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Q01855

- RS15_YEAST

UniProt

Q01855 - RS15_YEAST

Protein

40S ribosomal protein S15

Gene

RPS15

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Involved in the nuclear export of the small ribosomal subunit. Has a role in the late stage of the assembly of pre-40S particles within the nucleus and controls their export to the cytoplasm.1 Publication

    GO - Molecular functioni

    1. RNA binding Source: InterPro
    2. structural constituent of ribosome Source: SGD

    GO - Biological processi

    1. cytoplasmic translation Source: SGD
    2. rRNA export from nucleus Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Biological processi

    Ribosome biogenesis

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33454-MONOMER.
    ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    40S ribosomal protein S15
    Alternative name(s):
    RIG protein
    RP52
    S21
    YS21
    Gene namesi
    Name:RPS15
    Synonyms:RPS21
    Ordered Locus Names:YOL040C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XV

    Organism-specific databases

    CYGDiYOL040c.
    SGDiS000005400. RPS15.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytosolic small ribosomal subunit Source: SGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 14214140S ribosomal protein S15PRO_0000130051Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine2 Publications

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ01855.
    PaxDbiQ01855.
    PeptideAtlasiQ01855.

    Expressioni

    Gene expression databases

    GenevestigatoriQ01855.

    Interactioni

    Subunit structurei

    Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

    Protein-protein interaction databases

    BioGridi34362. 73 interactions.
    IntActiQ01855. 5 interactions.
    MINTiMINT-4986189.
    STRINGi4932.YOL040C.

    Structurei

    Secondary structure

    1
    142
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi16 – 194
    Helixi22 – 265
    Helixi30 – 367
    Helixi39 – 468
    Helixi54 – 6613
    Beta strandi69 – 713
    Beta strandi76 – 783
    Helixi87 – 893
    Beta strandi93 – 10614
    Helixi109 – 1113
    Helixi116 – 1194

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1K5Xmodel-S47-126[»]
    1S1Helectron microscopy11.70S47-126[»]
    1VW9electron microscopy6.10Q1-142[»]
    1VWVelectron microscopy6.10Q1-142[»]
    3IZBelectron microscopy-R1-142[»]
    3O2ZX-ray4.00I1-142[»]
    3O30X-ray4.00I1-142[»]
    3U5CX-ray3.00P1-142[»]
    3U5GX-ray3.00P1-142[»]
    4BYLelectron microscopy4.30P1-142[»]
    4BYTelectron microscopy6.60P1-142[»]
    4CUYelectron microscopy3.70P12-126[»]
    ProteinModelPortaliQ01855.
    SMRiQ01855. Positions 4-138.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ01855.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S19P family.Curated

    Phylogenomic databases

    eggNOGiCOG0185.
    GeneTreeiENSGT00390000000475.
    HOGENOMiHOG000111561.
    KOiK02958.
    OMAiYCARQRR.
    OrthoDBiEOG7FBRW1.

    Family and domain databases

    Gene3Di3.30.860.10. 1 hit.
    HAMAPiMF_00531. Ribosomal_S19.
    InterProiIPR002222. Ribosomal_S19.
    IPR020934. Ribosomal_S19_CS.
    IPR023575. Ribosomal_S19_SF.
    IPR005713. Ribosomal_S19A/S15e.
    [Graphical view]
    PANTHERiPTHR11880. PTHR11880. 1 hit.
    PfamiPF00203. Ribosomal_S19. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002144. Ribosomal_S19. 1 hit.
    PRINTSiPR00975. RIBOSOMALS19.
    SUPFAMiSSF54570. SSF54570. 1 hit.
    TIGRFAMsiTIGR01025. rpsS_arch. 1 hit.
    PROSITEiPS00323. RIBOSOMAL_S19. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q01855-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQAVNAKKR VFKTHSYRGV DLEKLLEMST EDFVKLAPAR VRRRFARGMT    50
    SKPAGFMKKL RAAKLAAPEN EKPAPVRTHM RNMIIVPEMI GSVVGIYNGK 100
    AFNQVEIRPE MLGHYLGEFS ITYTPVRHGR AGATTSRFIP LK 142
    Length:142
    Mass (Da):16,002
    Last modified:April 1, 1993 - v1
    Checksum:i06B564FD68051CD2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D11386 mRNA. Translation: BAA01982.1.
    D11387 Genomic DNA. Translation: BAA01983.1.
    Z74782 Genomic DNA. Translation: CAA99042.1.
    AY558426 Genomic DNA. Translation: AAS56752.1.
    BK006948 Genomic DNA. Translation: DAA10742.1.
    PIRiS24053.
    RefSeqiNP_014602.1. NM_001183294.1.

