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Protein

POU domain, class 5, transcription factor 1

Gene

POU5F1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi230 – 28960HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: HGNC
  2. miRNA binding Source: UniProtKB
  3. poly(A) RNA binding Source: UniProtKB
  4. sequence-specific DNA binding Source: MGI
  5. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: BHF-UCL
  6. sequence-specific DNA binding transcription factor activity Source: HGNC
  7. transcription factor binding Source: BHF-UCL
  8. transcription regulatory region DNA binding Source: BHF-UCL
  9. ubiquitin protein ligase binding Source: BHF-UCL

GO - Biological processi

  1. anatomical structure morphogenesis Source: ProtInc
  2. blastocyst development Source: BHF-UCL
  3. BMP signaling pathway involved in heart induction Source: BHF-UCL
  4. cardiac cell fate determination Source: BHF-UCL
  5. cell fate commitment involved in formation of primary germ layer Source: BHF-UCL
  6. endodermal cell fate specification Source: MGI
  7. mRNA transcription from RNA polymerase II promoter Source: BHF-UCL
  8. negative regulation of gene silencing by miRNA Source: UniProtKB
  9. positive regulation of catenin import into nucleus Source: BHF-UCL
  10. positive regulation of SMAD protein import into nucleus Source: BHF-UCL
  11. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  12. regulation of asymmetric cell division Source: BHF-UCL
  13. regulation of gene expression Source: UniProtKB
  14. regulation of heart induction by regulation of canonical Wnt signaling pathway Source: BHF-UCL
  15. regulation of methylation-dependent chromatin silencing Source: BHF-UCL
  16. regulation of transcription, DNA-templated Source: HGNC
  17. response to wounding Source: UniProtKB
  18. somatic stem cell maintenance Source: UniProtKB
  19. transcription from RNA polymerase II promoter Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_200670. POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation.
REACT_200759. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.
REACT_200812. Transcriptional regulation of pluripotent stem cells.
SignaLinkiQ01860.

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 5, transcription factor 1
Alternative name(s):
Octamer-binding protein 3
Short name:
Oct-3
Octamer-binding protein 4
Short name:
Oct-4
Octamer-binding transcription factor 3
Short name:
OTF-3
Gene namesi
Name:POU5F1
Synonyms:OCT3, OCT4, OTF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6, UP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:9221. POU5F1.

Subcellular locationi

Cytoplasm. Nucleus
Note: Expressed in a diffuse and slightly punctuate pattern.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosol Source: UniProtKB
  3. nucleoplasm Source: BHF-UCL
  4. nucleus Source: UniProtKB
  5. transcription factor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Biotechnological usei

POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes.1 Publication

Organism-specific databases

PharmGKBiPA33545.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360POU domain, class 5, transcription factor 1PRO_0000100747Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei111 – 1111Phosphoserine; by MAPK2 Publications
Cross-linki123 – 123Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residuei235 – 2351Phosphothreonine1 Publication
Modified residuei236 – 2361Phosphoserine1 Publication
Modified residuei289 – 2891Phosphoserine1 Publication
Modified residuei290 – 2901Phosphoserine1 Publication
Modified residuei355 – 3551Phosphoserine1 Publication

Post-translational modificationi

Sumoylation enhances the protein stability, DNA binding and transactivation activity. Sumoylation is required for enhanced YES1 expression (By similarity).By similarity
Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination by WWP2 leading to proteasomal degradation.By similarity
ERK1/2-mediated phosphorylation at Ser-111 promotes nuclear exclusion and proteasomal degradation. Phosphorylation at Thr-235 and Ser-236 decrease DNA-binding and alters ability to activate transcription.2 Publications

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ01860.
PRIDEiQ01860.

PTM databases

PhosphoSiteiQ01860.

Expressioni

Tissue specificityi

Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues.2 Publications

Developmental stagei

Highly expressed in undifferentiated embryonic stem cells and expression decreases gradually after embryoid body (EB) formation.1 Publication

Inductioni

Transcriptional activity is positively regulated by PKM.1 Publication

Gene expression databases

BgeeiQ01860.
ExpressionAtlasiQ01860. baseline.
GenevestigatoriQ01860.

