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Reviewed, UniProtKB/Swiss-Prot Q01826 (SATB1_HUMAN)

Last modified May 26, 2009. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    DNA-binding protein SATB1
Alternative name(s):
    Special AT-rich sequence-binding protein 1
Gene names
Name: SATB1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length763 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Binds to DNA at special AT-rich sequences at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA.

Subcellular location

Nucleus.

Tissue specificity

Expressed predominantly in thymus.

Post-translational modification

Sumoylated. Ref.3

Sequence similarities

Belongs to the CUT homeobox family.

Contains 2 CUT DNA-binding domains.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 763763DNA-binding protein SATB1
PRO_0000202398

Regions

DNA binding361 – 44888CUT 1
DNA binding484 – 57188CUT 2
DNA binding645 – 70460Homeobox
Compositional bias591 – 60717Poly-Gln
Compositional bias609 – 6146Poly-Pro

Secondary structure

........... 763
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q01826-1 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: D4FE09B09FB7683B

FASTA76385,957
        10         20         30         40         50         60 
MDHLNEATQG KEHSEMSNNV SDPKGPPAKI ARLEQNGSPL GRGRLGSTGA KMQGVPLKHS 

        70         80         90        100        110        120 
GHLMKTNLRK GTMLPVFCVV EHYENAIEYD CKEEHAEFVL VRKDMLFNQL IEMALLSLGY 

       130        140        150        160        170        180 
SHSSAAQAKG LIQVGKWNPV PLSYVTDAPD ATVADMLQDV YHVVTLKIQL HSCPKLEDLP 

       190        200        210        220        230        240 
PEQWSHTTVR NALKDLLKDM NQSSLAKECP LSQSMISSIV NSTYYANVSA AKCQEFGRWY 

       250        260        270        280        290        300 
KHFKKTKDMM VEMDSLSELS QQGANHVNFG QQPVPGNTAE QPPSPAQLSH GSQPSVRTPL 

       310        320        330        340        350        360 
PNLHPGLVST PISPQLVNQQ LVMAQLLNQQ YAVNRLLAQQ SLNQQYLNHP PPVSRSMNKP 

       370        380        390        400        410        420 
LEQQVSTNTE VSSEIYQWVR DELKRAGISQ AVFARVAFNR TQGLLSEILR KEEDPKTASQ 

       430        440        450        460        470        480 
SLLVNLRAMQ NFLQLPEAER DRIYQDERER SLNAASAMGP APLISTPPSR PPQVKTATIA 

       490        500        510        520        530        540 
TERNGKPENN TMNINASIYD EIQQEMKRAK VSQALFAKVA ATKSQGWLCE LLRWKEDPSP 

       550        560        570        580        590        600 
ENRTLWENLS MIRRFLSLPQ PERDAIYEQE SNAVHHHGDR PPHIIHVPAE QIQQQQQQQQ 

       610        620        630        640        650        660 
QQQQQQQAPP PPQPQQQPQT GPRLPPRQPT VASPAESDEE NRQKTRPRTK ISVEALGILQ 

       670        680        690        700        710        720 
SFIQDVGLYP DEEAIQTLSA QLDLPKYTII KFFQNQRYYL KHHGKLKDNS GLEVDVAEYK 

       730        740        750        760 
EEELLKDLEE SVQDKNTNTL FSVKLEEELS VEGNTDINTD LKD 

« Hide

References

« Hide 'large scale' references
[1]"A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition."
Dickinson L.A., Joh T., Kohwi Y., Kohwi-Shigematsu T.
Cell 70:631-645(1992) [PubMed: 1505028] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[3]"Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates."
Gocke C.B., Yu H., Kang J.
J. Biol. Chem. 280:5004-5012(2005) [PubMed: 15561718] [Abstract]
Cited for: SUMOYLATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

M97287 mRNA. Translation: AAA60304.1.
BC001744 mRNA. Translation: AAH01744.1.
IPIIPI00009804.
PIRA43314.
RefSeqNP_001124482.1.
NP_002962.1.
UniGeneHs.517717

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1YSENMR-A353-490[»]
2O49X-ray2.00A368-452[»]
2O4AX-ray1.75A368-452[»]
SMRQ01826. Positions 486-573, 646-704.
ModBaseSearch...

Protein-protein interaction databases

IntActQ01826. 1 interaction.

PTM databases

PhosphoSiteQ01826.

Proteomic databases

PRIDEQ01826.

Genome annotation databases

EnsemblENSG00000182568. Homo sapiens. [Contig view]
GeneID6304.
KEGGhsa:6304.

Organism-specific databases

GeneCardsGC03M018364.
H-InvDBHIX0017285.
HGNCHGNC:10541. SATB1.
MIM602075. gene.
PharmGKBPA34951.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ01826.

Enzyme and pathway databases

Pathway_Interaction_DBcaspase_pathway. Caspase cascade in apoptosis.

Gene expression databases

ArrayExpressQ01826.
BgeeQ01826.
CleanExHS_SATB1.
GermOnlineENSG00000182568. Homo sapiens.

Family and domain databases

InterProIPR003350. Hmoeo_CUT.
IPR001356. Homeobox.
IPR017970. Homeobox_CS.
[Graphical view]
PfamPF02376. CUT. 2 hits.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
PROSITEPS51042. CUT. 2 hits.
PS00027. HOMEOBOX_1. False negative.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio24475.
PMAP-CutDBQ01826.
SOURCESearch...

Entry information

Entry nameSATB1_HUMAN
AccessionPrimary (citable) accession number: Q01826
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 26, 2009
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents