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Q01815

- CAC1C_MOUSE

UniProt

Q01815 - CAC1C_MOUSE

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Protein
Voltage-dependent L-type calcium channel subunit alpha-1C
Gene
Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei363 – 3631Calcium ion selectivity and permeability By similarity
Sitei706 – 7061Calcium ion selectivity and permeability By similarity
Sitei1115 – 11151Calcium ion selectivity and permeability By similarity
Sitei1416 – 14161Calcium ion selectivity and permeability By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi1505 – 151612 By similarity
Add
BLAST

GO - Molecular functioni

  1. enzyme binding Source: BHF-UCL
  2. high voltage-gated calcium channel activity Source: RefGenome
  3. metal ion binding Source: UniProtKB-KW
  4. protein binding Source: BHF-UCL
  5. voltage-gated calcium channel activity Source: MGI
Complete GO annotation...

GO - Biological processi

  1. adult walking behavior Source: MGI
  2. calcium ion import Source: RefGenome
  3. calcium ion transport Source: MGI
  4. calcium ion-dependent exocytosis Source: MGI
  5. cellular calcium ion homeostasis Source: MGI
  6. glucose homeostasis Source: MGI
  7. growth hormone secretion Source: MGI
  8. insulin secretion Source: MGI
  9. membrane depolarization during action potential Source: RefGenome
  10. regulation of blood pressure Source: MGI
  11. regulation of organ growth Source: MGI
  12. regulation of vasoconstriction Source: MGI
  13. smooth muscle contraction Source: MGI
  14. smooth muscle contraction involved in micturition Source: MGI
  15. synaptic transmission Source: MGI
  16. visual learning Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium, Metal-binding

Protein family/group databases

TCDBi1.A.1.11.6. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit alpha-1C
Alternative name(s):
Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle
MELC-CC
Mouse brain class C
Short name:
MBC
Voltage-gated calcium channel subunit alpha Cav1.2
Gene namesi
Name:Cacna1c
Synonyms:Cach2, Cacn2, Cacnl1a1, Cchl1a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:103013. Cacna1c.

