Q01846 (MDM1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Structural protein MDM1

Alternative name(s):
Mitochondrial distribution and morphology protein 1

Gene names

Name:	MDM1
Ordered Locus Names:	YML104C
ORF Names:	YM8339.15C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	1127 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Essential for mitotic growth. Mediates organelle inheritance. Ref.3
Subcellular location	Cytoplasm Ref.3.
Miscellaneous	Present with 784 molecules/cell in log phase SD medium. Ref.5
Sequence similarities	Belongs to the sorting nexin family. Contains 1 PX (phox homology) domain. Contains 1 PXA domain.
Sequence caution	The sequence CAA47014.1 differs from that shown. Reason: Frameshift at position 638. The sequence CAA89114.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell communication Inferred from electronic annotation. Source: InterPro mitochondrion inheritance Inferred from direct assay. Source: SGD nuclear migration Traceable author statement. Source: SGD
Cellular component	cytoplasm Traceable author statement. Source: SGD intermediate filament Traceable author statement. Source: SGD
Molecular function	phosphatidylinositol-3-phosphate binding Inferred from direct assay. Source: SGD structural constituent of cytoskeleton Traceable author statement. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1127	1127	Structural protein MDM1		PRO_0000096330
Regions
	Domain	85 – 273	189	PXA
	Domain	782 – 905	124	PX
	Coiled coil	705 – 762	58	Potential
Experimental info
	Sequence conflict	635	1	H → D in CAA47014. Ref.3
	Sequence conflict	772	1	Q → R in CAA47014. Ref.3
	Sequence conflict	899	1	T → I in CAA47014. Ref.3
	Sequence conflict	1063	1	R → K in CAA47014. Ref.3
	Sequence conflict	1081	1	T → S in CAA47014. Ref.3
	Sequence conflict	1096	1	G → R in CAA47014. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q01846 [UniParc]. Last modified September 26, 2001. Version 3. Checksum: 7C9177B87FDAF512	FASTA	1,127	129,981
	10 20 30 40 50 60 MPKFPQFRLI LVLFYLISMI QWSVITFSLG FFLNVCIFAY FVFFKSLPDL PKPQPRFVDI 70 80 90 100 110 120 VPESSNTVDV DKELKSVEGL IQDGNAQIGK ELESIVNLII KDFVQPWFTK IDKNSDAEFL 130 140 150 160 170 180 KVIKWRLLQT LLVVKDKLMK NDSASLIVLK LLPIFNKHFS TFCDAREAVL SDLTLERHKS 190 200 210 220 230 240 ANIDLQIAVE FNKNYKIHKS LSLKPNALQK EIEKSIRKTV IGLLPHLFDN DELDSLLVFT 250 260 270 280 290 300 LMTEVLTTCI ISPLIFKFTD PDSWNLRIVS LSQNYFEEKH KVHKIRRMLS KELQDHRKVM 310 320 330 340 350 360 NDVANKDVGE PSSEKLELNA EYTGKQFEHY LNQLDSLLDL SDIKYVAYSL ALKIYQLKEN 370 380 390 400 410 420 EHLTKENLKY KKRLLLSLNL IESKLSFPGS EIDTASKKLA REANYPDLNM DNGIVLKEMA 430 440 450 460 470 480 SFLTSITLKD IVDDSEFLPF FESFLGSVPE TQGSTFLEYS QTIESFKNPL EDATSEDIIS 490 500 510 520 530 540 GYSGISTMQL QEISSKFFHN NNLQNMKLLD EGLVKNIILF RNSFQINNDE DTFILARKSV 550 560 570 580 590 600 LLLQTEAIKY LDDRFLPLFK KTPSFLKMLS TSHIISTDIY AHFLSRIGGV NNPEQNKIIK 610 620 630 640 650 660 DNVKTDFMNP VRIFANPGIT DALDNIVNGS GSKPHKSRIS SNPRYSQLFG SENDNIFKDK 670 680 690 700 710 720 LFDDENDNTS EISVVEDQLD HPRNMEKVSV SSGNSGLNPS QFYGSNNFRD NIASLTISID 730 740 750 760 770 780 QIEKELELLR HLILKADLTN NQMQLKILKK SQRTLLKELE MKELLKQQYM VQENGNSLFR 790 800 810 820 830 840 KTKIYIRSYF SENSSNGLKE ITYYIINIHH FNNGQVSSWD MARRYNEFFE LNTYLKKNFR 850 860 870 880 890 900 DLMRQLQDLF PSKVKMSLKY HVTKTLLYEE RKQKLEKYLR ELLSISEICE DNIFRRFLTD 910 920 930 940 950 960 PTPFKLNKEY MHDDILEEPL HEPIGSSNST SNSSSVVDLQ SSEDGGELNF YEDERHFFTD 970 980 990 1000 1010 1020 SGYPFYSQNK SFVKQICDLF ISLFALNKAN AGWLRGRAII TVLQQLLGST IEKYIKVSIQ 1030 1040 1050 1060 1070 1080 KLRSEDQVFE AIVTFKNMLW GDNGLFERKR NETAEATRSE GERLRTEQLA LTSLQRLFAD 1090 1100 1110 1120 TCGRVVGLRD SHEAAGRVHA MLQNPYLNAS LLLEALDAIL LDIICND

