Q01850 (CDR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cerebellar degeneration-related protein 2

Alternative name(s):
Major Yo paraneoplastic antigen
Paraneoplastic cerebellar degeneration-associated antigen

Gene names

Name:	CDR2
Synonyms:	PCD17

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	454 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Belongs to the CDR2 family.
Sequence caution	The sequence AAA51961.1 differs from that shown. Reason: Frameshift at positions 379, 384 and 393. The sequence AAB20813.1 differs from that shown. Reason: Erroneous initiation. The sequence BAA02360.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara nucleus Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
MORF4L2	Q15014	6	EBI-1181367,EBI-399257

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 454	454	Cerebellar degeneration-related protein 2		PRO_0000089456
Regions
	Coiled coil	44 – 142	99	Potential
	Coiled coil	192 – 265	74	Potential
	Coiled coil	346 – 380	35	Potential
Experimental info
	Sequence conflict	6	1	L → R in AAB20813. Ref.5
	Sequence conflict	7	1	V → T in AAB20813. Ref.5
	Sequence conflict	7	1	V → T in BAA02360. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q01850 [UniParc]. Last modified July 5, 2005. Version 2. Checksum: A7615F2C5AE08D2C	FASTA	454	51,855
	10 20 30 40 50 60 MLAENLVEEF EMKEDEPWYD HQDLQQDLQL AAELGKTLLD RNTELEDSVQ QMYTTNQEQL 70 80 90 100 110 120 QEIEYLTKQV ELLRQMNEQH AKVYEQLDVT ARELEETNQK LVADSKASQQ KILSLTETIE 130 140 150 160 170 180 CLQTNIDHLQ SQVEELKSSG QGRRSPGKCD QEKPAPSFAC LKELYDLRQH FVYDHVFAEK 190 200 210 220 230 240 ITSLQGQPSP DEEENEHLKK TVTMLQAQLS LERQKRVTME EEYGLVLKEN SELEQQLGAT 250 260 270 280 290 300 GAYRARALEL EAEVAEMRQM LQSEHPFVNG VEKLVPDSLY VPFKEPSQSL LEEMFLTVPE 310 320 330 340 350 360 SHRKPLKRSS SETILSSLAG SDIVKGHEET CIRRAKAVKQ RGISLLHEVD TQYSALKVKY 370 380 390 400 410 420 EELLKKCQEE QDSLSHKAVQ TSRAAAKDLT GVNAQSEPVA SGWELASVNP EPVSSPTTPP 430 440 450 EYKALFKEIF SCIKKTKQEI DEQRTKYRSL SSHS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a leucine-zipper protein recognized by the sera of patients with antibody-associated paraneoplastic cerebellar degeneration." Fathallah-Shaykh H., Wolf S., Wong E., Posner J.B., Furneaux H.M. Proc. Natl. Acad. Sci. U.S.A. 88:3451-3454(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[5]	"Isolation of a complementary DNA clone encoding an autoantigen recognized by an anti-neuronal cell antibody from a patient with paraneoplastic cerebellar degeneration." Sakai K., Mitchell D.J., Tsukamoto T., Steinman L. Ann. Neurol. 28:692-698(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-454. Tissue: Cerebellum.
[6]	Erratum Sakai K., Mitchell D.J., Tsukamoto T., Steinman L. Ann. Neurol. 30:738-738(1991) [PubMed] [Europe PMC] [Abstract]
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[8]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[9]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M63256 mRNA. Translation: AAA51961.1. Sequence problems. AK292273 mRNA. Translation: BAF84962.1. CH471249 Genomic DNA. Translation: EAW50609.1. BC017503 mRNA. Translation: AAH17503.2. D12981 mRNA. Translation: BAA02360.1. Different initiation. S78388 mRNA. Translation: AAB20813.1. Different initiation.
IPI	IPI00009862.
PIR	A40448.
RefSeq	NP_001793.1. NM_001802.1.
UniGene	Hs.513430.
3D structure databases
ProteinModelPortal	Q01850.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q01850. 4 interactions.
STRING	9606.ENSP00000268383.
PTM databases
PhosphoSite	Q01850.
Polymorphism databases
DMDM	68839004.
Proteomic databases
PaxDb	Q01850.
PRIDE	Q01850.
Protocols and materials databases
DNASU	1039.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000268383; ENSP00000268383; ENSG00000140743.
GeneID	1039.
KEGG	hsa:1039.
UCSC	uc002dkn.3. human.
Organism-specific databases
CTD	1039.
GeneCards	GC16M022357.
HGNC	HGNC:1799. CDR2.
HPA	HPA018151. HPA023870.
MIM	117340. gene.
neXtProt	NX_Q01850.
PharmGKB	PA26331.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG80525.
HOGENOM	HOG000013160.
HOVERGEN	HBG006695.
InParanoid	Q01850.
OMA	HKAVQTS.
OrthoDB	EOG4ZCT4J.
Gene expression databases
ArrayExpress	Q01850.
Bgee	Q01850.
CleanEx	HS_CDR2.
Genevestigator	Q01850.
GermOnline	ENSG00000140743. Homo sapiens.
Family and domain databases
InterPro	IPR026079. CDR2. [Graphical view]
PANTHER	PTHR19232. PTHR19232. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	CDR2. human.
GenomeRNAi	1039.
NextBio	4361.
SOURCE	Search...

Entry information

Entry name

CDR2_HUMAN

Accession

Primary (citable) accession number: Q01850
Secondary accession number(s): A8K8A8, Q13977

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 5, 2005
Last modified:	April 3, 2013
This is version 94 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.