Reviewed, UniProtKB/Swiss-Prot Q01814 (AT2B2_HUMAN)

Names and origin

Protein names

Recommended name:
    Plasma membrane calcium-transporting ATPase 2
      Short name=PMCA2
    EC=3.6.3.8
Alternative name(s):
    Plasma membrane calcium ATPase isoform 2
    Plasma membrane calcium pump isoform 2

Gene names

Name:	ATP2B2
Synonyms:	PMCA2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1243 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.
Catalytic activity	ATP + H2O + Ca2+(Cis) = ADP + phosphate + Ca2+(Trans).
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Mainly expressed in brain cortex. Found in low levels in skeletal muscle, heart muscle, stomach, liver, kidney and lung. Isoforms containing segment B are found in brain cortex and at low levels in other tissues. Isoforms containing segments X and W are found at low levels in all tissues. Isoforms containing segment A and segment Z are found at low levels in skeletal muscle and heart muscle.
Sequence similarities	Belongs to the cation transport ATPase (P-type) family. Type IIB subfamily.

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane
Ligand	ATP-binding Calcium Calmodulin-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro calcium ion transport Inferred from electronic annotation. Source: UniProtKB-KW neuron differentiation Inferred from direct assay. Source: UniProtKB sensory perception of sound Inferred from mutant phenotype. Source: UniProtKB
Cellular component	cytoplasm Inferred from direct assay. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Ref.3 Inferred from direct assay. Source: UniProtKB
Molecular function	ATP binding Inferred from direct assay. Source: UniProtKB PDZ domain binding Inferred from direct assay. Source: UniProtKB calcium ion binding Inferred from direct assay. Source: UniProtKB calcium-transporting ATPase activity Ref.3 Inferred from direct assay. Source: UniProtKB calmodulin binding Inferred from direct assay. Source: UniProtKB magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein C-terminus binding Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Dlg1	Q62696	1	EBI-1174262,EBI-389325	From a different organism.
Dlg2	Q63622	2	EBI-1174262,EBI-396947	From a different organism.
Dlg4	P31016	1	EBI-1174262,EBI-375655	From a different organism.
SLC9A3R2	Q8SQG9	2	EBI-1174262,EBI-1174758	From a different organism.

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Note: There is a combination of two alternative spliced domains at N-terminal site A (W, X and Z) and at C-terminal site C (A and B). So far the splice sites have only been studied independently. Experimental confirmation may be lacking for some isoforms.

Isoform WB (identifier: Q01814-1)

Also known as: AIIICI;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform WA (identifier: Q01814-2)

Also known as: AIIICII;

The sequence of this isoform differs from the canonical sequence as follows:
     1141-1243: IRVVKAFRSS...SPIHSLETSL → IEVVNTFKSG...SLPPAAAGQG

Isoform XA (identifier: Q01814-3)

Also known as: AIICII;

The sequence of this isoform differs from the canonical sequence as follows:
     334-347: Missing.
     1141-1243: IRVVKAFRSS...SPIHSLETSL → IEVVNTFKSG...SLPPAAAGQG

Isoform ZA (identifier: Q01814-4)

Also known as: AICII;

The sequence of this isoform differs from the canonical sequence as follows:
     303-347: Missing.
     1141-1243: IRVVKAFRSS...SPIHSLETSL → IEVVNTFKSG...SLPPAAAGQG

Isoform XB (identifier: Q01814-5)

Also known as: AIICI;

The sequence of this isoform differs from the canonical sequence as follows:
     334-347: Missing.

Isoform ZB (identifier: Q01814-6)

Also known as: AICI;

The sequence of this isoform differs from the canonical sequence as follows:
     303-347: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1243	1243	Plasma membrane calcium-transporting ATPase 2		PRO_0000046214
Regions
	Topological domain	1 – 94	94	Cytoplasmic Potential
	Transmembrane	95 – 115	21	Potential
	Topological domain	116 – 152	37	Extracellular Potential
	Transmembrane	153 – 173	21	Potential
	Topological domain	174 – 390	217	Cytoplasmic Potential
	Transmembrane	391 – 410	20	Potential
	Topological domain	411 – 443	33	Extracellular Potential
	Transmembrane	444 – 461	18	Potential
	Topological domain	462 – 875	414	Cytoplasmic Potential
	Transmembrane	876 – 895	20	Potential
	Topological domain	896 – 905	10	Extracellular Potential
	Transmembrane	906 – 926	21	Potential
	Topological domain	927 – 946	20	Cytoplasmic Potential
	Transmembrane	947 – 969	23	Potential
	Topological domain	970 – 987	18	Extracellular Potential
	Transmembrane	988 – 1009	22	Potential
	Topological domain	1010 – 1028	19	Cytoplasmic Potential
	Transmembrane	1029 – 1050	22	Potential
	Topological domain	1051 – 1060	10	Extracellular Potential
	Transmembrane	1061 – 1082	22	Potential
	Topological domain	1083 – 1243	161	Cytoplasmic Potential
	Region	1123 – 1140	18	Calmodulin-binding subdomain A By similarity
	Region	1141 – 1150	10	Calmodulin-binding subdomain B By similarity
	Compositional bias	294 – 297	4	Poly-Glu
Sites
	Active site	499	1	4-aspartylphosphate intermediate
	Metal binding	820	1	Magnesium By similarity
	Metal binding	824	1	Magnesium By similarity
Amino acid modifications
	Modified residue	1139	1	Phosphothreonine; by PKC By similarity
	Modified residue	1201	1	Phosphoserine; by PKA By similarity
	Modified residue	1231	1	Phosphoserine Ref.6
	Modified residue	1234	1	Phosphoserine Ref.6
	Modified residue	1238	1	Phosphoserine Ref.6
	Modified residue	1241	1	Phosphothreonine Ref.6
	Modified residue	1242	1	Phosphoserine Ref.6 Ref.8
Natural variations
	Alternative sequence	303 – 347	45	Missing in isoform ZA and isoform ZB.		VSP_000384
	Alternative sequence	334 – 347	14	Missing in isoform XA and isoform XB.		VSP_000385
	Alternative sequence	1141 – 1243	103	IRVVK…LETSL → IEVVNTFKSGASFQGALRRQ SSVTSQSQDVANLSSPSRVS LSNALSSPTSLPPAAAGQG in isoform WA, isoform XA and isoform ZA.		VSP_000386
Experimental info
	Sequence conflict	92 – 94	3	PKT → AKP in AAA36456. Ref.1
