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Q01855

- RS15_YEAST

UniProt

Q01855 - RS15_YEAST

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Protein

40S ribosomal protein S15

Gene

RPS15

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the nuclear export of the small ribosomal subunit. Has a role in the late stage of the assembly of pre-40S particles within the nucleus and controls their export to the cytoplasm.1 Publication

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. structural constituent of ribosome Source: SGD

GO - Biological processi

  1. cytoplasmic translation Source: SGD
  2. rRNA export from nucleus Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Biological processi

Ribosome biogenesis

Enzyme and pathway databases

BioCyciYEAST:G3O-33454-MONOMER.
ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_217188. Formation of a pool of free 40S subunits.
REACT_232946. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_248935. Ribosomal scanning and start codon recognition.
REACT_252688. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_257608. Formation of the ternary complex, and subsequently, the 43S complex.
REACT_257951. Peptide chain elongation.

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S15
Alternative name(s):
RIG protein
RP52
S21
YS21
Gene namesi
Name:RPS15
Synonyms:RPS21
Ordered Locus Names:YOL040C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XV

Organism-specific databases

CYGDiYOL040c.
SGDiS000005400. RPS15.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytosolic small ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 14214140S ribosomal protein S15PRO_0000130051Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine2 Publications

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ01855.
PaxDbiQ01855.
PeptideAtlasiQ01855.

Expressioni

Gene expression databases

GenevestigatoriQ01855.

Interactioni

Subunit structurei

Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi34362. 74 interactions.
IntActiQ01855. 5 interactions.
MINTiMINT-4986189.
STRINGi4932.YOL040C.

Structurei

Secondary structure

1
142
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi16 – 194Combined sources
Helixi22 – 265Combined sources
Helixi30 – 367Combined sources
Helixi39 – 468Combined sources
Helixi54 – 6613Combined sources
Beta strandi69 – 713Combined sources
Beta strandi76 – 783Combined sources
Helixi87 – 893Combined sources
Beta strandi93 – 10614Combined sources
Helixi109 – 1113Combined sources
Helixi116 – 1194Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K5Xmodel-S47-126[»]
1S1Helectron microscopy11.70S47-126[»]
1VW9electron microscopy6.10Q1-142[»]
1VWVelectron microscopy6.10Q1-142[»]
1VXWelectron microscopy6.20P1-142[»]
1VXZelectron microscopy6.30P1-142[»]
3IZBelectron microscopy-R1-142[»]
3O2ZX-ray4.00I1-142[»]
3O30X-ray4.00I1-142[»]
3U5CX-ray3.00P1-142[»]
3U5GX-ray3.00P1-142[»]
4BYLelectron microscopy4.30P1-142[»]
4BYTelectron microscopy6.60P1-142[»]
4CUYelectron microscopy3.70P12-126[»]
ProteinModelPortaliQ01855.
SMRiQ01855. Positions 4-138.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ01855.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S19P family.Curated

Phylogenomic databases

eggNOGiCOG0185.
GeneTreeiENSGT00390000000475.
HOGENOMiHOG000111561.
InParanoidiQ01855.
KOiK02958.
OMAiYCARQRR.
OrthoDBiEOG7FBRW1.

Family and domain databases

Gene3Di3.30.860.10. 1 hit.
HAMAPiMF_00531. Ribosomal_S19.
InterProiIPR002222. Ribosomal_S19.
IPR020934. Ribosomal_S19_CS.
IPR023575. Ribosomal_S19_SF.
IPR005713. Ribosomal_S19A/S15e.
[Graphical view]
PANTHERiPTHR11880. PTHR11880. 1 hit.
PfamiPF00203. Ribosomal_S19. 1 hit.
[Graphical view]
PIRSFiPIRSF002144. Ribosomal_S19. 1 hit.
PRINTSiPR00975. RIBOSOMALS19.
SUPFAMiSSF54570. SSF54570. 1 hit.
TIGRFAMsiTIGR01025. rpsS_arch. 1 hit.
PROSITEiPS00323. RIBOSOMAL_S19. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01855-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQAVNAKKR VFKTHSYRGV DLEKLLEMST EDFVKLAPAR VRRRFARGMT
60 70 80 90 100
SKPAGFMKKL RAAKLAAPEN EKPAPVRTHM RNMIIVPEMI GSVVGIYNGK
110 120 130 140
AFNQVEIRPE MLGHYLGEFS ITYTPVRHGR AGATTSRFIP LK
Length:142
Mass (Da):16,002
Last modified:April 1, 1993 - v1
Checksum:i06B564FD68051CD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11386 mRNA. Translation: BAA01982.1.
D11387 Genomic DNA. Translation: BAA01983.1.
Z74782 Genomic DNA. Translation: CAA99042.1.
AY558426 Genomic DNA. Translation: AAS56752.1.
BK006948 Genomic DNA. Translation: DAA10742.1.
PIRiS24053.
RefSeqiNP_014602.1. NM_001183294.1.

