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Q01841 (TGM2_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein-glutamine gamma-glutamyltransferase 2

EC=2.3.2.13
Alternative name(s):
Tissue transglutaminase
Transglutaminase C
Short name=TG(C)
Short name=TGC
Short name=TGase C
Transglutaminase-2
Short name=TGase-2
Gene names
Name:TGL2
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length689 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

Catalytic activity

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.

Cofactor

Binds 1 calcium ion per subunit By similarity.

Subunit structure

Monomer.

Tissue specificity

Predominates in mature erythrocytes. Also found in kidney and cardiac muscle.

Sequence similarities

Belongs to the transglutaminase superfamily. Transglutaminase family.

Sequence caution

The sequence AAA49104.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 689689Protein-glutamine gamma-glutamyltransferase 2
PRO_0000213709

Sites

Active site2781 By similarity
Active site3361 By similarity
Active site3591 By similarity
Metal binding3991Calcium By similarity
Metal binding4011Calcium By similarity
Metal binding4471Calcium By similarity
Metal binding4521Calcium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q01841 [UniParc].

Last modified July 5, 2004. Version 3.
Checksum: ACA3FA84B48A5AB3

FASTA68977,970
        10         20         30         40         50         60 
MAEELVLETC DLQCERNGRE HRTEEMGSQQ LVVRRGQPFT ITLNFAGRGY EEGVDKLAFD 

        70         80         90        100        110        120 
VETGPCPVET SGTRSHFTLT DCPEEGTWSA VLQQQDGATL CVSLCSPSIA RVGRYRLTLE 

       130        140        150        160        170        180 
ASTGYQGSSF HLGDFVLLFN AWHPEDAVYL KEEDERREYV LSQQGLIYMG SRDYITSTPW 

       190        200        210        220        230        240 
NFGQFEDEIL AICLEMLDIN PKFLRDQNLD CSRRNDPVYI GRVVSAMVNC NDEDHGVLLG 

       250        260        270        280        290        300 
RWDNHYEDGM SPMAWIGSVD ILKRWRRLGC QPVKYGQCWV FAAVACTVMR CLGVPSRVVT 

       310        320        330        340        350        360 
NYNSAHDTNG NLVIDRYLSE TGMEERRSTD MIWNFHCWVE CWMTRPDLAP GYDGWQALDP 

       370        380        390        400        410        420 
TPQEKSEGVY CCGPAPVKAI KEGDLQVQYD IPFVFAEVNA DVVYWIVQSD GEKKKSTHSS 

       430        440        450        460        470        480 
VVGKNISTKS VGRDSREDIT HTYKYPEGSE KEREVFSKAE HEKSSLGEQE EGLHMRIKLS 

       490        500        510        520        530        540 
EGANNGSDFD VFAFISNDTD KERECRLRLC ARTASYNGEV GPQCGFKDLL NLSLQPHMEQ 

       550        560        570        580        590        600 
SVPLRILYEQ YGPNLTQDNM IKVVALLTEY ETGDSVVAIR DVYIQNPEIK IRILGEPMQE 

       610        620        630        640        650        660 
RKLVAEIRLV NPLAEPLNNC IFVVEGAGLT EGQRIEELED PVEPQAEAKF RMEFVPRQAG 

       670        680 
LHKLMVDFES DKLTGVKGYR NVIIAPLPK 

« Hide

References

[1]"Cloning and expression of chicken erythrocyte transglutaminase."
Weraarchakul-Boonmark N., Jeong J.M., Murthy S.N.P., Engel J.D., Lorand L.
Proc. Natl. Acad. Sci. U.S.A. 89:9804-9808(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 9-22; 181-191; 242-262; 383-401; 406-416; 430-448 AND 457-483.
Tissue: Erythrocyte.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L02270 mRNA. Translation: AAA49104.1. Different initiation.
PIRA47203.
RefSeqNP_990779.1. NM_205448.1.
UniGeneGga.31956.

3D structure databases

ProteinModelPortalQ01841.
SMRQ01841. Positions 1-683.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ01841.
PRIDEQ01841.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID396432.
KEGGgga:396432.

Organism-specific databases

CTD7052.

Phylogenomic databases

eggNOGNOG80379.
HOGENOMHOG000231695.
HOVERGENHBG004342.
KOK05625.
PhylomeDBQ01841.

Family and domain databases

Gene3D2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERPTHR11590. PTHR11590. 1 hit.
PfamPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFPIRSF000459. TGM_EBP42. 1 hit.
SMARTSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816473.
PROQ01841.

Entry information

Entry nameTGM2_CHICK
AccessionPrimary (citable) accession number: Q01841
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families