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Q01841

- TGM2_CHICK

UniProt

Q01841 - TGM2_CHICK

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Protein

Protein-glutamine gamma-glutamyltransferase 2

Gene
TGL2
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

Catalytic activityi

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.

Cofactori

Binds 1 calcium ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei278 – 2781 By similarity
Active sitei336 – 3361 By similarity
Active sitei359 – 3591 By similarity
Metal bindingi399 – 3991Calcium By similarity
Metal bindingi401 – 4011Calcium By similarity
Metal bindingi447 – 4471Calcium By similarity
Metal bindingi452 – 4521Calcium By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. peptide cross-linking Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamine gamma-glutamyltransferase 2 (EC:2.3.2.13)
Alternative name(s):
Tissue transglutaminase
Transglutaminase C
Short name:
TG(C)
Short name:
TGC
Short name:
TGase C
Transglutaminase-2
Short name:
TGase-2
Gene namesi
Name:TGL2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 689689Protein-glutamine gamma-glutamyltransferase 2PRO_0000213709Add
BLAST

Proteomic databases

PaxDbiQ01841.
PRIDEiQ01841.

Expressioni

Tissue specificityi

Predominates in mature erythrocytes. Also found in kidney and cardiac muscle.

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliQ01841.
SMRiQ01841. Positions 1-683.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG80379.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
KOiK05625.
PhylomeDBiQ01841.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01841-1 [UniParc]FASTAAdd to Basket

« Hide

MAEELVLETC DLQCERNGRE HRTEEMGSQQ LVVRRGQPFT ITLNFAGRGY    50
EEGVDKLAFD VETGPCPVET SGTRSHFTLT DCPEEGTWSA VLQQQDGATL 100
CVSLCSPSIA RVGRYRLTLE ASTGYQGSSF HLGDFVLLFN AWHPEDAVYL 150
KEEDERREYV LSQQGLIYMG SRDYITSTPW NFGQFEDEIL AICLEMLDIN 200
PKFLRDQNLD CSRRNDPVYI GRVVSAMVNC NDEDHGVLLG RWDNHYEDGM 250
SPMAWIGSVD ILKRWRRLGC QPVKYGQCWV FAAVACTVMR CLGVPSRVVT 300
NYNSAHDTNG NLVIDRYLSE TGMEERRSTD MIWNFHCWVE CWMTRPDLAP 350
GYDGWQALDP TPQEKSEGVY CCGPAPVKAI KEGDLQVQYD IPFVFAEVNA 400
DVVYWIVQSD GEKKKSTHSS VVGKNISTKS VGRDSREDIT HTYKYPEGSE 450
KEREVFSKAE HEKSSLGEQE EGLHMRIKLS EGANNGSDFD VFAFISNDTD 500
KERECRLRLC ARTASYNGEV GPQCGFKDLL NLSLQPHMEQ SVPLRILYEQ 550
YGPNLTQDNM IKVVALLTEY ETGDSVVAIR DVYIQNPEIK IRILGEPMQE 600
RKLVAEIRLV NPLAEPLNNC IFVVEGAGLT EGQRIEELED PVEPQAEAKF 650
RMEFVPRQAG LHKLMVDFES DKLTGVKGYR NVIIAPLPK 689
Length:689
Mass (Da):77,970
Last modified:July 5, 2004 - v3
Checksum:iACA3FA84B48A5AB3
GO

Sequence cautioni

The sequence AAA49104.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L02270 mRNA. Translation: AAA49104.1. Different initiation.
PIRiA47203.
RefSeqiNP_990779.1. NM_205448.1.
UniGeneiGga.31956.

Genome annotation databases

GeneIDi396432.
KEGGigga:396432.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L02270 mRNA. Translation: AAA49104.1 . Different initiation.
PIRi A47203.
RefSeqi NP_990779.1. NM_205448.1.
UniGenei Gga.31956.

3D structure databases

ProteinModelPortali Q01841.
SMRi Q01841. Positions 1-683.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q01841.
PRIDEi Q01841.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396432.
KEGGi gga:396432.

Organism-specific databases

CTDi 7052.

Phylogenomic databases

eggNOGi NOG80379.
HOGENOMi HOG000231695.
HOVERGENi HBG004342.
KOi K05625.
PhylomeDBi Q01841.

Miscellaneous databases

NextBioi 20816473.
PROi Q01841.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view ]
PANTHERi PTHR11590. PTHR11590. 1 hit.
Pfami PF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
SMARTi SM00460. TGc. 1 hit.
[Graphical view ]
SUPFAMi SSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 9-22; 181-191; 242-262; 383-401; 406-416; 430-448 AND 457-483.
    Tissue: Erythrocyte.

Entry informationi

Entry nameiTGM2_CHICK
AccessioniPrimary (citable) accession number: Q01841
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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