Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Chromaffin granule amine transporter

Gene

Slc18a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells.1 Publication

Enzyme regulationi

Strongly inhibited by reserpine. Also inhibited weakly by tetrabenazine.1 Publication

GO - Molecular functioni

GO - Biological processi

  • aminergic neurotransmitter loading into synaptic vesicle Source: GO_Central
  • cellular response to lithium ion Source: RGD
  • negative regulation of serotonin uptake Source: RGD
  • positive regulation of dopamine secretion Source: RGD
  • serotonin uptake Source: RGD

Keywordsi

Biological processNeurotransmitter transport, Transport

Protein family/group databases

TCDBi2.A.1.2.11 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Chromaffin granule amine transporter
Alternative name(s):
Solute carrier family 18 member 1
Vesicular amine transporter 1
Short name:
VAT1
Gene namesi
Name:Slc18a1
Synonyms:Cgat, Vmat1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3693 Slc18a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21CytoplasmicSequence analysisAdd BLAST21
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Topological domaini43 – 135Lumenal, vesicleSequence analysisAdd BLAST93
Transmembranei136 – 155HelicalSequence analysisAdd BLAST20
Topological domaini156 – 164CytoplasmicSequence analysis9
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Topological domaini186 – 194Lumenal, vesicleSequence analysis9
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Topological domaini216 – 224CytoplasmicSequence analysis9
Transmembranei225 – 247HelicalSequence analysisAdd BLAST23
Topological domaini248 – 253Lumenal, vesicleSequence analysis6
Transmembranei254 – 276HelicalSequence analysisAdd BLAST23
Topological domaini277 – 296CytoplasmicSequence analysisAdd BLAST20
Transmembranei297 – 316HelicalSequence analysisAdd BLAST20
Topological domaini317 – 332Lumenal, vesicleSequence analysisAdd BLAST16
Transmembranei333 – 357HelicalSequence analysisAdd BLAST25
Topological domaini358 – 362CytoplasmicSequence analysis5
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
Topological domaini384 – 394Lumenal, vesicleSequence analysisAdd BLAST11
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21
Topological domaini416 – 419CytoplasmicSequence analysis4
Transmembranei420 – 440HelicalSequence analysisAdd BLAST21
Topological domaini441 – 445Lumenal, vesicleSequence analysis5
Transmembranei446 – 467HelicalSequence analysisAdd BLAST22
Topological domaini468 – 521CytoplasmicSequence analysisAdd BLAST54

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001275121 – 521Chromaffin granule amine transporterAdd BLAST521

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ01818

PTM databases

PhosphoSitePlusiQ01818

Expressioni

Tissue specificityi

Adrenal gland.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016193

Structurei

3D structure databases

ProteinModelPortaliQ01818
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3764 Eukaryota
ENOG410XW69 LUCA
HOGENOMiHOG000018545
HOVERGENiHBG055082
InParanoidiQ01818
KOiK08155
PhylomeDBiQ01818

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004734 Multidrug-R
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR00880 2_A_01_02, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

Q01818-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQVVLGAPQ RLLKEGRQSR KLVLVVVFVA LLLDNMLLTV VVPIVPTFLY
60 70 80 90 100
ATEFKDSNSS LHRGPSVSSQ QALTSPAFST IFSFFDNTTT TVEEHVPFRV
110 120 130 140 150
TWTNGTIPPP VTEASSVPKN NCLQGIEFLE EENVRIGILF ASKALMQLLV
160 170 180 190 200
NPFVGPLTNR IGYHIPMFVG FMIMFLSTLM FAFSGTYALL FVARTLQGIG
210 220 230 240 250
SSFSSVAGLG MLASVYTDNY ERGRAMGIAL GGLALGLLVG APFGSVMYEF
260 270 280 290 300
VGKSSPFLIL AFLALLDGAL QLCILWPSKV SPESAMGTSL LTLLKDPYIL
310 320 330 340 350
VAAGSICLAN MGVAILEPTL PIWMMQTMCS PEWQLGLAFL PASVAYLIGT
360 370 380 390 400
NLFGVLANKM GRWLCSLVGM VAVGISLLCV PLAHNIFGLI GPNAGLGFAI
410 420 430 440 450
GMVDSSLMPI MGYLVDLRHT SVYGSVYAIA DVAFCVGFAI GPSTGGVIVQ
460 470 480 490 500
VIGFPWLMVI IGTINIIYAP LCCFLQNPPA KEEKRAILSQ ECPTETQMYT
510 520
FQKPTKAFPL GENSDDPSSG E
Length:521
Mass (Da):55,935
Last modified:July 1, 1993 - v1
Checksum:iDCDC0D0AF0EC15D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97380 mRNA Translation: AAA40921.1
PIRiA43319
RefSeqiNP_037284.2, NM_013152.2
UniGeneiRn.89261

Genome annotation databases

GeneIDi25693
KEGGirno:25693
UCSCiRGD:3693 rat

Similar proteinsi

Entry informationi

Entry nameiVMAT1_RAT
AccessioniPrimary (citable) accession number: Q01818
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health