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Q01814

- AT2B2_HUMAN

UniProt

Q01814 - AT2B2_HUMAN

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Protein

Plasma membrane calcium-transporting ATPase 2

Gene

ATP2B2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei499 – 49914-aspartylphosphate intermediate
Metal bindingi820 – 8201MagnesiumBy similarity
Metal bindingi824 – 8241MagnesiumBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. calcium-dependent ATPase activity Source: Ensembl
  3. calcium ion binding Source: UniProtKB
  4. calcium-transporting ATPase activity Source: UniProtKB
  5. calmodulin binding Source: UniProtKB
  6. metal ion binding Source: UniProtKB-KW
  7. PDZ domain binding Source: UniProtKB
  8. protein C-terminus binding Source: UniProtKB

GO - Biological processi

  1. auditory receptor cell stereocilium organization Source: Ensembl
  2. blood coagulation Source: Reactome
  3. calcium ion transmembrane transport Source: GOC
  4. calcium ion transport Source: DFLAT
  5. cerebellar granule cell differentiation Source: Ensembl
  6. cerebellar Purkinje cell differentiation Source: Ensembl
  7. cGMP metabolic process Source: Ensembl
  8. cochlea development Source: Ensembl
  9. cytosolic calcium ion homeostasis Source: DFLAT
  10. detection of mechanical stimulus involved in sensory perception of sound Source: Ensembl
  11. ion transmembrane transport Source: Reactome
  12. lactation Source: Ensembl
  13. locomotion Source: Ensembl
  14. locomotory behavior Source: Ensembl
  15. neuromuscular process controlling balance Source: Ensembl
  16. neuron differentiation Source: UniProtKB
  17. organelle organization Source: Ensembl
  18. otolith mineralization Source: Ensembl
  19. positive regulation of calcium ion transport Source: Ensembl
  20. regulation of cell size Source: Ensembl
  21. regulation of synaptic plasticity Source: Ensembl
  22. sensory perception of sound Source: UniProtKB
  23. serotonin metabolic process Source: Ensembl
  24. synapse organization Source: Ensembl
  25. transmembrane transport Source: Reactome
  26. transport Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Calcium, Calmodulin-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_23765. Reduction of cytosolic Ca++ levels.
REACT_25149. Ion transport by P-type ATPases.

Protein family/group databases

TCDBi3.A.3.2.40. the p-type atpase (p-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Plasma membrane calcium-transporting ATPase 2 (EC:3.6.3.8)
Short name:
PMCA2
Alternative name(s):
Plasma membrane calcium ATPase isoform 2
Plasma membrane calcium pump isoform 2
Gene namesi
Name:ATP2B2
Synonyms:PMCA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:815. ATP2B2.

Subcellular locationi

Cell junctionsynapse By similarity. Cell membrane Sequence Analysis; Multi-pass membrane protein Sequence Analysis

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9494CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei95 – 11521HelicalSequence AnalysisAdd
BLAST
Topological domaini116 – 15237ExtracellularSequence AnalysisAdd
BLAST
Transmembranei153 – 17321HelicalSequence AnalysisAdd
BLAST
Topological domaini174 – 390217CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei391 – 41020HelicalSequence AnalysisAdd
BLAST
Topological domaini411 – 44333ExtracellularSequence AnalysisAdd
BLAST
Transmembranei444 – 46118HelicalSequence AnalysisAdd
BLAST
Topological domaini462 – 875414CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei876 – 89520HelicalSequence AnalysisAdd
BLAST
Topological domaini896 – 90510ExtracellularSequence Analysis
Transmembranei906 – 92621HelicalSequence AnalysisAdd
BLAST
Topological domaini927 – 94620CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei947 – 96923HelicalSequence AnalysisAdd
BLAST
Topological domaini970 – 98718ExtracellularSequence AnalysisAdd
BLAST
Transmembranei988 – 100922HelicalSequence AnalysisAdd
BLAST
Topological domaini1010 – 102819CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei1029 – 105022HelicalSequence AnalysisAdd
BLAST
Topological domaini1051 – 106010ExtracellularSequence Analysis
Transmembranei1061 – 108222HelicalSequence AnalysisAdd
BLAST
Topological domaini1083 – 1243161CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. cilium Source: Ensembl
  3. cytoplasm Source: UniProtKB
  4. endoplasmic reticulum Source: Ensembl
  5. integral component of membrane Source: UniProtKB-KW
  6. neuronal cell body Source: Ensembl
  7. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25108.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12431243Plasma membrane calcium-transporting ATPase 2PRO_0000046214Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1139 – 11391Phosphothreonine; by PKCBy similarity
Modified residuei1201 – 12011Phosphoserine; by PKABy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ01814.
PaxDbiQ01814.
PRIDEiQ01814.

