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Q01814

- AT2B2_HUMAN

UniProt

Q01814 - AT2B2_HUMAN

Protein

Plasma membrane calcium-transporting ATPase 2

Gene

ATP2B2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 155 (01 Oct 2014)
      Sequence version 2 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.

    Catalytic activityi

    ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei499 – 49914-aspartylphosphate intermediate
    Metal bindingi820 – 8201MagnesiumBy similarity
    Metal bindingi824 – 8241MagnesiumBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. calcium-dependent ATPase activity Source: Ensembl
    3. calcium ion binding Source: UniProtKB
    4. calcium-transporting ATPase activity Source: UniProtKB
    5. calmodulin binding Source: UniProtKB
    6. metal ion binding Source: UniProtKB-KW
    7. PDZ domain binding Source: UniProtKB
    8. protein binding Source: IntAct
    9. protein C-terminus binding Source: UniProtKB

    GO - Biological processi

    1. auditory receptor cell stereocilium organization Source: Ensembl
    2. blood coagulation Source: Reactome
    3. calcium ion transmembrane transport Source: GOC
    4. calcium ion transport Source: DFLAT
    5. cerebellar granule cell differentiation Source: Ensembl
    6. cerebellar Purkinje cell differentiation Source: Ensembl
    7. cGMP metabolic process Source: Ensembl
    8. cochlea development Source: Ensembl
    9. cytosolic calcium ion homeostasis Source: DFLAT
    10. detection of mechanical stimulus involved in sensory perception of sound Source: Ensembl
    11. ion transmembrane transport Source: Reactome
    12. lactation Source: Ensembl
    13. locomotion Source: Ensembl
    14. locomotory behavior Source: Ensembl
    15. neuromuscular process controlling balance Source: Ensembl
    16. neuron differentiation Source: UniProtKB
    17. organelle organization Source: Ensembl
    18. otolith mineralization Source: Ensembl
    19. positive regulation of calcium ion transport Source: Ensembl
    20. regulation of cell size Source: Ensembl
    21. regulation of synaptic plasticity Source: Ensembl
    22. sensory perception of sound Source: UniProtKB
    23. serotonin metabolic process Source: Ensembl
    24. synapse organization Source: Ensembl
    25. transmembrane transport Source: Reactome
    26. transport Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    ATP-binding, Calcium, Calmodulin-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_23765. Reduction of cytosolic Ca++ levels.
    REACT_25149. Ion transport by P-type ATPases.

    Protein family/group databases

    TCDBi3.A.3.2.40. the p-type atpase (p-atpase) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Plasma membrane calcium-transporting ATPase 2 (EC:3.6.3.8)
    Short name:
    PMCA2
    Alternative name(s):
    Plasma membrane calcium ATPase isoform 2
    Plasma membrane calcium pump isoform 2
    Gene namesi
    Name:ATP2B2
    Synonyms:PMCA2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:815. ATP2B2.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. cilium Source: Ensembl
    3. cytoplasm Source: UniProtKB
    4. endoplasmic reticulum Source: Ensembl
    5. integral component of membrane Source: UniProtKB-KW
    6. neuronal cell body Source: Ensembl
    7. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25108.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12431243Plasma membrane calcium-transporting ATPase 2PRO_0000046214Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1139 – 11391Phosphothreonine; by PKCBy similarity
    Modified residuei1201 – 12011Phosphoserine; by PKABy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ01814.
    PaxDbiQ01814.
    PRIDEiQ01814.

    PTM databases

    PhosphoSiteiQ01814.

    Expressioni

    Tissue specificityi

    Mainly expressed in brain cortex. Found in low levels in skeletal muscle, heart muscle, stomach, liver, kidney and lung. Isoforms containing segment B are found in brain cortex and at low levels in other tissues. Isoforms containing segments X and W are found at low levels in all tissues. Isoforms containing segment A and segment Z are found at low levels in skeletal muscle and heart muscle.

    Gene expression databases

    ArrayExpressiQ01814.
    BgeeiQ01814.
    CleanExiHS_ATP2B2.
    GenevestigatoriQ01814.

    Organism-specific databases

    HPAiCAB005606.

    Interactioni

    Subunit structurei

    Interacts with PDZD11.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CALCAP012582EBI-1174243,EBI-1018474
    Dlg2Q636222EBI-1174262,EBI-396947From a different organism.
    SLC9A3R2Q8SQG93EBI-1174262,EBI-1174758From a different organism.

