ID CDR2_HUMAN Reviewed; 454 AA. AC Q01850; A8K8A8; Q13977; DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot. DT 05-JUL-2005, sequence version 2. DT 24-JAN-2024, entry version 167. DE RecName: Full=Cerebellar degeneration-related protein 2; DE AltName: Full=Major Yo paraneoplastic antigen; DE AltName: Full=Paraneoplastic cerebellar degeneration-associated antigen; GN Name=CDR2; Synonyms=PCD17; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=2014264; DOI=10.1073/pnas.88.8.3451; RA Fathallah-Shaykh H., Wolf S., Wong E., Posner J.B., Furneaux H.M.; RT "Cloning of a leucine-zipper protein recognized by the sera of patients RT with antibody-associated paraneoplastic cerebellar degeneration."; RL Proc. Natl. Acad. Sci. U.S.A. 88:3451-3454(1991). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Testis; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Eye; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] OF 6-454. RC TISSUE=Cerebellum; RX PubMed=2260856; DOI=10.1002/ana.410280515; RA Sakai K., Mitchell D.J., Tsukamoto T., Steinman L.; RT "Isolation of a complementary DNA clone encoding an autoantigen recognized RT by an anti-neuronal cell antibody from a patient with paraneoplastic RT cerebellar degeneration."; RL Ann. Neurol. 28:692-698(1990). RN [6] RP ERRATUM OF PUBMED:2260856. RX PubMed=1763903; DOI=10.1002/ana.410300523; RA Sakai K., Mitchell D.J., Tsukamoto T., Steinman L.; RL Ann. Neurol. 30:738-738(1991). RN [7] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [8] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Leukemic T-cell; RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:RA46-RA46(2009). RN [9] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21406692; DOI=10.1126/scisignal.2001570; RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.; RT "System-wide temporal characterization of the proteome and phosphoproteome RT of human embryonic stem cell differentiation."; RL Sci. Signal. 4:RS3-RS3(2011). RN [10] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-311, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma, and Erythroleukemia; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [11] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., RA Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver RT phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC -!- INTERACTION: CC Q01850; Q9Y2J4-4: AMOTL2; NbExp=3; IntAct=EBI-1181367, EBI-10187270; CC Q01850; Q96IX9: ANKRD36BP1; NbExp=3; IntAct=EBI-1181367, EBI-744859; CC Q01850; P29972: AQP1; NbExp=3; IntAct=EBI-1181367, EBI-745213; CC Q01850; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-1181367, EBI-745073; CC Q01850; Q8TAB5: C1orf216; NbExp=6; IntAct=EBI-1181367, EBI-747505; CC Q01850; Q53TS8: C2CD6; NbExp=3; IntAct=EBI-1181367, EBI-739879; CC Q01850; Q504U0: C4orf46; NbExp=7; IntAct=EBI-1181367, EBI-6657981; CC Q01850; Q96HB5: CCDC120; NbExp=3; IntAct=EBI-1181367, EBI-744556; CC Q01850; Q8IYE1: CCDC13; NbExp=3; IntAct=EBI-1181367, EBI-10961312; CC Q01850; Q8IYE0: CCDC146; NbExp=3; IntAct=EBI-1181367, EBI-10749669; CC Q01850; Q494R4: CCDC153; NbExp=3; IntAct=EBI-1181367, EBI-10241443; CC Q01850; Q494R4-2: CCDC153; NbExp=3; IntAct=EBI-1181367, EBI-11974185; CC Q01850; Q9NVE4: CCDC87; NbExp=3; IntAct=EBI-1181367, EBI-749261; CC Q01850; Q8TD31-3: CCHCR1; NbExp=6; IntAct=EBI-1181367, EBI-10175300; CC Q01850; Q07002: CDK18; NbExp=3; IntAct=EBI-1181367, EBI-746238; CC Q01850; Q86X02: CDR2L; NbExp=5; IntAct=EBI-1181367, EBI-11063830; CC Q01850; Q8IYX8-2: CEP57L1; NbExp=3; IntAct=EBI-1181367, EBI-10181988; CC Q01850; Q9UKJ5: CHIC2; NbExp=7; IntAct=EBI-1181367, EBI-741528; CC Q01850; P10606: COX5B; NbExp=7; IntAct=EBI-1181367, EBI-1053725; CC Q01850; O60573: EIF4E2; NbExp=3; IntAct=EBI-1181367, EBI-398610; CC Q01850; Q9H0I2: ENKD1; NbExp=6; IntAct=EBI-1181367, EBI-744099; CC Q01850; Q9BQ89: FAM110A; NbExp=3; IntAct=EBI-1181367, EBI-1752811; CC Q01850; Q3B820: FAM161A; NbExp=6; IntAct=EBI-1181367, EBI-719941; CC Q01850; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-1181367, EBI-7225287; CC Q01850; Q9Y247: FAM50B; NbExp=3; IntAct=EBI-1181367, EBI-742802; CC Q01850; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-1181367, EBI-6658203; CC Q01850; O95995: GAS8; NbExp=3; IntAct=EBI-1181367, EBI-1052570; CC Q01850; P55040: GEM; NbExp=3; IntAct=EBI-1181367, EBI-744104; CC Q01850; Q96CS2: HAUS1; NbExp=3; IntAct=EBI-1181367, EBI-2514791; CC Q01850; P56524: HDAC4; NbExp=3; IntAct=EBI-1181367, EBI-308629; CC Q01850; P56524-2: HDAC4; NbExp=3; IntAct=EBI-1181367, EBI-11953488; CC Q01850; A0A0S2Z4Q4: HGS; NbExp=3; IntAct=EBI-1181367, EBI-16429135; CC Q01850; O14964: HGS; NbExp=6; IntAct=EBI-1181367, EBI-740220; CC Q01850; Q9C086: INO80B; NbExp=3; IntAct=EBI-1181367, EBI-715611; CC Q01850; Q7Z3B3: KANSL1; NbExp=4; IntAct=EBI-1181367, EBI-740244; CC Q01850; P33176: KIF5B; NbExp=3; IntAct=EBI-1181367, EBI-355878; CC Q01850; Q9BVG8: KIFC3; NbExp=3; IntAct=EBI-1181367, EBI-2125614; CC Q01850; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-1181367, EBI-14069005; CC Q01850; Q96BZ8: LENG1; NbExp=6; IntAct=EBI-1181367, EBI-726510; CC Q01850; Q96GY3: LIN37; NbExp=3; IntAct=EBI-1181367, EBI-748884; CC Q01850; Q8IVT4: MGC50722; NbExp=3; IntAct=EBI-1181367, EBI-14086479; CC Q01850; Q8IY33: MICALL2; NbExp=3; IntAct=EBI-1181367, EBI-2555563; CC Q01850; Q9NPJ1: MKKS; NbExp=3; IntAct=EBI-1181367, EBI-721319; CC Q01850; Q8NEH6: MNS1; NbExp=3; IntAct=EBI-1181367, EBI-743811; CC Q01850; Q15014: MORF4L2; NbExp=6; IntAct=EBI-1181367, EBI-399257; CC Q01850; Q13084: MRPL28; NbExp=3; IntAct=EBI-1181367, EBI-723426; CC Q01850; Q96HA8: NTAQ1; NbExp=4; IntAct=EBI-1181367, EBI-741158; CC Q01850; O95190: OAZ2; NbExp=3; IntAct=EBI-1181367, EBI-1051861; CC Q01850; Q17RL8: PDZD4; NbExp=3; IntAct=EBI-1181367, EBI-10239064; CC Q01850; Q16512: PKN1; NbExp=6; IntAct=EBI-1181367, EBI-602382; CC Q01850; P54646: PRKAA2; NbExp=3; IntAct=EBI-1181367, EBI-1383852; CC Q01850; Q99633: PRPF18; NbExp=3; IntAct=EBI-1181367, EBI-2798416; CC Q01850; P25786: PSMA1; NbExp=3; IntAct=EBI-1181367, EBI-359352; CC Q01850; Q9P2K3: RCOR3; NbExp=3; IntAct=EBI-1181367, EBI-743428; CC Q01850; Q9UHP6: RSPH14; NbExp=3; IntAct=EBI-1181367, EBI-748350; CC Q01850; Q06455-2: RUNX1T1; NbExp=3; IntAct=EBI-1181367, EBI-11984663; CC Q01850; Q9BWG6: SCNM1; NbExp=6; IntAct=EBI-1181367, EBI-748391; CC Q01850; Q9H788: SH2D4A; NbExp=6; IntAct=EBI-1181367, EBI-747035; CC Q01850; Q9H788-2: SH2D4A; NbExp=3; IntAct=EBI-1181367, EBI-10308083; CC Q01850; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-1181367, EBI-358489; CC Q01850; Q969G3: SMARCE1; NbExp=6; IntAct=EBI-1181367, EBI-455078; CC Q01850; Q9NU19: TBC1D22B; NbExp=4; IntAct=EBI-1181367, EBI-8787464; CC Q01850; Q9BT92: TCHP; NbExp=8; IntAct=EBI-1181367, EBI-740781; CC Q01850; Q15561: TEAD4; NbExp=3; IntAct=EBI-1181367, EBI-747736; CC Q01850; O15482: TEX28P2; NbExp=3; IntAct=EBI-1181367, EBI-751954; CC Q01850; P36406: TRIM23; NbExp=6; IntAct=EBI-1181367, EBI-740098; CC Q01850; Q8N7C3: TRIML2; NbExp=3; IntAct=EBI-1181367, EBI-11059915; CC Q01850; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-1181367, EBI-10241197; CC Q01850; Q5W5X9-3: TTC23; NbExp=3; IntAct=EBI-1181367, EBI-9090990; CC Q01850; P02766: TTR; NbExp=3; IntAct=EBI-1181367, EBI-711909; CC Q01850; P40222: TXLNA; NbExp=7; IntAct=EBI-1181367, EBI-359793; CC Q01850; Q8N3L3: TXLNB; NbExp=3; IntAct=EBI-1181367, EBI-6116822; CC Q01850; P0CB47: UBTFL1; NbExp=3; IntAct=EBI-1181367, EBI-17208936; CC Q01850; A0A0S2Z6H0: ZGPAT; NbExp=4; IntAct=EBI-1181367, EBI-16428984; CC Q01850; Q8N5A5-2: ZGPAT; NbExp=6; IntAct=EBI-1181367, EBI-10183064; CC Q01850; Q96NC0: ZMAT2; NbExp=3; IntAct=EBI-1181367, EBI-2682299; CC Q01850; P15622-3: ZNF250; NbExp=3; IntAct=EBI-1181367, EBI-10177272; CC Q01850; P13682: ZNF35; NbExp=3; IntAct=EBI-1181367, EBI-11041653; CC Q01850; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-1181367, EBI-740727; CC -!- SIMILARITY: Belongs to the CDR2 family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAA51961.1; Type=Frameshift; Evidence={ECO:0000305}; CC Sequence=AAB20813.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC Sequence=BAA02360.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M63256; AAA51961.1; ALT_SEQ; mRNA. DR EMBL; AK292273; BAF84962.1; -; mRNA. DR EMBL; CH471249; EAW50609.1; -; Genomic_DNA. DR EMBL; BC017503; AAH17503.2; -; mRNA. DR EMBL; D12981; BAA02360.1; ALT_INIT; mRNA. DR EMBL; S78388; AAB20813.1; ALT_INIT; mRNA. DR CCDS; CCDS32404.1; -. DR PIR; A40448; A40448. DR RefSeq; NP_001793.1; NM_001802.1. DR RefSeq; XP_005276559.1; XM_005276502.1. DR AlphaFoldDB; Q01850; -. DR SMR; Q01850; -. DR BioGRID; 107470; 138. DR IntAct; Q01850; 113. DR MINT; Q01850; -. DR STRING; 9606.ENSP00000268383; -. DR GlyGen; Q01850; 1 site, 1 O-linked glycan (1 site). DR iPTMnet; Q01850; -. DR