Subcellular locationi

Membrane; Multi-pass membrane protein. Cell membrane By similarity
Note: The interaction between RRAD and CACNB2 regulates its trafficking to the cell membrane By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 124124Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei125 – 14319Helical; Name=S1 of repeat I; Reviewed prediction
Add
BLAST
Topological domaini144 – 16017Extracellular Reviewed prediction
Add
BLAST
Transmembranei161 – 18121Helical; Name=S2 of repeat I; Reviewed prediction
Add
BLAST
Topological domaini182 – 19312Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei194 – 21219Helical; Name=S3 of repeat I; Reviewed prediction
Add
BLAST
Topological domaini213 – 23220Extracellular Reviewed prediction
Add
BLAST
Transmembranei233 – 25119Helical; Name=S4 of repeat I; Reviewed prediction
Add
BLAST
Topological domaini252 – 27019Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei271 – 29020Helical; Name=S5 of repeat I; Reviewed prediction
Add
BLAST
Topological domaini291 – 38090Extracellular Reviewed prediction
Add
BLAST
Transmembranei381 – 40525Helical; Name=S6 of repeat I; Reviewed prediction
Add
BLAST
Topological domaini406 – 524119Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei525 – 54319Helical; Name=S1 of repeat II; Reviewed prediction
Add
BLAST
Topological domaini544 – 55815Extracellular Reviewed prediction
Add
BLAST
Transmembranei559 – 57820Helical; Name=S2 of repeat II; Reviewed prediction
Add
BLAST
Topological domaini579 – 5868Cytoplasmic Reviewed prediction
Transmembranei587 – 60519Helical; Name=S3 of repeat II; Reviewed prediction
Add
BLAST
Topological domaini606 – 61510Extracellular Reviewed prediction
Transmembranei616 – 63419Helical; Name=S4 of repeat II; Reviewed prediction
Add
BLAST
Topological domaini635 – 65319Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei654 – 67320Helical; Name=S5 of repeat II; Reviewed prediction
Add
BLAST
Topological domaini674 – 72855Extracellular Reviewed prediction
Add
BLAST
Transmembranei729 – 75325Helical; Name=S6 of repeat II; Reviewed prediction
Add
BLAST
Topological domaini754 – 900147Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei901 – 91919Helical; Name=S1 of repeat III; Reviewed prediction
Add
BLAST
Topological domaini920 – 93516Extracellular Reviewed prediction
Add
BLAST
Transmembranei936 – 95520Helical; Name=S2 of repeat III; Reviewed prediction
Add
BLAST
Topological domaini956 – 96712Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei968 – 98619Helical; Name=S3 of repeat III; Reviewed prediction
Add
BLAST
Topological domaini987 – 9937Extracellular Reviewed prediction
Transmembranei994 – 101219Helical; Name=S4 of repeat III; Reviewed prediction
Add
BLAST
Topological domaini1013 – 103119Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1032 – 105120Helical; Name=S5 of repeat III; Reviewed prediction
Add
BLAST
Topological domaini1052 – 114190Extracellular Reviewed prediction
Add
BLAST
Transmembranei1142 – 116625Helical; Name=S6 of repeat III; Reviewed prediction
Add
BLAST
Topological domaini1167 – 121953Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1220 – 123819Helical; Name=S1 of repeat IV; Reviewed prediction
Add
BLAST
Topological domaini1239 – 125315Extracellular Reviewed prediction
Add
BLAST
Transmembranei1254 – 127320Helical; Name=S2 of repeat IV; Reviewed prediction
Add
BLAST
Topological domaini1274 – 12818Cytoplasmic Reviewed prediction
Transmembranei1282 – 130019Helical; Name=S3 of repeat IV; Reviewed prediction
Add
BLAST
Topological domaini1301 – 132424Extracellular Reviewed prediction
Add
BLAST
Transmembranei1325 – 134319Helical; Name=S4 of repeat IV; Reviewed prediction
Add
BLAST
Topological domaini1344 – 136219Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1363 – 138220Helical; Name=S5 of repeat IV; Reviewed prediction
Add
BLAST
Topological domaini1383 – 145169Extracellular Reviewed prediction
Add
BLAST
Transmembranei1452 – 147625Helical; Name=S6 of repeat IV; Reviewed prediction
Add
BLAST
Topological domaini1477 – 2139663Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. T-tubule Source: MGI
  2. Z disc Source: MGI
  3. caveolar macromolecular signaling complex Source: MGI
  4. dendritic shaft Source: MGI
  5. membrane Source: MGI
  6. neuronal cell body Source: MGI
  7. plasma membrane Source: MGI
  8. voltage-gated calcium channel complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21392139Voltage-dependent L-type calcium channel subunit alpha-1C
PRO_0000053929Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi153 – 1531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi328 – 3281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1388 – 13881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1439 – 14391N-linked (GlcNAc...) Reviewed prediction
Modified residuei1487 – 14871Phosphoserine; by PKA Reviewed prediction
Modified residuei1889 – 18891Phosphoserine; by PKA Reviewed prediction
Modified residuei1897 – 18971Phosphoserine; by PKA Reviewed prediction

Post-translational modificationi

Phosphorylation by PKA activates the channel By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ01815.
PRIDEiQ01815.

PTM databases

PhosphoSiteiQ01815.

Expressioni

Tissue specificityi

High expression in heart, followed by brain and spinal cord. Expressed in retina in rod bipolar cells.1 Publication

Gene expression databases

ArrayExpressiQ01815.
BgeeiQ01815.
GenevestigatoriQ01815.

Interactioni

Subunit structurei

Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts (via C-terminal CDB motif) with CABP5; in a calcium-dependent manner. Interacts with CABP1 and CACNA2D4 By similarity. Interacts with CIB1; the interaction increases upon cardiomyocytes hypertrophy.2 Publications

Protein-protein interaction databases

BioGridi198432. 4 interactions.
IntActiQ01815. 4 interactions.
MINTiMINT-103522.

