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Q01850 (CDR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cerebellar degeneration-related protein 2
Alternative name(s):
Major Yo paraneoplastic antigen
Paraneoplastic cerebellar degeneration-associated antigen
Gene names
Name:CDR2
Synonyms:PCD17
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length454 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the CDR2 family.

Sequence caution

The sequence AAA51961.1 differs from that shown. Reason: Frameshift at positions 379, 384 and 393.

The sequence AAB20813.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAA02360.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

MORF4L2Q150146EBI-1181367,EBI-399257

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 454454Cerebellar degeneration-related protein 2
PRO_0000089456

Regions

Coiled coil44 – 14299 Potential
Coiled coil192 – 26574 Potential
Coiled coil346 – 38035 Potential

Experimental info

Sequence conflict61L → R in AAB20813. Ref.5
Sequence conflict71V → T in AAB20813. Ref.5
Sequence conflict71V → T in BAA02360. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q01850 [UniParc].

Last modified July 5, 2005. Version 2.
Checksum: A7615F2C5AE08D2C

FASTA45451,855
        10         20         30         40         50         60 
MLAENLVEEF EMKEDEPWYD HQDLQQDLQL AAELGKTLLD RNTELEDSVQ QMYTTNQEQL 

        70         80         90        100        110        120 
QEIEYLTKQV ELLRQMNEQH AKVYEQLDVT ARELEETNQK LVADSKASQQ KILSLTETIE 

       130        140        150        160        170        180 
CLQTNIDHLQ SQVEELKSSG QGRRSPGKCD QEKPAPSFAC LKELYDLRQH FVYDHVFAEK 

       190        200        210        220        230        240 
ITSLQGQPSP DEEENEHLKK TVTMLQAQLS LERQKRVTME EEYGLVLKEN SELEQQLGAT 

       250        260        270        280        290        300 
GAYRARALEL EAEVAEMRQM LQSEHPFVNG VEKLVPDSLY VPFKEPSQSL LEEMFLTVPE 

       310        320        330        340        350        360 
SHRKPLKRSS SETILSSLAG SDIVKGHEET CIRRAKAVKQ RGISLLHEVD TQYSALKVKY 

       370        380        390        400        410        420 
EELLKKCQEE QDSLSHKAVQ TSRAAAKDLT GVNAQSEPVA SGWELASVNP EPVSSPTTPP 

       430        440        450 
EYKALFKEIF SCIKKTKQEI DEQRTKYRSL SSHS 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of a leucine-zipper protein recognized by the sera of patients with antibody-associated paraneoplastic cerebellar degeneration."
Fathallah-Shaykh H., Wolf S., Wong E., Posner J.B., Furneaux H.M.
Proc. Natl. Acad. Sci. U.S.A. 88:3451-3454(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
[5]"Isolation of a complementary DNA clone encoding an autoantigen recognized by an anti-neuronal cell antibody from a patient with paraneoplastic cerebellar degeneration."
Sakai K., Mitchell D.J., Tsukamoto T., Steinman L.
Ann. Neurol. 28:692-698(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-454.
Tissue: Cerebellum.
[6]Erratum
Sakai K., Mitchell D.J., Tsukamoto T., Steinman L.
Ann. Neurol. 30:738-738(1991) [PubMed] [Europe PMC] [Abstract]
[7]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[9]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M63256 mRNA. Translation: AAA51961.1. Sequence problems.
AK292273 mRNA. Translation: BAF84962.1.
CH471249 Genomic DNA. Translation: EAW50609.1.
BC017503 mRNA. Translation: AAH17503.2.
D12981 mRNA. Translation: BAA02360.1. Different initiation.
S78388 mRNA. Translation: AAB20813.1. Different initiation.
PIRA40448.
RefSeqNP_001793.1. NM_001802.1.
XP_005276559.1. XM_005276502.1.
UniGeneHs.513430.

3D structure databases

ProteinModelPortalQ01850.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107470. 8 interactions.
IntActQ01850. 4 interactions.
STRING9606.ENSP00000268383.

PTM databases

PhosphoSiteQ01850.

Polymorphism databases

DMDM68839004.

Proteomic databases

PaxDbQ01850.
PRIDEQ01850.

Protocols and materials databases

DNASU1039.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000268383; ENSP00000268383; ENSG00000140743.
GeneID101060399.
1039.
KEGGhsa:101060399.
hsa:1039.
UCSCuc002dkn.3. human.

Organism-specific databases

CTD1039.
GeneCardsGC16M022357.
HGNCHGNC:1799. CDR2.
HPAHPA018151.
HPA023870.
MIM117340. gene.
neXtProtNX_Q01850.
PharmGKBPA26331.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG80525.
HOGENOMHOG000013160.
HOVERGENHBG006695.
InParanoidQ01850.
OMALQTNIDH.
OrthoDBEOG70ZZNB.
PhylomeDBQ01850.
TreeFamTF326183.

Gene expression databases

ArrayExpressQ01850.
BgeeQ01850.
CleanExHS_CDR2.
GenevestigatorQ01850.

Family and domain databases

InterProIPR026079. CDR2.
[Graphical view]
PANTHERPTHR19232. PTHR19232. 1 hit.
ProtoNetSearch...

Other

ChiTaRSCDR2. human.
GeneWikiCDR2_(gene).
NextBio4361.
PROQ01850.
SOURCESearch...

Entry information

Entry nameCDR2_HUMAN
AccessionPrimary (citable) accession number: Q01850
Secondary accession number(s): A8K8A8, Q13977
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 5, 2005
Last modified: April 16, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM