DNA-binding protein SATB1 - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot Q01826 (SATB1_HUMAN)

Last modified May 26, 2009. Version 89. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
DNA-binding protein SATB1
Alternative name(s):
Special AT-rich sequence-binding protein 1

Gene names

Name:

SATB1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	763 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Binds to DNA at special AT-rich sequences at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA.
Subcellular location	Nucleus.
Tissue specificity	Expressed predominantly in thymus.
Post-translational modification	Sumoylated. Ref.3
Sequence similarities	Belongs to the CUT homeobox family. Contains 2 CUT DNA-binding domains. Contains 1 homeobox DNA-binding domain.

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Ontologies

Keywords
Cellular component	Nucleus
Domain	Homeobox Repeat
Ligand	DNA-binding
PTM	Ubl conjugation
Technical term	3D-structure
Gene Ontology (GO)
Biological process	establishment or maintenance of chromatin architecture Ref.1 Traceable author statement. Source: ProtInc negative regulation of transcription from RNA polymerase II promoter Inferred from mutant phenotype. Source: MGI
Cellular component	nucleus Ref.1 Traceable author statement. Source: ProtInc
Molecular function	double-stranded DNA binding Ref.1 Traceable author statement. Source: ProtInc sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 763

763

DNA-binding protein SATB1

PRO_0000202398

Regions

DNA binding

361 – 448

CUT 1

DNA binding

484 – 571

CUT 2

DNA binding

645 – 704

Homeobox

Compositional bias

591 – 607

Poly-Gln

Compositional bias

609 – 614

Poly-Pro

Secondary structure

763

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q01826-1 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: D4FE09B09FB7683B
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FASTA

763

85,957

        10         20         30         40         50         60 
MDHLNEATQG KEHSEMSNNV SDPKGPPAKI ARLEQNGSPL GRGRLGSTGA KMQGVPLKHS 

        70         80         90        100        110        120 
GHLMKTNLRK GTMLPVFCVV EHYENAIEYD CKEEHAEFVL VRKDMLFNQL IEMALLSLGY 

       130        140        150        160        170        180 
SHSSAAQAKG LIQVGKWNPV PLSYVTDAPD ATVADMLQDV YHVVTLKIQL HSCPKLEDLP 

       190        200        210        220        230        240 
PEQWSHTTVR NALKDLLKDM NQSSLAKECP LSQSMISSIV NSTYYANVSA AKCQEFGRWY 

       250        260        270        280        290        300 
KHFKKTKDMM VEMDSLSELS QQGANHVNFG QQPVPGNTAE QPPSPAQLSH GSQPSVRTPL 

       310        320        330        340        350        360 
PNLHPGLVST PISPQLVNQQ LVMAQLLNQQ YAVNRLLAQQ SLNQQYLNHP PPVSRSMNKP 

       370        380        390        400        410        420 
LEQQVSTNTE VSSEIYQWVR DELKRAGISQ AVFARVAFNR TQGLLSEILR KEEDPKTASQ 

       430        440        450        460        470        480 
SLLVNLRAMQ NFLQLPEAER DRIYQDERER SLNAASAMGP APLISTPPSR PPQVKTATIA 

       490        500        510        520        530        540 
TERNGKPENN TMNINASIYD EIQQEMKRAK VSQALFAKVA ATKSQGWLCE LLRWKEDPSP 

       550        560        570        580        590        600 
ENRTLWENLS MIRRFLSLPQ PERDAIYEQE SNAVHHHGDR PPHIIHVPAE QIQQQQQQQQ 

       610        620        630        640        650        660 
QQQQQQQAPP PPQPQQQPQT GPRLPPRQPT VASPAESDEE NRQKTRPRTK ISVEALGILQ 

       670        680        690        700        710        720 
SFIQDVGLYP DEEAIQTLSA QLDLPKYTII KFFQNQRYYL KHHGKLKDNS GLEVDVAEYK 

       730        740        750        760 
EEELLKDLEE SVQDKNTNTL FSVKLEEELS VEGNTDINTD LKD

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition." Dickinson L.A., Joh T., Kohwi Y., Kohwi-Shigematsu T. Cell 70:631-645(1992) [PubMed: 1505028] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[3]	"Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates." Gocke C.B., Yu H., Kang J. J. Biol. Chem. 280:5004-5012(2005) [PubMed: 15561718] [Abstract] Cited for: SUMOYLATION.
+	Additional computationally mapped references.

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Cross-references

Sequence databases

M97287 mRNA. Translation: AAA60304.1.
BC001744 mRNA. Translation: AAH01744.1.

IPI

IPI00009804.

PIR

A43314.

RefSeq

NP_001124482.1.
NP_002962.1.

UniGene

Hs.517717

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1YSE	NMR	-	A	353-490	[»]
2O49	X-ray	2.00	A	368-452	[»]
2O4A	X-ray	1.75	A	368-452	[»]

SMR

Q01826. Positions 486-573, 646-704.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q01826. 1 interaction.

PTM databases

PhosphoSite

Q01826.

Proteomic databases

PRIDE

Q01826.

Genome annotation databases

Ensembl

ENSG00000182568. Homo sapiens. [Contig view]

GeneID

6304.

KEGG

hsa:6304.

Organism-specific databases

GeneCards

GC03M018364.

H-InvDB

HIX0017285.

HGNC

HGNC:10541. SATB1.

MIM

602075. gene.

PharmGKB

PA34951.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

Q01826.

Enzyme and pathway databases

Pathway_Interaction_DB

caspase_pathway. Caspase cascade in apoptosis.

Gene expression databases

ArrayExpress

Q01826.

Bgee

Q01826.

CleanEx

HS_SATB1.

GermOnline

ENSG00000182568. Homo sapiens.

Family and domain databases

InterPro

IPR003350. Hmoeo_CUT.
IPR001356. Homeobox.
IPR017970. Homeobox_CS.
[Graphical view]

Pfam

PF02376. CUT. 2 hits.
PF00046. Homeobox. 1 hit.
[Graphical view]

SMART

SM00389. HOX. 1 hit.
[Graphical view]

PROSITE

PS51042. CUT. 2 hits.
PS00027. HOMEOBOX_1. False negative.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

24475.

PMAP-CutDB

Q01826.

SOURCE

Search...

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Entry information

Entry name

SATB1_HUMAN

Accession

Primary (citable) accession number: Q01826

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	May 26, 2009
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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