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Q01814 (AT2B2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 153. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Plasma membrane calcium-transporting ATPase 2

Short name=PMCA2
EC=3.6.3.8
Alternative name(s):
Plasma membrane calcium ATPase isoform 2
Plasma membrane calcium pump isoform 2
Gene names
Name:ATP2B2
Synonyms:PMCA2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1243 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.

Catalytic activity

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

Subunit structure

Interacts with PDZD11. Ref.7

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Mainly expressed in brain cortex. Found in low levels in skeletal muscle, heart muscle, stomach, liver, kidney and lung. Isoforms containing segment B are found in brain cortex and at low levels in other tissues. Isoforms containing segments X and W are found at low levels in all tissues. Isoforms containing segment A and segment Z are found at low levels in skeletal muscle and heart muscle.

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. [View classification]

Ontologies

Keywords
   Biological processCalcium transport
Ion transport
Transport
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   LigandATP-binding
Calcium
Calmodulin-binding
Magnesium
Metal-binding
Nucleotide-binding
   Molecular functionHydrolase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processauditory receptor cell stereocilium organization

Inferred from electronic annotation. Source: Ensembl

blood coagulation

Traceable author statement. Source: Reactome

cGMP metabolic process

Inferred from electronic annotation. Source: Ensembl

calcium ion transmembrane transport

Inferred from direct assay PubMed 7929331PubMed 7929331PubMed 7929331. Source: GOC

calcium ion transport

Inferred from mutant phenotype PubMed 17234811. Source: DFLAT

cerebellar Purkinje cell differentiation

Inferred from electronic annotation. Source: Ensembl

cerebellar granule cell differentiation

Inferred from electronic annotation. Source: Ensembl

cochlea development

Inferred from electronic annotation. Source: Ensembl

cytosolic calcium ion homeostasis

Inferred from mutant phenotype PubMed 17234811. Source: DFLAT

detection of mechanical stimulus involved in sensory perception of sound

Inferred from electronic annotation. Source: Ensembl

ion transmembrane transport

Traceable author statement. Source: Reactome

lactation

Inferred from electronic annotation. Source: Ensembl

locomotion

Inferred from electronic annotation. Source: Ensembl

locomotory behavior

Inferred from electronic annotation. Source: Ensembl

neuromuscular process controlling balance

Inferred from electronic annotation. Source: Ensembl

neuron differentiation

Inferred from direct assay PubMed 11259493. Source: UniProtKB

organelle organization

Inferred from electronic annotation. Source: Ensembl

otolith mineralization

Inferred from electronic annotation. Source: Ensembl

positive regulation of calcium ion transport

Inferred from electronic annotation. Source: Ensembl

regulation of cell size

Inferred from electronic annotation. Source: Ensembl

regulation of synaptic plasticity

Inferred from electronic annotation. Source: Ensembl

sensory perception of sound

Inferred from mutant phenotype PubMed 15829536. Source: UniProtKB

serotonin metabolic process

Inferred from electronic annotation. Source: Ensembl

synapse organization

Inferred from electronic annotation. Source: Ensembl

transmembrane transport

Traceable author statement. Source: Reactome

transport

Non-traceable author statement Ref.3. Source: UniProtKB

   Cellular_componentapical plasma membrane

Inferred from electronic annotation. Source: Ensembl

cilium

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from direct assay PubMed 15765049. Source: UniProtKB

endoplasmic reticulum

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

neuronal cell body

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from direct assay PubMed 11786550PubMed 12624087PubMed 7929331PubMed 12624087PubMed 7929331PubMed 12624087PubMed 7929331. Source: UniProtKB

   Molecular_functionATP binding

Inferred from direct assay PubMed 7929331. Source: UniProtKB

PDZ domain binding

Inferred from direct assay PubMed 11786550. Source: UniProtKB

calcium ion binding

Inferred from direct assay PubMed 7929331. Source: UniProtKB

calcium-dependent ATPase activity

Inferred from electronic annotation. Source: Ensembl

calcium-transporting ATPase activity

Inferred from direct assay PubMed 7929331PubMed 7929331PubMed 7929331. Source: UniProtKB

calmodulin binding

Inferred from direct assay PubMed 7929331PubMed 7929331PubMed 7929331. Source: UniProtKB

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein C-terminus binding

Inferred from physical interaction PubMed 11786550. Source: UniProtKB

protein binding

Inferred from physical interaction PubMed 11786550PubMed 17689535. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CALCAP012582EBI-1174243,EBI-1018474
Dlg2Q636222EBI-1174262,EBI-396947From a different organism.
SLC9A3R2Q8SQG93EBI-1174262,EBI-1174758From a different organism.

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Note: There is a combination of two alternative spliced domains at N-terminal site A (Z, X, Y and W) and at C-terminal site C (A and B). So far the splice sites have only been studied independently. Experimental confirmation may be lacking for some isoforms.
Isoform WB (identifier: Q01814-1)

Also known as: AIIICI;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform WA (identifier: Q01814-2)

Also known as: AIIICII;

The sequence of this isoform differs from the canonical sequence as follows:
     1141-1243: IRVVKAFRSS...SPIHSLETSL → IEVVNTFKSG...SLPPAAAGQG
Note: Contains a phosphoserine at position 1177.
Isoform YA (identifier: Q01814-3)

Also known as: AIICII;

The sequence of this isoform differs from the canonical sequence as follows:
     334-347: Missing.
     1141-1243: IRVVKAFRSS...SPIHSLETSL → IEVVNTFKSG...SLPPAAAGQG
Note: Contains a phosphoserine at position 1163.
Isoform ZA (identifier: Q01814-4)

Also known as: AICII;

The sequence of this isoform differs from the canonical sequence as follows:
     303-347: Missing.
     1141-1243: IRVVKAFRSS...SPIHSLETSL → IEVVNTFKSG...SLPPAAAGQG
Note: Contains a phosphoserine at position 1132.
Isoform YB (identifier: Q01814-5)

Also known as: AIICI;

The sequence of this isoform differs from the canonical sequence as follows:
     334-347: Missing.
Isoform ZB (identifier: Q01814-6)

Also known as: AICI;

The sequence of this isoform differs from the canonical sequence as follows:
     303-347: Missing.
Isoform XA (identifier: Q01814-7)

The sequence of this isoform differs from the canonical sequence as follows:
     304-334: Missing.
     1141-1243: IRVVKAFRSS...SPIHSLETSL → IEVVNTFKSG...SLPPAAAGQG
Note: Contains a phosphoserine at position 1146.
Isoform XB (identifier: Q01814-8)

The sequence of this isoform differs from the canonical sequence as follows:
     304-334: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12431243Plasma membrane calcium-transporting ATPase 2
PRO_0000046214

Regions

Topological domain1 – 9494Cytoplasmic Potential
Transmembrane95 – 11521Helical; Potential
Topological domain116 – 15237Extracellular Potential
Transmembrane153 – 17321Helical; Potential
Topological domain174 – 390217Cytoplasmic Potential
Transmembrane391 – 41020Helical; Potential
Topological domain411 – 44333Extracellular Potential
Transmembrane444 – 46118Helical; Potential
Topological domain462 – 875414Cytoplasmic Potential
Transmembrane876 – 89520Helical; Potential
Topological domain896 – 90510Extracellular Potential
Transmembrane906 – 92621Helical; Potential
Topological domain927 – 94620Cytoplasmic Potential
Transmembrane947 – 96923Helical; Potential
Topological domain970 – 98718Extracellular Potential
Transmembrane988 – 100922Helical; Potential
Topological domain1010 – 102819Cytoplasmic Potential
Transmembrane1029 – 105022Helical; Potential
Topological domain1051 – 106010Extracellular Potential
Transmembrane1061 – 108222Helical; Potential
Topological domain1083 – 1243161Cytoplasmic Potential
Region1123 – 114018Calmodulin-binding subdomain A By similarity
Region1141 – 115010Calmodulin-binding subdomain B By similarity
Compositional bias294 – 2974Poly-Glu

