Skip Header

 
Contribute Send feedback

Reviewed, UniProtKB/Swiss-Prot Q01850 (CDR2_HUMAN)

Last modified November 4, 2008. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Cerebellar degeneration-related protein 2
Alternative name(s):
    Paraneoplastic cerebellar degeneration-associated antigen
    Major Yo paraneoplastic antigen
Gene names
Name: CDR2
Synonyms: PCD17
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length454 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Sequence similarities

Belongs to the CDR2 family.

Sequence caution

The sequence AAA51961.1 differs from that shown. Reason: Frameshift at positions 379, 384 and 393.

Ontologies

Keywords

   DomainCoiled coil

Gene Ontology (GO)

   Cellular componentnucleus

Non-traceable author statement. Source: UniProtKB

   Molecular functionprotein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

MORF4L2Q150144EBI-1181367,EBI-399257

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 454454Cerebellar degeneration-related protein 2
PRO_0000089456

Regions

Coiled coil44 – 14299 Potential
Coiled coil192 – 26574 Potential
Coiled coil346 – 38035 Potential

Experimental info

Sequence conflict61L → R in AAB20813. Ref.3
Sequence conflict71V → T in AAB20813 and BAA02360. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q01850-1 [UniParc].

Last modified July 5, 2005. Version 2.
Checksum: A7615F2C5AE08D2C

FASTA45451,855
        10         20         30         40         50         60 
MLAENLVEEF EMKEDEPWYD HQDLQQDLQL AAELGKTLLD RNTELEDSVQ QMYTTNQEQL 

        70         80         90        100        110        120 
QEIEYLTKQV ELLRQMNEQH AKVYEQLDVT ARELEETNQK LVADSKASQQ KILSLTETIE 

       130        140        150        160        170        180 
CLQTNIDHLQ SQVEELKSSG QGRRSPGKCD QEKPAPSFAC LKELYDLRQH FVYDHVFAEK 

       190        200        210        220        230        240 
ITSLQGQPSP DEEENEHLKK TVTMLQAQLS LERQKRVTME EEYGLVLKEN SELEQQLGAT 

       250        260        270        280        290        300 
GAYRARALEL EAEVAEMRQM LQSEHPFVNG VEKLVPDSLY VPFKEPSQSL LEEMFLTVPE 

       310        320        330        340        350        360 
SHRKPLKRSS SETILSSLAG SDIVKGHEET CIRRAKAVKQ RGISLLHEVD TQYSALKVKY 

       370        380        390        400        410        420 
EELLKKCQEE QDSLSHKAVQ TSRAAAKDLT GVNAQSEPVA SGWELASVNP EPVSSPTTPP 

       430        440        450 
EYKALFKEIF SCIKKTKQEI DEQRTKYRSL SSHS 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of a leucine-zipper protein recognized by the sera of patients with antibody-associated paraneoplastic cerebellar degeneration."
Fathallah-Shaykh H., Wolf S., Wong E., Posner J.B., Furneaux H.M.
Proc. Natl. Acad. Sci. U.S.A. 88:3451-3454(1991) [PubMed: 2014264] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
[3]"Isolation of a complementary DNA clone encoding an autoantigen recognized by an anti-neuronal cell antibody from a patient with paraneoplastic cerebellar degeneration."
Sakai K., Mitchell D.J., Tsukamoto T., Steinman L.
Ann. Neurol. 28:692-698(1990) [PubMed: 2260856] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-454.
Tissue: Cerebellum.
[4]Erratum
Sakai K., Mitchell D.J., Tsukamoto T., Steinman L.
Ann. Neurol. 30:738-738(1991) [PubMed: 1763903] [Abstract]
+Additional computationally mapped references.

Cross-references

Sequence databases

M63256 mRNA. Translation: AAA51961.1. Sequence problems.
BC017503 mRNA. Translation: AAH17503.2.
D12981 mRNA. Translation: BAA02360.1. Different initiation.
S78388 mRNA. Translation: AAB20813.1. Different initiation.
PIRA40448.
RefSeqNP_001793.1.
UniGeneHs.513430

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ01850.

PTM databases

PhosphoSiteQ01850.

Genome annotation databases

EnsemblENSG00000140743. Homo sapiens. [Contig view]
GeneID1039.
KEGGhsa:1039.

Organism-specific databases

H-InvDBHIX0012884.
HGNCHGNC:1799. CDR2.
HPAHPA018151.
MIM117340. gene.
PharmGKBPA26331.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMQ01850.
HOVERGENQ01850.

Gene expression databases

ArrayExpressQ01850.
CleanExHS_CDR2.
GermOnlineENSG00000140743. Homo sapiens.

Family and domain databases

ProtoNetSearch...

Other Resources

LinkHubQ01850.
NextBio4361.
SOURCESearch...

Entry information

Entry nameCDR2_HUMAN
AccessionPrimary (citable) accession number: Q01850
Secondary accession number(s): Q13977
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 5, 2005
Last modified: November 4, 2008
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents