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Q01850

- CDR2_HUMAN

UniProt

Q01850 - CDR2_HUMAN

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Protein

Cerebellar degeneration-related protein 2

Gene

CDR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Cerebellar degeneration-related protein 2
Alternative name(s):
Major Yo paraneoplastic antigen
Paraneoplastic cerebellar degeneration-associated antigen
Gene namesi
Name:CDR2
Synonyms:PCD17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:1799. CDR2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26331.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 454454Cerebellar degeneration-related protein 2PRO_0000089456Add
BLAST

Proteomic databases

MaxQBiQ01850.
PaxDbiQ01850.
PRIDEiQ01850.

PTM databases

PhosphoSiteiQ01850.

Expressioni

Gene expression databases

BgeeiQ01850.
CleanExiHS_CDR2.
ExpressionAtlasiQ01850. baseline and differential.
GenevestigatoriQ01850.

Organism-specific databases

HPAiHPA018151.
HPA023870.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MORF4L2Q150146EBI-1181367,EBI-399257

Protein-protein interaction databases

BioGridi107470. 13 interactions.
IntActiQ01850. 4 interactions.
STRINGi9606.ENSP00000268383.

Structurei

3D structure databases

ProteinModelPortaliQ01850.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili44 – 14299Sequence AnalysisAdd
BLAST
Coiled coili192 – 26574Sequence AnalysisAdd
BLAST
Coiled coili346 – 38035Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the CDR2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG80525.
GeneTreeiENSGT00390000018570.
HOGENOMiHOG000013160.
HOVERGENiHBG006695.
InParanoidiQ01850.
OMAiLQTNIDH.
OrthoDBiEOG70ZZNB.
PhylomeDBiQ01850.
TreeFamiTF326183.

Family and domain databases

InterProiIPR026079. CDR2.
[Graphical view]
PANTHERiPTHR19232. PTHR19232. 1 hit.

Sequencei

Sequence statusi: Complete.

Q01850-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLAENLVEEF EMKEDEPWYD HQDLQQDLQL AAELGKTLLD RNTELEDSVQ
60 70 80 90 100
QMYTTNQEQL QEIEYLTKQV ELLRQMNEQH AKVYEQLDVT ARELEETNQK
110 120 130 140 150
LVADSKASQQ KILSLTETIE CLQTNIDHLQ SQVEELKSSG QGRRSPGKCD
160 170 180 190 200
QEKPAPSFAC LKELYDLRQH FVYDHVFAEK ITSLQGQPSP DEEENEHLKK
210 220 230 240 250
TVTMLQAQLS LERQKRVTME EEYGLVLKEN SELEQQLGAT GAYRARALEL
260 270 280 290 300
EAEVAEMRQM LQSEHPFVNG VEKLVPDSLY VPFKEPSQSL LEEMFLTVPE
310 320 330 340 350
SHRKPLKRSS SETILSSLAG SDIVKGHEET CIRRAKAVKQ RGISLLHEVD
360 370 380 390 400
TQYSALKVKY EELLKKCQEE QDSLSHKAVQ TSRAAAKDLT GVNAQSEPVA
410 420 430 440 450
SGWELASVNP EPVSSPTTPP EYKALFKEIF SCIKKTKQEI DEQRTKYRSL

SSHS
Length:454
Mass (Da):51,855
Last modified:July 5, 2005 - v2
Checksum:iA7615F2C5AE08D2C
GO

Sequence cautioni

The sequence AAA51961.1 differs from that shown. Reason: Frameshift at positions 379, 384 and 393.
The sequence AAB20813.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAA02360.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61L → R in AAB20813. (PubMed:2260856)Curated
Sequence conflicti7 – 71V → T in AAB20813. (PubMed:2260856)Curated
Sequence conflicti7 – 71V → T in BAA02360. (PubMed:2260856)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M63256 mRNA. Translation: AAA51961.1. Sequence problems.
AK292273 mRNA. Translation: BAF84962.1.
CH471249 Genomic DNA. Translation: EAW50609.1.
BC017503 mRNA. Translation: AAH17503.2.
D12981 mRNA. Translation: BAA02360.1. Different initiation.
S78388 mRNA. Translation: AAB20813.1. Different initiation.
CCDSiCCDS32404.1.
PIRiA40448.
RefSeqiNP_001793.1. NM_001802.1.
XP_005276559.1. XM_005276502.1.
UniGeneiHs.513430.