	Sequence conflict	126	1	P → R in AAA50877. Ref.2
	Sequence conflict	126	1	P → R in AAA51893. Ref.2
	Sequence conflict	517	1	G → D in AAA50877. Ref.2
	Sequence conflict	517	1	G → D in AAA51893. Ref.2
	Sequence conflict	667 – 668	2	DG → EW in AAA36456. Ref.1
	Sequence conflict	1212	1	A → S in AAA36456. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform WB (AIIICI) [UniParc]. Last modified June 1, 2001. Version 2. Checksum: 7F10221B7B9AC3A2	FASTA	1,243	136,876
	10 20 30 40 50 60 MGDMTNSDFY SKNQRNESSH GGEFGCTMEE LRSLMELRGT EAVVKIKETY GDTEAICRRL 70 80 90 100 110 120 KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW EALQDVTLII LEIAAIISLG 130 140 150 160 170 180 LSFYHPPGEG NEGCATAQGG AEDEGEAEAG WIEGAAILLS VICVVLVTAF NDWSKEKQFR 190 200 210 220 230 240 GLQSRIEQEQ KFTVVRAGQV VQIPVAEIVV GDIAQVKYGD LLPADGLFIQ GNDLKIDESS 250 260 270 280 290 300 LTGESDQVRK SVDKDPMLLS GTHVMEGSGR MLVTAVGVNS QTGIIFTLLG AGGEEEEKKD 310 320 330 340 350 360 KKGVKKGDGL QLPAADGAAA SNAADSANAS LVNGKMQDGN VDASQSKAKQ QDGAAAMEMQ 370 380 390 400 410 420 PLKSAEGGDA DDRKKASMHK KEKSVLQGKL TKLAVQIGKA GLVMSAITVI ILVLYFTVDT 430 440 450 460 470 480 FVVNKKPWLP ECTPVYVQYF VKFFIIGVTV LVVAVPEGLP LAVTISLAYS VKKMMKDNNL 490 500 510 520 530 540 VRHLDACETM GNATAICSDK TGTLTTNRMT VVQAYVGDVH YKEIPDPSSI NTKTMELLIN 550 560 570 580 590 600 AIAINSAYTT KILPPEKEGA LPRQVGNKTE CGLLGFVLDL KQDYEPVRSQ MPEEKLYKVY 610 620 630 640 650 660 TFNSVRKSMS TVIKLPDESF RMYSKGASEI VLKKCCKILN GAGEPRVFRP RDRDEMVKKV 670 680 690 700 710 720 IEPMACDGLR TICVAYRDFP SSPEPDWDNE NDILNELTCI CVVGIEDPVR PEVPEAIRKC 730 740 750 760 770 780 QRAGITVRMV TGDNINTARA IAIKCGIIHP GEDFLCLEGK EFNRRIRNEK GEIEQERIDK 790 800 810 820 830 840 IWPKLRVLAR SSPTDKHTLV KGIIDSTHTE QRQVVAVTGD GTNDGPALKK ADVGFAMGIA 850 860 870 880 890 900 GTDVAKEASD IILTDDNFSS IVKAVMWGRN VYDSISKFLQ FQLTVNVVAV IVAFTGACIT 910 920 930 940 950 960 QDSPLKAVQM LWVNLIMDTF ASLALATEPP TETLLLRKPY GRNKPLISRT MMKNILGHAV 970 980 990 1000 1010 1020 YQLALIFTLL FVGEKMFQID SGRNAPLHSP PSEHYTIIFN TFVMMQLFNE INARKIHGER 1030 1040 1050 1060 1070 1080 NVFDGIFRNP IFCTIVLGTF AIQIVIVQFG GKPFSCSPLQ LDQWMWCIFI GLGELVWGQV 1090 1100 1110 1120 1130 1140 IATIPTSRLK FLKEAGRLTQ KEEIPEEELN EDVEEIDHAE RELRRGQILW FRGLNRIQTQ 1150 1160 1170 1180 1190 1200 IRVVKAFRSS LYEGLEKPES RTSIHNFMAH PEFRIEDSQP HIPLIDDTDL EEDAALKQNS 1210 1220 1230 1240 SPPSSLNKNN SAIDSGINLT TDTSKSATSS SPGSPIHSLE TSL
