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Q01822

- HXD1_MOUSE

UniProt

Q01822 - HXD1_MOUSE

Protein

Homeobox protein Hox-D1

Gene

Hoxd1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (16 Oct 2013)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi229 – 28860HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. embryonic skeletal system development Source: MGI
    2. neuron differentiation Source: MGI
    3. sensory perception of pain Source: MGI
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-D1
    Alternative name(s):
    Homeobox protein Hox-4.9
    Gene namesi
    Name:Hoxd1
    Synonyms:Hox-4.9, Hoxd-1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:96201. Hoxd1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 328328Homeobox protein Hox-D1PRO_0000200202Add
    BLAST

    Proteomic databases

    PaxDbiQ01822.
    PRIDEiQ01822.

    Expressioni

    Developmental stagei

    Is first detected at the end of the late streak stage in presumptive lateral and extraembryonic mesoderm. During early neurogenesis, it is detected solely in lateral mesoderm. By late neurogenesis and through mid-gestation, it is found in a restricted region of presumed trunk neural crest and the dermatome.

    Gene expression databases

    CleanExiMM_HOXD1.
    GenevestigatoriQ01822.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01822.
    SMRiQ01822. Positions 204-290.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi204 – 2096Antp-type hexapeptide

    Sequence similaritiesi

    Belongs to the Antp homeobox family. Labial subfamily.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG314488.
    GeneTreeiENSGT00750000117389.
    HOGENOMiHOG000247020.
    HOVERGENiHBG006089.
    InParanoidiQ01822.
    KOiK09301.
    OMAiYLEYVSC.
    OrthoDBiEOG7PK91P.
    PhylomeDBiQ01822.
    TreeFamiTF317730.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q01822-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSYLEYVSC AAGGGSGGVG GDVLGFAPKF CRADARPVAL QPAFPLGSGD    50
    GAFVSCLPLA TARPTPSPPA GPAQSPVPQP AAPRYAPCTL EGAYERGAAP 100
    ASAAEYGFLG SGPAFDFPGA LGRAADEGGA HVHYATSAVF SGGGSFLLSG 150
    QVDFAAFGEP GPFPACLKEP ADGHPGPFQT VSPAPGACPK PASPTSSLPA 200
    AHSTFEWMKV KRNAPKKSKL SEYGATSPPS AIRTNFSTKQ LTELEKEFHF 250
    NKYLTRARRI EIANCLQLND TQVKIWFQNR RMKQKKRERE GLLATAASVA 300
    SIKLPRSETS PIKSGRNLGS PSQAQEPS 328
    Length:328
    Mass (Da):34,180
    Last modified:October 16, 2013 - v2
    Checksum:i3452480CACED2FF7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti25 – 251G → A in CAA42637. (PubMed:1356009)Curated
    Sequence conflicti32 – 321Missing in CAA42637. (PubMed:1356009)Curated
    Sequence conflicti48 – 481S → N in CAA42637. (PubMed:1356009)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60034 mRNA. Translation: CAA42637.1.
    AL928733 Genomic DNA. No translation available.
    CH466519 Genomic DNA. Translation: EDL27181.1.
    BC120537 mRNA. Translation: AAI20538.1.
    BC120539 mRNA. Translation: AAI20540.1.
    M87802 Genomic DNA. Translation: AAA37853.1.
    CCDSiCCDS16147.1.
    PIRiA56553.
    RefSeqiNP_034597.2. NM_010467.2.
    UniGeneiMm.4932.

    Genome annotation databases

    EnsembliENSMUST00000047793; ENSMUSP00000043078; ENSMUSG00000042448.
    GeneIDi15429.
    KEGGimmu:15429.
    UCSCiuc008kei.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60034 mRNA. Translation: CAA42637.1 .
    AL928733 Genomic DNA. No translation available.
    CH466519 Genomic DNA. Translation: EDL27181.1 .
    BC120537 mRNA. Translation: AAI20538.1 .
    BC120539 mRNA. Translation: AAI20540.1 .
    M87802 Genomic DNA. Translation: AAA37853.1 .
    CCDSi CCDS16147.1.
    PIRi A56553.
    RefSeqi NP_034597.2. NM_010467.2.
    UniGenei Mm.4932.

    3D structure databases

    ProteinModelPortali Q01822.
    SMRi Q01822. Positions 204-290.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q01822.
    PRIDEi Q01822.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000047793 ; ENSMUSP00000043078 ; ENSMUSG00000042448 .
    GeneIDi 15429.
    KEGGi mmu:15429.
    UCSCi uc008kei.1. mouse.

    Organism-specific databases

    CTDi 3231.
    MGIi MGI:96201. Hoxd1.

    Phylogenomic databases

    eggNOGi NOG314488.
    GeneTreei ENSGT00750000117389.
    HOGENOMi HOG000247020.
    HOVERGENi HBG006089.
    InParanoidi Q01822.
    KOi K09301.
    OMAi YLEYVSC.
    OrthoDBi EOG7PK91P.
    PhylomeDBi Q01822.
    TreeFami TF317730.

    Miscellaneous databases

    NextBioi 288186.
    PROi Q01822.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_HOXD1.
    Genevestigatori Q01822.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and analysis of embryonic expression of Hox-4.9, a member of the murine labial-like gene family."
      Frohman M.A., Martin G.R.
      Mech. Dev. 38:55-67(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ICR.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 219-328.
      Strain: ICR X Swiss Webster.
      Tissue: Liver.

    Entry informationi

    Entry nameiHXD1_MOUSE
    AccessioniPrimary (citable) accession number: Q01822
    Secondary accession number(s): Q0VBQ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: October 16, 2013
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3