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Protein

Protein-glutamine gamma-glutamyltransferase 2

Gene

TGL2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

Catalytic activityi

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei278 – 2781PROSITE-ProRule annotation
Active sitei336 – 3361PROSITE-ProRule annotation
Active sitei359 – 3591PROSITE-ProRule annotation
Metal bindingi399 – 3991CalciumBy similarity
Metal bindingi401 – 4011CalciumBy similarity
Metal bindingi447 – 4471CalciumBy similarity
Metal bindingi452 – 4521CalciumBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. peptide cross-linking Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamine gamma-glutamyltransferase 2 (EC:2.3.2.13)
Alternative name(s):
Tissue transglutaminase
Transglutaminase C
Short name:
TG(C)
Short name:
TGC
Short name:
TGase C
Transglutaminase-2
Short name:
TGase-2
Gene namesi
Name:TGL2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 689689Protein-glutamine gamma-glutamyltransferase 2PRO_0000213709Add
BLAST

Proteomic databases

PaxDbiQ01841.
PRIDEiQ01841.

Expressioni

Tissue specificityi

Predominates in mature erythrocytes. Also found in kidney and cardiac muscle.

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliQ01841.
SMRiQ01841. Positions 1-683.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG80379.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiQ01841.
KOiK05625.
PhylomeDBiQ01841.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01841-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEELVLETC DLQCERNGRE HRTEEMGSQQ LVVRRGQPFT ITLNFAGRGY
60 70 80 90 100
EEGVDKLAFD VETGPCPVET SGTRSHFTLT DCPEEGTWSA VLQQQDGATL
110 120 130 140 150
CVSLCSPSIA RVGRYRLTLE ASTGYQGSSF HLGDFVLLFN AWHPEDAVYL
160 170 180 190 200
KEEDERREYV LSQQGLIYMG SRDYITSTPW NFGQFEDEIL AICLEMLDIN
210 220 230 240 250
PKFLRDQNLD CSRRNDPVYI GRVVSAMVNC NDEDHGVLLG RWDNHYEDGM
260 270 280 290 300
SPMAWIGSVD ILKRWRRLGC QPVKYGQCWV FAAVACTVMR CLGVPSRVVT
310 320 330 340 350
NYNSAHDTNG NLVIDRYLSE TGMEERRSTD MIWNFHCWVE CWMTRPDLAP
360 370 380 390 400
GYDGWQALDP TPQEKSEGVY CCGPAPVKAI KEGDLQVQYD IPFVFAEVNA
410 420 430 440 450
DVVYWIVQSD GEKKKSTHSS VVGKNISTKS VGRDSREDIT HTYKYPEGSE
460 470 480 490 500
KEREVFSKAE HEKSSLGEQE EGLHMRIKLS EGANNGSDFD VFAFISNDTD
510 520 530 540 550
KERECRLRLC ARTASYNGEV GPQCGFKDLL NLSLQPHMEQ SVPLRILYEQ
560 570 580 590 600
YGPNLTQDNM IKVVALLTEY ETGDSVVAIR DVYIQNPEIK IRILGEPMQE
610 620 630 640 650
RKLVAEIRLV NPLAEPLNNC IFVVEGAGLT EGQRIEELED PVEPQAEAKF
660 670 680
RMEFVPRQAG LHKLMVDFES DKLTGVKGYR NVIIAPLPK
Length:689
Mass (Da):77,970
Last modified:July 4, 2004 - v3
Checksum:iACA3FA84B48A5AB3
GO

Sequence cautioni

The sequence AAA49104.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02270 mRNA. Translation: AAA49104.1. Different initiation.
PIRiA47203.
RefSeqiNP_990779.1. NM_205448.1.
UniGeneiGga.31956.

Genome annotation databases

GeneIDi396432.
KEGGigga:396432.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02270 mRNA. Translation: AAA49104.1. Different initiation.
PIRiA47203.
RefSeqiNP_990779.1. NM_205448.1.
UniGeneiGga.31956.

3D structure databases

ProteinModelPortaliQ01841.
SMRiQ01841. Positions 1-683.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ01841.
PRIDEiQ01841.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396432.
KEGGigga:396432.

Organism-specific databases

CTDi7052.

Phylogenomic databases

eggNOGiNOG80379.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiQ01841.
KOiK05625.
PhylomeDBiQ01841.

Miscellaneous databases

NextBioi20816473.
PROiQ01841.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 9-22; 181-191; 242-262; 383-401; 406-416; 430-448 AND 457-483.
    Tissue: Erythrocyte.

Entry informationi

Entry nameiTGM2_CHICK
AccessioniPrimary (citable) accession number: Q01841
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 31, 1993
Last sequence update: July 4, 2004
Last modified: February 3, 2015
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.