Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein Hox-D1

Gene

Hoxd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi229 – 28860HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. embryonic skeletal system development Source: MGI
  2. neuron differentiation Source: MGI
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
  4. sensory perception of pain Source: MGI
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D1
Alternative name(s):
Homeobox protein Hox-4.9
Gene namesi
Name:Hoxd1
Synonyms:Hox-4.9, Hoxd-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96201. Hoxd1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Homeobox protein Hox-D1PRO_0000200202Add
BLAST

Proteomic databases

PaxDbiQ01822.
PRIDEiQ01822.

Expressioni

Developmental stagei

Is first detected at the end of the late streak stage in presumptive lateral and extraembryonic mesoderm. During early neurogenesis, it is detected solely in lateral mesoderm. By late neurogenesis and through mid-gestation, it is found in a restricted region of presumed trunk neural crest and the dermatome.

Gene expression databases

CleanExiMM_HOXD1.
GenevestigatoriQ01822.

Structurei

3D structure databases

ProteinModelPortaliQ01822.
SMRiQ01822. Positions 204-290.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi204 – 2096Antp-type hexapeptide

Sequence similaritiesi

Belongs to the Antp homeobox family. Labial subfamily.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG314488.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000247020.
HOVERGENiHBG006089.
InParanoidiQ01822.
KOiK09301.
OMAiYLEYVSC.
OrthoDBiEOG7PK91P.
PhylomeDBiQ01822.
TreeFamiTF317730.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01822-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSYLEYVSC AAGGGSGGVG GDVLGFAPKF CRADARPVAL QPAFPLGSGD
60 70 80 90 100
GAFVSCLPLA TARPTPSPPA GPAQSPVPQP AAPRYAPCTL EGAYERGAAP
110 120 130 140 150
ASAAEYGFLG SGPAFDFPGA LGRAADEGGA HVHYATSAVF SGGGSFLLSG
160 170 180 190 200
QVDFAAFGEP GPFPACLKEP ADGHPGPFQT VSPAPGACPK PASPTSSLPA
210 220 230 240 250
AHSTFEWMKV KRNAPKKSKL SEYGATSPPS AIRTNFSTKQ LTELEKEFHF
260 270 280 290 300
NKYLTRARRI EIANCLQLND TQVKIWFQNR RMKQKKRERE GLLATAASVA
310 320
SIKLPRSETS PIKSGRNLGS PSQAQEPS
Length:328
Mass (Da):34,180
Last modified:October 16, 2013 - v2
Checksum:i3452480CACED2FF7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251G → A in CAA42637 (PubMed:1356009).Curated
Sequence conflicti32 – 321Missing in CAA42637 (PubMed:1356009).Curated
Sequence conflicti48 – 481S → N in CAA42637 (PubMed:1356009).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60034 mRNA. Translation: CAA42637.1.
AL928733 Genomic DNA. No translation available.
CH466519 Genomic DNA. Translation: EDL27181.1.
BC120537 mRNA. Translation: AAI20538.1.
BC120539 mRNA. Translation: AAI20540.1.
M87802 Genomic DNA. Translation: AAA37853.1.
CCDSiCCDS16147.1.
PIRiA56553.
RefSeqiNP_034597.2. NM_010467.2.
UniGeneiMm.4932.

Genome annotation databases

EnsembliENSMUST00000047793; ENSMUSP00000043078; ENSMUSG00000042448.
GeneIDi15429.
KEGGimmu:15429.
UCSCiuc008kei.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60034 mRNA. Translation: CAA42637.1.
AL928733 Genomic DNA. No translation available.
CH466519 Genomic DNA. Translation: EDL27181.1.
BC120537 mRNA. Translation: AAI20538.1.
BC120539 mRNA. Translation: AAI20540.1.
M87802 Genomic DNA. Translation: AAA37853.1.
CCDSiCCDS16147.1.
PIRiA56553.
RefSeqiNP_034597.2. NM_010467.2.
UniGeneiMm.4932.

3D structure databases

ProteinModelPortaliQ01822.
SMRiQ01822. Positions 204-290.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ01822.
PRIDEiQ01822.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047793; ENSMUSP00000043078; ENSMUSG00000042448.
GeneIDi15429.
KEGGimmu:15429.
UCSCiuc008kei.1. mouse.

Organism-specific databases

CTDi3231.
MGIiMGI:96201. Hoxd1.

Phylogenomic databases

eggNOGiNOG314488.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000247020.
HOVERGENiHBG006089.
InParanoidiQ01822.
KOiK09301.
OMAiYLEYVSC.
OrthoDBiEOG7PK91P.
PhylomeDBiQ01822.
TreeFamiTF317730.

Miscellaneous databases

NextBioi288186.
PROiQ01822.
SOURCEiSearch...

Gene expression databases

CleanExiMM_HOXD1.
GenevestigatoriQ01822.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and analysis of embryonic expression of Hox-4.9, a member of the murine labial-like gene family."
    Frohman M.A., Martin G.R.
    Mech. Dev. 38:55-67(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 219-328.
    Strain: ICR X Swiss Webster.
    Tissue: Liver.

Entry informationi

Entry nameiHXD1_MOUSE
AccessioniPrimary (citable) accession number: Q01822
Secondary accession number(s): Q0VBQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: October 16, 2013
Last modified: January 7, 2015
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.