Sites

Active site49914-aspartylphosphate intermediate
Metal binding8201Magnesium By similarity
Metal binding8241Magnesium By similarity

Amino acid modifications

Modified residue11391Phosphothreonine; by PKC By similarity
Modified residue12011Phosphoserine; by PKA By similarity

Natural variations

Alternative sequence303 – 34745Missing in isoform ZA and isoform ZB.
VSP_000384
Alternative sequence304 – 33431Missing in isoform XA and isoform XB.
VSP_040837
Alternative sequence334 – 34714Missing in isoform YA and isoform YB.
VSP_000385
Alternative sequence1141 – 1243103IRVVK…LETSL → IEVVNTFKSGASFQGALRRQ SSVTSQSQDVANLSSPSRVS LSNALSSPTSLPPAAAGQG in isoform WA, isoform XA, isoform YA and isoform ZA.
VSP_000386

Experimental info

Sequence conflict92 – 943PKT → AKP in AAA36456. Ref.1
Sequence conflict1261P → R in AAA50877. Ref.2
Sequence conflict1261P → R in AAA51893. Ref.2
Sequence conflict5171G → D in AAA50877. Ref.2
Sequence conflict5171G → D in AAA51893. Ref.2
Sequence conflict667 – 6682DG → EW in AAA36456. Ref.1
Sequence conflict12121A → S in AAA36456. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform WB (AIIICI) [UniParc].

Last modified June 1, 2001. Version 2.
Checksum: 7F10221B7B9AC3A2

FASTA1,243136,876
        10         20         30         40         50         60 
MGDMTNSDFY SKNQRNESSH GGEFGCTMEE LRSLMELRGT EAVVKIKETY GDTEAICRRL 

        70         80         90        100        110        120 
KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW EALQDVTLII LEIAAIISLG 

       130        140        150        160        170        180 
LSFYHPPGEG NEGCATAQGG AEDEGEAEAG WIEGAAILLS VICVVLVTAF NDWSKEKQFR 

       190        200        210        220        230        240 
GLQSRIEQEQ KFTVVRAGQV VQIPVAEIVV GDIAQVKYGD LLPADGLFIQ GNDLKIDESS 

       250        260        270        280        290        300 
LTGESDQVRK SVDKDPMLLS GTHVMEGSGR MLVTAVGVNS QTGIIFTLLG AGGEEEEKKD 

       310        320        330        340        350        360 
KKGVKKGDGL QLPAADGAAA SNAADSANAS LVNGKMQDGN VDASQSKAKQ QDGAAAMEMQ 

       370        380        390        400        410        420 
PLKSAEGGDA DDRKKASMHK KEKSVLQGKL TKLAVQIGKA GLVMSAITVI ILVLYFTVDT 

       430        440        450        460        470        480 
FVVNKKPWLP ECTPVYVQYF VKFFIIGVTV LVVAVPEGLP LAVTISLAYS VKKMMKDNNL 

       490        500        510        520        530        540 
VRHLDACETM GNATAICSDK TGTLTTNRMT VVQAYVGDVH YKEIPDPSSI NTKTMELLIN 

       550        560        570        580        590        600 
AIAINSAYTT KILPPEKEGA LPRQVGNKTE CGLLGFVLDL KQDYEPVRSQ MPEEKLYKVY 

       610        620        630        640        650        660 
TFNSVRKSMS TVIKLPDESF RMYSKGASEI VLKKCCKILN GAGEPRVFRP RDRDEMVKKV 

       670        680        690        700        710        720 
IEPMACDGLR TICVAYRDFP SSPEPDWDNE NDILNELTCI CVVGIEDPVR PEVPEAIRKC 

       730        740        750        760        770        780 
QRAGITVRMV TGDNINTARA IAIKCGIIHP GEDFLCLEGK EFNRRIRNEK GEIEQERIDK 

       790        800        810        820        830        840 
IWPKLRVLAR SSPTDKHTLV KGIIDSTHTE QRQVVAVTGD GTNDGPALKK ADVGFAMGIA 