Organism-specific databases

HPAiCAB025600.
CAB026380.

Interactioni

Subunit structurei

Interacts with UBE2I and ZSCAN10 (By similarity). Interacts with PKM. Interacts with WWP2.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
P032592EBI-475687,EBI-6947456From a different organism.
E1AQ8JSK42EBI-475687,EBI-7453955From a different organism.
FOXD3Q9UJU52EBI-475687,EBI-475674
Hmgb1P631583EBI-475687,EBI-6665811From a different organism.
WWP2O003084EBI-475687,EBI-743923

Protein-protein interaction databases

BioGridi111456. 61 interactions.
DIPiDIP-33440N.
IntActiQ01860. 11 interactions.
MINTiMINT-87567.

Structurei

3D structure databases

ProteinModelPortaliQ01860.
SMRiQ01860. Positions 138-289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini138 – 21275POU-specificPROSITE-ProRule annotationAdd
BLAST

Domaini

The POU-specific domain mediates interaction with PKM.1 Publication

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG329627.
GeneTreeiENSGT00760000118935.
HOVERGENiHBG057998.
InParanoidiQ01860.
KOiK09367.
OMAiLENMFLQ.
PhylomeDBiQ01860.
TreeFamiTF316413.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR015585. POU_dom_5.
IPR000327. POU_specific.
[Graphical view]
PANTHERiPTHR11636:SF15. PTHR11636:SF15. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: Q01860-1) [UniParc]FASTAAdd to basket

Also known as: Oct-3A, Oct3A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGHLASDFA FSPPPGGGGD GPGGPEPGWV DPRTWLSFQG PPGGPGIGPG
60 70 80 90 100
VGPGSEVWGI PPCPPPYEFC GGMAYCGPQV GVGLVPQGGL ETSQPEGEAG
110 120 130 140 150
VGVESNSDGA SPEPCTVTPG AVKLEKEKLE QNPEESQDIK ALQKELEQFA
160 170 180 190 200
KLLKQKRITL GYTQADVGLT LGVLFGKVFS QTTICRFEAL QLSFKNMCKL
210 220 230 240 250
RPLLQKWVEE ADNNENLQEI CKAETLVQAR KRKRTSIENR VRGNLENLFL
260 270 280 290 300
QCPKPTLQQI SHIAQQLGLE KDVVRVWFCN RRQKGKRSSS DYAQREDFEA
310 320 330 340 350
AGSPFSGGPV SFPLAPGPHF GTPGYGSPHF TALYSSVPFP EGEAFPPVSV
360
TTLGSPMHSN
Length:360
Mass (Da):38,571
Last modified:July 1, 1993 - v1
Checksum:i934C58DAEA0C535B
GO
Isoform B (identifier: Q01860-2) [UniParc]FASTAAdd to basket

Also known as: Oct-3B, Oct3B

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: MAGHLASDFA...KEKLEQNPEE → MHFYRLFLGA...LTSLLPFKIQ

Show »
Length:265
Mass (Da):30,085
Checksum:i41C21E136EFBCBB2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti189 – 1891A → G in CAA79974 (PubMed:7908264).Curated
Sequence conflicti220 – 2201I → T in CAA79974 (PubMed:7908264).Curated
Sequence conflicti227 – 2271V → L in CAA79974 (PubMed:7908264).Curated
Sequence conflicti230 – 2301R → G in CAA79975 (PubMed:7908264).Curated
Sequence conflicti240 – 2401R → Q in CAA79975 (PubMed:7908264).Curated
Sequence conflicti251 – 2511Q → R in CAA79975 (PubMed:7908264).Curated
Sequence conflicti272 – 2721D → DVVR in AAB35990 (PubMed:8567814).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti226 – 2261L → F.
Corresponds to variant rs1150767 [ dbSNP | Ensembl ].
VAR_046203
Natural varianti322 – 3221T → A.1 Publication
VAR_003774
Natural varianti351 – 3511T → I.
Corresponds to variant rs1061120 [ dbSNP | Ensembl ].
VAR_046204
Natural varianti357 – 3571M → L.1 Publication
VAR_003775

