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Q01860 (PO5F1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 156. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
POU domain, class 5, transcription factor 1
Alternative name(s):
Octamer-binding protein 3
Short name=Oct-3
Octamer-binding protein 4
Short name=Oct-4
Octamer-binding transcription factor 3
Short name=OTF-3
Gene names
Name:POU5F1
Synonyms:OCT3, OCT4, OTF3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. Ref.11

Subunit structure

Interacts with UBE2I and ZSCAN10 By similarity. Interacts with PKM. Interacts with WWP2. Ref.12 Ref.13

Subcellular location

Cytoplasm. Nucleus. Note: Expressed in a diffuse and slightly punctuate pattern. Ref.12 Ref.13 Ref.14

Tissue specificity

Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues. Ref.1 Ref.8

Developmental stage

Highly expressed in undifferentiated embryonic stem cells and expression decreases gradually after embryoid body (EB) formation. Ref.13

Induction

Transcriptional activity is positively regulated by PKM. Ref.12

Domain

The POU-specific domain mediates interaction with PKM. Ref.12

Post-translational modification

Sumoylation enhances the protein stability, DNA binding and transactivation activity. Sumoylation is required for enhanced YES1 expression By similarity.

Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination by WWP2 leading to proteasomal degradation By similarity. Ref.13

ERK1/2-mediated phosphorylation at Ser-111 promotes nuclear exclusion and proteasomal degradation. Phosphorylation at Thr-235 and Ser-236 decrease DNA-binding and alters ability to activate transcription.

Biotechnological use

POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes. Ref.11

Miscellaneous

Several pseudogenes of POU5F1 have been described on chromosomes 1, 3, 8, 10 and 12. 2 of them, localized in chromosomes 8 and 10, are transcribed in cancer tissues but not in normal ones and may be involved in the regulation of POU5F1 gene activity in carcinogenesis.

Sequence similarities

Belongs to the POU transcription factor family. Class-5 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   PTMIsopeptide bond
Phosphoprotein
Ubl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processBMP signaling pathway involved in heart induction

Inferred from mutant phenotype PubMed 19736317. Source: BHF-UCL

anatomical structure morphogenesis

Traceable author statement PubMed 9814708. Source: ProtInc

blastocyst development

Inferred from sequence or structural similarity. Source: BHF-UCL

cardiac cell fate determination

Inferred from direct assay PubMed 19736317. Source: BHF-UCL

cell fate commitment involved in formation of primary germ layer

Inferred from mutant phenotype PubMed 19736317. Source: BHF-UCL

endodermal cell fate specification

Inferred from direct assay PubMed 20713518. Source: MGI

mRNA transcription from RNA polymerase II promoter

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of gene silencing by miRNA

Inferred from mutant phenotype PubMed 19409607. Source: UniProtKB

positive regulation of SMAD protein import into nucleus

Inferred from direct assay PubMed 19736317. Source: BHF-UCL

positive regulation of catenin import into nucleus

Inferred from direct assay PubMed 19736317. Source: BHF-UCL

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 19736317. Source: BHF-UCL

regulation of asymmetric cell division

Inferred from sequence or structural similarity. Source: BHF-UCL

regulation of gene expression

Inferred from mutant phenotype PubMed 18388306. Source: UniProtKB

regulation of heart induction by regulation of canonical Wnt signaling pathway

Inferred from mutant phenotype PubMed 19736317. Source: BHF-UCL

regulation of methylation-dependent chromatin silencing

Inferred from direct assay PubMed 19736317. Source: BHF-UCL

regulation of transcription, DNA-templated

Inferred from direct assay PubMed 16153702. Source: HGNC

response to wounding

Inferred from expression pattern PubMed 17982423. Source: UniProtKB

somatic stem cell maintenance

Inferred from direct assay PubMed 19409607. Source: UniProtKB

transcription from RNA polymerase II promoter

Inferred from sequence or structural similarity. Source: BHF-UCL

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 18281244. Source: UniProtKB