    Protein-protein interaction databases

    BioGridi106981. 10 interactions.
    IntActiQ01814. 8 interactions.
    MINTiMINT-470839.
    STRINGi9606.ENSP00000324172.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01814.
    SMRiQ01814. Positions 70-298, 364-948, 1123-1150.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9494CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini116 – 15237ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini174 – 390217CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini411 – 44333ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini462 – 875414CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini896 – 90510ExtracellularSequence Analysis
    Topological domaini927 – 94620CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini970 – 98718ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1010 – 102819CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1051 – 106010ExtracellularSequence Analysis
    Topological domaini1083 – 1243161CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei95 – 11521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei153 – 17321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei391 – 41020HelicalSequence AnalysisAdd
    BLAST
    Transmembranei444 – 46118HelicalSequence AnalysisAdd
    BLAST
    Transmembranei876 – 89520HelicalSequence AnalysisAdd
    BLAST
    Transmembranei906 – 92621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei947 – 96923HelicalSequence AnalysisAdd
    BLAST
    Transmembranei988 – 100922HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1029 – 105022HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1061 – 108222HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1123 – 114018Calmodulin-binding subdomain ABy similarityAdd
    BLAST
    Regioni1141 – 115010Calmodulin-binding subdomain BBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi294 – 2974Poly-Glu

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0474.
    HOGENOMiHOG000265623.
    HOVERGENiHBG061286.
    InParanoidiQ01814.
    KOiK05850.
    OMAiGRINNLK.
    OrthoDBiEOG7SN8BN.
    PhylomeDBiQ01814.
    TreeFamiTF300330.

    Family and domain databases

    Gene3Di1.20.1110.10. 1 hit.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProiIPR022141. ATP_Ca_trans_C.
    IPR006408. ATPase_P-typ_Ca-transp_plasma.
    IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PfamiPF12424. ATP_Ca_trans_C. 1 hit.
    PF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    SMARTiSM00831. Cation_ATPase_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 2 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsiTIGR01517. ATPase-IIB_Ca. 1 hit.
    TIGR01494. ATPase_P-type. 3 hits.
    PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view]

    Sequences (8)i

    Sequence statusi: Complete.

    This entry describes 8 isoformsi produced by alternative splicing. Align

    Note: There is a combination of two alternative spliced domains at N-terminal site A (Z, X, Y and W) and at C-terminal site C (A and B). So far the splice sites have only been studied independently. Experimental confirmation may be lacking for some isoforms.

    Isoform WB (identifier: Q01814-1) [UniParc]FASTAAdd to Basket

    Also known as: AIIICI

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGDMTNSDFY SKNQRNESSH GGEFGCTMEE LRSLMELRGT EAVVKIKETY     50
    GDTEAICRRL KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW 100
    EALQDVTLII LEIAAIISLG LSFYHPPGEG NEGCATAQGG AEDEGEAEAG 150
    WIEGAAILLS VICVVLVTAF NDWSKEKQFR GLQSRIEQEQ KFTVVRAGQV 200
    VQIPVAEIVV GDIAQVKYGD LLPADGLFIQ GNDLKIDESS LTGESDQVRK 250
    SVDKDPMLLS GTHVMEGSGR MLVTAVGVNS QTGIIFTLLG AGGEEEEKKD 300
    KKGVKKGDGL QLPAADGAAA SNAADSANAS LVNGKMQDGN VDASQSKAKQ 350
    QDGAAAMEMQ PLKSAEGGDA DDRKKASMHK KEKSVLQGKL TKLAVQIGKA 400
    GLVMSAITVI ILVLYFTVDT FVVNKKPWLP ECTPVYVQYF VKFFIIGVTV 450
    LVVAVPEGLP LAVTISLAYS VKKMMKDNNL VRHLDACETM GNATAICSDK 500
    TGTLTTNRMT VVQAYVGDVH YKEIPDPSSI NTKTMELLIN AIAINSAYTT 550
    KILPPEKEGA LPRQVGNKTE CGLLGFVLDL KQDYEPVRSQ MPEEKLYKVY 600
    TFNSVRKSMS TVIKLPDESF RMYSKGASEI VLKKCCKILN GAGEPRVFRP 650
    RDRDEMVKKV IEPMACDGLR TICVAYRDFP SSPEPDWDNE NDILNELTCI 700
    CVVGIEDPVR PEVPEAIRKC QRAGITVRMV TGDNINTARA IAIKCGIIHP 750
    GEDFLCLEGK EFNRRIRNEK GEIEQERIDK IWPKLRVLAR SSPTDKHTLV 800
    KGIIDSTHTE QRQVVAVTGD GTNDGPALKK ADVGFAMGIA GTDVAKEASD 850
    IILTDDNFSS IVKAVMWGRN VYDSISKFLQ FQLTVNVVAV IVAFTGACIT 900
    QDSPLKAVQM LWVNLIMDTF ASLALATEPP TETLLLRKPY GRNKPLISRT 950
    MMKNILGHAV YQLALIFTLL FVGEKMFQID SGRNAPLHSP PSEHYTIIFN 1000
    TFVMMQLFNE INARKIHGER NVFDGIFRNP IFCTIVLGTF AIQIVIVQFG 1050
    GKPFSCSPLQ LDQWMWCIFI GLGELVWGQV IATIPTSRLK FLKEAGRLTQ 1100
    KEEIPEEELN EDVEEIDHAE RELRRGQILW FRGLNRIQTQ IRVVKAFRSS 1150
    LYEGLEKPES RTSIHNFMAH PEFRIEDSQP HIPLIDDTDL EEDAALKQNS 1200
    SPPSSLNKNN SAIDSGINLT TDTSKSATSS SPGSPIHSLE TSL 1243
    Length:1,243
    Mass (Da):136,876
    Last modified:June 1, 2001 - v2
    Checksum:i7F10221B7B9AC3A2
    GO
    Isoform WA (identifier: Q01814-2) [UniParc]FASTAAdd to Basket

