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Q01841

- TGM2_CHICK

UniProt

Q01841 - TGM2_CHICK

Protein

Protein-glutamine gamma-glutamyltransferase 2

Gene

TGL2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 3 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

    Catalytic activityi

    Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

    Cofactori

    Binds 1 calcium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei278 – 2781PROSITE-ProRule annotation
    Active sitei336 – 3361PROSITE-ProRule annotation
    Active sitei359 – 3591PROSITE-ProRule annotation
    Metal bindingi399 – 3991CalciumBy similarity
    Metal bindingi401 – 4011CalciumBy similarity
    Metal bindingi447 – 4471CalciumBy similarity
    Metal bindingi452 – 4521CalciumBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. peptide cross-linking Source: InterPro

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein-glutamine gamma-glutamyltransferase 2 (EC:2.3.2.13)
    Alternative name(s):
    Tissue transglutaminase
    Transglutaminase C
    Short name:
    TG(C)
    Short name:
    TGC
    Short name:
    TGase C
    Transglutaminase-2
    Short name:
    TGase-2
    Gene namesi
    Name:TGL2
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 689689Protein-glutamine gamma-glutamyltransferase 2PRO_0000213709Add
    BLAST

    Proteomic databases

    PaxDbiQ01841.
    PRIDEiQ01841.

    Expressioni

    Tissue specificityi

    Predominates in mature erythrocytes. Also found in kidney and cardiac muscle.

    Interactioni

    Subunit structurei

    Monomer.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01841.
    SMRiQ01841. Positions 1-683.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG80379.
    HOGENOMiHOG000231695.
    HOVERGENiHBG004342.
    KOiK05625.
    PhylomeDBiQ01841.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    3.90.260.10. 1 hit.
    InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002931. Transglutaminase-like.
    IPR008958. Transglutaminase_C.
    IPR013808. Transglutaminase_CS.
    IPR001102. Transglutaminase_N.
    [Graphical view]
    PANTHERiPTHR11590. PTHR11590. 1 hit.
    PfamiPF00927. Transglut_C. 2 hits.
    PF01841. Transglut_core. 1 hit.
    PF00868. Transglut_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
    SMARTiSM00460. TGc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49309. SSF49309. 2 hits.
    SSF81296. SSF81296. 1 hit.
    PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q01841-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEELVLETC DLQCERNGRE HRTEEMGSQQ LVVRRGQPFT ITLNFAGRGY    50
    EEGVDKLAFD VETGPCPVET SGTRSHFTLT DCPEEGTWSA VLQQQDGATL 100
    CVSLCSPSIA RVGRYRLTLE ASTGYQGSSF HLGDFVLLFN AWHPEDAVYL 150
    KEEDERREYV LSQQGLIYMG SRDYITSTPW NFGQFEDEIL AICLEMLDIN 200
    PKFLRDQNLD CSRRNDPVYI GRVVSAMVNC NDEDHGVLLG RWDNHYEDGM 250
    SPMAWIGSVD ILKRWRRLGC QPVKYGQCWV FAAVACTVMR CLGVPSRVVT 300
    NYNSAHDTNG NLVIDRYLSE TGMEERRSTD MIWNFHCWVE CWMTRPDLAP 350
    GYDGWQALDP TPQEKSEGVY CCGPAPVKAI KEGDLQVQYD IPFVFAEVNA 400
    DVVYWIVQSD GEKKKSTHSS VVGKNISTKS VGRDSREDIT HTYKYPEGSE 450
    KEREVFSKAE HEKSSLGEQE EGLHMRIKLS EGANNGSDFD VFAFISNDTD 500
    KERECRLRLC ARTASYNGEV GPQCGFKDLL NLSLQPHMEQ SVPLRILYEQ 550
    YGPNLTQDNM IKVVALLTEY ETGDSVVAIR DVYIQNPEIK IRILGEPMQE 600
    RKLVAEIRLV NPLAEPLNNC IFVVEGAGLT EGQRIEELED PVEPQAEAKF 650
    RMEFVPRQAG LHKLMVDFES DKLTGVKGYR NVIIAPLPK 689
    Length:689
    Mass (Da):77,970
    Last modified:July 5, 2004 - v3
    Checksum:iACA3FA84B48A5AB3
    GO

    Sequence cautioni

    The sequence AAA49104.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L02270 mRNA. Translation: AAA49104.1. Different initiation.
    PIRiA47203.
    RefSeqiNP_990779.1. NM_205448.1.
    UniGeneiGga.31956.

    Genome annotation databases

    GeneIDi396432.
    KEGGigga:396432.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L02270 mRNA. Translation: AAA49104.1 . Different initiation.
    PIRi A47203.
    RefSeqi NP_990779.1. NM_205448.1.
    UniGenei Gga.31956.

    3D structure databases

    ProteinModelPortali Q01841.
    SMRi Q01841. Positions 1-683.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q01841.
    PRIDEi Q01841.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396432.
    KEGGi gga:396432.

    Organism-specific databases

    CTDi 7052.

    Phylogenomic databases

    eggNOGi NOG80379.
    HOGENOMi HOG000231695.
    HOVERGENi HBG004342.
    KOi K05625.
    PhylomeDBi Q01841.

    Miscellaneous databases

    NextBioi 20816473.
    PROi Q01841.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    3.90.260.10. 1 hit.
    InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002931. Transglutaminase-like.
    IPR008958. Transglutaminase_C.
    IPR013808. Transglutaminase_CS.
    IPR001102. Transglutaminase_N.
    [Graphical view ]
    PANTHERi PTHR11590. PTHR11590. 1 hit.
    Pfami PF00927. Transglut_C. 2 hits.
    PF01841. Transglut_core. 1 hit.
    PF00868. Transglut_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
    SMARTi SM00460. TGc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49309. SSF49309. 2 hits.
    SSF81296. SSF81296. 1 hit.
    PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 9-22; 181-191; 242-262; 383-401; 406-416; 430-448 AND 457-483.
      Tissue: Erythrocyte.

    Entry informationi

    Entry nameiTGM2_CHICK
    AccessioniPrimary (citable) accession number: Q01841
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 106 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3