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Q01815

- CAC1C_MOUSE

UniProt

Q01815 - CAC1C_MOUSE

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Protein

Voltage-dependent L-type calcium channel subunit alpha-1C

Gene

Cacna1c

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei363 – 3631Calcium ion selectivity and permeabilityBy similarity
Sitei706 – 7061Calcium ion selectivity and permeabilityBy similarity
Sitei1115 – 11151Calcium ion selectivity and permeabilityBy similarity
Sitei1416 – 14161Calcium ion selectivity and permeabilityBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi1505 – 151612By similarityAdd
BLAST

GO - Molecular functioni

  1. enzyme binding Source: BHF-UCL
  2. high voltage-gated calcium channel activity Source: RefGenome
  3. metal ion binding Source: UniProtKB-KW
  4. voltage-gated calcium channel activity Source: MGI

GO - Biological processi

  1. adult walking behavior Source: MGI
  2. calcium ion-dependent exocytosis Source: MGI
  3. calcium ion import Source: RefGenome
  4. calcium ion transport Source: MGI
  5. cellular calcium ion homeostasis Source: MGI
  6. glucose homeostasis Source: MGI
  7. growth hormone secretion Source: MGI
  8. insulin secretion Source: MGI
  9. membrane depolarization during action potential Source: RefGenome
  10. regulation of blood pressure Source: MGI
  11. regulation of organ growth Source: MGI
  12. regulation of vasoconstriction Source: MGI
  13. smooth muscle contraction Source: MGI
  14. smooth muscle contraction involved in micturition Source: MGI
  15. synaptic transmission Source: MGI
  16. visual learning Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_236183. NCAM1 interactions.
REACT_263148. Regulation of insulin secretion.

Protein family/group databases

TCDBi1.A.1.11.6. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit alpha-1C
Alternative name(s):
Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle
MELC-CC
Mouse brain class C
Short name:
MBC
Voltage-gated calcium channel subunit alpha Cav1.2
Gene namesi
Name:Cacna1c
Synonyms:Cach2, Cacn2, Cacnl1a1, Cchl1a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:103013. Cacna1c.