    Genome annotation databases

    EnsemblFungiiYOL040C; YOL040C; YOL040C.
    GeneIDi854117.
    KEGGisce:YOL040C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D11386 mRNA. Translation: BAA01982.1 .
    D11387 Genomic DNA. Translation: BAA01983.1 .
    Z74782 Genomic DNA. Translation: CAA99042.1 .
    AY558426 Genomic DNA. Translation: AAS56752.1 .
    BK006948 Genomic DNA. Translation: DAA10742.1 .
    PIRi S24053.
    RefSeqi NP_014602.1. NM_001183294.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1K5X model - S 47-126 [» ]
    1S1H electron microscopy 11.70 S 47-126 [» ]
    1VW9 electron microscopy 6.10 Q 1-142 [» ]
    1VWV electron microscopy 6.10 Q 1-142 [» ]
    3IZB electron microscopy - R 1-142 [» ]
    3O2Z X-ray 4.00 I 1-142 [» ]
    3O30 X-ray 4.00 I 1-142 [» ]
    3U5C X-ray 3.00 P 1-142 [» ]
    3U5G X-ray 3.00 P 1-142 [» ]
    4BYL electron microscopy 4.30 P 1-142 [» ]
    4BYT electron microscopy 6.60 P 1-142 [» ]
    4CUY electron microscopy 3.70 P 12-126 [» ]
    ProteinModelPortali Q01855.
    SMRi Q01855. Positions 4-138.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34362. 73 interactions.
    IntActi Q01855. 5 interactions.
    MINTi MINT-4986189.
    STRINGi 4932.YOL040C.

    Proteomic databases

    MaxQBi Q01855.
    PaxDbi Q01855.
    PeptideAtlasi Q01855.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YOL040C ; YOL040C ; YOL040C .
    GeneIDi 854117.
    KEGGi sce:YOL040C.

    Organism-specific databases

    CYGDi YOL040c.
    SGDi S000005400. RPS15.

    Phylogenomic databases

    eggNOGi COG0185.
    GeneTreei ENSGT00390000000475.
    HOGENOMi HOG000111561.
    KOi K02958.
    OMAi YCARQRR.
    OrthoDBi EOG7FBRW1.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33454-MONOMER.
    Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Miscellaneous databases

    EvolutionaryTracei Q01855.
    NextBioi 975816.
    PROi Q01855.

    Gene expression databases

    Genevestigatori Q01855.

    Family and domain databases

    Gene3Di 3.30.860.10. 1 hit.
    HAMAPi MF_00531. Ribosomal_S19.
    InterProi IPR002222. Ribosomal_S19.
    IPR020934. Ribosomal_S19_CS.
    IPR023575. Ribosomal_S19_SF.
    IPR005713. Ribosomal_S19A/S15e.
    [Graphical view ]
    PANTHERi PTHR11880. PTHR11880. 1 hit.
    Pfami PF00203. Ribosomal_S19. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002144. Ribosomal_S19. 1 hit.
    PRINTSi PR00975. RIBOSOMALS19.
    SUPFAMi SSF54570. SSF54570. 1 hit.
    TIGRFAMsi TIGR01025. rpsS_arch. 1 hit.
    PROSITEi PS00323. RIBOSOMAL_S19. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural determination of Saccharomyces cerevisiae rig gene and identification of its product as ribosomal protein S21."
      Takasawa S., Tohgo A., Unno M., Yonekura H., Okamoto H.
      FEBS Lett. 307:318-323(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
      Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
      , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
      Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
      Planta R.J., Mager W.H.
      Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE, SUBUNIT.
    6. "The action of N-terminal acetyltransferases on yeast ribosomal proteins."
      Arnold R.J., Polevoda B., Reilly J.P., Sherman F.
      J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2 BY NATA.
    7. "The ribosomal protein Rps15p is required for nuclear exit of the 40S subunit precursors in yeast."
      Leger-Silvestre I., Milkereit P., Ferreira-Cerca S., Saveanu C., Rousselle J.-C., Choesmel V., Guinefoleau C., Gas N., Gleizes P.-E.
      EMBO J. 23:2336-2347(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
      Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
      Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
      Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
      Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions."
      Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J.
      Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF 47-126, ELECTRON MICROSCOPY.
    13. "Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation."
      Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J.
      EMBO J. 23:1008-1019(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF 47-126, ELECTRON MICROSCOPY.

    Entry informationi

    Entry nameiRS15_YEAST
    AccessioniPrimary (citable) accession number: Q01855
    Secondary accession number(s): D6W226
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families
    4. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    5. Yeast chromosome XV
      Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

    External Data

    Dasty 3