       850        860        870        880        890        900 
GTDVAKEASD IILTDDNFSS IVKAVMWGRN VYDSISKFLQ FQLTVNVVAV IVAFTGACIT 

       910        920        930        940        950        960 
QDSPLKAVQM LWVNLIMDTF ASLALATEPP TETLLLRKPY GRNKPLISRT MMKNILGHAV 

       970        980        990       1000       1010       1020 
YQLALIFTLL FVGEKMFQID SGRNAPLHSP PSEHYTIIFN TFVMMQLFNE INARKIHGER 

      1030       1040       1050       1060       1070       1080 
NVFDGIFRNP IFCTIVLGTF AIQIVIVQFG GKPFSCSPLQ LDQWMWCIFI GLGELVWGQV 

      1090       1100       1110       1120       1130       1140 
IATIPTSRLK FLKEAGRLTQ KEEIPEEELN EDVEEIDHAE RELRRGQILW FRGLNRIQTQ 

      1150       1160       1170       1180       1190       1200 
IRVVKAFRSS LYEGLEKPES RTSIHNFMAH PEFRIEDSQP HIPLIDDTDL EEDAALKQNS 

      1210       1220       1230       1240 
SPPSSLNKNN SAIDSGINLT TDTSKSATSS SPGSPIHSLE TSL 

« Hide

Isoform WA (AIIICII) [UniParc].

Checksum: 63CF042CC00776B1
Show »

FASTA1,199131,618
Isoform YA (AIICII) [UniParc].

Checksum: DED471E8D9102EF2
Show »

FASTA1,185130,171
Isoform ZA (AICII) [UniParc].

Checksum: ECB232AA4AC37BE8
Show »

FASTA1,154127,335
Isoform YB (AIICI) [UniParc].

Checksum: A7E663E42EBDEAA9
Show »

FASTA1,229135,430
Isoform ZB (AICI) [UniParc].

Checksum: EEF94C16D4C1C73E
Show »

FASTA1,198132,594
Isoform XA [UniParc].

Checksum: DF137BD7DE5AAA8E
Show »

FASTA1,168128,781
Isoform XB [UniParc].

Checksum: 988E5FEBD1F3A880
Show »

FASTA1,212134,040

References

« Hide 'large scale' references
[1]"Determination of the nucleotide sequence and chromosomal localization of the ATP2B2 gene encoding human Ca(2+)-pumping ATPase isoform PMCA2."
Brandt P., Ibrahim E., Bruns G.A.P., Neve R.L.
Genomics 14:484-487(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ZB).
Tissue: Brain.
[2]"von Hippel-Lindau syndrome: cloning and identification of the plasma membrane Ca(++)-transporting ATPase isoform 2 gene that resides in the von Hippel-Lindau gene region."
Latif F., Duh F.-M., Gnarra J., Tory K., Kuzmin I., Yao M., Stackhouse T., Modi W., Geil L., Schmidt L., Li H., Orcutt M.L., Maher E., Richards F., Phipps M., Ferguson-Smith M., le Paslier D., Linehan W.M., Zbar B., Lerman M.I.
Cancer Res. 53:861-867(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ZB), ALTERNATIVE SPLICING.
[3]"Microdiversity of human-plasma-membrane calcium-pump isoform 2 generated by alternative RNA splicing in the N-terminal coding region."
Heim R., Hug M., Iwata T., Strehler E.E., Carafoli E.
Eur. J. Biochem. 205:333-340(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM WB), ALTERNATIVE SPLICING.
Tissue: Brain and Skeletal muscle.
[4]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes."
Stauffer T.P., Hilfiker H., Carafoli E., Strehler E.E.
J. Biol. Chem. 268:25993-26003(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS WA/YA/ZA).
Tissue: Brain cortex.
[6]Erratum
Stauffer T.P., Hilfiker H., Carafoli E., Strehler E.E.
J. Biol. Chem. 269:32022-32022(1994) [PubMed] [Europe PMC] [Abstract]
[7]"Characterization of PISP, a novel single-PDZ protein that binds to all plasma membrane Ca2+-ATPase b-splice variants."
Goellner G.M., DeMarco S.J., Strehler E.E.
Ann. N. Y. Acad. Sci. 986:461-471(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PDZD11.
[8]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1177 (ISOFORM WA), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1146 (ISOFORM XA), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1163 (ISOFORM YA), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1132 (ISOFORM ZA), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M97260 mRNA. Translation: AAA36456.1.
L20977 mRNA. Translation: AAA50877.1.
L00620 mRNA. Translation: AAA51893.1.
X63575 mRNA. Translation: CAA45131.1.
AC018839 Genomic DNA. No translation available.
AC090841 Genomic DNA. No translation available.
U15688 mRNA. Translation: AAA60985.1.
CCDSCCDS2601.1. [Q01814-6]
CCDS33701.1. [Q01814-1]
PIRS22393.
RefSeqNP_001001331.1. NM_001001331.2. [Q01814-1]
NP_001674.2. NM_001683.3. [Q01814-6]
XP_005265236.1. XM_005265179.2. [Q01814-1]
XP_006713238.1. XM_006713175.1. [Q01814-1]
XP_006713239.1. XM_006713176.1. [Q01814-1]
XP_006713241.1. XM_006713178.1. [Q01814-8]
XP_006713243.1. XM_006713180.1. [Q01814-2]
XP_006713244.1. XM_006713181.1. [Q01814-6]
UniGeneHs.268942.