Subcellular locationi

Membrane; Multi-pass membrane protein. Cell membrane By similarity
Note: The interaction between RRAD and CACNB2 regulates its trafficking to the cell membrane.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 124124CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei125 – 14319Helical; Name=S1 of repeat ISequence AnalysisAdd
BLAST
Topological domaini144 – 16017ExtracellularSequence AnalysisAdd
BLAST
Transmembranei161 – 18121Helical; Name=S2 of repeat ISequence AnalysisAdd
BLAST
Topological domaini182 – 19312CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei194 – 21219Helical; Name=S3 of repeat ISequence AnalysisAdd
BLAST
Topological domaini213 – 23220ExtracellularSequence AnalysisAdd
BLAST
Transmembranei233 – 25119Helical; Name=S4 of repeat ISequence AnalysisAdd
BLAST
Topological domaini252 – 27019CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei271 – 29020Helical; Name=S5 of repeat ISequence AnalysisAdd
BLAST
Topological domaini291 – 38090ExtracellularSequence AnalysisAdd
BLAST
Transmembranei381 – 40525Helical; Name=S6 of repeat ISequence AnalysisAdd
BLAST
Topological domaini406 – 524119CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei525 – 54319Helical; Name=S1 of repeat IISequence AnalysisAdd
BLAST
Topological domaini544 – 55815ExtracellularSequence AnalysisAdd
BLAST
Transmembranei559 – 57820Helical; Name=S2 of repeat IISequence AnalysisAdd
BLAST
Topological domaini579 – 5868CytoplasmicSequence Analysis
Transmembranei587 – 60519Helical; Name=S3 of repeat IISequence AnalysisAdd
BLAST
Topological domaini606 – 61510ExtracellularSequence Analysis
Transmembranei616 – 63419Helical; Name=S4 of repeat IISequence AnalysisAdd
BLAST
Topological domaini635 – 65319CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei654 – 67320Helical; Name=S5 of repeat IISequence AnalysisAdd
BLAST
Topological domaini674 – 72855ExtracellularSequence AnalysisAdd
BLAST
Transmembranei729 – 75325Helical; Name=S6 of repeat IISequence AnalysisAdd
BLAST
Topological domaini754 – 900147CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei901 – 91919Helical; Name=S1 of repeat IIISequence AnalysisAdd
BLAST
Topological domaini920 – 93516ExtracellularSequence AnalysisAdd
BLAST
Transmembranei936 – 95520Helical; Name=S2 of repeat IIISequence AnalysisAdd
BLAST
Topological domaini956 – 96712CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei968 – 98619Helical; Name=S3 of repeat IIISequence AnalysisAdd
BLAST
Topological domaini987 – 9937ExtracellularSequence Analysis
Transmembranei994 – 101219Helical; Name=S4 of repeat IIISequence AnalysisAdd
BLAST
Topological domaini1013 – 103119CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei1032 – 105120Helical; Name=S5 of repeat IIISequence AnalysisAdd
BLAST
Topological domaini1052 – 114190ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1142 – 116625Helical; Name=S6 of repeat IIISequence AnalysisAdd
BLAST
Topological domaini1167 – 121953CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei1220 – 123819Helical; Name=S1 of repeat IVSequence AnalysisAdd
BLAST
Topological domaini1239 – 125315ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1254 – 127320Helical; Name=S2 of repeat IVSequence AnalysisAdd
BLAST
Topological domaini1274 – 12818CytoplasmicSequence Analysis
Transmembranei1282 – 130019Helical; Name=S3 of repeat IVSequence AnalysisAdd
BLAST
Topological domaini1301 – 132424ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1325 – 134319Helical; Name=S4 of repeat IVSequence AnalysisAdd
BLAST
Topological domaini1344 – 136219CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei1363 – 138220Helical; Name=S5 of repeat IVSequence AnalysisAdd
BLAST
Topological domaini1383 – 145169ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1452 – 147625Helical; Name=S6 of repeat IVSequence AnalysisAdd
BLAST
Topological domaini1477 – 2139663CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. caveolar macromolecular signaling complex Source: MGI
  2. dendritic shaft Source: MGI
  3. membrane Source: MGI
  4. neuronal cell body Source: MGI
  5. plasma membrane Source: MGI
  6. T-tubule Source: MGI
  7. voltage-gated calcium channel complex Source: MGI
  8. Z disc Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21392139Voltage-dependent L-type calcium channel subunit alpha-1CPRO_0000053929Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi328 – 3281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1388 – 13881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1439 – 14391N-linked (GlcNAc...)Sequence Analysis
Modified residuei1487 – 14871Phosphoserine; by PKASequence Analysis
Modified residuei1889 – 18891Phosphoserine; by PKASequence Analysis
Modified residuei1897 – 18971Phosphoserine; by PKASequence Analysis

Post-translational modificationi

Phosphorylation by PKA activates the channel.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ01815.
PRIDEiQ01815.

PTM databases

PhosphoSiteiQ01815.

Expressioni

Tissue specificityi

High expression in heart, followed by brain and spinal cord. Expressed in retina in rod bipolar cells.1 Publication

Gene expression databases

BgeeiQ01815.
ExpressionAtlasiQ01815. baseline and differential.
GenevestigatoriQ01815.

Interactioni

Subunit structurei

Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts (via C-terminal CDB motif) with CABP5; in a calcium-dependent manner. Interacts with CABP1 and CACNA2D4 (By similarity). Interacts with CIB1; the interaction increases upon cardiomyocytes hypertrophy.By similarity2 Publications

Protein-protein interaction databases

BioGridi198432. 4 interactions.
IntActiQ01815. 4 interactions.
MINTiMINT-103522.

Structurei

3D structure databases

ProteinModelPortaliQ01815.
SMRiQ01815. Positions 128-416, 419-447, 519-808, 891-1165, 1221-1480, 1560-1640.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati111 – 408298IAdd
BLAST
Repeati510 – 756247IIAdd
BLAST
Repeati887 – 1169283IIIAdd
BLAST
Repeati1206 – 1479274IVAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni428 – 44518Binding to the beta subunitBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi654 – 6607Poly-Leu
Compositional biasi768 – 7747Poly-Glu
Compositional biasi1147 – 11537Poly-Ile

Domaini

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
Binding of intracellular calcium through the EF-hand motif inhibits the opening of the channel.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118827.
HOGENOMiHOG000231529.
HOVERGENiHBG050763.
InParanoidiQ01815.
KOiK04850.
PhylomeDBiQ01815.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005451. VDCC_L_a1csu.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01635. LVDCCALPHA1C.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q01815-1) [UniParc]FASTAAdd to Basket

Also known as: CACH2A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVNENTRMYV PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGGTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIIDVPAE EDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WMQDAMGYEL PWVYFVSLVI FGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEDK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS
510 520 530 540 550
KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPH
560 570 580 590 600
WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFIVCGGI
610 620 630 640 650
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS
660 670 680 690 700
IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF
710 720 730 740 750
QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA
760 770 780 790 800
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEV MEKPAVEESK
810 820 830 840 850
EEKIELKSIT ADGESPPTTK INMDDLQPSE NEDKSPHSNP DTAGEEDEEE
860 870 880 890 900
PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSPNNRFR LQCHRIVNDT
910 920 930 940 950
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILGNADYVF TSIFTLEIIL
960 970 980 990 1000
KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS LISFGIQSSA INVVKILRVL
1010 1020 1030 1040 1050
RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG NIVIVTTLLQ FMFACIGVQL
1060 1070 1080 1090 1100
FKGKLYTCSD SSKQTEAECK GNYITYKDGE VDHPIIQPRS WENSKFDFDN
1110 1120 1130 1140 1150
VLAAMMALFT VSTFEGWPEL LYRSIDSHTE DKGPIYNYRV EISIFFIIYI
1160 1170 1180 1190 1200
IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC ELDKNQRQCV EYALKARPLR
1210 1220 1230 1240 1250
RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL LNTICLAMQH YGQSCLFKIA
1260 1270 1280 1290 1300
MNILNMLFTG LFTVEMILKL IAFKPKGYFS DPWNVFDFLI VIGSIIDVIL
1310 1320 1330 1340 1350
SETNPAEHTQ CSPSMSAEEN SRISITFFRL FRVMRLVKLL SRGEGIRTLL
1360 1370 1380 1390 1400
WTFIKSFQAL PYVALLIVML FFIYAVIGMQ VFGKIALNDT TEINRNNNFQ
1410 1420 1430 1440 1450
TFPQAVLLLF RCATGEAWQD IMLACMPGKK CAPESEPSNS TEGETPCGSS
1460 1470 1480 1490 1500
FAVFYFISFY MLCAFLIINL FVAVIMDNFD YLTRDWSILG PHHLDEFKRI
1510 1520 1530 1540 1550
WAEYDPEAKG RIKHLDVVTL LRRIQPPLGF GKLCPHRVAC KRLVSMNMPL
1560 1570 1580 1590 1600
NSDGTVMFNA TLFALVRTAL RIKTEGNLEQ ANEELRAIIK KIWKRTSMKL
1610 1620 1630 1640 1650
LDQVVPPAGD DEVTVGKFYA TFLIQEYFRK FKKRKEQGLV GKPSQRNALS
1660 1670 1680 1690 1700
LQAGLRTLHD IGPEIRRAIS GDLTAEEELD KAMKEAVSAA SEDDIFRRAG
1710 1720 1730 1740 1750
GLFGNHVTYY QSDSRGNFPQ TFATQRPLHI NKTGNNQADT ESPSHEKLVD
1760 1770 1780 1790 1800
STFTPSSYSS TGSNANINNA NNTALGRFPH PAGYSSTVST VEGHGPPLSP
1810 1820 1830 1840 1850
AVRVQEAAWK LSSKRCHSRE SQGATVNQEI FPDETRSVRM SEEAEYCSEP
1860 1870 1880 1890 1900
SLLSTDMFSY QEDEHRQLTC PEEDKREIQP SPKRSFLRSA SLGRRASFHL
1910 1920 1930 1940 1950
ECLKRQKDQG GDISQKTALP LHLVHHQALA VAGLSPLLQR SHSPTTFPRP
1960 1970 1980 1990 2000
CPTPPVTPGS RGRPLRPIPT LRLEGAESSE KLNSSFPSIH CSSWSEETTA
2010 2020 2030 2040 2050
CSGSSSMARR ARPVSLTVPS QAGAPGRQFH GSASSLVEAV LISEGLGQFA
2060 2070 2080 2090 2100
QDPKFIEVTT QELADACDMT IEEMENAADN ILSGGAQQSP NGTLLPFVNC
2110 2120 2130
RDPGQDRAVA PEDESCAYAL GRGRSEEALA DSRSYVSNL
Length:2,139
Mass (Da):240,138
Last modified:November 1, 1996 - v1
Checksum:iB564C57A8644E165
GO
Isoform 2 (identifier: Q01815-2) [UniParc]FASTAAdd to Basket

Also known as: CACH2D

The sequence of this isoform differs from the canonical sequence as follows:
     1277-1304: GYFSDPWNVFDFLIVIGSIIDVILSETN → HYFCDAWNTFDALIVVGSIVDIAITEVH
     1305-1315: Missing.