Genome annotation databases

EnsembliENST00000268383; ENSP00000268383; ENSG00000140743.
GeneIDi101060399.
1039.
KEGGihsa:101060399.
hsa:1039.
UCSCiuc002dkn.3. human.

Polymorphism databases

DMDMi68839004.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M63256 mRNA. Translation: AAA51961.1 . Sequence problems.
AK292273 mRNA. Translation: BAF84962.1 .
CH471249 Genomic DNA. Translation: EAW50609.1 .
BC017503 mRNA. Translation: AAH17503.2 .
D12981 mRNA. Translation: BAA02360.1 . Different initiation.
S78388 mRNA. Translation: AAB20813.1 . Different initiation.
CCDSi CCDS32404.1.
PIRi A40448.
RefSeqi NP_001793.1. NM_001802.1.
XP_005276559.1. XM_005276502.1.
UniGenei Hs.513430.

3D structure databases

ProteinModelPortali Q01850.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107470. 13 interactions.
IntActi Q01850. 4 interactions.
STRINGi 9606.ENSP00000268383.

PTM databases

PhosphoSitei Q01850.

Polymorphism databases

DMDMi 68839004.

Proteomic databases

MaxQBi Q01850.
PaxDbi Q01850.
PRIDEi Q01850.

Protocols and materials databases

DNASUi 1039.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000268383 ; ENSP00000268383 ; ENSG00000140743 .
GeneIDi 101060399.
1039.
KEGGi hsa:101060399.
hsa:1039.
UCSCi uc002dkn.3. human.

Organism-specific databases

CTDi 1039.
GeneCardsi GC16M022357.
HGNCi HGNC:1799. CDR2.
HPAi HPA018151.
HPA023870.
MIMi 117340. gene.
neXtProti NX_Q01850.
PharmGKBi PA26331.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG80525.
GeneTreei ENSGT00390000018570.
HOGENOMi HOG000013160.
HOVERGENi HBG006695.
InParanoidi Q01850.
OMAi LQTNIDH.
OrthoDBi EOG70ZZNB.
PhylomeDBi Q01850.
TreeFami TF326183.

Miscellaneous databases

ChiTaRSi CDR2. human.
GeneWikii CDR2_(gene).
NextBioi 4361.
PROi Q01850.
SOURCEi Search...

Gene expression databases

Bgeei Q01850.
CleanExi HS_CDR2.
ExpressionAtlasi Q01850. baseline and differential.
Genevestigatori Q01850.

Family and domain databases

InterProi IPR026079. CDR2.
[Graphical view ]
PANTHERi PTHR19232. PTHR19232. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a leucine-zipper protein recognized by the sera of patients with antibody-associated paraneoplastic cerebellar degeneration."
    Fathallah-Shaykh H., Wolf S., Wong E., Posner J.B., Furneaux H.M.
    Proc. Natl. Acad. Sci. U.S.A. 88:3451-3454(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  5. "Isolation of a complementary DNA clone encoding an autoantigen recognized by an anti-neuronal cell antibody from a patient with paraneoplastic cerebellar degeneration."
    Sakai K., Mitchell D.J., Tsukamoto T., Steinman L.
    Ann. Neurol. 28:692-698(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-454.
    Tissue: Cerebellum.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCDR2_HUMAN
AccessioniPrimary (citable) accession number: Q01850
Secondary accession number(s): A8K8A8, Q13977
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 5, 2005
Last modified: October 29, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3