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Q01812

- GRIK4_RAT

UniProt

Q01812 - GRIK4_RAT

Protein

Glutamate receptor ionotropic, kainate 4

Gene

Grik4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > glutamate >> AMPA.

    GO - Molecular functioni

    1. extracellular-glutamate-gated ion channel activity Source: RefGenome
    2. ionotropic glutamate receptor activity Source: RGD
    3. kainate selective glutamate receptor activity Source: RefGenome

    GO - Biological processi

    1. ionotropic glutamate receptor signaling pathway Source: RefGenome
    2. ion transmembrane transport Source: RefGenome
    3. ion transport Source: RGD
    4. response to corticosteroid Source: RGD
    5. synaptic transmission Source: RGD
    6. synaptic transmission, glutamatergic Source: RefGenome

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate receptor ionotropic, kainate 4
    Short name:
    GluK4
    Alternative name(s):
    Glutamate receptor KA-1
    Short name:
    KA1
    Gene namesi
    Name:Grik4
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 8

    Organism-specific databases

    RGDi2734. Grik4.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: RGD
    2. cell junction Source: UniProtKB-KW
    3. dendrite Source: RGD
    4. ionotropic glutamate receptor complex Source: RGD
    5. kainate selective glutamate receptor complex Source: RefGenome
    6. nucleus Source: RGD
    7. perikaryon Source: RGD
    8. postsynaptic membrane Source: RefGenome
    9. presynaptic membrane Source: RefGenome
    10. terminal bouton Source: RGD

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 956936Glutamate receptor ionotropic, kainate 4PRO_0000011551Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi272 – 2721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi286 – 2861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi323 – 3231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi408 – 4081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi415 – 4151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi479 – 4791N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ01812.
    PRIDEiQ01812.

    Expressioni

    Tissue specificityi

    Strong expression in hippocampal CA3 pyramidal cells. Low expression in hippocampal dentate granule cells, in layers II, V and VI of the cortex, and in cerebellar Purkinje cells. No expression in the striatum, reticular thalamus, hypothalamus or amygdaloid complex.

    Developmental stagei

    Expressed at embryonic day 15 in brain and spinal cord. At embryonic day 19 expression accumulates in the hippocampal formation. Prominent expression in the subicular cortex at postnatal days P1, P8 and P15 but then markedly reduced in the adult.

    Gene expression databases

    GenevestigatoriQ01812.

    Interactioni

    Subunit structurei

    Forms a heteromeric channel with GRIK1 or GRIK3.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000047794.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01812.
    SMRiQ01812. Positions 407-527, 652-786.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 545525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini567 – 62357CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini645 – 804160ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini826 – 956131CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei546 – 56621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei624 – 64421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei805 – 82521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi862 – 8654Poly-Arg

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG316680.
    GeneTreeiENSGT00740000114953.
    HOGENOMiHOG000234371.
    HOVERGENiHBG051839.
    InParanoidiQ01812.
    KOiK05204.
    OrthoDBiEOG71G9W6.
    PhylomeDBiQ01812.

    Family and domain databases

    InterProiIPR001828. ANF_lig-bd_rcpt.
    IPR019594. Glu_rcpt_Glu/Gly-bd.
    IPR001320. Iontro_glu_rcpt.
    IPR001508. NMDA_rcpt.
    IPR028082. Peripla_BP_I.
    [Graphical view]
    PfamiPF01094. ANF_receptor. 1 hit.
    PF00060. Lig_chan. 1 hit.
    PF10613. Lig_chan-Glu_bd. 1 hit.
    [Graphical view]
    PRINTSiPR00177. NMDARECEPTOR.
    SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
    SM00079. PBPe. 1 hit.
    [Graphical view]
    SUPFAMiSSF53822. SSF53822. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q01812-1 [UniParc]FASTAAdd to Basket

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    MPRVSAPLVL LPAWLLMVAC SPHSLRIAAI LDDPMECSRG ERLSITLAKN    50
    RINRAPERLG KAKVEVDIFE LLRDSEYETA ETMCQILPKG VVAVLGPSSS 100
    PASSSIISNI CGEKEVPHFK VAPEEFVRFQ LQRFTTLNLH PSNTDISVAV 150
    AGILNFFNCT TACLICAKAE CLLNLEKLLR QFLISKDTLS VRMLDDTRDP 200
    TPLLKEIRDD KTATIIIHAN ASMSHTILLK AAELGMVSAY YTYIFTNLEF 250
    SLQRMDSLVD DRVNILGFSI FNQSHAFFQE FSQSLNQSWQ ENCDHVPFTG 300
    PALSSALLFD AVYAVVTAVQ ELNRSQEIGV KPLSCGSAQI WQHGTSLMNY 350
    LRMVELEGLT GHIEFNSKGQ RSNYALKILQ FTRNGFRQIG QWHVAEGLSM 400
    DSRLYASNIS DSLFNTTLVV TTILENPYLM LKGNHQDMEG NDRYEGFCVD 450
    MLKELAEILR FNYKIRLVGD GVYGVPEANG TWTGMVGELI ARKADLAVAG 500
    LTITAEREKV IDFSKPFMTL GISILYRVHM GRRPGYFSSL DPFSPGVWLF 550
    MLLAYLAVSC VLFLVARLTP YEWYSPHPCA QGRCNLLVNQ YSLGNSLWFP 600
    VGGFMQQGST IAPRALSTRC VSGVWWAFTL IIISSYTANL AAFLTVQRME 650
    VPIESVDDLA DQTAIEYGTI HGGSSMTFFQ NSRYQTYQRM WNYMYSKQPS 700
    VFVKSTEEGI ARVLNSNYAF LLESTMNEYY RQRNCNLTQI GGLLDTKGYG 750
    IGMPVGSVFR DEFDLAILQL QENNRLEILK RKWWEGGKCP KEEDHRAKGL 800
    GMENIGGIFV VLICGLIVAI FMAMLEFLWT LRHSEASEVS VCQEMMTELR 850
    SIILCQDNIH PRRRRSGGLP PQPPVLEERR PRGTATLSNG KLCGAGEPDQ 900
    LAQRLAQEAA LVARGCTHIR VCPECRRFQG LRARPSPARS EESLEWDKTT 950
    NSSEPE 956
    Length:956
    Mass (Da):107,223
    Last modified:November 1, 1996 - v1
    Checksum:i970C9D72C8D74700
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti539 – 5391S → F in AAA17830. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59996 mRNA. Translation: CAA42615.1.
    U08257 mRNA. Translation: AAA17830.1.
    PIRiJS0685.
    RefSeqiNP_036704.1. NM_012572.1.
    XP_006242917.1. XM_006242855.1.
    UniGeneiRn.10049.

    Genome annotation databases

    EnsembliENSRNOT00000048347; ENSRNOP00000047794; ENSRNOG00000030910.
    GeneIDi24406.
    KEGGirno:24406.
    UCSCiRGD:2734. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59996 mRNA. Translation: CAA42615.1 .
    U08257 mRNA. Translation: AAA17830.1 .
    PIRi JS0685.
    RefSeqi NP_036704.1. NM_012572.1.
    XP_006242917.1. XM_006242855.1.
    UniGenei Rn.10049.

    3D structure databases

    ProteinModelPortali Q01812.
    SMRi Q01812. Positions 407-527, 652-786.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000047794.

    Chemistry

    BindingDBi Q01812.
    ChEMBLi CHEMBL3044.
    GuidetoPHARMACOLOGYi 453.

    Proteomic databases

    PaxDbi Q01812.
    PRIDEi Q01812.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000048347 ; ENSRNOP00000047794 ; ENSRNOG00000030910 .
    GeneIDi 24406.
    KEGGi rno:24406.
    UCSCi RGD:2734. rat.

    Organism-specific databases

    CTDi 2900.
    RGDi 2734. Grik4.

    Phylogenomic databases

    eggNOGi NOG316680.
    GeneTreei ENSGT00740000114953.
    HOGENOMi HOG000234371.
    HOVERGENi HBG051839.
    InParanoidi Q01812.
    KOi K05204.
    OrthoDBi EOG71G9W6.
    PhylomeDBi Q01812.

    Miscellaneous databases

    NextBioi 603213.
    PROi Q01812.

    Gene expression databases

    Genevestigatori Q01812.

    Family and domain databases

    InterProi IPR001828. ANF_lig-bd_rcpt.
    IPR019594. Glu_rcpt_Glu/Gly-bd.
    IPR001320. Iontro_glu_rcpt.
    IPR001508. NMDA_rcpt.
    IPR028082. Peripla_BP_I.
    [Graphical view ]
    Pfami PF01094. ANF_receptor. 1 hit.
    PF00060. Lig_chan. 1 hit.
    PF10613. Lig_chan-Glu_bd. 1 hit.
    [Graphical view ]
    PRINTSi PR00177. NMDARECEPTOR.
    SMARTi SM00918. Lig_chan-Glu_bd. 1 hit.
    SM00079. PBPe. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53822. SSF53822. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a putative high-affinity kainate receptor expressed predominantly in hippocampal CA3 cells."
      Werner P., Voigt M., Keinaenen K., Wisden W., Seeburg P.H.
      Nature 351:742-744(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. Boulter J., Pecht G.
      Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Brain.

    Entry informationi

    Entry nameiGRIK4_RAT
    AccessioniPrimary (citable) accession number: Q01812
    Secondary accession number(s): Q62642
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3