cytosol

Inferred from direct assay PubMed 18000303. Source: UniProtKB

nucleoplasm

Inferred from direct assay PubMed 20458727. Source: BHF-UCL

nucleus

Inferred from direct assay PubMed 18000303Ref.12. Source: UniProtKB

transcription factor complex

Inferred from direct assay PubMed 19736317. Source: BHF-UCL

   Molecular_functionDNA binding

Inferred from direct assay PubMed 16153702. Source: HGNC

miRNA binding

Inferred from direct assay PubMed 18710938PubMed 19409607. Source: UniProtKB

poly(A) RNA binding

Inferred from direct assay PubMed 22658674. Source: UniProtKB

sequence-specific DNA binding

Inferred from direct assay PubMed 20713518. Source: MGI

sequence-specific DNA binding RNA polymerase II transcription factor activity

Inferred from sequence or structural similarity. Source: BHF-UCL

sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 16153702. Source: HGNC

transcription factor binding

Inferred from physical interaction PubMed 19736317. Source: BHF-UCL

transcription regulatory region DNA binding

Inferred from direct assay PubMed 19736317. Source: BHF-UCL

ubiquitin protein ligase binding

Inferred from physical interaction Ref.13. Source: BHF-UCL

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

P032592EBI-475687,EBI-6947456From a different organism.
E1AQ8JSK42EBI-475687,EBI-7453955From a different organism.
FOXD3Q9UJU52EBI-475687,EBI-475674
Hmgb1P631583EBI-475687,EBI-6665811From a different organism.
WWP2O003084EBI-475687,EBI-743923

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform A (identifier: Q01860-1)

Also known as: Oct-3A; Oct3A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform B (identifier: Q01860-2)

Also known as: Oct-3B; Oct3B;

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: MAGHLASDFA...KEKLEQNPEE → MHFYRLFLGA...LTSLLPFKIQ

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 360360POU domain, class 5, transcription factor 1
PRO_0000100747

Regions

Domain138 – 21275POU-specific
DNA binding230 – 28960Homeobox

Amino acid modifications

Modified residue1111Phosphoserine; by MAPK Ref.14 Ref.15
Modified residue2351Phosphothreonine Ref.15
Modified residue2361Phosphoserine Ref.15
Modified residue2891Phosphoserine Ref.15
Modified residue2901Phosphoserine Ref.15
Modified residue3551Phosphoserine Ref.15
Cross-link123Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) By similarity

Natural variations

Alternative sequence1 – 135135MAGHL…QNPEE → MHFYRLFLGATRRFLNPEWK GEIDNWCVYVLTSLLPFKIQ in isoform B.
VSP_002333
Natural variant2261L → F.
Corresponds to variant rs1150767 [ dbSNP | Ensembl ].
VAR_046203
Natural variant3221T → A. Ref.1
VAR_003774
Natural variant3511T → I.
Corresponds to variant rs1061120 [ dbSNP | Ensembl ].
VAR_046204
Natural variant3571M → L. Ref.1
VAR_003775

Experimental info

Sequence conflict1891A → G in CAA79974. Ref.8
Sequence conflict2201I → T in CAA79974. Ref.8
Sequence conflict2271V → L in CAA79974. Ref.8
Sequence conflict2301R → G in CAA79975. Ref.8
Sequence conflict2401R → Q in CAA79975. Ref.8
Sequence conflict2511Q → R in CAA79975. Ref.8
Sequence conflict2721D → DVVR in AAB35990. Ref.9

Sequences

Sequence LengthMass (Da)Tools
Isoform A (Oct-3A) (Oct3A) [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 934C58DAEA0C535B

FASTA36038,571
        10         20         30         40         50         60 
MAGHLASDFA FSPPPGGGGD GPGGPEPGWV DPRTWLSFQG PPGGPGIGPG VGPGSEVWGI 

        70         80         90        100        110        120 
PPCPPPYEFC GGMAYCGPQV GVGLVPQGGL ETSQPEGEAG VGVESNSDGA SPEPCTVTPG 

       130        140        150        160        170        180 
AVKLEKEKLE QNPEESQDIK ALQKELEQFA KLLKQKRITL GYTQADVGLT LGVLFGKVFS 

       190        200        210        220        230        240 
QTTICRFEAL QLSFKNMCKL RPLLQKWVEE ADNNENLQEI CKAETLVQAR KRKRTSIENR 

       250        260        270        280        290        300 
VRGNLENLFL QCPKPTLQQI SHIAQQLGLE KDVVRVWFCN RRQKGKRSSS DYAQREDFEA 

       310        320        330        340        350        360 
AGSPFSGGPV SFPLAPGPHF GTPGYGSPHF TALYSSVPFP EGEAFPPVSV TTLGSPMHSN 

« Hide

Isoform B (Oct-3B) (Oct3B) [UniParc].

Checksum: 41C21E136EFBCBB2
Show »

FASTA26530,085

References

« Hide 'large scale' references
[1]"Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues."
Takeda J., Seino S., Bell G.I.
Nucleic Acids Res. 20:4613-4620(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B), VARIANTS ALA-322 AND LEU-357, TISSUE SPECIFICITY.
Tissue: Kidney.
[2]"Comparison of MHC class I risk haplotypes in Thai and Caucasian psoriatics shows locus heterogeneity at PSORS1."
Stuart P.E., Nair R.P., Hiremagalore R., Kullavanijaya P., Kullavanijaya P., Tejasvi T., Lim H.W., Voorhees J.J., Elder J.T.
Tissue Antigens 76:387-397(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Blood.
[3]"Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity."
Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M., Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K., Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A. expand/collapse author list , Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T., Inoko H., Bahram S.
Genetics 173:1555-1570(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Peripheral blood leukocyte.
[4]"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
Shiina S., Tamiya G., Oka A., Inoko H.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[8]"A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues."
Wey E., Lyons G.E., Schaefer B.W.
Eur. J. Biochem. 220:753-762(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 188-274, TISSUE SPECIFICITY.
Tissue: Heart and Skeletal muscle.
[9]"Expression of transcription regulating genes in human preimplantation embryos."
Abdel-Rahman B., Fiddler M., Rappolee D., Pergament E.
Hum. Reprod. 10:2787-2792(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 212-283.
[10]"Oct4 pseudogenes are transcribed in cancers."
Suo G., Han J., Wang X., Zhang J., Zhao Y., Zhao Y., Dai J.
Biochem. Biophys. Res. Commun. 337:1047-1051(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[11]"Induction of pluripotent stem cells from adult human fibroblasts by defined factors."
Takahashi K., Tanabe K., Ohnuki M., Narita M., Ichisaka T., Tomoda K., Yamanaka S.
Cell 131:861-872(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: BIOTECHNOLOGY, FUNCTION.
[12]"Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription."
Lee J., Kim H.K., Han Y.-M., Kim J.
Int. J. Biochem. Cell Biol. 40:1043-1054(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PKM, SUBCELLULAR LOCATION, DOMAIN, INDUCTION.
[13]"WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells."
Xu H., Wang W., Li C., Yu H., Yang A., Wang B., Jin Y.
Cell Res. 19:561-573(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: UBIQUITINATION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, INTERACTION WITH WWP2.
[14]"Serine 111 phosphorylation regulates OCT4A protein subcellular distribution and degradation."
Spelat R., Ferro F., Curcio F.
J. Biol. Chem. 287:38279-38288(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT SER-111, SUBCELLULAR LOCATION.
[15]"Phosphorylation regulates human OCT4."
Brumbaugh J., Hou Z., Russell J.D., Howden S.E., Yu P., Ledvina A.R., Coon J.J., Thomson J.A.
Proc. Natl. Acad. Sci. U.S.A. 109:7162-7168(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT SER-111; THR-235; SER-236; SER-289; SER-290 AND SER-355.
+Additional computationally mapped references.

