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Q01822

- HXD1_MOUSE

UniProt

Q01822 - HXD1_MOUSE

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Protein
Homeobox protein Hox-D1
Gene
Hoxd1, Hox-4.9, Hoxd-1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi229 – 28860Homeobox
Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. embryonic skeletal system development Source: MGI
  2. neuron differentiation Source: MGI
  3. sensory perception of pain Source: MGI
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D1
Alternative name(s):
Homeobox protein Hox-4.9
Gene namesi
Name:Hoxd1
Synonyms:Hox-4.9, Hoxd-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:96201. Hoxd1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Homeobox protein Hox-D1
PRO_0000200202Add
BLAST

Proteomic databases

PaxDbiQ01822.
PRIDEiQ01822.

Expressioni

Developmental stagei

Is first detected at the end of the late streak stage in presumptive lateral and extraembryonic mesoderm. During early neurogenesis, it is detected solely in lateral mesoderm. By late neurogenesis and through mid-gestation, it is found in a restricted region of presumed trunk neural crest and the dermatome.

Gene expression databases

CleanExiMM_HOXD1.
GenevestigatoriQ01822.

Structurei

3D structure databases

ProteinModelPortaliQ01822.
SMRiQ01822. Positions 204-290.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi204 – 2096Antp-type hexapeptide

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG314488.
GeneTreeiENSGT00750000117389.
HOGENOMiHOG000247020.
HOVERGENiHBG006089.
InParanoidiQ01822.
KOiK09301.
OMAiYLEYVSC.
OrthoDBiEOG7PK91P.
PhylomeDBiQ01822.
TreeFamiTF317730.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01822-1 [UniParc]FASTAAdd to Basket

« Hide

MSSYLEYVSC AAGGGSGGVG GDVLGFAPKF CRADARPVAL QPAFPLGSGD    50
GAFVSCLPLA TARPTPSPPA GPAQSPVPQP AAPRYAPCTL EGAYERGAAP 100
ASAAEYGFLG SGPAFDFPGA LGRAADEGGA HVHYATSAVF SGGGSFLLSG 150
QVDFAAFGEP GPFPACLKEP ADGHPGPFQT VSPAPGACPK PASPTSSLPA 200
AHSTFEWMKV KRNAPKKSKL SEYGATSPPS AIRTNFSTKQ LTELEKEFHF 250
NKYLTRARRI EIANCLQLND TQVKIWFQNR RMKQKKRERE GLLATAASVA 300
SIKLPRSETS PIKSGRNLGS PSQAQEPS 328
Length:328
Mass (Da):34,180
Last modified:October 16, 2013 - v2
Checksum:i3452480CACED2FF7
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251G → A in CAA42637. 1 Publication
Sequence conflicti32 – 321Missing in CAA42637. 1 Publication
Sequence conflicti48 – 481S → N in CAA42637. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X60034 mRNA. Translation: CAA42637.1.
AL928733 Genomic DNA. No translation available.
CH466519 Genomic DNA. Translation: EDL27181.1.
BC120537 mRNA. Translation: AAI20538.1.
BC120539 mRNA. Translation: AAI20540.1.
M87802 Genomic DNA. Translation: AAA37853.1.
CCDSiCCDS16147.1.
PIRiA56553.
RefSeqiNP_034597.2. NM_010467.2.
UniGeneiMm.4932.

Genome annotation databases

EnsembliENSMUST00000047793; ENSMUSP00000043078; ENSMUSG00000042448.
GeneIDi15429.
KEGGimmu:15429.
UCSCiuc008kei.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X60034 mRNA. Translation: CAA42637.1 .
AL928733 Genomic DNA. No translation available.
CH466519 Genomic DNA. Translation: EDL27181.1 .
BC120537 mRNA. Translation: AAI20538.1 .
BC120539 mRNA. Translation: AAI20540.1 .
M87802 Genomic DNA. Translation: AAA37853.1 .
CCDSi CCDS16147.1.
PIRi A56553.
RefSeqi NP_034597.2. NM_010467.2.
UniGenei Mm.4932.

3D structure databases

ProteinModelPortali Q01822.
SMRi Q01822. Positions 204-290.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q01822.
PRIDEi Q01822.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000047793 ; ENSMUSP00000043078 ; ENSMUSG00000042448 .
GeneIDi 15429.
KEGGi mmu:15429.
UCSCi uc008kei.1. mouse.

Organism-specific databases

CTDi 3231.
MGIi MGI:96201. Hoxd1.

Phylogenomic databases

eggNOGi NOG314488.
GeneTreei ENSGT00750000117389.
HOGENOMi HOG000247020.
HOVERGENi HBG006089.
InParanoidi Q01822.
KOi K09301.
OMAi YLEYVSC.
OrthoDBi EOG7PK91P.
PhylomeDBi Q01822.
TreeFami TF317730.

Miscellaneous databases

NextBioi 288186.
PROi Q01822.
SOURCEi Search...

Gene expression databases

CleanExi MM_HOXD1.
Genevestigatori Q01822.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and analysis of embryonic expression of Hox-4.9, a member of the murine labial-like gene family."
    Frohman M.A., Martin G.R.
    Mech. Dev. 38:55-67(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 219-328.
    Strain: ICR X Swiss Webster.
    Tissue: Liver.

Entry informationi

Entry nameiHXD1_MOUSE
AccessioniPrimary (citable) accession number: Q01822
Secondary accession number(s): Q0VBQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: October 16, 2013
Last modified: July 9, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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