Structurei

3D structure databases

ProteinModelPortaliQ01815.
SMRiQ01815. Positions 128-416, 419-447, 519-808, 891-1165, 1221-1480, 1560-1640.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati111 – 408298I
Add
BLAST
Repeati510 – 756247II
Add
BLAST
Repeati887 – 1169283III
Add
BLAST
Repeati1206 – 1479274IV
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni428 – 44518Binding to the beta subunit By similarity
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi654 – 6607Poly-Leu
Compositional biasi768 – 7747Poly-Glu
Compositional biasi1147 – 11537Poly-Ile

Domaini

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
Binding of intracellular calcium through the EF-hand motif inhibits the opening of the channel By similarity.

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00750000117620.
HOGENOMiHOG000231529.
HOVERGENiHBG050763.
KOiK04850.
PhylomeDBiQ01815.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005451. VDCC_L_a1csu.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01635. LVDCCALPHA1C.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q01815-1) [UniParc]FASTAAdd to Basket

Also known as: CACH2A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVNENTRMYV PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL     50
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGGTTATRP 100
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED 150
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF 200
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG 250
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN 300
QEGIIDVPAE EDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA 350
FAMLTVFQCI TMEGWTDVLY WMQDAMGYEL PWVYFVSLVI FGSFFVLNLV 400
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE 450
NEDEGMDEDK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS 500
KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPH 550
WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFIVCGGI 600
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS 650
IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF 700
QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA 750
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEV MEKPAVEESK 800
EEKIELKSIT ADGESPPTTK INMDDLQPSE NEDKSPHSNP DTAGEEDEEE 850
PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSPNNRFR LQCHRIVNDT 900
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILGNADYVF TSIFTLEIIL 950
KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS LISFGIQSSA INVVKILRVL 1000
RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG NIVIVTTLLQ FMFACIGVQL 1050
FKGKLYTCSD SSKQTEAECK GNYITYKDGE VDHPIIQPRS WENSKFDFDN 1100
VLAAMMALFT VSTFEGWPEL LYRSIDSHTE DKGPIYNYRV EISIFFIIYI 1150
IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC ELDKNQRQCV EYALKARPLR 1200
RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL LNTICLAMQH YGQSCLFKIA 1250
MNILNMLFTG LFTVEMILKL IAFKPKGYFS DPWNVFDFLI VIGSIIDVIL 1300
SETNPAEHTQ CSPSMSAEEN SRISITFFRL FRVMRLVKLL SRGEGIRTLL 1350
WTFIKSFQAL PYVALLIVML FFIYAVIGMQ VFGKIALNDT TEINRNNNFQ 1400
TFPQAVLLLF RCATGEAWQD IMLACMPGKK CAPESEPSNS TEGETPCGSS 1450
FAVFYFISFY MLCAFLIINL FVAVIMDNFD YLTRDWSILG PHHLDEFKRI 1500
WAEYDPEAKG RIKHLDVVTL LRRIQPPLGF GKLCPHRVAC KRLVSMNMPL 1550
NSDGTVMFNA TLFALVRTAL RIKTEGNLEQ ANEELRAIIK KIWKRTSMKL 1600
LDQVVPPAGD DEVTVGKFYA TFLIQEYFRK FKKRKEQGLV GKPSQRNALS 1650
LQAGLRTLHD IGPEIRRAIS GDLTAEEELD KAMKEAVSAA SEDDIFRRAG 1700
GLFGNHVTYY QSDSRGNFPQ TFATQRPLHI NKTGNNQADT ESPSHEKLVD 1750
STFTPSSYSS TGSNANINNA NNTALGRFPH PAGYSSTVST VEGHGPPLSP 1800
AVRVQEAAWK LSSKRCHSRE SQGATVNQEI FPDETRSVRM SEEAEYCSEP 1850
SLLSTDMFSY QEDEHRQLTC PEEDKREIQP SPKRSFLRSA SLGRRASFHL 1900
ECLKRQKDQG GDISQKTALP LHLVHHQALA VAGLSPLLQR SHSPTTFPRP 1950
CPTPPVTPGS RGRPLRPIPT LRLEGAESSE KLNSSFPSIH CSSWSEETTA 2000
CSGSSSMARR ARPVSLTVPS QAGAPGRQFH GSASSLVEAV LISEGLGQFA 2050
QDPKFIEVTT QELADACDMT IEEMENAADN ILSGGAQQSP NGTLLPFVNC 2100
RDPGQDRAVA PEDESCAYAL GRGRSEEALA DSRSYVSNL 2139
Length:2,139
Mass (Da):240,138
Last modified:November 1, 1996 - v1
Checksum:iB564C57A8644E165
GO
Isoform 2 (identifier: Q01815-2) [UniParc]FASTAAdd to Basket