PhosphoSitePlus; Q01850; -. DR BioMuta; CDR2; -. DR DMDM; 68839004; -. DR EPD; Q01850; -. DR jPOST; Q01850; -. DR MassIVE; Q01850; -. DR MaxQB; Q01850; -. DR PaxDb; 9606-ENSP00000268383; -. DR PeptideAtlas; Q01850; -. DR ProteomicsDB; 58009; -. DR Pumba; Q01850; -. DR Antibodypedia; 12516; 429 antibodies from 29 providers. DR DNASU; 1039; -. DR Ensembl; ENST00000268383.7; ENSP00000268383.2; ENSG00000140743.8. DR GeneID; 1039; -. DR KEGG; hsa:1039; -. DR MANE-Select; ENST00000268383.7; ENSP00000268383.2; NM_001802.2; NP_001793.1. DR UCSC; uc002dkn.3; human. DR AGR; HGNC:1799; -. DR CTD; 1039; -. DR DisGeNET; 1039; -. DR GeneCards; CDR2; -. DR HGNC; HGNC:1799; CDR2. DR HPA; ENSG00000140743; Low tissue specificity. DR MIM; 117340; gene. DR neXtProt; NX_Q01850; -. DR OpenTargets; ENSG00000140743; -. DR PharmGKB; PA26331; -. DR VEuPathDB; HostDB:ENSG00000140743; -. DR eggNOG; ENOG502QUPP; Eukaryota. DR GeneTree; ENSGT00390000018570; -. DR HOGENOM; CLU_048751_0_0_1; -. DR InParanoid; Q01850; -. DR OMA; GCRARQK; -. DR OrthoDB; 2903182at2759; -. DR PhylomeDB; Q01850; -. DR TreeFam; TF326183; -. DR PathwayCommons; Q01850; -. DR SignaLink; Q01850; -. DR SIGNOR; Q01850; -. DR BioGRID-ORCS; 1039; 16 hits in 1165 CRISPR screens. DR ChiTaRS; CDR2; human. DR GeneWiki; CDR2_(gene); -. DR Pharos; Q01850; Tbio. DR PRO; PR:Q01850; -. DR Proteomes; UP000005640; Chromosome 16. DR RNAct; Q01850; Protein. DR Bgee; ENSG00000140743; Expressed in secondary oocyte and 171 other cell types or tissues. DR ExpressionAtlas; Q01850; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl. DR InterPro; IPR026079; CDR2. DR PANTHER; PTHR19232; CENTROCORTIN FAMILY MEMBER; 1. DR PANTHER; PTHR19232:SF1; CEREBELLAR DEGENERATION-RELATED PROTEIN 2; 1. DR Genevisible; Q01850; HS. PE 1: Evidence at protein level; KW Coiled coil; Phosphoprotein; Reference proteome. FT CHAIN 1..454 FT /note="Cerebellar degeneration-related protein 2" FT /id="PRO_0000089456" FT REGION 134..153 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 44..142 FT /evidence="ECO:0000255" FT COILED 192..265 FT /evidence="ECO:0000255" FT COILED 346..380 FT /evidence="ECO:0000255" FT MOD_RES 311 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:23186163" FT CONFLICT 6 FT /note="L -> R (in Ref. 5; AAB20813)" FT /evidence="ECO:0000305" FT CONFLICT 7 FT /note="V -> T (in Ref. 5; AAB20813/BAA02360)" FT /evidence="ECO:0000305" SQ SEQUENCE 454 AA; 51855 MW; A7615F2C5AE08D2C CRC64; MLAENLVEEF EMKEDEPWYD HQDLQQDLQL AAELGKTLLD RNTELEDSVQ QMYTTNQEQL QEIEYLTKQV ELLRQMNEQH AKVYEQLDVT ARELEETNQK LVADSKASQQ KILSLTETIE CLQTNIDHLQ SQVEELKSSG QGRRSPGKCD QEKPAPSFAC LKELYDLRQH FVYDHVFAEK ITSLQGQPSP DEEENEHLKK TVTMLQAQLS LERQKRVTME EEYGLVLKEN SELEQQLGAT GAYRARALEL EAEVAEMRQM LQSEHPFVNG VEKLVPDSLY VPFKEPSQSL LEEMFLTVPE SHRKPLKRSS SETILSSLAG SDIVKGHEET CIRRAKAVKQ RGISLLHEVD TQYSALKVKY EELLKKCQEE QDSLSHKAVQ TSRAAAKDLT GVNAQSEPVA SGWELASVNP EPVSSPTTPP EYKALFKEIF SCIKKTKQEI DEQRTKYRSL SSHS //