Web resources

Wikipedia

Oct-4 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z11898 mRNA. Translation: CAA77951.1.
Z11899 mRNA. Translation: CAA77952.1.
GQ472773 Genomic DNA. Translation: ACZ95700.1.
AB088113 Genomic DNA. Translation: BAC54946.1.
AB202105 Genomic DNA. Translation: BAE78630.1.
AB103619 Genomic DNA. Translation: BAF31281.1.
BA000025 Genomic DNA. Translation: BAB63311.1.
AL662833 Genomic DNA. Translation: CAI17407.1.
AL662833 Genomic DNA. Translation: CAI17408.1.
AL662844 Genomic DNA. Translation: CAI18331.1.
AL773544 Genomic DNA. Translation: CAI18485.1.
AL773544 Genomic DNA. Translation: CAI18486.1.
BX088580 Genomic DNA. Translation: CAI18708.1.
BX088580 Genomic DNA. Translation: CAI18709.1.
CR759815 Genomic DNA. Translation: CAQ07092.1.
CR759815 Genomic DNA. Translation: CAQ07093.1.
CR388229 Genomic DNA. Translation: CAQ09226.1.
CR388229 Genomic DNA. Translation: CAQ09227.1.
CR847794 Genomic DNA. Translation: CAQ10780.1.
CR847794 Genomic DNA. Translation: CAQ10781.1.
CH471081 Genomic DNA. Translation: EAX03367.1.
CH471081 Genomic DNA. Translation: EAX03368.1.
BC117435 mRNA. Translation: AAI17436.1.
BC117437 mRNA. Translation: AAI17438.1.
Z21963 mRNA. Translation: CAA79974.1.
Z21964 mRNA. Translation: CAA79975.1.
S81255 mRNA. Translation: AAB35990.1.
PIRS25561.
S32652.
RefSeqNP_001272916.1. NM_001285987.1.
NP_002692.2. NM_002701.5.
UniGeneHs.249184.
Hs.632482.
Hs.646545.

3D structure databases

ProteinModelPortalQ01860.
SMRQ01860. Positions 138-289.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111456. 60 interactions.
DIPDIP-33440N.
IntActQ01860. 9 interactions.
MINTMINT-87567.

PTM databases

PhosphoSiteQ01860.

Polymorphism databases

DMDM400659.

Proteomic databases

PaxDbQ01860.
PRIDEQ01860.

Protocols and materials databases

DNASU5460.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000259915; ENSP00000259915; ENSG00000204531. [Q01860-1]
ENST00000376243; ENSP00000365419; ENSG00000206454. [Q01860-2]
ENST00000383524; ENSP00000373016; ENSG00000206454. [Q01860-1]
ENST00000412166; ENSP00000387646; ENSG00000229094. [Q01860-2]
ENST00000419095; ENSP00000413622; ENSG00000235068. [Q01860-2]
ENST00000429314; ENSP00000387619; ENSG00000237582. [Q01860-2]
ENST00000429603; ENSP00000392877; ENSG00000233911. [Q01860-1]
ENST00000433063; ENSP00000405041; ENSG00000235068. [Q01860-1]
ENST00000433348; ENSP00000412665; ENSG00000230336. [Q01860-2]
ENST00000434616; ENSP00000388842; ENSG00000229094. [Q01860-1]
ENST00000437747; ENSP00000391681; ENSG00000237582. [Q01860-1]
ENST00000451077; ENSP00000391507; ENSG00000233911. [Q01860-2]
ENST00000454714; ENSP00000400047; ENSG00000230336. [Q01860-1]
GeneID5460.
KEGGhsa:5460.
UCSCuc003nsu.3. human. [Q01860-1]

Organism-specific databases

CTD5460.
GeneCardsGC06M031136.
GC06Mj31119.
GC06Mk31120.
GC06Ml31172.
GC06Mm31210.
GC06Mn31119.
GC06Mo31121.
H-InvDBHIX0159939.
HIX0164984.
HIX0166817.
HIX0167068.
HIX0167306.
HIX0167552.
HIX0168865.
HIX0201948.
HGNCHGNC:9221. POU5F1.
HPACAB025600.
CAB026380.
MIM164177. gene.
neXtProtNX_Q01860.
PharmGKBPA33545.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG329627.
HOVERGENHBG057998.
InParanoidQ01860.
KOK09367.
OMALENMFLQ.
PhylomeDBQ01860.
TreeFamTF316413.

Enzyme and pathway databases

SignaLinkQ01860.

Gene expression databases

BgeeQ01860.
GenevestigatorQ01860.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR015585. POU_dom_5/6.
IPR000327. POU_specific.
[Graphical view]
PANTHERPTHR11636:SF15. PTHR11636:SF15. 1 hit.
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSPR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi5460.
NextBio21135.
PROQ01860.
SOURCESearch...

Entry information

Entry namePO5F1_HUMAN
AccessionPrimary (citable) accession number: Q01860
Secondary accession number(s): A6NCS1 expand/collapse secondary AC list , A6NLL8, D2IYK4, P31359, Q15167, Q15168, Q16422, Q5STF3, Q5STF4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: April 16, 2014
This is version 156 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM