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Q01860

- PO5F1_HUMAN

UniProt

Q01860 - PO5F1_HUMAN

Protein

POU domain, class 5, transcription factor 1

Gene

POU5F1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 161 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi230 – 28960HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: HGNC
    2. miRNA binding Source: UniProtKB
    3. poly(A) RNA binding Source: UniProtKB
    4. protein binding Source: UniProtKB
    5. sequence-specific DNA binding Source: MGI
    6. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: BHF-UCL
    7. sequence-specific DNA binding transcription factor activity Source: HGNC
    8. transcription factor binding Source: BHF-UCL
    9. transcription regulatory region DNA binding Source: BHF-UCL
    10. ubiquitin protein ligase binding Source: BHF-UCL

    GO - Biological processi

    1. anatomical structure morphogenesis Source: ProtInc
    2. blastocyst development Source: BHF-UCL
    3. BMP signaling pathway involved in heart induction Source: BHF-UCL
    4. cardiac cell fate determination Source: BHF-UCL
    5. cell fate commitment involved in formation of primary germ layer Source: BHF-UCL
    6. endodermal cell fate specification Source: MGI
    7. mRNA transcription from RNA polymerase II promoter Source: BHF-UCL
    8. negative regulation of gene silencing by miRNA Source: UniProtKB
    9. positive regulation of catenin import into nucleus Source: BHF-UCL
    10. positive regulation of SMAD protein import into nucleus Source: BHF-UCL
    11. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    12. regulation of asymmetric cell division Source: BHF-UCL
    13. regulation of gene expression Source: UniProtKB
    14. regulation of heart induction by regulation of canonical Wnt signaling pathway Source: BHF-UCL
    15. regulation of methylation-dependent chromatin silencing Source: BHF-UCL
    16. regulation of transcription, DNA-templated Source: HGNC
    17. response to wounding Source: UniProtKB
    18. somatic stem cell maintenance Source: UniProtKB
    19. transcription from RNA polymerase II promoter Source: BHF-UCL

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_200670. POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation.
    REACT_200759. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.
    REACT_200812. Transcriptional regulation of pluripotent stem cells.
    SignaLinkiQ01860.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain, class 5, transcription factor 1
    Alternative name(s):
    Octamer-binding protein 3
    Short name:
    Oct-3
    Octamer-binding protein 4
    Short name:
    Oct-4
    Octamer-binding transcription factor 3
    Short name:
    OTF-3
    Gene namesi
    Name:POU5F1
    Synonyms:OCT3, OCT4, OTF3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:9221. POU5F1.

    Subcellular locationi

    Cytoplasm. Nucleus
    Note: Expressed in a diffuse and slightly punctuate pattern.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: UniProtKB
    3. nucleoplasm Source: BHF-UCL
    4. nucleus Source: UniProtKB
    5. transcription factor complex Source: BHF-UCL

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Biotechnological usei

    POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes.1 Publication

    Organism-specific databases

    PharmGKBiPA33545.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 360360POU domain, class 5, transcription factor 1PRO_0000100747Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei111 – 1111Phosphoserine; by MAPK2 Publications
    Cross-linki123 – 123Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
    Modified residuei235 – 2351Phosphothreonine1 Publication
    Modified residuei236 – 2361Phosphoserine1 Publication
    Modified residuei289 – 2891Phosphoserine1 Publication
    Modified residuei290 – 2901Phosphoserine1 Publication
    Modified residuei355 – 3551Phosphoserine1 Publication

    Post-translational modificationi

    Sumoylation enhances the protein stability, DNA binding and transactivation activity. Sumoylation is required for enhanced YES1 expression By similarity.By similarity
    Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination by WWP2 leading to proteasomal degradation.By similarity
    ERK1/2-mediated phosphorylation at Ser-111 promotes nuclear exclusion and proteasomal degradation. Phosphorylation at Thr-235 and Ser-236 decrease DNA-binding and alters ability to activate transcription.2 Publications

    Keywords - PTMi

    Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ01860.
    PRIDEiQ01860.

    PTM databases

    PhosphoSiteiQ01860.

    Expressioni

    Tissue specificityi

    Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues.2 Publications

    Developmental stagei

    Highly expressed in undifferentiated embryonic stem cells and expression decreases gradually after embryoid body (EB) formation.1 Publication

    Inductioni

    Transcriptional activity is positively regulated by PKM.1 Publication

    Gene expression databases

    BgeeiQ01860.
    GenevestigatoriQ01860.

    Organism-specific databases

    HPAiCAB025600.
    CAB026380.

    Interactioni

    Subunit structurei

    Interacts with UBE2I and ZSCAN10 By similarity. Interacts with PKM. Interacts with WWP2.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    P032592EBI-475687,EBI-6947456From a different organism.
    E1AQ8JSK42EBI-475687,EBI-7453955From a different organism.
    FOXD3Q9UJU52EBI-475687,EBI-475674
    Hmgb1P631583EBI-475687,EBI-6665811From a different organism.
    WWP2O003084EBI-475687,EBI-743923

    Protein-protein interaction databases

    BioGridi111456. 60 interactions.
    DIPiDIP-33440N.
    IntActiQ01860. 11 interactions.
    MINTiMINT-87567.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01860.
    SMRiQ01860. Positions 138-289.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini138 – 21275POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The POU-specific domain mediates interaction with PKM.1 Publication

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG329627.
    HOVERGENiHBG057998.
    InParanoidiQ01860.
    KOiK09367.
    OMAiLENMFLQ.
    PhylomeDBiQ01860.
    TreeFamiTF316413.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR015585. POU_dom_5.
    IPR000327. POU_specific.
    [Graphical view]
    PANTHERiPTHR11636:SF15. PTHR11636:SF15. 1 hit.
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform A (identifier: Q01860-1) [UniParc]FASTAAdd to Basket

    Also known as: Oct-3A, Oct3A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGHLASDFA FSPPPGGGGD GPGGPEPGWV DPRTWLSFQG PPGGPGIGPG    50
    VGPGSEVWGI PPCPPPYEFC GGMAYCGPQV GVGLVPQGGL ETSQPEGEAG 100
    VGVESNSDGA SPEPCTVTPG AVKLEKEKLE QNPEESQDIK ALQKELEQFA 150
    KLLKQKRITL GYTQADVGLT LGVLFGKVFS QTTICRFEAL QLSFKNMCKL 200
    RPLLQKWVEE ADNNENLQEI CKAETLVQAR KRKRTSIENR VRGNLENLFL 250
    QCPKPTLQQI SHIAQQLGLE KDVVRVWFCN RRQKGKRSSS DYAQREDFEA 300
    AGSPFSGGPV SFPLAPGPHF GTPGYGSPHF TALYSSVPFP EGEAFPPVSV 350
    TTLGSPMHSN 360
    Length:360
    Mass (Da):38,571
    Last modified:July 1, 1993 - v1
    Checksum:i934C58DAEA0C535B
    GO
    Isoform B (identifier: Q01860-2) [UniParc]FASTAAdd to Basket

    Also known as: Oct-3B, Oct3B

    The sequence of this isoform differs from the canonical sequence as follows:
         1-135: MAGHLASDFA...KEKLEQNPEE → MHFYRLFLGA...LTSLLPFKIQ

    Show »
    Length:265
    Mass (Da):30,085
    Checksum:i41C21E136EFBCBB2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti189 – 1891A → G in CAA79974. (PubMed:7908264)Curated
    Sequence conflicti220 – 2201I → T in CAA79974. (PubMed:7908264)Curated
    Sequence conflicti227 – 2271V → L in CAA79974. (PubMed:7908264)Curated
    Sequence conflicti230 – 2301R → G in CAA79975. (PubMed:7908264)Curated
    Sequence conflicti240 – 2401R → Q in CAA79975. (PubMed:7908264)Curated
    Sequence conflicti251 – 2511Q → R in CAA79975. (PubMed:7908264)Curated
    Sequence conflicti272 – 2721D → DVVR in AAB35990. (PubMed:8567814)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti226 – 2261L → F.
    Corresponds to variant rs1150767 [ dbSNP | Ensembl ].
    VAR_046203
    Natural varianti322 – 3221T → A.1 Publication
    VAR_003774
    Natural varianti351 – 3511T → I.
    Corresponds to variant rs1061120 [ dbSNP | Ensembl ].
    VAR_046204
    Natural varianti357 – 3571M → L.1 Publication
    VAR_003775

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 135135MAGHL…QNPEE → MHFYRLFLGATRRFLNPEWK GEIDNWCVYVLTSLLPFKIQ in isoform B. 1 PublicationVSP_002333Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z11898 mRNA. Translation: CAA77951.1.
    Z11899 mRNA. Translation: CAA77952.1.
    GQ472773 Genomic DNA. Translation: ACZ95700.1.
    AB088113 Genomic DNA. Translation: BAC54946.1.
    AB202105 Genomic DNA. Translation: BAE78630.1.
    AB103619 Genomic DNA. Translation: BAF31281.1.
    BA000025 Genomic DNA. Translation: BAB63311.1.
    AL662833 Genomic DNA. Translation: CAI17407.1.
    AL662833 Genomic DNA. Translation: CAI17408.1.
    AL662844 Genomic DNA. Translation: CAI18331.1.
    AL773544 Genomic DNA. Translation: CAI18485.1.
    AL773544 Genomic DNA. Translation: CAI18486.1.
    BX088580 Genomic DNA. Translation: CAI18708.1.
    BX088580 Genomic DNA. Translation: CAI18709.1.
    CR759815 Genomic DNA. Translation: CAQ07092.1.
    CR759815 Genomic DNA. Translation: CAQ07093.1.
    CR388229 Genomic DNA. Translation: CAQ09226.1.
    CR388229 Genomic DNA. Translation: CAQ09227.1.
    CR847794 Genomic DNA. Translation: CAQ10780.1.
    CR847794 Genomic DNA. Translation: CAQ10781.1.
    CH471081 Genomic DNA. Translation: EAX03367.1.
    CH471081 Genomic DNA. Translation: EAX03368.1.
    BC117435 mRNA. Translation: AAI17436.1.
    BC117437 mRNA. Translation: AAI17438.1.
    Z21963 mRNA. Translation: CAA79974.1.
    Z21964 mRNA. Translation: CAA79975.1.
    S81255 mRNA. Translation: AAB35990.1.
    CCDSiCCDS34391.1. [Q01860-1]
    PIRiS25561.
    S32652.
    RefSeqiNP_001272916.1. NM_001285987.1. [Q01860-2]
    NP_002692.2. NM_002701.5. [Q01860-1]
    UniGeneiHs.249184.
    Hs.632482.
    Hs.646545.

    Genome annotation databases

    EnsembliENST00000259915; ENSP00000259915; ENSG00000204531. [Q01860-1]
    ENST00000376243; ENSP00000365419; ENSG00000206454. [Q01860-2]
    ENST00000383524; ENSP00000373016; ENSG00000206454. [Q01860-1]
    ENST00000412166; ENSP00000387646; ENSG00000229094. [Q01860-2]
    ENST00000419095; ENSP00000413622; ENSG00000235068. [Q01860-2]
    ENST00000429314; ENSP00000387619; ENSG00000237582. [Q01860-2]
    ENST00000429603; ENSP00000392877; ENSG00000233911. [Q01860-1]
    ENST00000433063; ENSP00000405041; ENSG00000235068. [Q01860-1]
    ENST00000433348; ENSP00000412665; ENSG00000230336. [Q01860-2]
    ENST00000434616; ENSP00000388842; ENSG00000229094. [Q01860-1]
    ENST00000437747; ENSP00000391681; ENSG00000237582. [Q01860-1]
    ENST00000451077; ENSP00000391507; ENSG00000233911. [Q01860-2]
    ENST00000454714; ENSP00000400047; ENSG00000230336. [Q01860-1]
    GeneIDi5460.
    KEGGihsa:5460.
    UCSCiuc003nsu.3. human. [Q01860-1]

    Polymorphism databases

    DMDMi400659.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Oct-4 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z11898 mRNA. Translation: CAA77951.1 .
    Z11899 mRNA. Translation: CAA77952.1 .
    GQ472773 Genomic DNA. Translation: ACZ95700.1 .
    AB088113 Genomic DNA. Translation: BAC54946.1 .
    AB202105 Genomic DNA. Translation: BAE78630.1 .
    AB103619 Genomic DNA. Translation: BAF31281.1 .
    BA000025 Genomic DNA. Translation: BAB63311.1 .
    AL662833 Genomic DNA. Translation: CAI17407.1 .
    AL662833 Genomic DNA. Translation: CAI17408.1 .
    AL662844 Genomic DNA. Translation: CAI18331.1 .
    AL773544 Genomic DNA. Translation: CAI18485.1 .
    AL773544 Genomic DNA. Translation: CAI18486.1 .
    BX088580 Genomic DNA. Translation: CAI18708.1 .
    BX088580 Genomic DNA. Translation: CAI18709.1 .
    CR759815 Genomic DNA. Translation: CAQ07092.1 .
    CR759815 Genomic DNA. Translation: CAQ07093.1 .
    CR388229 Genomic DNA. Translation: CAQ09226.1 .
    CR388229 Genomic DNA. Translation: CAQ09227.1 .
    CR847794 Genomic DNA. Translation: CAQ10780.1 .
    CR847794 Genomic DNA. Translation: CAQ10781.1 .
    CH471081 Genomic DNA. Translation: EAX03367.1 .
    CH471081 Genomic DNA. Translation: EAX03368.1 .
    BC117435 mRNA. Translation: AAI17436.1 .
    BC117437 mRNA. Translation: AAI17438.1 .
    Z21963 mRNA. Translation: CAA79974.1 .
    Z21964 mRNA. Translation: CAA79975.1 .
    S81255 mRNA. Translation: AAB35990.1 .
    CCDSi CCDS34391.1. [Q01860-1 ]
    PIRi S25561.
    S32652.
    RefSeqi NP_001272916.1. NM_001285987.1. [Q01860-2 ]
    NP_002692.2. NM_002701.5. [Q01860-1 ]
    UniGenei Hs.249184.
    Hs.632482.
    Hs.646545.

    3D structure databases

    ProteinModelPortali Q01860.
    SMRi Q01860. Positions 138-289.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111456. 60 interactions.
    DIPi DIP-33440N.
    IntActi Q01860. 11 interactions.
    MINTi MINT-87567.

    PTM databases

    PhosphoSitei Q01860.

    Polymorphism databases

    DMDMi 400659.

    Proteomic databases

    PaxDbi Q01860.
    PRIDEi Q01860.

    Protocols and materials databases

    DNASUi 5460.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000259915 ; ENSP00000259915 ; ENSG00000204531 . [Q01860-1 ]
    ENST00000376243 ; ENSP00000365419 ; ENSG00000206454 . [Q01860-2 ]
    ENST00000383524 ; ENSP00000373016 ; ENSG00000206454 . [Q01860-1 ]
    ENST00000412166 ; ENSP00000387646 ; ENSG00000229094 . [Q01860-2 ]
    ENST00000419095 ; ENSP00000413622 ; ENSG00000235068 . [Q01860-2 ]
    ENST00000429314 ; ENSP00000387619 ; ENSG00000237582 . [Q01860-2 ]
    ENST00000429603 ; ENSP00000392877 ; ENSG00000233911 . [Q01860-1 ]
    ENST00000433063 ; ENSP00000405041 ; ENSG00000235068 . [Q01860-1 ]
    ENST00000433348 ; ENSP00000412665 ; ENSG00000230336 . [Q01860-2 ]
    ENST00000434616 ; ENSP00000388842 ; ENSG00000229094 . [Q01860-1 ]
    ENST00000437747 ; ENSP00000391681 ; ENSG00000237582 . [Q01860-1 ]
    ENST00000451077 ; ENSP00000391507 ; ENSG00000233911 . [Q01860-2 ]
    ENST00000454714 ; ENSP00000400047 ; ENSG00000230336 . [Q01860-1 ]
    GeneIDi 5460.
    KEGGi hsa:5460.
    UCSCi uc003nsu.3. human. [Q01860-1 ]

    Organism-specific databases

    CTDi 5460.
    GeneCardsi GC06M031136.
    GC06Mj31119.
    GC06Mk31120.
    GC06Ml31172.
    GC06Mm31210.
    GC06Mn31119.
    GC06Mo31121.
    H-InvDB HIX0159939.
    HIX0164984.
    HIX0166817.
    HIX0167068.
    HIX0167306.
    HIX0167552.
    HIX0168865.
    HIX0201948.
    HGNCi HGNC:9221. POU5F1.
    HPAi CAB025600.
    CAB026380.
    MIMi 164177. gene.
    neXtProti NX_Q01860.
    PharmGKBi PA33545.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG329627.
    HOVERGENi HBG057998.
    InParanoidi Q01860.
    KOi K09367.
    OMAi LENMFLQ.
    PhylomeDBi Q01860.
    TreeFami TF316413.

    Enzyme and pathway databases

    Reactomei REACT_200670. POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation.
    REACT_200759. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.
    REACT_200812. Transcriptional regulation of pluripotent stem cells.
    SignaLinki Q01860.

    Miscellaneous databases

    GenomeRNAii 5460.
    NextBioi 21135.
    PROi Q01860.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q01860.
    Genevestigatori Q01860.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR015585. POU_dom_5.
    IPR000327. POU_specific.
    [Graphical view ]
    PANTHERi PTHR11636:SF15. PTHR11636:SF15. 1 hit.
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues."
      Takeda J., Seino S., Bell G.I.
      Nucleic Acids Res. 20:4613-4620(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B), VARIANTS ALA-322 AND LEU-357, TISSUE SPECIFICITY.
      Tissue: Kidney.
    2. "Comparison of MHC class I risk haplotypes in Thai and Caucasian psoriatics shows locus heterogeneity at PSORS1."
      Stuart P.E., Nair R.P., Hiremagalore R., Kullavanijaya P., Kullavanijaya P., Tejasvi T., Lim H.W., Voorhees J.J., Elder J.T.
      Tissue Antigens 76:387-397(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Blood.
    3. "Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity."
      Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M., Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K., Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A.
      , Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T., Inoko H., Bahram S.
      Genetics 173:1555-1570(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Peripheral blood leukocyte.
    4. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
      Shiina S., Tamiya G., Oka A., Inoko H.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    8. "A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues."
      Wey E., Lyons G.E., Schaefer B.W.
      Eur. J. Biochem. 220:753-762(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 188-274, TISSUE SPECIFICITY.
      Tissue: Heart and Skeletal muscle.
    9. "Expression of transcription regulating genes in human preimplantation embryos."
      Abdel-Rahman B., Fiddler M., Rappolee D., Pergament E.
      Hum. Reprod. 10:2787-2792(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 212-283.
    10. Cited for: IDENTIFICATION.
    11. "Induction of pluripotent stem cells from adult human fibroblasts by defined factors."
      Takahashi K., Tanabe K., Ohnuki M., Narita M., Ichisaka T., Tomoda K., Yamanaka S.
      Cell 131:861-872(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: BIOTECHNOLOGY, FUNCTION.
    12. "Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription."
      Lee J., Kim H.K., Han Y.-M., Kim J.
      Int. J. Biochem. Cell Biol. 40:1043-1054(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PKM, SUBCELLULAR LOCATION, DOMAIN, INDUCTION.
    13. "WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells."
      Xu H., Wang W., Li C., Yu H., Yang A., Wang B., Jin Y.
      Cell Res. 19:561-573(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, INTERACTION WITH WWP2.
    14. "Serine 111 phosphorylation regulates OCT4A protein subcellular distribution and degradation."
      Spelat R., Ferro F., Curcio F.
      J. Biol. Chem. 287:38279-38288(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-111, SUBCELLULAR LOCATION.
    15. Cited for: PHOSPHORYLATION AT SER-111; THR-235; SER-236; SER-289; SER-290 AND SER-355.

    Entry informationi

    Entry nameiPO5F1_HUMAN
    AccessioniPrimary (citable) accession number: Q01860
    Secondary accession number(s): A6NCS1
    , A6NLL8, D2IYK4, P31359, Q15167, Q15168, Q16422, Q5STF3, Q5STF4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 161 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Several pseudogenes of POU5F1 have been described on chromosomes 1, 3, 8, 10 and 12. 2 of them, localized in chromosomes 8 and 10, are transcribed in cancer tissues but not in normal ones and may be involved in the regulation of POU5F1 gene activity in carcinogenesis.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3