3D structure databases

ProteinModelPortalQ01814.
SMRQ01814. Positions 70-298, 364-948, 1123-1150.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid106981. 9 interactions.
IntActQ01814. 8 interactions.
MINTMINT-470839.
STRING9606.ENSP00000324172.

Protein family/group databases

TCDB3.A.3.2.40. the p-type atpase (p-atpase) superfamily.

PTM databases

PhosphoSiteQ01814.

Polymorphism databases

DMDM14286115.

Proteomic databases

MaxQBQ01814.
PaxDbQ01814.
PRIDEQ01814.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000343816; ENSP00000344677; ENSG00000157087. [Q01814-5]
ENST00000352432; ENSP00000324172; ENSG00000157087. [Q01814-1]
ENST00000360273; ENSP00000353414; ENSG00000157087. [Q01814-1]
ENST00000383800; ENSP00000373311; ENSG00000157087. [Q01814-6]
ENST00000397077; ENSP00000380267; ENSG00000157087. [Q01814-6]
ENST00000460129; ENSP00000424494; ENSG00000157087. [Q01814-4]
GeneID491.
KEGGhsa:491.
UCSCuc003bvt.3. human. [Q01814-1]
uc003bvv.3. human. [Q01814-6]

Organism-specific databases

CTD491.
GeneCardsGC03M010365.
HGNCHGNC:815. ATP2B2.
HPACAB005606.
MIM108733. gene.
neXtProtNX_Q01814.
PharmGKBPA25108.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0474.
HOGENOMHOG000265623.
HOVERGENHBG061286.
InParanoidQ01814.
KOK05850.
OMAGRINNLK.
OrthoDBEOG7SN8BN.
PhylomeDBQ01814.
TreeFamTF300330.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.
REACT_604. Hemostasis.

Gene expression databases

ArrayExpressQ01814.
BgeeQ01814.
CleanExHS_ATP2B2.
GenevestigatorQ01814.

Family and domain databases

Gene3D1.20.1110.10. 1 hit.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProIPR022141. ATP_Ca_trans_C.
IPR006408. ATPase_P-typ_Ca-transp_plasma.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamPF12424. ATP_Ca_trans_C. 1 hit.
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
SMARTSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsTIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSAtp2b2. human.
GeneWikiATP2B2.
GenomeRNAi491.
NextBio2059.
PROQ01814.
SOURCESearch...

Entry information

Entry nameAT2B2_HUMAN
AccessionPrimary (citable) accession number: Q01814
Secondary accession number(s): O00766, Q12994, Q16818
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM