.
CR388229 Genomic DNA. Translation: CAQ09226.1.
CR388229 Genomic DNA. Translation: CAQ09227.1.
CR847794 Genomic DNA. Translation: CAQ10780.1.
CR847794 Genomic DNA. Translation: CAQ10781.1.
CH471081 Genomic DNA. Translation: EAX03367.1.
CH471081 Genomic DNA. Translation: EAX03368.1.
BC117435 mRNA. Translation: AAI17436.1.
BC117437 mRNA. Translation: AAI17438.1.
Z21963 mRNA. Translation: CAA79974.1.
Z21964 mRNA. Translation: CAA79975.1.
S81255 mRNA. Translation: AAB35990.1.
CCDSiCCDS34391.1. [Q01860-1]
PIRiS25561.
S32652.
RefSeqiNP_001272916.1. NM_001285987.1. [Q01860-2]
NP_002692.2. NM_002701.5. [Q01860-1]
UniGeneiHs.249184.
Hs.632482.
Hs.646545.

3D structure databases

ProteinModelPortaliQ01860.
SMRiQ01860.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111456. 317 interactors.
DIPiDIP-33440N.
IntActiQ01860. 12 interactors.
MINTiMINT-87567.
STRINGi9606.ENSP00000259915.

Chemistry databases

ChEMBLiCHEMBL3580526.
DrugBankiDB00988. Dopamine.
DB00368. Norepinephrine.

PTM databases

iPTMnetiQ01860.
PhosphoSitePlusiQ01860.

Polymorphism and mutation databases

DMDMi400659.

Proteomic databases

EPDiQ01860.
MaxQBiQ01860.
PaxDbiQ01860.
PeptideAtlasiQ01860.
PRIDEiQ01860.

Protocols and materials databases

DNASUi5460.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259915; ENSP00000259915; ENSG00000204531. [Q01860-1]
ENST00000376243; ENSP00000365419; ENSG00000206454. [Q01860-2]
ENST00000383524; ENSP00000373016; ENSG00000206454. [Q01860-1]
ENST00000412166; ENSP00000387646; ENSG00000229094. [Q01860-2]
ENST00000419095; ENSP00000413622; ENSG00000235068. [Q01860-2]
ENST00000429314; ENSP00000387619; ENSG00000237582. [Q01860-2]
ENST00000429603; ENSP00000392877; ENSG00000233911. [Q01860-1]
ENST00000433063; ENSP00000405041; ENSG00000235068. [Q01860-1]
ENST00000433348; ENSP00000412665; ENSG00000230336. [Q01860-2]
ENST00000434616; ENSP00000388842; ENSG00000229094. [Q01860-1]
ENST00000437747; ENSP00000391681; ENSG00000237582. [Q01860-1]
ENST00000451077; ENSP00000391507; ENSG00000233911. [Q01860-2]
ENST00000454714; ENSP00000400047; ENSG00000230336. [Q01860-1]
GeneIDi5460.
KEGGihsa:5460.
UCSCiuc003nsv.4. human. [Q01860-1]

Organism-specific databases

CTDi5460.
DisGeNETi5460.
GeneCardsiPOU5F1.
H-InvDBHIX0159939.
HIX0164984.
HIX0166817.
HIX0167068.
HIX0167306.
HIX0167552.
HIX0168865.
HIX0201948.
HGNCiHGNC:9221. POU5F1.
HPAiCAB025600.
CAB026380.
MIMi164177. gene.
neXtProtiNX_Q01860.
OpenTargetsiENSG00000204531.
ENSG00000206454.
ENSG00000229094.
ENSG00000230336.
ENSG00000233911.
ENSG00000235068.
ENSG00000237582.
PharmGKBiPA33545.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3802. Eukaryota.
ENOG410XQ7X. LUCA.
GeneTreeiENSGT00760000118935.
HOVERGENiHBG057998.
InParanoidiQ01860.
KOiK09367.
OMAiLENMFLQ.
OrthoDBiEOG091G0U0S.
PhylomeDBiQ01860.
TreeFamiTF316413.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137369-MONOMER.
ReactomeiR-HSA-2892245. POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation.
R-HSA-2892247. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.
R-HSA-452723. Transcriptional regulation of pluripotent stem cells.
SignaLinkiQ01860.
SIGNORiQ01860.

Miscellaneous databases

GenomeRNAii5460.
PROiQ01860.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204531.
ExpressionAtlasiQ01860. baseline and differential.
GenevisibleiQ01860. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_dom.
IPR015585. POU_dom_5.
[Graphical view]
PANTHERiPTHR11636:SF86. PTHR11636:SF86. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPO5F1_HUMAN
AccessioniPrimary (citable) accession number: Q01860
Secondary accession number(s): A6NCS1
, A6NLL8, D2IYK4, P31359, Q15167, Q15168, Q16422, Q5STF3, Q5STF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 30, 2016
This is version 181 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Several pseudogenes of POU5F1 have been described on chromosomes 1, 3, 8, 10 and 12. 2 of them, localized in chromosomes 8 and 10, are transcribed in cancer tissues but not in normal ones and may be involved in the regulation of POU5F1 gene activity in carcinogenesis.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.