Reviewed, UniProtKB/Swiss-Prot Q01850 (CDR2_HUMAN)

Names and origin

Protein names

Recommended name:
    Cerebellar degeneration-related protein 2
Alternative name(s):
    Paraneoplastic cerebellar degeneration-associated antigen
    Major Yo paraneoplastic antigen

Gene names

Name:	CDR2
Synonyms:	PCD17

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	454 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities	Belongs to the CDR2 family.
Sequence caution	The sequence AAA51961.1 differs from that shown. Reason: Frameshift at positions 379, 384 and 393.

Ontologies

Keywords
Domain	Coiled coil
Gene Ontology (GO)
Cellular component	nucleus Non-traceable author statement. Source: UniProtKB
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
MORF4L2	Q15014	4	EBI-1181367,EBI-399257

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 454	454	Cerebellar degeneration-related protein 2		PRO_0000089456
Regions
	Coiled coil	44 – 142	99	Potential
	Coiled coil	192 – 265	74	Potential
	Coiled coil	346 – 380	35	Potential
Experimental info
	Sequence conflict	6	1	L → R in AAB20813. Ref.3
	Sequence conflict	7	1	V → T in AAB20813 and BAA02360. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q01850-1 [UniParc]. Last modified July 5, 2005. Version 2. Checksum: A7615F2C5AE08D2C	FASTA	454	51,855
	10 20 30 40 50 60 MLAENLVEEF EMKEDEPWYD HQDLQQDLQL AAELGKTLLD RNTELEDSVQ QMYTTNQEQL 70 80 90 100 110 120 QEIEYLTKQV ELLRQMNEQH AKVYEQLDVT ARELEETNQK LVADSKASQQ KILSLTETIE 130 140 150 160 170 180 CLQTNIDHLQ SQVEELKSSG QGRRSPGKCD QEKPAPSFAC LKELYDLRQH FVYDHVFAEK 190 200 210 220 230 240 ITSLQGQPSP DEEENEHLKK TVTMLQAQLS LERQKRVTME EEYGLVLKEN SELEQQLGAT 250 260 270 280 290 300 GAYRARALEL EAEVAEMRQM LQSEHPFVNG VEKLVPDSLY VPFKEPSQSL LEEMFLTVPE 310 320 330 340 350 360 SHRKPLKRSS SETILSSLAG SDIVKGHEET CIRRAKAVKQ RGISLLHEVD TQYSALKVKY 370 380 390 400 410 420 EELLKKCQEE QDSLSHKAVQ TSRAAAKDLT GVNAQSEPVA SGWELASVNP EPVSSPTTPP 430 440 450 EYKALFKEIF SCIKKTKQEI DEQRTKYRSL SSHS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a leucine-zipper protein recognized by the sera of patients with antibody-associated paraneoplastic cerebellar degeneration." Fathallah-Shaykh H., Wolf S., Wong E., Posner J.B., Furneaux H.M. Proc. Natl. Acad. Sci. U.S.A. 88:3451-3454(1991) [PubMed: 2014264] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[3]	"Isolation of a complementary DNA clone encoding an autoantigen recognized by an anti-neuronal cell antibody from a patient with paraneoplastic cerebellar degeneration." Sakai K., Mitchell D.J., Tsukamoto T., Steinman L. Ann. Neurol. 28:692-698(1990) [PubMed: 2260856] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-454. Tissue: Cerebellum.
[4]	Erratum Sakai K., Mitchell D.J., Tsukamoto T., Steinman L. Ann. Neurol. 30:738-738(1991) [PubMed: 1763903] [Abstract]
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M63256 mRNA. Translation: AAA51961.1. Sequence problems. BC017503 mRNA. Translation: AAH17503.2. D12981 mRNA. Translation: BAA02360.1. Different initiation. S78388 mRNA. Translation: AAB20813.1. Different initiation.
PIR	A40448.
RefSeq	NP_001793.1.
UniGene	Hs.513430
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q01850.
PTM databases
PhosphoSite	Q01850.
Genome annotation databases
Ensembl	ENSG00000140743. Homo sapiens. [Contig view]
GeneID	1039.
KEGG	hsa:1039.
Organism-specific databases
H-InvDB	HIX0012884.
HGNC	HGNC:1799. CDR2.
HPA	HPA018151.
MIM	117340. gene.
PharmGKB	PA26331.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q01850.
HOVERGEN	Q01850.
Gene expression databases
ArrayExpress	Q01850.
CleanEx	HS_CDR2.
GermOnline	ENSG00000140743. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
LinkHub	Q01850.
NextBio	4361.
SOURCE	Search...

Entry information

Entry name

CDR2_HUMAN

Accession

Primary (citable) accession number: Q01850
Secondary accession number(s): Q13977

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 5, 2005
Last modified:	November 4, 2008
This is version 59 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)