PTM databases

PhosphoSiteiQ01814.

Expressioni

Tissue specificityi

Mainly expressed in brain cortex. Found in low levels in skeletal muscle, heart muscle, stomach, liver, kidney and lung. Isoforms containing segment B are found in brain cortex and at low levels in other tissues. Isoforms containing segments X and W are found at low levels in all tissues. Isoforms containing segment A and segment Z are found at low levels in skeletal muscle and heart muscle.

Gene expression databases

BgeeiQ01814.
CleanExiHS_ATP2B2.
ExpressionAtlasiQ01814. baseline and differential.
GenevestigatoriQ01814.

Organism-specific databases

HPAiCAB005606.

Interactioni

Subunit structurei

Interacts with PDZD11.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CALCAP012582EBI-1174243,EBI-1018474
Dlg2Q636222EBI-1174262,EBI-396947From a different organism.
SLC9A3R2Q8SQG93EBI-1174262,EBI-1174758From a different organism.

Protein-protein interaction databases

BioGridi106981. 31 interactions.
IntActiQ01814. 8 interactions.
MINTiMINT-470839.
STRINGi9606.ENSP00000324172.

Structurei

3D structure databases

ProteinModelPortaliQ01814.
SMRiQ01814. Positions 70-298, 364-948, 1123-1150.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1123 – 114018Calmodulin-binding subdomain ABy similarityAdd
BLAST
Regioni1141 – 115010Calmodulin-binding subdomain BBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi294 – 2974Poly-Glu

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0474.
GeneTreeiENSGT00510000046331.
HOGENOMiHOG000265623.
HOVERGENiHBG061286.
InParanoidiQ01814.
KOiK05850.
OMAiGRINNLK.
OrthoDBiEOG7SN8BN.
PhylomeDBiQ01814.
TreeFamiTF300330.

Family and domain databases

Gene3Di1.20.1110.10. 1 hit.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR022141. ATP_Ca_trans_C.
IPR006408. ATPase_P-typ_Ca-transp_plasma.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF12424. ATP_Ca_trans_C. 1 hit.
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. Align

Note: There is a combination of two alternative spliced domains at N-terminal site A (Z, X, Y and W) and at C-terminal site C (A and B). So far the splice sites have only been studied independently. Experimental confirmation may be lacking for some isoforms.