	Isoform WA (AIIICII). Checksum: 63CF042CC00776B1	FASTA	1,199	131,618
	10 20 30 40 50 60 MGDMTNSDFY SKNQRNESSH GGEFGCTMEE LRSLMELRGT EAVVKIKETY GDTEAICRRL 70 80 90 100 110 120 KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW EALQDVTLII LEIAAIISLG 130 140 150 160 170 180 LSFYHPPGEG NEGCATAQGG AEDEGEAEAG WIEGAAILLS VICVVLVTAF NDWSKEKQFR 190 200 210 220 230 240 GLQSRIEQEQ KFTVVRAGQV VQIPVAEIVV GDIAQVKYGD LLPADGLFIQ GNDLKIDESS 250 260 270 280 290 300 LTGESDQVRK SVDKDPMLLS GTHVMEGSGR MLVTAVGVNS QTGIIFTLLG AGGEEEEKKD 310 320 330 340 350 360 KKGVKKGDGL QLPAADGAAA SNAADSANAS LVNGKMQDGN VDASQSKAKQ QDGAAAMEMQ 370 380 390 400 410 420 PLKSAEGGDA DDRKKASMHK KEKSVLQGKL TKLAVQIGKA GLVMSAITVI ILVLYFTVDT 430 440 450 460 470 480 FVVNKKPWLP ECTPVYVQYF VKFFIIGVTV LVVAVPEGLP LAVTISLAYS VKKMMKDNNL 490 500 510 520 530 540 VRHLDACETM GNATAICSDK TGTLTTNRMT VVQAYVGDVH YKEIPDPSSI NTKTMELLIN 550 560 570 580 590 600 AIAINSAYTT KILPPEKEGA LPRQVGNKTE CGLLGFVLDL KQDYEPVRSQ MPEEKLYKVY 610 620 630 640 650 660 TFNSVRKSMS TVIKLPDESF RMYSKGASEI VLKKCCKILN GAGEPRVFRP RDRDEMVKKV 670 680 690 700 710 720 IEPMACDGLR TICVAYRDFP SSPEPDWDNE NDILNELTCI CVVGIEDPVR PEVPEAIRKC 730 740 750 760 770 780 QRAGITVRMV TGDNINTARA IAIKCGIIHP GEDFLCLEGK EFNRRIRNEK GEIEQERIDK 790 800 810 820 830 840 IWPKLRVLAR SSPTDKHTLV KGIIDSTHTE QRQVVAVTGD GTNDGPALKK ADVGFAMGIA 850 860 870 880 890 900 GTDVAKEASD IILTDDNFSS IVKAVMWGRN VYDSISKFLQ FQLTVNVVAV IVAFTGACIT 910 920 930 940 950 960 QDSPLKAVQM LWVNLIMDTF ASLALATEPP TETLLLRKPY GRNKPLISRT MMKNILGHAV 970 980 990 1000 1010 1020 YQLALIFTLL FVGEKMFQID SGRNAPLHSP PSEHYTIIFN TFVMMQLFNE INARKIHGER 1030 1040 1050 1060 1070 1080 NVFDGIFRNP IFCTIVLGTF AIQIVIVQFG GKPFSCSPLQ LDQWMWCIFI GLGELVWGQV 1090 1100 1110 1120 1130 1140 IATIPTSRLK FLKEAGRLTQ KEEIPEEELN EDVEEIDHAE RELRRGQILW FRGLNRIQTQ 1150 1160 1170 1180 1190 IEVVNTFKSG ASFQGALRRQ SSVTSQSQDV ANLSSPSRVS LSNALSSPTS LPPAAAGQG
	Isoform XA (AIICII). Checksum: DED471E8D9102EF2	FASTA	1,185	130,171
	10 20 30 40 50 60 MGDMTNSDFY SKNQRNESSH GGEFGCTMEE LRSLMELRGT EAVVKIKETY GDTEAICRRL 70 80 90 100 110 120 KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW EALQDVTLII LEIAAIISLG 130 140 150 160 170 180 LSFYHPPGEG NEGCATAQGG AEDEGEAEAG WIEGAAILLS VICVVLVTAF NDWSKEKQFR 190 200 210 220 230 240 GLQSRIEQEQ KFTVVRAGQV VQIPVAEIVV GDIAQVKYGD LLPADGLFIQ GNDLKIDESS 250 260 270 280 290 