Also known as: CACH2D

The sequence of this isoform differs from the canonical sequence as follows:
     1277-1304: GYFSDPWNVFDFLIVIGSIIDVILSETN → HYFCDAWNTFDALIVVGSIVDIAITEVH
     1305-1315: Missing.

Show »
Length:2,128
Mass (Da):238,944
Checksum:iDF7AFC8BF97FE15B
GO
Isoform 3 (identifier: Q01815-3) [UniParc]FASTAAdd to Basket

Also known as: Truncated

The sequence of this isoform differs from the canonical sequence as follows:
     1-264: Missing.
     372-391: MQDAMGYELPWVYFVSLVIF → VNDAVGRDWPWIYFVTLIII
     464-464: M → RGAPAGLHDQKKGKFAWFSHSTETHV
     932-951: Missing.
     1305-1315: Missing.

Show »
Length:1,869
Mass (Da):210,822
Checksum:iA8DC3D7154C30AE2
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 264264Missing in isoform 3.
VSP_000896Add
BLAST
Alternative sequencei372 – 39120MQDAM…SLVIF → VNDAVGRDWPWIYFVTLIII in isoform 3.
VSP_000897Add
BLAST
Alternative sequencei464 – 4641M → RGAPAGLHDQKKGKFAWFSH STETHV in isoform 3.
VSP_000898
Alternative sequencei932 – 95120Missing in isoform 3.
VSP_000899Add
BLAST
Alternative sequencei1277 – 130428GYFSD…LSETN → HYFCDAWNTFDALIVVGSIV DIAITEVH in isoform 2.
VSP_000900Add
BLAST
Alternative sequencei1305 – 131511Missing in isoform 2 and isoform 3.
VSP_000901Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti310 – 3101E → K in AAA62612. 1 Publication
Sequence conflicti477 – 4771E → D in AAA62612. 1 Publication
Sequence conflicti555 – 5551V → D in AAA62612. 1 Publication
Sequence conflicti811 – 8122AD → GS in AAA62612. 1 Publication
Sequence conflicti822 – 8221N → H in AAA62612. 1 Publication
Sequence conflicti825 – 8251D → A in AAA62612. 1 Publication
Sequence conflicti831 – 8311N → P in AAA62612. 1 Publication
Sequence conflicti837 – 8415HSNPD → TPTQT in AAA37351. 1 Publication
Sequence conflicti934 – 9385GNADY → FYFDI in AAA37351. 1 Publication
Sequence conflicti942 – 9421S → T in AAA37351. 1 Publication
Sequence conflicti946 – 9461L → I in AAA37351. 1 Publication
Sequence conflicti949 – 9491I → A in AAA37351. 1 Publication
Sequence conflicti977 – 9782VS → LC in AAA62612. 1 Publication
Sequence conflicti1065 – 10651T → A in AAA62612. 1 Publication
Sequence conflicti1507 – 15071E → K in AAA62612. 1 Publication
Sequence conflicti1525 – 15251Q → H in AAA62612. 1 Publication
Sequence conflicti1633 – 16331K → E in AAA62612. 1 Publication
Sequence conflicti1959 – 19591G → A in AAA62612. 1 Publication
Sequence conflicti1963 – 19642RP → ST in AAA62612. 1 Publication
Sequence conflicti1970 – 19701T → H in AAA62612. 1 Publication
Sequence conflicti1974 – 19741E → K in AAA62612. 1 Publication
Sequence conflicti2086 – 20861A → R in AAA62612. 1 Publication
Sequence conflicti2097 – 20971F → L in AAA62612. 1 Publication
Sequence conflicti2110 – 21101A → V in AAA62612. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L01776 mRNA. Translation: AAB59633.1.
M57973 mRNA. Translation: AAA63291.1.
L06233 mRNA. Translation: AAA37351.1.
U17869 mRNA. Translation: AAA62612.1.
CCDSiCCDS71821.1. [Q01815-3]
PIRiA44467.
RefSeqiNP_001153005.1. NM_001159533.2. [Q01815-1]
UniGeneiMm.41628.
Mm.436656.