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 135135MAGHL…QNPEE → MHFYRLFLGATRRFLNPEWK GEIDNWCVYVLTSLLPFKIQ in isoform B. 1 PublicationVSP_002333Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11898 mRNA. Translation: CAA77951.1.
Z11899 mRNA. Translation: CAA77952.1.
GQ472773 Genomic DNA. Translation: ACZ95700.1.
AB088113 Genomic DNA. Translation: BAC54946.1.
AB202105 Genomic DNA. Translation: BAE78630.1.
AB103619 Genomic DNA. Translation: BAF31281.1.
BA000025 Genomic DNA. Translation: BAB63311.1.
AL662833 Genomic DNA. Translation: CAI17407.1.
AL662833 Genomic DNA. Translation: CAI17408.1.
AL662844 Genomic DNA. Translation: CAI18331.1.
AL773544 Genomic DNA. Translation: CAI18485.1.
AL773544 Genomic DNA. Translation: CAI18486.1.
BX088580 Genomic DNA. Translation: CAI18708.1.
BX088580 Genomic DNA. Translation: CAI18709.1.
CR759815 Genomic DNA. Translation: CAQ07092.1.
CR759815 Genomic DNA. Translation: CAQ07093.1.
CR388229 Genomic DNA. Translation: CAQ09226.1.
CR388229 Genomic DNA. Translation: CAQ09227.1.
CR847794 Genomic DNA. Translation: CAQ10780.1.
CR847794 Genomic DNA. Translation: CAQ10781.1.
CH471081 Genomic DNA. Translation: EAX03367.1.
CH471081 Genomic DNA. Translation: EAX03368.1.
BC117435 mRNA. Translation: AAI17436.1.
BC117437 mRNA. Translation: AAI17438.1.
Z21963 mRNA. Translation: CAA79974.1.
Z21964 mRNA. Translation: CAA79975.1.
S81255 mRNA. Translation: AAB35990.1.
CCDSiCCDS34391.1. [Q01860-1]
PIRiS25561.
S32652.
RefSeqiNP_001272916.1. NM_001285987.1. [Q01860-2]
NP_002692.2. NM_002701.5. [Q01860-1]
UniGeneiHs.249184.
Hs.632482.
Hs.646545.

Genome annotation databases

EnsembliENST00000259915; ENSP00000259915; ENSG00000204531. [Q01860-1]
ENST00000376243; ENSP00000365419; ENSG00000206454. [Q01860-2]
ENST00000383524; ENSP00000373016; ENSG00000206454. [Q01860-1]
ENST00000412166; ENSP00000387646; ENSG00000229094. [Q01860-2]
ENST00000419095; ENSP00000413622; ENSG00000235068. [Q01860-2]
ENST00000429314; ENSP00000387619; ENSG00000237582. [Q01860-2]
ENST00000429603; ENSP00000392877; ENSG00000233911. [Q01860-1]
ENST00000433063; ENSP00000405041; ENSG00000235068. [Q01860-1]
ENST00000433348; ENSP00000412665; ENSG00000230336. [Q01860-2]
ENST00000434616; ENSP00000388842; ENSG00000229094. [Q01860-1]
ENST00000437747; ENSP00000391681; ENSG00000237582. [Q01860-1]
ENST00000451077; ENSP00000391507; ENSG00000233911. [Q01860-2]
ENST00000454714; ENSP00000400047; ENSG00000230336. [Q01860-1]
GeneIDi5460.
KEGGihsa:5460.
UCSCiuc003nsu.3. human. [Q01860-1]

Polymorphism databases

DMDMi400659.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Oct-4 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11898 mRNA. Translation: CAA77951.1.
Z11899 mRNA. Translation: CAA77952.1.
GQ472773 Genomic DNA. Translation: ACZ95700.1.
AB088113 Genomic DNA. Translation: BAC54946.1.
AB202105 Genomic DNA. Translation: BAE78630.1.
AB103619 Genomic DNA. Translation: BAF31281.1.
BA000025 Genomic DNA. Translation: BAB63311.1.
AL662833 Genomic DNA. Translation: CAI17407.1.
AL662833 Genomic DNA. Translation: CAI17408.1.
AL662844 Genomic DNA. Translation: CAI18331.1.
AL773544 Genomic DNA. Translation: CAI18485.1.
AL773544 Genomic DNA. Translation: CAI18486.1.
BX088580 Genomic DNA. Translation: CAI18708.1.
BX088580 Genomic DNA. Translation: CAI18709.1.
CR759815 Genomic DNA. Translation: CAQ07092.1.
CR759815 Genomic DNA. Translation: CAQ07093.1.
CR388229 Genomic DNA. Translation: CAQ09226.1.
CR388229 Genomic DNA. Translation: CAQ09227.1.
CR847794 Genomic DNA. Translation: CAQ10780.1.
CR847794 Genomic DNA. Translation: CAQ10781.1.
CH471081 Genomic DNA. Translation: EAX03367.1.
CH471081 Genomic DNA. Translation: EAX03368.1.
BC117435 mRNA. Translation: AAI17436.1.
BC117437 mRNA. Translation: AAI17438.1.
Z21963 mRNA. Translation: CAA79974.1.
Z21964 mRNA. Translation: CAA79975.1.
S81255 mRNA. Translation: AAB35990.1.
CCDSiCCDS34391.1. [Q01860-1]
PIRiS25561.
S32652.
RefSeqiNP_001272916.1. NM_001285987.1. [Q01860-2]
NP_002692.2. NM_002701.5. [Q01860-1]
UniGeneiHs.249184.
Hs.632482.
Hs.646545.

3D structure databases

ProteinModelPortaliQ01860.
SMRiQ01860. Positions 138-289.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111456. 61 interactions.
DIPiDIP-33440N.
IntActiQ01860. 11 interactions.
MINTiMINT-87567.

Chemistry

DrugBankiDB00988. Dopamine.
DB00368. Norepinephrine.

PTM databases

PhosphoSiteiQ01860.

Polymorphism databases

DMDMi400659.

Proteomic databases

PaxDbiQ01860.
PRIDEiQ01860.

Protocols and materials databases

DNASUi5460.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259915; ENSP00000259915; ENSG00000204531. [Q01860-1]
ENST00000376243; ENSP00000365419; ENSG00000206454. [Q01860-2]
ENST00000383524; ENSP00000373016; ENSG00000206454. [Q01860-1]
ENST00000412166; ENSP00000387646; ENSG00000229094. [Q01860-2]
ENST00000419095; ENSP00000413622; ENSG00000235068. [Q01860-2]
ENST00000429314; ENSP00000387619; ENSG00000237582. [Q01860-2]
ENST00000429603; ENSP00000392877; ENSG00000233911. [Q01860-1]
ENST00000433063; ENSP00000405041; ENSG00000235068. [Q01860-1]
ENST00000433348; ENSP00000412665; ENSG00000230336. [Q01860-2]
ENST00000434616; ENSP00000388842; ENSG00000229094. [Q01860-1]
ENST00000437747; ENSP00000391681; ENSG00000237582. [Q01860-1]
ENST00000451077; ENSP00000391507; ENSG00000233911. [Q01860-2]
ENST00000454714; ENSP00000400047; ENSG00000230336. [Q01860-1]
GeneIDi5460.
KEGGihsa:5460.
UCSCiuc003nsu.3. human. [Q01860-1]

Organism-specific databases

CTDi5460.
GeneCardsiGC06M031136.
GC06Mj31119.
GC06Mk31120.
GC06Ml31172.
GC06Mm31210.
GC06Mn31119.
GC06Mo31121.
H-InvDBHIX0159939.
HIX0164984.
HIX0166817.
HIX0167068.
HIX0167306.
HIX0167552.
HIX0168865.
HIX0201948.
HGNCiHGNC:9221. POU5F1.
HPAiCAB025600.
CAB026380.
MIMi164177. gene.
neXtProtiNX_Q01860.
PharmGKBiPA33545.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG329627.
GeneTreeiENSGT00760000118935.
HOVERGENiHBG057998.
InParanoidiQ01860.
KOiK09367.
OMAiLENMFLQ.
PhylomeDBiQ01860.
TreeFamiTF316413.