300 LTGESDQVRK SVDKDPMLLS GTHVMEGSGR MLVTAVGVNS QTGIIFTLLG AGGEEEEKKD 310 320 330 340 350 360 KKGVKKGDGL QLPAADGAAA SNAADSANAS LVNAKQQDGA AAMEMQPLKS AEGGDADDRK 370 380 390 400 410 420 KASMHKKEKS VLQGKLTKLA VQIGKAGLVM SAITVIILVL YFTVDTFVVN KKPWLPECTP 430 440 450 460 470 480 VYVQYFVKFF IIGVTVLVVA VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT 490 500 510 520 530 540 AICSDKTGTL TTNRMTVVQA YVGDVHYKEI PDPSSINTKT MELLINAIAI NSAYTTKILP 550 560 570 580 590 600 PEKEGALPRQ VGNKTECGLL GFVLDLKQDY EPVRSQMPEE KLYKVYTFNS VRKSMSTVIK 610 620 630 640 650 660 LPDESFRMYS KGASEIVLKK CCKILNGAGE PRVFRPRDRD EMVKKVIEPM ACDGLRTICV 670 680 690 700 710 720 AYRDFPSSPE PDWDNENDIL NELTCICVVG IEDPVRPEVP EAIRKCQRAG ITVRMVTGDN 730 740 750 760 770 780 INTARAIAIK CGIIHPGEDF LCLEGKEFNR RIRNEKGEIE QERIDKIWPK LRVLARSSPT 790 800 810 820 830 840 DKHTLVKGII DSTHTEQRQV VAVTGDGTND GPALKKADVG FAMGIAGTDV AKEASDIILT 850 860 870 880 890 900 DDNFSSIVKA VMWGRNVYDS ISKFLQFQLT VNVVAVIVAF TGACITQDSP LKAVQMLWVN 910 920 930 940 950 960 LIMDTFASLA LATEPPTETL LLRKPYGRNK PLISRTMMKN ILGHAVYQLA LIFTLLFVGE 970 980 990 1000 1010 1020 KMFQIDSGRN APLHSPPSEH YTIIFNTFVM MQLFNEINAR KIHGERNVFD GIFRNPIFCT 1030 1040 1050 1060 1070 1080 IVLGTFAIQI VIVQFGGKPF SCSPLQLDQW MWCIFIGLGE LVWGQVIATI PTSRLKFLKE 1090 1100 1110 1120 1130 1140 AGRLTQKEEI PEEELNEDVE EIDHAERELR RGQILWFRGL NRIQTQIEVV NTFKSGASFQ 1150 1160 1170 1180 GALRRQSSVT SQSQDVANLS SPSRVSLSNA LSSPTSLPPA AAGQG
	Isoform ZA (AICII). Checksum: ECB232AA4AC37BE8	FASTA	1,154	127,335
	10 20 30 40 50 60 MGDMTNSDFY SKNQRNESSH GGEFGCTMEE LRSLMELRGT EAVVKIKETY GDTEAICRRL 70 80 90 100 110 120 KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW EALQDVTLII LEIAAIISLG 130 140 150 160 170 180 LSFYHPPGEG NEGCATAQGG AEDEGEAEAG WIEGAAILLS VICVVLVTAF NDWSKEKQFR 190 200 210 220 230 240 GLQSRIEQEQ KFTVVRAGQV VQIPVAEIVV GDIAQVKYGD LLPADGLFIQ GNDLKIDESS 250 260 270 280 290 300 LTGESDQVRK SVDKDPMLLS GTHVMEGSGR MLVTAVGVNS QTGIIFTLLG AGGEEEEKKD 310 320 330 340 350 360 KKAKQQDGAA AMEMQPLKSA EGGDADDRKK ASMHKKEKSV LQGKLTKLAV QIGKAGLVMS 370 380 390 400 410 420 AITVIILVLY FTVDTFVVNK KPWLPECTPV YVQYFVKFFI IGVTVLVVAV PEGLPLAVTI 430 440 450 460 470 480 SLAYSVKKMM KDNNLVRHLD ACETMGNATA ICSDKTGTLT TNRMTVVQAY VGDVHYKEIP 490 500 510 520 530 540 DPSSINTKTM ELLINAIAIN SAYTTKILPP EKEGALPRQV GNKTECGLLG FVLDLKQDYE 550 560 570 580 590 600 PVRSQMPEEK LYKVYTFNSV RKSMSTVIKL PDESFRMYSK GASEIVLKKC CKILNGAGEP 610 620 630 640 650 660 RVFRPRDRDE MVKKVIEPMA CDGLRTICVA YRDFPSSPEP DWDNENDILN ELTCICVVGI 670 680 690 700 710 720 EDPVRPEVPE AIRKCQRAGI TVRMVTGDNI NTARAIAIKC GIIHPGEDFL CLEGKEFNRR 730 740 750 760 770 780 IRNEKGEIEQ ERIDKIWPKL RVLARSSPTD KHTLVKGIID STHTEQRQVV AVTGDGTNDG 790 800 810 820 830 840 PALKKADVGF AMGIAGTDVA KEASDIILTD DNFSSIVKAV MWGRNVYDSI SKFLQFQLTV 850 860 870 880 890 900 NVVAVIVAFT GACITQDSPL KAVQMLWVNL IMDTFASLAL ATEPPTETLL LRKPYGRNKP 910 920 930 940 950 960 LISRTMMKNI LGHAVYQLAL IFTLLFVGEK MFQIDSGRNA PLHSPPSEHY TIIFNTFVMM 970 980 990 1000 1010 1020 QLFNEINARK IHGERNVFDG IFRNPIFCTI VLGTFAIQIV IVQFGGKPFS CSPLQLDQWM 1030 1040 1050 1060 1070 1080 WCIFIGLGEL VWGQVIATIP TSRLKFLKEA GRLTQKEEIP EEELNEDVEE IDHAERELRR 1090 1100 1110 1120 1130 1140 GQILWFRGLN RIQTQIEVVN TFKSGASFQG ALRRQSSVTS QSQDVANLSS PSRVSLSNAL 1150 SSPTSLPPAA AGQG
	Isoform XB (AIICI). Checksum: A7E663E42EBDEAA9	FASTA	1,229	135,430
	10 20 30 40 50 60 MGDMTNSDFY SKNQRNESSH GGEFGCTMEE LRSLMELRGT EAVVKIKETY GDTEAICRRL 70 80 90 100 110 120 KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW EALQDVTLII LEIAAIISLG 130 140 150 160 170 180 LSFYHPPGEG NEGCATAQGG AEDEGEAEAG WIEGAAILLS VICVVLVTAF NDWSKEKQFR 190 200 210 220 230 240 GLQSRIEQEQ KFTVVRAGQV VQIPVAEIVV GDIAQVKYGD LLPADGLFIQ GNDLKIDESS 250 260 270 280 290 300 LTGESDQVRK SVDKDPMLLS GTHVMEGSGR MLVTAVGVNS QTGIIFTLLG AGGEEEEKKD 310 320 330 340 350 360 KKGVKKGDGL QLPAADGAAA SNAADSANAS LVNAKQQDGA AAMEMQPLKS AEGGDADDRK 370 380 390 400 410 420 KASMHKKEKS VLQGKLTKLA VQIGKAGLVM SAITVIILVL YFTVDTFVVN KKPWLPECTP 430 440 450 460 470 480 VYVQYFVKFF IIGVTVLVVA VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT 490 500 510 520 530 540 AICSDKTGTL TTNRMTVVQA YVGDVHYKEI PDPSSINTKT MELLINAIAI NSAYTTKILP 550 560 570 580 590 600 PEKEGALPRQ VGNKTECGLL GFVLDLKQDY EPVRSQMPEE KLYKVYTFNS VRKSMSTVIK 610 620 630 640 650 660 LPDESFRMYS KGASEIVLKK CCKILNGAGE PRVFRPRDRD EMVKKVIEPM ACDGLRTICV 670 680 690 700 710 720 AYRDFPSSPE PDWDNENDIL NELTCICVVG IEDPVRPEVP EAIRKCQRAG ITVRMVTGDN 730 740 750 760 770 780 INTARAIAIK CGIIHPGEDF LCLEGKEFNR RIRNEKGEIE QERIDKIWPK LRVLARSSPT 790 800 810 820 830 840 DKHTLVKGII DSTHTEQRQV VAVTGDGTND GPALKKADVG FAMGIAGTDV AKEASDIILT 850 860 870 880 890 900 DDNFSSIVKA VMWGRNVYDS ISKFLQFQLT VNVVAVIVAF TGACITQDSP LKAVQMLWVN 910 920 930 940 950 960 LIMDTFASLA