Genome annotation databases

EnsembliENSMUST00000112825; ENSMUSP00000108444; ENSMUSG00000051331. [Q01815-3]
GeneIDi12288.
KEGGimmu:12288.
UCSCiuc009dls.2. mouse. [Q01815-3]
uc012erl.1. mouse. [Q01815-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L01776 mRNA. Translation: AAB59633.1 .
M57973 mRNA. Translation: AAA63291.1 .
L06233 mRNA. Translation: AAA37351.1 .
U17869 mRNA. Translation: AAA62612.1 .
CCDSi CCDS71821.1. [Q01815-3 ]
PIRi A44467.
RefSeqi NP_001153005.1. NM_001159533.2. [Q01815-1 ]
UniGenei Mm.41628.
Mm.436656.

3D structure databases

ProteinModelPortali Q01815.
SMRi Q01815. Positions 128-416, 419-447, 519-808, 891-1165, 1221-1480, 1560-1640.
ModBasei Search...

Protein-protein interaction databases

BioGridi 198432. 4 interactions.
IntActi Q01815. 4 interactions.
MINTi MINT-103522.

Chemistry

BindingDBi Q01815.
ChEMBLi CHEMBL2529.
GuidetoPHARMACOLOGYi 529.

Protein family/group databases

TCDBi 1.A.1.11.6. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSitei Q01815.

Proteomic databases

PaxDbi Q01815.
PRIDEi Q01815.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000112825 ; ENSMUSP00000108444 ; ENSMUSG00000051331 . [Q01815-3 ]
GeneIDi 12288.
KEGGi mmu:12288.
UCSCi uc009dls.2. mouse. [Q01815-3 ]
uc012erl.1. mouse. [Q01815-1 ]

Organism-specific databases

CTDi 775.
MGIi MGI:103013. Cacna1c.

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00750000117620.
HOGENOMi HOG000231529.
HOVERGENi HBG050763.
KOi K04850.
PhylomeDBi Q01815.

Miscellaneous databases

ChiTaRSi CACNA1C. mouse.
NextBioi 280766.
PROi Q01815.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q01815.
Bgeei Q01815.
Genevestigatori Q01815.

Family and domain databases

Gene3Di 1.20.120.350. 4 hits.
InterProi IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005451. VDCC_L_a1csu.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view ]
Pfami PF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view ]
PRINTSi PR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01635. LVDCCALPHA1C.
SMARTi SM01062. Ca_chan_IQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression of a cDNA for a neuronal calcium channel alpha1 subunit enhances secretion from adrenal chromaffin cells."
    Ma W.-J., Holz R.W., Uhler M.D.
    J. Biol. Chem. 267:22728-22732(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
    Tissue: Brain.
  2. "Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genes."
    Perez-Reyes E., Wei X., Castellano A., Birnbaumer L.
    J. Biol. Chem. 265:20430-20436(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1162-1455 (ISOFORMS 1 AND 2).
    Strain: ICR.
    Tissue: Ovary.
  3. Chaudhari N.
    Submitted (JAN-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 762-1070.
  4. "Cloning and expression of a novel truncated calcium channel from non-excitable cells."
    Ma Y., Kobrinsky E., Marks A.R.
    J. Biol. Chem. 270:483-493(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 265-2139 (ISOFORM 3).
    Strain: DBA/2J.
    Tissue: Erythroleukemia.
  5. "Characterization of Ca2+-binding protein 5 knockout mouse retina."
    Rieke F., Lee A., Haeseleer F.
    Invest. Ophthalmol. Vis. Sci. 49:5126-5135(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CABP5, TISSUE SPECIFICITY.
  6. Cited for: INTERACTION WITH CIB1.

Entry informationi

Entry nameiCAC1C_MOUSE
AccessioniPrimary (citable) accession number: Q01815
Secondary accession number(s): Q04476, Q61242, Q99242
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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