Q01841 (TGM2_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein-glutamine gamma-glutamyltransferase 2
EC=2.3.2.13

Alternative name(s):
Tissue transglutaminase
Transglutaminase C
Short name=TG(C)
Short name=TGC
Short name=TGase C
Transglutaminase-2
Short name=TGase-2

Gene names

Name:

TGL2

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	689 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
Catalytic activity	Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.
Cofactor	Binds 1 calcium ion per subunit By similarity.
Subunit structure	Monomer.
Tissue specificity	Predominates in mature erythrocytes. Also found in kidney and cardiac muscle.
Sequence similarities	Belongs to the transglutaminase superfamily. Transglutaminase family.
Sequence caution	The sequence AAA49104.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Ligand	Calcium Metal-binding
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	peptide cross-linking Inferred from electronic annotation. Source: InterPro
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein-glutamine gamma-glutamyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 689	689	Protein-glutamine gamma-glutamyltransferase 2		PRO_0000213709
Sites
	Active site	278	1	By similarity
	Active site	336	1	By similarity
	Active site	359	1	By similarity
	Metal binding	399	1	Calcium By similarity
	Metal binding	401	1	Calcium By similarity
	Metal binding	447	1	Calcium By similarity
	Metal binding	452	1	Calcium By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q01841 [UniParc]. Last modified July 5, 2004. Version 3. Checksum: ACA3FA84B48A5AB3	FASTA	689	77,970
	10 20 30 40 50 60 MAEELVLETC DLQCERNGRE HRTEEMGSQQ LVVRRGQPFT ITLNFAGRGY EEGVDKLAFD 70 80 90 100 110 120 VETGPCPVET SGTRSHFTLT DCPEEGTWSA VLQQQDGATL CVSLCSPSIA RVGRYRLTLE 130 140 150 160 170 180 ASTGYQGSSF HLGDFVLLFN AWHPEDAVYL KEEDERREYV LSQQGLIYMG SRDYITSTPW 190 200 210 220 230 240 NFGQFEDEIL AICLEMLDIN PKFLRDQNLD CSRRNDPVYI GRVVSAMVNC NDEDHGVLLG 250 260 270 280 290 300 RWDNHYEDGM SPMAWIGSVD ILKRWRRLGC QPVKYGQCWV FAAVACTVMR CLGVPSRVVT 310 320 330 340 350 360 NYNSAHDTNG NLVIDRYLSE TGMEERRSTD MIWNFHCWVE CWMTRPDLAP GYDGWQALDP 370 380 390 400 410 420 TPQEKSEGVY CCGPAPVKAI KEGDLQVQYD IPFVFAEVNA DVVYWIVQSD GEKKKSTHSS 430 440 450 460 470 480 VVGKNISTKS VGRDSREDIT HTYKYPEGSE KEREVFSKAE HEKSSLGEQE EGLHMRIKLS 490 500 510 520 530 540 EGANNGSDFD VFAFISNDTD KERECRLRLC ARTASYNGEV GPQCGFKDLL NLSLQPHMEQ 550 560 570 580 590 600 SVPLRILYEQ YGPNLTQDNM IKVVALLTEY ETGDSVVAIR DVYIQNPEIK IRILGEPMQE 610 620 630 640 650 660 RKLVAEIRLV NPLAEPLNNC IFVVEGAGLT EGQRIEELED PVEPQAEAKF RMEFVPRQAG 670 680 LHKLMVDFES DKLTGVKGYR NVIIAPLPK

References

[1]

"Cloning and expression of chicken erythrocyte transglutaminase." Weraarchakul-Boonmark N., Jeong J.M., Murthy S.N.P., Engel J.D., Lorand L. Proc. Natl. Acad. Sci. U.S.A. 89:9804-9808(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 9-22; 181-191; 242-262; 383-401; 406-416; 430-448 AND 457-483. Tissue: Erythrocyte.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L02270 mRNA. Translation: AAA49104.1. Different initiation.
IPI	IPI00599913.
PIR	A47203.
RefSeq	NP_990779.1. NM_205448.1.
UniGene	Gga.31956.
3D structure databases
ProteinModelPortal	Q01841.
SMR	Q01841. Positions 1-683.
ModBase	Search...
Proteomic databases
PaxDb	Q01841.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	396432.
KEGG	gga:396432.
Organism-specific databases
CTD	7052.
Phylogenomic databases
eggNOG	NOG80379.
HOGENOM	HOG000231695.
HOVERGEN	HBG004342.
KO	K05625.
Family and domain databases
Gene3D	2.60.40.10. 3 hits. 3.90.260.10. 1 hit.
InterPro	IPR023608. Gln_gamma-glutamylTfrase_euk. IPR013783. Ig-like_fold. IPR014756. Ig_E-set. IPR002931. Transglutaminase-like. IPR008958. Transglutaminase_C. IPR013808. Transglutaminase_CS. IPR001102. Transglutaminase_N. [Graphical view]
PANTHER	PTHR11590. PTHR11590. 1 hit.
Pfam	PF00927. Transglut_C. 2 hits. PF01841. Transglut_core. 1 hit. PF00868. Transglut_N. 1 hit. [Graphical view]
PIRSF	PIRSF000459. TGM_EBP42. 1 hit.
SMART	SM00460. TGc. 1 hit. [Graphical view]
SUPFAM	SSF81296. Ig_E-set. 1 hit. SSF49309. Transglut_C. 2 hits.
PROSITE	PS00547. TRANSGLUTAMINASES. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20816473.

Entry information

Entry name

TGM2_CHICK

Accession

Primary (citable) accession number: Q01841

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	July 5, 2004
Last modified:	May 29, 2013
This is version 100 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program