Genome annotation databases

EnsemblFungiiYOL040C; YOL040C; YOL040C.
GeneIDi854117.
KEGGisce:YOL040C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11386 mRNA. Translation: BAA01982.1 .
D11387 Genomic DNA. Translation: BAA01983.1 .
Z74782 Genomic DNA. Translation: CAA99042.1 .
AY558426 Genomic DNA. Translation: AAS56752.1 .
BK006948 Genomic DNA. Translation: DAA10742.1 .
PIRi S24053.
RefSeqi NP_014602.1. NM_001183294.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1K5X model - S 47-126 [» ]
1S1H electron microscopy 11.70 S 47-126 [» ]
1VW9 electron microscopy 6.10 Q 1-142 [» ]
1VWV electron microscopy 6.10 Q 1-142 [» ]
1VXW electron microscopy 6.20 P 1-142 [» ]
1VXZ electron microscopy 6.30 P 1-142 [» ]
3IZB electron microscopy - R 1-142 [» ]
3O2Z X-ray 4.00 I 1-142 [» ]
3O30 X-ray 4.00 I 1-142 [» ]
3U5C X-ray 3.00 P 1-142 [» ]
3U5G X-ray 3.00 P 1-142 [» ]
4BYL electron microscopy 4.30 P 1-142 [» ]
4BYT electron microscopy 6.60 P 1-142 [» ]
4CUY electron microscopy 3.70 P 12-126 [» ]
ProteinModelPortali Q01855.
SMRi Q01855. Positions 4-138.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34362. 74 interactions.
IntActi Q01855. 5 interactions.
MINTi MINT-4986189.
STRINGi 4932.YOL040C.

Proteomic databases

MaxQBi Q01855.
PaxDbi Q01855.
PeptideAtlasi Q01855.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YOL040C ; YOL040C ; YOL040C .
GeneIDi 854117.
KEGGi sce:YOL040C.

Organism-specific databases

CYGDi YOL040c.
SGDi S000005400. RPS15.

Phylogenomic databases

eggNOGi COG0185.
GeneTreei ENSGT00390000000475.
HOGENOMi HOG000111561.
InParanoidi Q01855.
KOi K02958.
OMAi YCARQRR.
OrthoDBi EOG7FBRW1.

Enzyme and pathway databases

BioCyci YEAST:G3O-33454-MONOMER.
Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_217188. Formation of a pool of free 40S subunits.
REACT_232946. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_248935. Ribosomal scanning and start codon recognition.
REACT_252688. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_257608. Formation of the ternary complex, and subsequently, the 43S complex.
REACT_257951. Peptide chain elongation.

Miscellaneous databases

EvolutionaryTracei Q01855.
NextBioi 975816.
PROi Q01855.

Gene expression databases

Genevestigatori Q01855.

Family and domain databases

Gene3Di 3.30.860.10. 1 hit.
HAMAPi MF_00531. Ribosomal_S19.
InterProi IPR002222. Ribosomal_S19.
IPR020934. Ribosomal_S19_CS.
IPR023575. Ribosomal_S19_SF.
IPR005713. Ribosomal_S19A/S15e.
[Graphical view ]
PANTHERi PTHR11880. PTHR11880. 1 hit.
Pfami PF00203. Ribosomal_S19. 1 hit.
[Graphical view ]
PIRSFi PIRSF002144. Ribosomal_S19. 1 hit.
PRINTSi PR00975. RIBOSOMALS19.
SUPFAMi SSF54570. SSF54570. 1 hit.
TIGRFAMsi TIGR01025. rpsS_arch. 1 hit.
PROSITEi PS00323. RIBOSOMAL_S19. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural determination of Saccharomyces cerevisiae rig gene and identification of its product as ribosomal protein S21."
    Takasawa S., Tohgo A., Unno M., Yonekura H., Okamoto H.
    FEBS Lett. 307:318-323(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
    Planta R.J., Mager W.H.
    Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE, SUBUNIT.
  6. "The action of N-terminal acetyltransferases on yeast ribosomal proteins."
    Arnold R.J., Polevoda B., Reilly J.P., Sherman F.
    J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2 BY NATA.
  7. "The ribosomal protein Rps15p is required for nuclear exit of the 40S subunit precursors in yeast."
    Leger-Silvestre I., Milkereit P., Ferreira-Cerca S., Saveanu C., Rousselle J.-C., Choesmel V., Guinefoleau C., Gas N., Gleizes P.-E.
    EMBO J. 23:2336-2347(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
    Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
    Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions."
    Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J.
    Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF 47-126, ELECTRON MICROSCOPY.
  13. "Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation."
    Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J.
    EMBO J. 23:1008-1019(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF 47-126, ELECTRON MICROSCOPY.

Entry informationi

Entry nameiRS15_YEAST
AccessioniPrimary (citable) accession number: Q01855
Secondary accession number(s): D6W226
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 26, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

External Data

Dasty 3