LATEPPTETL LLRKPYGRNK PLISRTMMKN ILGHAVYQLA LIFTLLFVGE 970 980 990 1000 1010 1020 KMFQIDSGRN APLHSPPSEH YTIIFNTFVM MQLFNEINAR KIHGERNVFD GIFRNPIFCT 1030 1040 1050 1060 1070 1080 IVLGTFAIQI VIVQFGGKPF SCSPLQLDQW MWCIFIGLGE LVWGQVIATI PTSRLKFLKE 1090 1100 1110 1120 1130 1140 AGRLTQKEEI PEEELNEDVE EIDHAERELR RGQILWFRGL NRIQTQIRVV KAFRSSLYEG 1150 1160 1170 1180 1190 1200 LEKPESRTSI HNFMAHPEFR IEDSQPHIPL IDDTDLEEDA ALKQNSSPPS SLNKNNSAID 1210 1220 SGINLTTDTS KSATSSSPGS PIHSLETSL
	Isoform ZB (AICI). Checksum: EEF94C16D4C1C73E	FASTA	1,198	132,594
	10 20 30 40 50 60 MGDMTNSDFY SKNQRNESSH GGEFGCTMEE LRSLMELRGT EAVVKIKETY GDTEAICRRL 70 80 90 100 110 120 KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW EALQDVTLII LEIAAIISLG 130 140 150 160 170 180 LSFYHPPGEG NEGCATAQGG AEDEGEAEAG WIEGAAILLS VICVVLVTAF NDWSKEKQFR 190 200 210 220 230 240 GLQSRIEQEQ KFTVVRAGQV VQIPVAEIVV GDIAQVKYGD LLPADGLFIQ GNDLKIDESS 250 260 270 280 290 300 LTGESDQVRK SVDKDPMLLS GTHVMEGSGR MLVTAVGVNS QTGIIFTLLG AGGEEEEKKD 310 320 330 340 350 360 KKAKQQDGAA AMEMQPLKSA EGGDADDRKK ASMHKKEKSV LQGKLTKLAV QIGKAGLVMS 370 380 390 400 410 420 AITVIILVLY FTVDTFVVNK KPWLPECTPV YVQYFVKFFI IGVTVLVVAV PEGLPLAVTI 430 440 450 460 470 480 SLAYSVKKMM KDNNLVRHLD ACETMGNATA ICSDKTGTLT TNRMTVVQAY VGDVHYKEIP 490 500 510 520 530 540 DPSSINTKTM ELLINAIAIN SAYTTKILPP EKEGALPRQV GNKTECGLLG FVLDLKQDYE 550 560 570 580 590 600 PVRSQMPEEK LYKVYTFNSV RKSMSTVIKL PDESFRMYSK GASEIVLKKC CKILNGAGEP 610 620 630 640 650 660 RVFRPRDRDE MVKKVIEPMA CDGLRTICVA YRDFPSSPEP DWDNENDILN ELTCICVVGI 670 680 690 700 710 720 EDPVRPEVPE AIRKCQRAGI TVRMVTGDNI NTARAIAIKC GIIHPGEDFL CLEGKEFNRR 730 740 750 760 770 780 IRNEKGEIEQ ERIDKIWPKL RVLARSSPTD KHTLVKGIID STHTEQRQVV AVTGDGTNDG 790 800 810 820 830 840 PALKKADVGF AMGIAGTDVA KEASDIILTD DNFSSIVKAV MWGRNVYDSI SKFLQFQLTV 850 860 870 880 890 900 NVVAVIVAFT GACITQDSPL KAVQMLWVNL IMDTFASLAL ATEPPTETLL LRKPYGRNKP 910 920 930 940 950 960 LISRTMMKNI LGHAVYQLAL IFTLLFVGEK MFQIDSGRNA PLHSPPSEHY TIIFNTFVMM 970 980 990 1000 1010 1020 QLFNEINARK IHGERNVFDG IFRNPIFCTI VLGTFAIQIV IVQFGGKPFS CSPLQLDQWM 1030 1040 1050 1060 1070 1080 WCIFIGLGEL VWGQVIATIP TSRLKFLKEA GRLTQKEEIP EEELNEDVEE IDHAERELRR 1090 1100 1110 1120 1130 1140 GQILWFRGLN RIQTQIRVVK AFRSSLYEGL EKPESRTSIH NFMAHPEFRI EDSQPHIPLI 1150 1160 1170 1180 1190 DDTDLEEDAA LKQNSSPPSS LNKNNSAIDS GINLTTDTSK SATSSSPGSP IHSLETSL