Isoform WB (identifier: Q01814-1) [UniParc]FASTAAdd to Basket

Also known as: AIIICI

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDMTNSDFY SKNQRNESSH GGEFGCTMEE LRSLMELRGT EAVVKIKETY
60 70 80 90 100
GDTEAICRRL KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW
110 120 130 140 150
EALQDVTLII LEIAAIISLG LSFYHPPGEG NEGCATAQGG AEDEGEAEAG
160 170 180 190 200
WIEGAAILLS VICVVLVTAF NDWSKEKQFR GLQSRIEQEQ KFTVVRAGQV
210 220 230 240 250
VQIPVAEIVV GDIAQVKYGD LLPADGLFIQ GNDLKIDESS LTGESDQVRK
260 270 280 290 300
SVDKDPMLLS GTHVMEGSGR MLVTAVGVNS QTGIIFTLLG AGGEEEEKKD
310 320 330 340 350
KKGVKKGDGL QLPAADGAAA SNAADSANAS LVNGKMQDGN VDASQSKAKQ
360 370 380 390 400
QDGAAAMEMQ PLKSAEGGDA DDRKKASMHK KEKSVLQGKL TKLAVQIGKA
410 420 430 440 450
GLVMSAITVI ILVLYFTVDT FVVNKKPWLP ECTPVYVQYF VKFFIIGVTV
460 470 480 490 500
LVVAVPEGLP LAVTISLAYS VKKMMKDNNL VRHLDACETM GNATAICSDK
510 520 530 540 550
TGTLTTNRMT VVQAYVGDVH YKEIPDPSSI NTKTMELLIN AIAINSAYTT
560 570 580 590 600
KILPPEKEGA LPRQVGNKTE CGLLGFVLDL KQDYEPVRSQ MPEEKLYKVY
610 620 630 640 650
TFNSVRKSMS TVIKLPDESF RMYSKGASEI VLKKCCKILN GAGEPRVFRP
660 670 680 690 700
RDRDEMVKKV IEPMACDGLR TICVAYRDFP SSPEPDWDNE NDILNELTCI
710 720 730 740 750
CVVGIEDPVR PEVPEAIRKC QRAGITVRMV TGDNINTARA IAIKCGIIHP
760 770 780 790 800
GEDFLCLEGK EFNRRIRNEK GEIEQERIDK IWPKLRVLAR SSPTDKHTLV
810 820 830 840 850
KGIIDSTHTE QRQVVAVTGD GTNDGPALKK ADVGFAMGIA GTDVAKEASD
860 870 880 890 900
IILTDDNFSS IVKAVMWGRN VYDSISKFLQ FQLTVNVVAV IVAFTGACIT
910 920 930 940 950
QDSPLKAVQM LWVNLIMDTF ASLALATEPP TETLLLRKPY GRNKPLISRT
960 970 980 990 1000
MMKNILGHAV YQLALIFTLL FVGEKMFQID SGRNAPLHSP PSEHYTIIFN
1010 1020 1030 1040 1050
TFVMMQLFNE INARKIHGER NVFDGIFRNP IFCTIVLGTF AIQIVIVQFG
1060 1070 1080 1090 1100
GKPFSCSPLQ LDQWMWCIFI GLGELVWGQV IATIPTSRLK FLKEAGRLTQ
1110 1120 1130 1140 1150
KEEIPEEELN EDVEEIDHAE RELRRGQILW FRGLNRIQTQ IRVVKAFRSS
1160 1170 1180 1190 1200
LYEGLEKPES RTSIHNFMAH PEFRIEDSQP HIPLIDDTDL EEDAALKQNS
1210 1220 1230 1240
SPPSSLNKNN SAIDSGINLT TDTSKSATSS SPGSPIHSLE TSL
Length:1,243
Mass (Da):136,876
Last modified:June 1, 2001 - v2
Checksum:i7F10221B7B9AC3A2
GO
Isoform WA (identifier: Q01814-2) [UniParc]FASTAAdd to Basket

Also known as: AIIICII

The sequence of this isoform differs from the canonical sequence as follows:
     1141-1243: IRVVKAFRSS...SPIHSLETSL → IEVVNTFKSG...SLPPAAAGQG

Note: Contains a phosphoserine at position 1177.

Show »
Length:1,199
Mass (Da):131,618
Checksum:i63CF042CC00776B1
GO
Isoform YA (identifier: Q01814-3) [UniParc]FASTAAdd to Basket

Also known as: AIICII

The sequence of this isoform differs from the canonical sequence as follows:
     334-347: Missing.
     1141-1243: IRVVKAFRSS...SPIHSLETSL → IEVVNTFKSG...SLPPAAAGQG

Note: Contains a phosphoserine at position 1163.

Show »
Length:1,185
Mass (Da):130,171
Checksum:iDED471E8D9102EF2
GO
Isoform ZA (identifier: Q01814-4) [UniParc]FASTAAdd to Basket

Also known as: AICII

The sequence of this isoform differs from the canonical sequence as follows:
     303-347: Missing.
     1141-1243: IRVVKAFRSS...SPIHSLETSL → IEVVNTFKSG...SLPPAAAGQG

Note: Contains a phosphoserine at position 1132.

Show »
Length:1,154
Mass (Da):127,335
Checksum:iECB232AA4AC37BE8
GO
Isoform YB (identifier: Q01814-5) [UniParc]FASTAAdd to Basket

Also known as: AIICI

The sequence of this isoform differs from the canonical sequence as follows:
     334-347: Missing.

Show »
Length:1,229
Mass (Da):135,430
Checksum:iA7E663E42EBDEAA9
GO
Isoform ZB (identifier: Q01814-6) [UniParc]FASTAAdd to Basket

Also known as: AICI

The sequence of this isoform differs from the canonical sequence as follows:
     303-347: Missing.

Show »
Length:1,198
Mass (Da):132,594
Checksum:iEEF94C16D4C1C73E
GO
Isoform XA (identifier: Q01814-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     304-334: Missing.
     1141-1243: IRVVKAFRSS...SPIHSLETSL → IEVVNTFKSG...SLPPAAAGQG

Note: Contains a phosphoserine at position 1146.

Show »
Length:1,168
Mass (Da):128,781
Checksum:iDF137BD7DE5AAA8E
GO
Isoform XB (identifier: Q01814-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     304-334: Missing.

