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Protein

Cerebellar degeneration-related protein 2

Gene

CDR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

SIGNORiQ01850

Names & Taxonomyi

Protein namesi
Recommended name:
Cerebellar degeneration-related protein 2
Alternative name(s):
Major Yo paraneoplastic antigen
Paraneoplastic cerebellar degeneration-associated antigen
Gene namesi
Name:CDR2
Synonyms:PCD17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000140743.7
HGNCiHGNC:1799 CDR2
MIMi117340 gene
neXtProtiNX_Q01850

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi101060399
1039
OpenTargetsiENSG00000140743
PharmGKBiPA26331

Polymorphism and mutation databases

BioMutaiCDR2
DMDMi68839004

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000894561 – 454Cerebellar degeneration-related protein 2Add BLAST454

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei311PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ01850
MaxQBiQ01850
PaxDbiQ01850
PeptideAtlasiQ01850
PRIDEiQ01850

PTM databases

iPTMnetiQ01850
PhosphoSitePlusiQ01850

Expressioni

Gene expression databases

BgeeiENSG00000140743
CleanExiHS_CDR2
ExpressionAtlasiQ01850 baseline and differential
GenevisibleiQ01850 HS

Organism-specific databases

HPAiHPA018151
HPA023870

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi107470, 72 interactors
IntActiQ01850, 81 interactors
STRINGi9606.ENSP00000268383

Structurei

3D structure databases

ProteinModelPortaliQ01850
SMRiQ01850
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili44 – 142Sequence analysisAdd BLAST99
Coiled coili192 – 265Sequence analysisAdd BLAST74
Coiled coili346 – 380Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the CDR2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IDY5 Eukaryota
ENOG410XNUZ LUCA
GeneTreeiENSGT00390000018570
HOGENOMiHOG000013160
HOVERGENiHBG006695
InParanoidiQ01850
OMAiQMNDQHA
OrthoDBiEOG091G071C
PhylomeDBiQ01850
TreeFamiTF326183

Family and domain databases

InterProiView protein in InterPro
IPR026079 CDR2
PANTHERiPTHR19232 PTHR19232, 1 hit

Sequencei

Sequence statusi: Complete.

Q01850-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAENLVEEF EMKEDEPWYD HQDLQQDLQL AAELGKTLLD RNTELEDSVQ
60 70 80 90 100
QMYTTNQEQL QEIEYLTKQV ELLRQMNEQH AKVYEQLDVT ARELEETNQK
110 120 130 140 150
LVADSKASQQ KILSLTETIE CLQTNIDHLQ SQVEELKSSG QGRRSPGKCD
160 170 180 190 200
QEKPAPSFAC LKELYDLRQH FVYDHVFAEK ITSLQGQPSP DEEENEHLKK
210 220 230 240 250
TVTMLQAQLS LERQKRVTME EEYGLVLKEN SELEQQLGAT GAYRARALEL
260 270 280 290 300
EAEVAEMRQM LQSEHPFVNG VEKLVPDSLY VPFKEPSQSL LEEMFLTVPE
310 320 330 340 350
SHRKPLKRSS SETILSSLAG SDIVKGHEET CIRRAKAVKQ RGISLLHEVD
360 370 380 390 400
TQYSALKVKY EELLKKCQEE QDSLSHKAVQ TSRAAAKDLT GVNAQSEPVA
410 420 430 440 450
SGWELASVNP EPVSSPTTPP EYKALFKEIF SCIKKTKQEI DEQRTKYRSL

SSHS
Length:454
Mass (Da):51,855
Last modified:July 5, 2005 - v2
Checksum:iA7615F2C5AE08D2C
GO

Sequence cautioni

The sequence AAA51961 differs from that shown. Reason: Frameshift at positions 379, 384 and 393.Curated
The sequence AAB20813 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA02360 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6L → R in AAB20813 (PubMed:2260856).Curated1
Sequence conflicti7V → T in AAB20813 (PubMed:2260856).Curated1
Sequence conflicti7V → T in BAA02360 (PubMed:2260856).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63256 mRNA Translation: AAA51961.1 Sequence problems.
AK292273 mRNA Translation: BAF84962.1
CH471249 Genomic DNA Translation: EAW50609.1
BC017503 mRNA Translation: AAH17503.2
D12981 mRNA Translation: BAA02360.1 Different initiation.
S78388 mRNA Translation: AAB20813.1 Different initiation.
CCDSiCCDS32404.1
PIRiA40448
RefSeqiNP_001793.1, NM_001802.1
XP_005276559.1, XM_005276502.1
UniGeneiHs.513430

Genome annotation databases

EnsembliENST00000268383; ENSP00000268383; ENSG00000140743
GeneIDi1039
KEGGihsa:101060399
hsa:1039
UCSCiuc002dkn.3 human

Similar proteinsi

Entry informationi

Entry nameiCDR2_HUMAN
AccessioniPrimary (citable) accession number: Q01850
Secondary accession number(s): A8K8A8, Q13977
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 5, 2005
Last modified: May 23, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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