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Protein

Cerebellar degeneration-related protein 2

Gene

CDR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

SIGNORiQ01850.

Names & Taxonomyi

Protein namesi
Recommended name:
Cerebellar degeneration-related protein 2
Alternative name(s):
Major Yo paraneoplastic antigen
Paraneoplastic cerebellar degeneration-associated antigen
Gene namesi
Name:CDR2
Synonyms:PCD17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:1799. CDR2.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

DisGeNETi101060399.
1039.
OpenTargetsiENSG00000140743.
PharmGKBiPA26331.

Polymorphism and mutation databases

BioMutaiCDR2.
DMDMi68839004.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000894561 – 454Cerebellar degeneration-related protein 2Add BLAST454

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei311PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ01850.
MaxQBiQ01850.
PaxDbiQ01850.
PeptideAtlasiQ01850.
PRIDEiQ01850.

PTM databases

iPTMnetiQ01850.
PhosphoSitePlusiQ01850.

Expressioni

Gene expression databases

BgeeiENSG00000140743.
CleanExiHS_CDR2.
ExpressionAtlasiQ01850. baseline and differential.
GenevisibleiQ01850. HS.

Organism-specific databases

HPAiHPA018151.
HPA023870.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi107470. 65 interactors.
IntActiQ01850. 80 interactors.
STRINGi9606.ENSP00000268383.

Structurei

3D structure databases

ProteinModelPortaliQ01850.
SMRiQ01850.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili44 – 142Sequence analysisAdd BLAST99
Coiled coili192 – 265Sequence analysisAdd BLAST74
Coiled coili346 – 380Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the CDR2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IDY5. Eukaryota.
ENOG410XNUZ. LUCA.
GeneTreeiENSGT00390000018570.
HOGENOMiHOG000013160.
HOVERGENiHBG006695.
InParanoidiQ01850.
OMAiRRSPGKC.
OrthoDBiEOG091G071C.
PhylomeDBiQ01850.
TreeFamiTF326183.

Family and domain databases

InterProiView protein in InterPro
IPR026079. CDR2.
PANTHERiPTHR19232. PTHR19232. 1 hit.

Sequencei

Sequence statusi: Complete.

Q01850-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAENLVEEF EMKEDEPWYD HQDLQQDLQL AAELGKTLLD RNTELEDSVQ
60 70 80 90 100
QMYTTNQEQL QEIEYLTKQV ELLRQMNEQH AKVYEQLDVT ARELEETNQK
110 120 130 140 150
LVADSKASQQ KILSLTETIE CLQTNIDHLQ SQVEELKSSG QGRRSPGKCD
160 170 180 190 200
QEKPAPSFAC LKELYDLRQH FVYDHVFAEK ITSLQGQPSP DEEENEHLKK
210 220 230 240 250
TVTMLQAQLS LERQKRVTME EEYGLVLKEN SELEQQLGAT GAYRARALEL
260 270 280 290 300
EAEVAEMRQM LQSEHPFVNG VEKLVPDSLY VPFKEPSQSL LEEMFLTVPE
310 320 330 340 350
SHRKPLKRSS SETILSSLAG SDIVKGHEET CIRRAKAVKQ RGISLLHEVD
360 370 380 390 400
TQYSALKVKY EELLKKCQEE QDSLSHKAVQ TSRAAAKDLT GVNAQSEPVA
410 420 430 440 450
SGWELASVNP EPVSSPTTPP EYKALFKEIF SCIKKTKQEI DEQRTKYRSL

SSHS
Length:454
Mass (Da):51,855
Last modified:July 5, 2005 - v2
Checksum:iA7615F2C5AE08D2C
GO

Sequence cautioni

The sequence AAA51961 differs from that shown. Reason: Frameshift at positions 379, 384 and 393.Curated
The sequence AAB20813 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA02360 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6L → R in AAB20813 (PubMed:2260856).Curated1
Sequence conflicti7V → T in AAB20813 (PubMed:2260856).Curated1
Sequence conflicti7V → T in BAA02360 (PubMed:2260856).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63256 mRNA. Translation: AAA51961.1. Sequence problems.
AK292273 mRNA. Translation: BAF84962.1.
CH471249 Genomic DNA. Translation: EAW50609.1.
BC017503 mRNA. Translation: AAH17503.2.
D12981 mRNA. Translation: BAA02360.1. Different initiation.
S78388 mRNA. Translation: AAB20813.1. Different initiation.
CCDSiCCDS32404.1.
PIRiA40448.
RefSeqiNP_001793.1. NM_001802.1.
XP_005276559.1. XM_005276502.1.
UniGeneiHs.513430.

Genome annotation databases

EnsembliENST00000268383; ENSP00000268383; ENSG00000140743.
GeneIDi101060399.
1039.
KEGGihsa:101060399.
hsa:1039.
UCSCiuc002dkn.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63256 mRNA. Translation: AAA51961.1. Sequence problems.
AK292273 mRNA. Translation: BAF84962.1.
CH471249 Genomic DNA. Translation: EAW50609.1.
BC017503 mRNA. Translation: AAH17503.2.
D12981 mRNA. Translation: BAA02360.1. Different initiation.
S78388 mRNA. Translation: AAB20813.1. Different initiation.
CCDSiCCDS32404.1.
PIRiA40448.
RefSeqiNP_001793.1. NM_001802.1.
XP_005276559.1. XM_005276502.1.
UniGeneiHs.513430.

3D structure databases

ProteinModelPortaliQ01850.
SMRiQ01850.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107470. 65 interactors.
IntActiQ01850. 80 interactors.
STRINGi9606.ENSP00000268383.

PTM databases

iPTMnetiQ01850.
PhosphoSitePlusiQ01850.

Polymorphism and mutation databases

BioMutaiCDR2.
DMDMi68839004.

Proteomic databases

EPDiQ01850.
MaxQBiQ01850.
PaxDbiQ01850.
PeptideAtlasiQ01850.
PRIDEiQ01850.

Protocols and materials databases

DNASUi1039.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268383; ENSP00000268383; ENSG00000140743.
GeneIDi101060399.
1039.
KEGGihsa:101060399.
hsa:1039.
UCSCiuc002dkn.3. human.

Organism-specific databases

CTDi1039.
DisGeNETi101060399.
1039.
GeneCardsiCDR2.
HGNCiHGNC:1799. CDR2.
HPAiHPA018151.
HPA023870.
MIMi117340. gene.
neXtProtiNX_Q01850.
OpenTargetsiENSG00000140743.
PharmGKBiPA26331.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IDY5. Eukaryota.
ENOG410XNUZ. LUCA.
GeneTreeiENSGT00390000018570.
HOGENOMiHOG000013160.
HOVERGENiHBG006695.
InParanoidiQ01850.
OMAiRRSPGKC.
OrthoDBiEOG091G071C.
PhylomeDBiQ01850.
TreeFamiTF326183.

Enzyme and pathway databases

SIGNORiQ01850.

Miscellaneous databases

ChiTaRSiCDR2. human.
GeneWikiiCDR2_(gene).
PROiPR:Q01850.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140743.
CleanExiHS_CDR2.
ExpressionAtlasiQ01850. baseline and differential.
GenevisibleiQ01850. HS.

Family and domain databases

InterProiView protein in InterPro
IPR026079. CDR2.
PANTHERiPTHR19232. PTHR19232. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCDR2_HUMAN
AccessioniPrimary (citable) accession number: Q01850
Secondary accession number(s): A8K8A8, Q13977
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 5, 2005
Last modified: May 10, 2017
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.