References

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[1]	"Determination of the nucleotide sequence and chromosomal localization of the ATP2B2 gene encoding human Ca(2+)-pumping ATPase isoform PMCA2." Brandt P., Ibrahim E., Bruns G.A.P., Neve R.L. Genomics 14:484-487(1992) [PubMed: 1427863] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ZB). Tissue: Brain.
[2]	"von Hippel-Lindau syndrome: cloning and identification of the plasma membrane Ca(++)-transporting ATPase isoform 2 gene that resides in the von Hippel-Lindau gene region." Latif F., Duh F.-M., Gnarra J., Tory K., Kuzmin I., Yao M., Stackhouse T., Modi W., Geil L., Schmidt L., Li H., Orcutt M.L., Maher E., Richards F., Phipps M., Ferguson-Smith M., le Paslier D., Linehan W.M., Zbar B., Lerman M.I. Cancer Res. 53:861-867(1993) [PubMed: 8428366] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ZB), ALTERNATIVE SPLICING.
[3]	"Microdiversity of human-plasma-membrane calcium-pump isoform 2 generated by alternative RNA splicing in the N-terminal coding region." Heim R., Hug M., Iwata T., Strehler E.E., Carafoli E. Eur. J. Biochem. 205:333-340(1992) [PubMed: 1313367] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM WB), ALTERNATIVE SPLICING. Tissue: Brain and Skeletal muscle.
[4]	"Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes." Stauffer T.P., Hilfiker H., Carafoli E., Strehler E.E. J. Biol. Chem. 268:25993-26003(1993) [PubMed: 8245032] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS WA/XA/ZA). Tissue: Brain cortex.
[5]	Erratum Stauffer T.P., Hilfiker H., Carafoli E., Strehler E.E. J. Biol. Chem. 269:32022-32022(1994) [PubMed: 7989379] [Abstract]
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1231; SER-1234; SER-1238; THR-1241 AND SER-1242, MASS SPECTROMETRY.
[7]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[8]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1242, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M97260 mRNA. Translation: AAA36456.1. L20977 mRNA. Translation: AAA50877.1. L00620 mRNA. Translation: AAA51893.1. X63575 mRNA. Translation: CAA45131.1. U15688 mRNA. Translation: AAA60985.1.
IPI	IPI00009791. IPI00219293. IPI00219294. IPI00219295. IPI00219296. IPI00219297.
PIR	S22393.
RefSeq	NP_001001331.1. NP_001674.2.
UniGene	Hs.268942
3D structure databases
SMR	Q01814. Positions 52-1084.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q01814. 6 interactions.
STRING	Q01814.
PTM databases
PhosphoSite	Q01814.
Proteomic databases
PRIDE	Q01814.
Genome annotation databases
Ensembl	ENST00000352432; ENSP00000324172; ENSG00000157087; Homo sapiens. [Genome view] ENST00000360273; ENSP00000353414; ENSG00000157087; Homo sapiens. [Genome view]
GeneID	491.
KEGG	hsa:491.
UCSC	uc003bvt.1. human. uc003bvu.1. human.
Organism-specific databases
CTD	491.
GeneCards	GC03M010342.
H-InvDB	HIX0030804.
HGNC	HGNC:815. ATP2B2.
HPA	CAB005606.
MIM	108733. gene.
PharmGKB	PA25108.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG456486.
HOVERGEN	Q01814.
InParanoid	Q01814.
OMA	GEKMFQI.
OrthoDB	EOG9KM1NM.
PhylomeDB	Q01814.
Enzyme and pathway databases
BRENDA	3.6.3.8. 247.
Gene expression databases
ArrayExpress	Q01814.
Bgee	Q01814.
CleanEx	HS_ATP2B2.
Genevestigator	Q01814.
GermOnline	ENSG00000157087. Homo sapiens.
Family and domain databases
InterPro	IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR006408. ATPase_P-typ_Ca-transp_PMCA. IPR006069. ATPase_P-typ_cation-exchng_asu. IPR006068. ATPase_P-typ_cation-transptr_C. IPR004014. ATPase_P-typ_cation-transptr_N. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR005834. Dehalogen-like_hydro. [Graphical view]
PANTHER	PTHR11939. ATPase_P. 1 hit.
Pfam	PF00689. Cation_ATPase_C. 1 hit. PF00690. Cation_ATPase_N. 1 hit. PF00122. E1-E2_ATPase. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00121. NAKATPASE.
SMART	SM00831. Cation_ATPase_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR01517. ATPase-IIB_Ca. 1 hit. TIGR01494. ATPase_P-type. 4 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	2059.
SOURCE	Search...

Entry information

Entry name

AT2B2_HUMAN

Accession

Primary (citable) accession number: Q01814
Secondary accession number(s): O00766, Q12994, Q16818

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	June 1, 2001
Last modified:	February 9, 2010
This is version 108 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.