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. , Skelton J., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:90-93(1997) [PubMed: 9169872] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Nuclear and mitochondrial inheritance in yeast depends on novel cytoplasmic structures defined by the MDM1 protein." McConnell S.J., Yaffe M.P. J. Cell Biol. 118:385-395(1992) [PubMed: 1378448] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 633-1127, FUNCTION, SUBCELLULAR LOCATION.
[4]	Stirling C.J. Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 874-1127.
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X80835 Genomic DNA. Translation: CAA56793.1. Z49210 Genomic DNA. Translation: CAA89114.1. Different initiation. X66371 Genomic DNA. Translation: CAA47014.1. Frameshift. X65783 Genomic DNA. Translation: CAA46664.1. BK006946 Genomic DNA. Translation: DAA09794.1.
PIR	S47445.
RefSeq	NP_013603.1. NM_001182466.1.
3D structure databases
ProteinModelPortal	Q01846.
SMR	Q01846. Positions 795-904.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-810N.
IntAct	Q01846. 2 interactions.
MINT	MINT-496882.
STRING	Q01846.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YML104C; YML104C; YML104C.
GeneID	854867.
KEGG	sce:YML104C.
NMPDR	fig|4932.3.peg.4639.
Organism-specific databases
CYGD	YML104c.
SGD	S000004572. MDM1.
Phylogenomic databases
eggNOG	fuNOG07899.
GeneTree	EFGT00050000005680.
HOGENOM	HBG203456.
OMA	NSLYGRS.
OrthoDB	EOG4BZR9P.
Gene expression databases
ArrayExpress	Q01846.
Genevestigator	Q01846.
GermOnline	YML104C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR001683. Phox. IPR003114. Phox_assoc. IPR013996. PX_assoc_Snx13. IPR013937. Sorting_nexin_C. [Graphical view]
Gene3D	G3DSA:3.30.1520.10. PX. 1 hit.
Pfam	PF08628. Nexin_C. 1 hit. PF00787. PX. 1 hit. PF02194. PXA. 1 hit. [Graphical view]
SMART	SM00312. PX. 1 hit. SM00313. PXA. 1 hit. [Graphical view]
SUPFAM	SSF64268. PX. 1 hit.
PROSITE	PS50195. PX. 1 hit. PS51207. PXA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	977795.

Entry information

Entry name

MDM1_YEAST

Accession

Primary (citable) accession number: Q01846
Secondary accession number(s): D6W0I0, Q04196

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	September 26, 2001
Last modified:	December 14, 2011
This is version 100 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program