Show »
Length:1,212
Mass (Da):134,040
Checksum:i988E5FEBD1F3A880
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 943PKT → AKP in AAA36456. (PubMed:1427863)Curated
Sequence conflicti126 – 1261P → R in AAA50877. (PubMed:8428366)Curated
Sequence conflicti126 – 1261P → R in AAA51893. (PubMed:8428366)Curated
Sequence conflicti517 – 5171G → D in AAA50877. (PubMed:8428366)Curated
Sequence conflicti517 – 5171G → D in AAA51893. (PubMed:8428366)Curated
Sequence conflicti667 – 6682DG → EW in AAA36456. (PubMed:1427863)Curated
Sequence conflicti1212 – 12121A → S in AAA36456. (PubMed:1427863)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei303 – 34745Missing in isoform ZA and isoform ZB. 2 PublicationsVSP_000384Add
BLAST
Alternative sequencei304 – 33431Missing in isoform XA and isoform XB. CuratedVSP_040837Add
BLAST
Alternative sequencei334 – 34714Missing in isoform YA and isoform YB. CuratedVSP_000385Add
BLAST
Alternative sequencei1141 – 1243103IRVVK…LETSL → IEVVNTFKSGASFQGALRRQ SSVTSQSQDVANLSSPSRVS LSNALSSPTSLPPAAAGQG in isoform WA, isoform XA, isoform YA and isoform ZA. CuratedVSP_000386Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97260 mRNA. Translation: AAA36456.1.
L20977 mRNA. Translation: AAA50877.1.
L00620 mRNA. Translation: AAA51893.1.
X63575 mRNA. Translation: CAA45131.1.
AC018839 Genomic DNA. No translation available.
AC090841 Genomic DNA. No translation available.
U15688 mRNA. Translation: AAA60985.1.
CCDSiCCDS2601.1. [Q01814-6]
CCDS33701.1. [Q01814-1]
PIRiS22393.
RefSeqiNP_001001331.1. NM_001001331.2. [Q01814-1]
NP_001674.2. NM_001683.3. [Q01814-6]
XP_005265236.1. XM_005265179.2. [Q01814-1]
XP_006713238.1. XM_006713175.1. [Q01814-1]
XP_006713239.1. XM_006713176.1. [Q01814-1]
XP_006713241.1. XM_006713178.1. [Q01814-8]
XP_006713243.1. XM_006713180.1. [Q01814-2]
UniGeneiHs.268942.

Genome annotation databases

EnsembliENST00000352432; ENSP00000324172; ENSG00000157087. [Q01814-1]
ENST00000360273; ENSP00000353414; ENSG00000157087. [Q01814-1]
ENST00000383800; ENSP00000373311; ENSG00000157087. [Q01814-6]
ENST00000397077; ENSP00000380267; ENSG00000157087. [Q01814-6]
ENST00000460129; ENSP00000424494; ENSG00000157087. [Q01814-4]
GeneIDi491.
KEGGihsa:491.
UCSCiuc003bvt.3. human. [Q01814-1]
uc003bvv.3. human. [Q01814-6]

Polymorphism databases

DMDMi14286115.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97260 mRNA. Translation: AAA36456.1 .
L20977 mRNA. Translation: AAA50877.1 .
L00620 mRNA. Translation: AAA51893.1 .
X63575 mRNA. Translation: CAA45131.1 .
AC018839 Genomic DNA. No translation available.
AC090841 Genomic DNA. No translation available.
U15688 mRNA. Translation: AAA60985.1 .
CCDSi CCDS2601.1. [Q01814-6 ]
CCDS33701.1. [Q01814-1 ]
PIRi S22393.
RefSeqi NP_001001331.1. NM_001001331.2. [Q01814-1 ]
NP_001674.2. NM_001683.3. [Q01814-6 ]
XP_005265236.1. XM_005265179.2. [Q01814-1 ]
XP_006713238.1. XM_006713175.1. [Q01814-1 ]
XP_006713239.1. XM_006713176.1. [Q01814-1 ]
XP_006713241.1. XM_006713178.1. [Q01814-8 ]
XP_006713243.1. XM_006713180.1. [Q01814-2 ]
UniGenei Hs.268942.

3D structure databases

ProteinModelPortali Q01814.
SMRi Q01814. Positions 70-298, 364-948, 1123-1150.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106981. 31 interactions.
IntActi Q01814. 8 interactions.
MINTi MINT-470839.
STRINGi 9606.ENSP00000324172.

Protein family/group databases

TCDBi 3.A.3.2.40. the p-type atpase (p-atpase) superfamily.

PTM databases

PhosphoSitei Q01814.

Polymorphism databases

DMDMi 14286115.