Enzyme and pathway databases

ReactomeiREACT_200670. POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation.
REACT_200759. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.
REACT_200812. Transcriptional regulation of pluripotent stem cells.
SignaLinkiQ01860.

Miscellaneous databases

GenomeRNAii5460.
NextBioi21135.
PROiQ01860.
SOURCEiSearch...

Gene expression databases

BgeeiQ01860.
ExpressionAtlasiQ01860. baseline.
GenevestigatoriQ01860.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR015585. POU_dom_5.
IPR000327. POU_specific.
[Graphical view]
PANTHERiPTHR11636:SF15. PTHR11636:SF15. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues."
    Takeda J., Seino S., Bell G.I.
    Nucleic Acids Res. 20:4613-4620(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B), VARIANTS ALA-322 AND LEU-357, TISSUE SPECIFICITY.
    Tissue: Kidney.
  2. "Comparison of MHC class I risk haplotypes in Thai and Caucasian psoriatics shows locus heterogeneity at PSORS1."
    Stuart P.E., Nair R.P., Hiremagalore R., Kullavanijaya P., Kullavanijaya P., Tejasvi T., Lim H.W., Voorhees J.J., Elder J.T.
    Tissue Antigens 76:387-397(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Blood.
  3. "Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity."
    Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M., Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K., Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A.
    , Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T., Inoko H., Bahram S.
    Genetics 173:1555-1570(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Peripheral blood leukocyte.
  4. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
    Shiina S., Tamiya G., Oka A., Inoko H.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  8. "A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues."
    Wey E., Lyons G.E., Schaefer B.W.
    Eur. J. Biochem. 220:753-762(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 188-274, TISSUE SPECIFICITY.
    Tissue: Heart and Skeletal muscle.
  9. "Expression of transcription regulating genes in human preimplantation embryos."
    Abdel-Rahman B., Fiddler M., Rappolee D., Pergament E.
    Hum. Reprod. 10:2787-2792(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 212-283.
  10. Cited for: IDENTIFICATION.
  11. "Induction of pluripotent stem cells from adult human fibroblasts by defined factors."
    Takahashi K., Tanabe K., Ohnuki M., Narita M., Ichisaka T., Tomoda K., Yamanaka S.
    Cell 131:861-872(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: BIOTECHNOLOGY, FUNCTION.
  12. "Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription."
    Lee J., Kim H.K., Han Y.-M., Kim J.
    Int. J. Biochem. Cell Biol. 40:1043-1054(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PKM, SUBCELLULAR LOCATION, DOMAIN, INDUCTION.
  13. "WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells."
    Xu H., Wang W., Li C., Yu H., Yang A., Wang B., Jin Y.
    Cell Res. 19:561-573(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, INTERACTION WITH WWP2.
  14. "Serine 111 phosphorylation regulates OCT4A protein subcellular distribution and degradation."
    Spelat R., Ferro F., Curcio F.
    J. Biol. Chem. 287:38279-38288(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-111, SUBCELLULAR LOCATION.
  15. Cited for: PHOSPHORYLATION AT SER-111; THR-235; SER-236; SER-289; SER-290 AND SER-355.

Entry informationi

Entry nameiPO5F1_HUMAN
AccessioniPrimary (citable) accession number: Q01860
Secondary accession number(s): A6NCS1
, A6NLL8, D2IYK4, P31359, Q15167, Q15168, Q16422, Q5STF3, Q5STF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: January 7, 2015
This is version 163 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Several pseudogenes of POU5F1 have been described on chromosomes 1, 3, 8, 10 and 12. 2 of them, localized in chromosomes 8 and 10, are transcribed in cancer tissues but not in normal ones and may be involved in the regulation of POU5F1 gene activity in carcinogenesis.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.