    Also known as: AIIICII

    The sequence of this isoform differs from the canonical sequence as follows:
         1141-1243: IRVVKAFRSS...SPIHSLETSL → IEVVNTFKSG...SLPPAAAGQG

    Note: Contains a phosphoserine at position 1177.

    Show »
    Length:1,199
    Mass (Da):131,618
    Checksum:i63CF042CC00776B1
    GO
    Isoform YA (identifier: Q01814-3) [UniParc]FASTAAdd to Basket

    Also known as: AIICII

    The sequence of this isoform differs from the canonical sequence as follows:
         334-347: Missing.
         1141-1243: IRVVKAFRSS...SPIHSLETSL → IEVVNTFKSG...SLPPAAAGQG

    Note: Contains a phosphoserine at position 1163.

    Show »
    Length:1,185
    Mass (Da):130,171
    Checksum:iDED471E8D9102EF2
    GO
    Isoform ZA (identifier: Q01814-4) [UniParc]FASTAAdd to Basket

    Also known as: AICII

    The sequence of this isoform differs from the canonical sequence as follows:
         303-347: Missing.
         1141-1243: IRVVKAFRSS...SPIHSLETSL → IEVVNTFKSG...SLPPAAAGQG

    Note: Contains a phosphoserine at position 1132.

    Show »
    Length:1,154
    Mass (Da):127,335
    Checksum:iECB232AA4AC37BE8
    GO
    Isoform YB (identifier: Q01814-5) [UniParc]FASTAAdd to Basket

    Also known as: AIICI

    The sequence of this isoform differs from the canonical sequence as follows:
         334-347: Missing.

    Show »
    Length:1,229
    Mass (Da):135,430
    Checksum:iA7E663E42EBDEAA9
    GO
    Isoform ZB (identifier: Q01814-6) [UniParc]FASTAAdd to Basket

    Also known as: AICI

    The sequence of this isoform differs from the canonical sequence as follows:
         303-347: Missing.

    Show »
    Length:1,198
    Mass (Da):132,594
    Checksum:iEEF94C16D4C1C73E
    GO
    Isoform XA (identifier: Q01814-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         304-334: Missing.
         1141-1243: IRVVKAFRSS...SPIHSLETSL → IEVVNTFKSG...SLPPAAAGQG

    Note: Contains a phosphoserine at position 1146.

    Show »
    Length:1,168
    Mass (Da):128,781
    Checksum:iDF137BD7DE5AAA8E
    GO
    Isoform XB (identifier: Q01814-8) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         304-334: Missing.

