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Protein

Chromaffin granule amine transporter

Gene

Slc18a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells.By similarity

GO - Molecular functioni

  • drug transmembrane transporter activity Source: InterPro
  • enzyme binding Source: RGD
  • serotonin transmembrane transporter activity Source: RGD

GO - Biological processi

  • aminergic neurotransmitter loading into synaptic vesicle Source: GO_Central
  • cellular response to lithium ion Source: RGD
  • negative regulation of serotonin uptake Source: RGD
  • positive regulation of dopamine secretion Source: RGD
  • serotonin uptake Source: RGD
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Transport

Protein family/group databases

TCDBi2.A.1.2.11. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Chromaffin granule amine transporter
Alternative name(s):
Solute carrier family 18 member 1
Vesicular amine transporter 1
Short name:
VAT1
Gene namesi
Name:Slc18a1
Synonyms:Cgat, Vmat1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3693. Slc18a1.

Subcellular locationi

  • Cytoplasmic vesicle membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21CytoplasmicSequence analysisAdd BLAST21
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Topological domaini43 – 135Lumenal, vesicleSequence analysisAdd BLAST93
Transmembranei136 – 155HelicalSequence analysisAdd BLAST20
Topological domaini156 – 164CytoplasmicSequence analysis9
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Topological domaini186 – 194Lumenal, vesicleSequence analysis9
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Topological domaini216 – 224CytoplasmicSequence analysis9
Transmembranei225 – 247HelicalSequence analysisAdd BLAST23
Topological domaini248 – 253Lumenal, vesicleSequence analysis6
Transmembranei254 – 276HelicalSequence analysisAdd BLAST23
Topological domaini277 – 296CytoplasmicSequence analysisAdd BLAST20
Transmembranei297 – 316HelicalSequence analysisAdd BLAST20
Topological domaini317 – 332Lumenal, vesicleSequence analysisAdd BLAST16
Transmembranei333 – 357HelicalSequence analysisAdd BLAST25
Topological domaini358 – 362CytoplasmicSequence analysis5
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
Topological domaini384 – 394Lumenal, vesicleSequence analysisAdd BLAST11
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21
Topological domaini416 – 419CytoplasmicSequence analysis4
Transmembranei420 – 440HelicalSequence analysisAdd BLAST21
Topological domaini441 – 445Lumenal, vesicleSequence analysis5
Transmembranei446 – 467HelicalSequence analysisAdd BLAST22
Topological domaini468 – 521CytoplasmicSequence analysisAdd BLAST54

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001275121 – 521Chromaffin granule amine transporterAdd BLAST521

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi58N-linked (GlcNAc...)Sequence analysis1
Glycosylationi87N-linked (GlcNAc...)Sequence analysis1
Glycosylationi104N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ01818.

PTM databases

PhosphoSitePlusiQ01818.

Expressioni

Tissue specificityi

Adrenal gland.

Interactioni

GO - Molecular functioni

  • enzyme binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016193.

Structurei

3D structure databases

ProteinModelPortaliQ01818.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3764. Eukaryota.
ENOG410XW69. LUCA.
HOGENOMiHOG000018545.
HOVERGENiHBG055082.
InParanoidiQ01818.
KOiK08155.
PhylomeDBiQ01818.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004734. Multidrug-R.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00880. 2_A_01_02. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01818-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQVVLGAPQ RLLKEGRQSR KLVLVVVFVA LLLDNMLLTV VVPIVPTFLY
60 70 80 90 100
ATEFKDSNSS LHRGPSVSSQ QALTSPAFST IFSFFDNTTT TVEEHVPFRV
110 120 130 140 150
TWTNGTIPPP VTEASSVPKN NCLQGIEFLE EENVRIGILF ASKALMQLLV
160 170 180 190 200
NPFVGPLTNR IGYHIPMFVG FMIMFLSTLM FAFSGTYALL FVARTLQGIG
210 220 230 240 250
SSFSSVAGLG MLASVYTDNY ERGRAMGIAL GGLALGLLVG APFGSVMYEF
260 270 280 290 300
VGKSSPFLIL AFLALLDGAL QLCILWPSKV SPESAMGTSL LTLLKDPYIL
310 320 330 340 350
VAAGSICLAN MGVAILEPTL PIWMMQTMCS PEWQLGLAFL PASVAYLIGT
360 370 380 390 400
NLFGVLANKM GRWLCSLVGM VAVGISLLCV PLAHNIFGLI GPNAGLGFAI
410 420 430 440 450
GMVDSSLMPI MGYLVDLRHT SVYGSVYAIA DVAFCVGFAI GPSTGGVIVQ
460 470 480 490 500
VIGFPWLMVI IGTINIIYAP LCCFLQNPPA KEEKRAILSQ ECPTETQMYT
510 520
FQKPTKAFPL GENSDDPSSG E
Length:521
Mass (Da):55,935
Last modified:July 1, 1993 - v1
Checksum:iDCDC0D0AF0EC15D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97380 mRNA. Translation: AAA40921.1.
PIRiA43319.
RefSeqiNP_037284.2. NM_013152.2.
UniGeneiRn.89261.

Genome annotation databases

GeneIDi25693.
KEGGirno:25693.
UCSCiRGD:3693. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97380 mRNA. Translation: AAA40921.1.
PIRiA43319.
RefSeqiNP_037284.2. NM_013152.2.
UniGeneiRn.89261.

3D structure databases

ProteinModelPortaliQ01818.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016193.

Protein family/group databases

TCDBi2.A.1.2.11. the major facilitator superfamily (mfs).

PTM databases

PhosphoSitePlusiQ01818.

Proteomic databases

PaxDbiQ01818.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25693.
KEGGirno:25693.
UCSCiRGD:3693. rat.

Organism-specific databases

CTDi6570.
RGDi3693. Slc18a1.

Phylogenomic databases

eggNOGiKOG3764. Eukaryota.
ENOG410XW69. LUCA.
HOGENOMiHOG000018545.
HOVERGENiHBG055082.
InParanoidiQ01818.
KOiK08155.
PhylomeDBiQ01818.

Miscellaneous databases

PROiQ01818.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004734. Multidrug-R.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00880. 2_A_01_02. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVMAT1_RAT
AccessioniPrimary (citable) accession number: Q01818
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.