Show »
Length:2,128
Mass (Da):238,944
Checksum:iDF7AFC8BF97FE15B
GO
Isoform 3 (identifier: Q01815-3) [UniParc]FASTAAdd to Basket

Also known as: Truncated

The sequence of this isoform differs from the canonical sequence as follows:
     1-264: Missing.
     372-391: MQDAMGYELPWVYFVSLVIF → VNDAVGRDWPWIYFVTLIII
     464-464: M → RGAPAGLHDQKKGKFAWFSHSTETHV
     932-951: Missing.
     1305-1315: Missing.

Show »
Length:1,869
Mass (Da):210,822
Checksum:iA8DC3D7154C30AE2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti310 – 3101E → K in AAA62612. (PubMed:7814415)Curated
Sequence conflicti477 – 4771E → D in AAA62612. (PubMed:7814415)Curated
Sequence conflicti555 – 5551V → D in AAA62612. (PubMed:7814415)Curated
Sequence conflicti811 – 8122AD → GS in AAA62612. (PubMed:7814415)Curated
Sequence conflicti822 – 8221N → H in AAA62612. (PubMed:7814415)Curated
Sequence conflicti825 – 8251D → A in AAA62612. (PubMed:7814415)Curated
Sequence conflicti831 – 8311N → P in AAA62612. (PubMed:7814415)Curated
Sequence conflicti837 – 8415HSNPD → TPTQT in AAA37351. 1 PublicationCurated
Sequence conflicti934 – 9385GNADY → FYFDI in AAA37351. 1 PublicationCurated
Sequence conflicti942 – 9421S → T in AAA37351. 1 PublicationCurated
Sequence conflicti946 – 9461L → I in AAA37351. 1 PublicationCurated
Sequence conflicti949 – 9491I → A in AAA37351. 1 PublicationCurated
Sequence conflicti977 – 9782VS → LC in AAA62612. (PubMed:7814415)Curated
Sequence conflicti1065 – 10651T → A in AAA62612. (PubMed:7814415)Curated
Sequence conflicti1507 – 15071E → K in AAA62612. (PubMed:7814415)Curated
Sequence conflicti1525 – 15251Q → H in AAA62612. (PubMed:7814415)Curated
Sequence conflicti1633 – 16331K → E in AAA62612. (PubMed:7814415)Curated
Sequence conflicti1959 – 19591G → A in AAA62612. (PubMed:7814415)Curated
Sequence conflicti1963 – 19642RP → ST in AAA62612. (PubMed:7814415)Curated
Sequence conflicti1970 – 19701T → H in AAA62612. (PubMed:7814415)Curated
Sequence conflicti1974 – 19741E → K in AAA62612. (PubMed:7814415)Curated
Sequence conflicti2086 – 20861A → R in AAA62612. (PubMed:7814415)Curated
Sequence conflicti2097 – 20971F → L in AAA62612. (PubMed:7814415)Curated
Sequence conflicti2110 – 21101A → V in AAA62612. (PubMed:7814415)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 264264Missing in isoform 3. 1 PublicationVSP_000896Add
BLAST
Alternative sequencei372 – 39120MQDAM…SLVIF → VNDAVGRDWPWIYFVTLIII in isoform 3. 1 PublicationVSP_000897Add
BLAST
Alternative sequencei464 – 4641M → RGAPAGLHDQKKGKFAWFSH STETHV in isoform 3. 1 PublicationVSP_000898
Alternative sequencei932 – 95120Missing in isoform 3. 1 PublicationVSP_000899Add
BLAST
Alternative sequencei1277 – 130428GYFSD…LSETN → HYFCDAWNTFDALIVVGSIV DIAITEVH in isoform 2. 1 PublicationVSP_000900Add
BLAST
Alternative sequencei1305 – 131511Missing in isoform 2 and isoform 3. 2 PublicationsVSP_000901Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01776 mRNA. Translation: AAB59633.1.
M57973 mRNA. Translation: AAA63291.1.
L06233 mRNA. Translation: AAA37351.1.
U17869 mRNA. Translation: AAA62612.1.
CCDSiCCDS71821.1. [Q01815-3]
PIRiA44467.
RefSeqiNP_001153005.1. NM_001159533.2. [Q01815-1]
UniGeneiMm.41628.
Mm.436656.