Proteomic databases

MaxQBi Q01814.
PaxDbi Q01814.
PRIDEi Q01814.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000352432 ; ENSP00000324172 ; ENSG00000157087 . [Q01814-1 ]
ENST00000360273 ; ENSP00000353414 ; ENSG00000157087 . [Q01814-1 ]
ENST00000383800 ; ENSP00000373311 ; ENSG00000157087 . [Q01814-6 ]
ENST00000397077 ; ENSP00000380267 ; ENSG00000157087 . [Q01814-6 ]
ENST00000460129 ; ENSP00000424494 ; ENSG00000157087 . [Q01814-4 ]
GeneIDi 491.
KEGGi hsa:491.
UCSCi uc003bvt.3. human. [Q01814-1 ]
uc003bvv.3. human. [Q01814-6 ]

Organism-specific databases

CTDi 491.
GeneCardsi GC03M010365.
HGNCi HGNC:815. ATP2B2.
HPAi CAB005606.
MIMi 108733. gene.
neXtProti NX_Q01814.
PharmGKBi PA25108.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0474.
GeneTreei ENSGT00510000046331.
HOGENOMi HOG000265623.
HOVERGENi HBG061286.
InParanoidi Q01814.
KOi K05850.
OMAi GRINNLK.
OrthoDBi EOG7SN8BN.
PhylomeDBi Q01814.
TreeFami TF300330.

Enzyme and pathway databases

Reactomei REACT_23765. Reduction of cytosolic Ca++ levels.
REACT_25149. Ion transport by P-type ATPases.

Miscellaneous databases

ChiTaRSi ATP2B2. human.
GeneWikii ATP2B2.
GenomeRNAii 491.
NextBioi 2059.
PROi Q01814.
SOURCEi Search...

Gene expression databases

Bgeei Q01814.
CleanExi HS_ATP2B2.
ExpressionAtlasi Q01814. baseline and differential.
Genevestigatori Q01814.

Family and domain databases

Gene3Di 1.20.1110.10. 1 hit.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProi IPR022141. ATP_Ca_trans_C.
IPR006408. ATPase_P-typ_Ca-transp_plasma.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF12424. ATP_Ca_trans_C. 1 hit.
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SMARTi SM00831. Cation_ATPase_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Determination of the nucleotide sequence and chromosomal localization of the ATP2B2 gene encoding human Ca(2+)-pumping ATPase isoform PMCA2."
    Brandt P., Ibrahim E., Bruns G.A.P., Neve R.L.
    Genomics 14:484-487(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ZB).
    Tissue: Brain.
  2. "von Hippel-Lindau syndrome: cloning and identification of the plasma membrane Ca(++)-transporting ATPase isoform 2 gene that resides in the von Hippel-Lindau gene region."
    Latif F., Duh F.-M., Gnarra J., Tory K., Kuzmin I., Yao M., Stackhouse T., Modi W., Geil L., Schmidt L., Li H., Orcutt M.L., Maher E., Richards F., Phipps M., Ferguson-Smith M., le Paslier D., Linehan W.M., Zbar B., Lerman M.I.
    Cancer Res. 53:861-867(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ZB), ALTERNATIVE SPLICING.
  3. "Microdiversity of human-plasma-membrane calcium-pump isoform 2 generated by alternative RNA splicing in the N-terminal coding region."
    Heim R., Hug M., Iwata T., Strehler E.E., Carafoli E.
    Eur. J. Biochem. 205:333-340(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM WB), ALTERNATIVE SPLICING.
    Tissue: Brain and Skeletal muscle.
  4. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes."
    Stauffer T.P., Hilfiker H., Carafoli E., Strehler E.E.
    J. Biol. Chem. 268:25993-26003(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS WA/YA/ZA).
    Tissue: Brain cortex.
  6. Erratum
    Stauffer T.P., Hilfiker H., Carafoli E., Strehler E.E.
    J. Biol. Chem. 269:32022-32022(1994) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of PISP, a novel single-PDZ protein that binds to all plasma membrane Ca2+-ATPase b-splice variants."
    Goellner G.M., DeMarco S.J., Strehler E.E.
    Ann. N. Y. Acad. Sci. 986:461-471(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PDZD11.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1177 (ISOFORM WA), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1146 (ISOFORM XA), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1163 (ISOFORM YA), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1132 (ISOFORM ZA), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiAT2B2_HUMAN
AccessioniPrimary (citable) accession number: Q01814
Secondary accession number(s): O00766, Q12994, Q16818
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 157 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3