    Show »
    Length:1,212
    Mass (Da):134,040
    Checksum:i988E5FEBD1F3A880
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti92 – 943PKT → AKP in AAA36456. (PubMed:1427863)Curated
    Sequence conflicti126 – 1261P → R in AAA50877. (PubMed:8428366)Curated
    Sequence conflicti126 – 1261P → R in AAA51893. (PubMed:8428366)Curated
    Sequence conflicti517 – 5171G → D in AAA50877. (PubMed:8428366)Curated
    Sequence conflicti517 – 5171G → D in AAA51893. (PubMed:8428366)Curated
    Sequence conflicti667 – 6682DG → EW in AAA36456. (PubMed:1427863)Curated
    Sequence conflicti1212 – 12121A → S in AAA36456. (PubMed:1427863)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei303 – 34745Missing in isoform ZA and isoform ZB. 2 PublicationsVSP_000384Add
    BLAST
    Alternative sequencei304 – 33431Missing in isoform XA and isoform XB. CuratedVSP_040837Add
    BLAST
    Alternative sequencei334 – 34714Missing in isoform YA and isoform YB. CuratedVSP_000385Add
    BLAST
    Alternative sequencei1141 – 1243103IRVVK…LETSL → IEVVNTFKSGASFQGALRRQ SSVTSQSQDVANLSSPSRVS LSNALSSPTSLPPAAAGQG in isoform WA, isoform XA, isoform YA and isoform ZA. CuratedVSP_000386Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M97260 mRNA. Translation: AAA36456.1.
    L20977 mRNA. Translation: AAA50877.1.
    L00620 mRNA. Translation: AAA51893.1.
    X63575 mRNA. Translation: CAA45131.1.
    AC018839 Genomic DNA. No translation available.
    AC090841 Genomic DNA. No translation available.
    U15688 mRNA. Translation: AAA60985.1.
    CCDSiCCDS2601.1. [Q01814-6]
    CCDS33701.1. [Q01814-1]
    PIRiS22393.
    RefSeqiNP_001001331.1. NM_001001331.2. [Q01814-1]
    NP_001674.2. NM_001683.3. [Q01814-6]
    XP_005265236.1. XM_005265179.2. [Q01814-1]
    XP_006713238.1. XM_006713175.1. [Q01814-1]
    XP_006713239.1. XM_006713176.1. [Q01814-1]
    XP_006713241.1. XM_006713178.1. [Q01814-8]
    XP_006713243.1. XM_006713180.1. [Q01814-2]
    UniGeneiHs.268942.

    Genome annotation databases

    EnsembliENST00000352432; ENSP00000324172; ENSG00000157087. [Q01814-1]
    ENST00000360273; ENSP00000353414; ENSG00000157087. [Q01814-1]
    ENST00000383800; ENSP00000373311; ENSG00000157087. [Q01814-6]
    ENST00000397077; ENSP00000380267; ENSG00000157087. [Q01814-6]
    ENST00000460129; ENSP00000424494; ENSG00000157087. [Q01814-4]
    GeneIDi491.
    KEGGihsa:491.
    UCSCiuc003bvt.3. human. [Q01814-1]
    uc003bvv.3. human. [Q01814-6]

    Polymorphism databases

    DMDMi14286115.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M97260 mRNA. Translation: AAA36456.1 .
    L20977 mRNA. Translation: AAA50877.1 .
    L00620 mRNA. Translation: AAA51893.1 .
    X63575 mRNA. Translation: CAA45131.1 .
    AC018839 Genomic DNA. No translation available.
    AC090841 Genomic DNA. No translation available.
    U15688 mRNA. Translation: AAA60985.1 .
    CCDSi CCDS2601.1. [Q01814-6 ]
    CCDS33701.1. [Q01814-1 ]
    PIRi S22393.
    RefSeqi NP_001001331.1. NM_001001331.2. [Q01814-1 ]
    NP_001674.2. NM_001683.3. [Q01814-6 ]
    XP_005265236.1. XM_005265179.2. [Q01814-1 ]
    XP_006713238.1. XM_006713175.1. [Q01814-1 ]
    XP_006713239.1. XM_006713176.1. [Q01814-1 ]
    XP_006713241.1. XM_006713178.1. [Q01814-8 ]
    XP_006713243.1. XM_006713180.1. [Q01814-2 ]
    UniGenei Hs.268942.

    3D structure databases

    ProteinModelPortali Q01814.
    SMRi Q01814. Positions 70-298, 364-948, 1123-1150.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106981. 10 interactions.
    IntActi Q01814. 8 interactions.
    MINTi MINT-470839.
    STRINGi 9606.ENSP00000324172.

    Protein family/group databases

    TCDBi 3.A.3.2.40. the p-type atpase (p-atpase) superfamily.

    PTM databases

    PhosphoSitei Q01814.

    Polymorphism databases

    DMDMi 14286115.