Genome annotation databases

EnsembliENSMUST00000075591; ENSMUSP00000075021; ENSMUSG00000051331. [Q01815-1]
ENSMUST00000078320; ENSMUSP00000077433; ENSMUSG00000051331. [Q01815-1]
ENSMUST00000112825; ENSMUSP00000108444; ENSMUSG00000051331. [Q01815-3]
GeneIDi12288.
KEGGimmu:12288.
UCSCiuc009dls.2. mouse. [Q01815-3]
uc012erl.1. mouse. [Q01815-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01776 mRNA. Translation: AAB59633.1 .
M57973 mRNA. Translation: AAA63291.1 .
L06233 mRNA. Translation: AAA37351.1 .
U17869 mRNA. Translation: AAA62612.1 .
CCDSi CCDS71821.1. [Q01815-3 ]
PIRi A44467.
RefSeqi NP_001153005.1. NM_001159533.2. [Q01815-1 ]
UniGenei Mm.41628.
Mm.436656.

3D structure databases

ProteinModelPortali Q01815.
SMRi Q01815. Positions 128-416, 419-447, 519-808, 891-1165, 1221-1480, 1560-1640.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198432. 4 interactions.
IntActi Q01815. 4 interactions.
MINTi MINT-103522.

Chemistry

BindingDBi Q01815.
ChEMBLi CHEMBL2529.
GuidetoPHARMACOLOGYi 529.

Protein family/group databases

TCDBi 1.A.1.11.6. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSitei Q01815.

Proteomic databases

PaxDbi Q01815.
PRIDEi Q01815.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000075591 ; ENSMUSP00000075021 ; ENSMUSG00000051331 . [Q01815-1 ]
ENSMUST00000078320 ; ENSMUSP00000077433 ; ENSMUSG00000051331 . [Q01815-1 ]
ENSMUST00000112825 ; ENSMUSP00000108444 ; ENSMUSG00000051331 . [Q01815-3 ]
GeneIDi 12288.
KEGGi mmu:12288.
UCSCi uc009dls.2. mouse. [Q01815-3 ]
uc012erl.1. mouse. [Q01815-1 ]

Organism-specific databases

CTDi 775.
MGIi MGI:103013. Cacna1c.

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00760000118827.
HOGENOMi HOG000231529.
HOVERGENi HBG050763.
InParanoidi Q01815.
KOi K04850.
PhylomeDBi Q01815.

Enzyme and pathway databases

Reactomei REACT_236183. NCAM1 interactions.
REACT_263148. Regulation of insulin secretion.

Miscellaneous databases

ChiTaRSi Cacna1c. mouse.
NextBioi 280766.
PROi Q01815.
SOURCEi Search...

Gene expression databases

Bgeei Q01815.
ExpressionAtlasi Q01815. baseline and differential.
Genevestigatori Q01815.

Family and domain databases

Gene3Di 1.20.120.350. 4 hits.
InterProi IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005451. VDCC_L_a1csu.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view ]
Pfami PF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view ]
PRINTSi PR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01635. LVDCCALPHA1C.
SMARTi SM01062. Ca_chan_IQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression of a cDNA for a neuronal calcium channel alpha1 subunit enhances secretion from adrenal chromaffin cells."
    Ma W.-J., Holz R.W., Uhler M.D.
    J. Biol. Chem. 267:22728-22732(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
    Tissue: Brain.
  2. "Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genes."
    Perez-Reyes E., Wei X., Castellano A., Birnbaumer L.
    J. Biol. Chem. 265:20430-20436(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1162-1455 (ISOFORMS 1 AND 2).
    Strain: ICR.
    Tissue: Ovary.
  3. Chaudhari N.
    Submitted (JAN-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 762-1070.
  4. "Cloning and expression of a novel truncated calcium channel from non-excitable cells."
    Ma Y., Kobrinsky E., Marks A.R.
    J. Biol. Chem. 270:483-493(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 265-2139 (ISOFORM 3).
    Strain: DBA/2J.
    Tissue: Erythroleukemia.
  5. "Characterization of Ca2+-binding protein 5 knockout mouse retina."
    Rieke F., Lee A., Haeseleer F.
    Invest. Ophthalmol. Vis. Sci. 49:5126-5135(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CABP5, TISSUE SPECIFICITY.
  6. Cited for: INTERACTION WITH CIB1.

Entry informationi

Entry nameiCAC1C_MOUSE
AccessioniPrimary (citable) accession number: Q01815
Secondary accession number(s): Q04476, Q61242, Q99242
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3