    Proteomic databases

    MaxQBi Q01814.
    PaxDbi Q01814.
    PRIDEi Q01814.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000352432 ; ENSP00000324172 ; ENSG00000157087 . [Q01814-1 ]
    ENST00000360273 ; ENSP00000353414 ; ENSG00000157087 . [Q01814-1 ]
    ENST00000383800 ; ENSP00000373311 ; ENSG00000157087 . [Q01814-6 ]
    ENST00000397077 ; ENSP00000380267 ; ENSG00000157087 . [Q01814-6 ]
    ENST00000460129 ; ENSP00000424494 ; ENSG00000157087 . [Q01814-4 ]
    GeneIDi 491.
    KEGGi hsa:491.
    UCSCi uc003bvt.3. human. [Q01814-1 ]
    uc003bvv.3. human. [Q01814-6 ]

    Organism-specific databases

    CTDi 491.
    GeneCardsi GC03M010365.
    HGNCi HGNC:815. ATP2B2.
    HPAi CAB005606.
    MIMi 108733. gene.
    neXtProti NX_Q01814.
    PharmGKBi PA25108.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0474.
    HOGENOMi HOG000265623.
    HOVERGENi HBG061286.
    InParanoidi Q01814.
    KOi K05850.
    OMAi GRINNLK.
    OrthoDBi EOG7SN8BN.
    PhylomeDBi Q01814.
    TreeFami TF300330.

    Enzyme and pathway databases

    Reactomei REACT_23765. Reduction of cytosolic Ca++ levels.
    REACT_25149. Ion transport by P-type ATPases.

    Miscellaneous databases

    ChiTaRSi Atp2b2. human.
    GeneWikii ATP2B2.
    GenomeRNAii 491.
    NextBioi 2059.
    PROi Q01814.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q01814.
    Bgeei Q01814.
    CleanExi HS_ATP2B2.
    Genevestigatori Q01814.

    Family and domain databases

    Gene3Di 1.20.1110.10. 1 hit.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProi IPR022141. ATP_Ca_trans_C.
    IPR006408. ATPase_P-typ_Ca-transp_plasma.
    IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    Pfami PF12424. ATP_Ca_trans_C. 1 hit.
    PF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    SMARTi SM00831. Cation_ATPase_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 2 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsi TIGR01517. ATPase-IIB_Ca. 1 hit.
    TIGR01494. ATPase_P-type. 3 hits.
    PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Determination of the nucleotide sequence and chromosomal localization of the ATP2B2 gene encoding human Ca(2+)-pumping ATPase isoform PMCA2."
      Brandt P., Ibrahim E., Bruns G.A.P., Neve R.L.
      Genomics 14:484-487(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ZB).
      Tissue: Brain.
    2. "von Hippel-Lindau syndrome: cloning and identification of the plasma membrane Ca(++)-transporting ATPase isoform 2 gene that resides in the von Hippel-Lindau gene region."
      Latif F., Duh F.-M., Gnarra J., Tory K., Kuzmin I., Yao M., Stackhouse T., Modi W., Geil L., Schmidt L., Li H., Orcutt M.L., Maher E., Richards F., Phipps M., Ferguson-Smith M., le Paslier D., Linehan W.M., Zbar B., Lerman M.I.
      Cancer Res. 53:861-867(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ZB), ALTERNATIVE SPLICING.
    3. "Microdiversity of human-plasma-membrane calcium-pump isoform 2 generated by alternative RNA splicing in the N-terminal coding region."
      Heim R., Hug M., Iwata T., Strehler E.E., Carafoli E.
      Eur. J. Biochem. 205:333-340(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM WB), ALTERNATIVE SPLICING.
      Tissue: Brain and Skeletal muscle.
    4. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes."
      Stauffer T.P., Hilfiker H., Carafoli E., Strehler E.E.
      J. Biol. Chem. 268:25993-26003(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS WA/YA/ZA).
      Tissue: Brain cortex.
    6. Erratum
      Stauffer T.P., Hilfiker H., Carafoli E., Strehler E.E.
      J. Biol. Chem. 269:32022-32022(1994) [PubMed] [Europe PMC] [Abstract]
    7. "Characterization of PISP, a novel single-PDZ protein that binds to all plasma membrane Ca2+-ATPase b-splice variants."
      Goellner G.M., DeMarco S.J., Strehler E.E.
      Ann. N. Y. Acad. Sci. 986:461-471(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PDZD11.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1177 (ISOFORM WA), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1146 (ISOFORM XA), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1163 (ISOFORM YA), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1132 (ISOFORM ZA), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiAT2B2_HUMAN
    AccessioniPrimary (citable) accession number: Q01814
    Secondary accession number(s): O00766, Q12994, Q16818
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 155 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3