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Protein

Glutamate receptor ionotropic, kainate 4

Gene

Grik4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > glutamate >> AMPA.

GO - Molecular functioni

GO - Biological processi

  • ionotropic glutamate receptor signaling pathway Source: GO_Central
  • ion transmembrane transport Source: GO_Central
  • ion transport Source: RGD
  • response to corticosteroid Source: RGD
  • synaptic transmission Source: RGD
  • synaptic transmission, glutamatergic Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_347698. Activation of Ca-permeable Kainate Receptor.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, kainate 4
Short name:
GluK4
Alternative name(s):
Glutamate receptor KA-1
Short name:
KA1
Gene namesi
Name:Grik4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2734. Grik4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 545525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei546 – 56621HelicalSequence AnalysisAdd
BLAST
Topological domaini567 – 62357CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei624 – 64421HelicalSequence AnalysisAdd
BLAST
Topological domaini645 – 804160ExtracellularSequence AnalysisAdd
BLAST
Transmembranei805 – 82521HelicalSequence AnalysisAdd
BLAST
Topological domaini826 – 956131CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • axon Source: RGD
  • cell junction Source: UniProtKB-KW
  • dendrite Source: RGD
  • ionotropic glutamate receptor complex Source: RGD
  • kainate selective glutamate receptor complex Source: GO_Central
  • nucleus Source: RGD
  • perikaryon Source: RGD
  • postsynaptic membrane Source: GO_Central
  • presynaptic membrane Source: GO_Central
  • terminal bouton Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 956936Glutamate receptor ionotropic, kainate 4PRO_0000011551Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi272 – 2721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi286 – 2861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi323 – 3231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi408 – 4081N-linked (GlcNAc...)Sequence Analysis
Glycosylationi415 – 4151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi479 – 4791N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ01812.
PRIDEiQ01812.

Expressioni

Tissue specificityi

Strong expression in hippocampal CA3 pyramidal cells. Low expression in hippocampal dentate granule cells, in layers II, V and VI of the cortex, and in cerebellar Purkinje cells. No expression in the striatum, reticular thalamus, hypothalamus or amygdaloid complex.

Developmental stagei

Expressed at embryonic day 15 in brain and spinal cord. At embryonic day 19 expression accumulates in the hippocampal formation. Prominent expression in the subicular cortex at postnatal days P1, P8 and P15 but then markedly reduced in the adult.

Gene expression databases

GenevestigatoriQ01812.

Interactioni

Subunit structurei

Forms a heteromeric channel with GRIK1 or GRIK3.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047794.

Structurei

3D structure databases

ProteinModelPortaliQ01812.
SMRiQ01812. Positions 407-527, 652-786.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi862 – 8654Poly-Arg

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG316680.
HOGENOMiHOG000234371.
HOVERGENiHBG051839.
InParanoidiQ01812.
KOiK05204.
OrthoDBiEOG71G9W6.
PhylomeDBiQ01812.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01812-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRVSAPLVL LPAWLLMVAC SPHSLRIAAI LDDPMECSRG ERLSITLAKN
60 70 80 90 100
RINRAPERLG KAKVEVDIFE LLRDSEYETA ETMCQILPKG VVAVLGPSSS
110 120 130 140 150
PASSSIISNI CGEKEVPHFK VAPEEFVRFQ LQRFTTLNLH PSNTDISVAV
160 170 180 190 200
AGILNFFNCT TACLICAKAE CLLNLEKLLR QFLISKDTLS VRMLDDTRDP
210 220 230 240 250
TPLLKEIRDD KTATIIIHAN ASMSHTILLK AAELGMVSAY YTYIFTNLEF
260 270 280 290 300
SLQRMDSLVD DRVNILGFSI FNQSHAFFQE FSQSLNQSWQ ENCDHVPFTG
310 320 330 340 350
PALSSALLFD AVYAVVTAVQ ELNRSQEIGV KPLSCGSAQI WQHGTSLMNY
360 370 380 390 400
LRMVELEGLT GHIEFNSKGQ RSNYALKILQ FTRNGFRQIG QWHVAEGLSM
410 420 430 440 450
DSRLYASNIS DSLFNTTLVV TTILENPYLM LKGNHQDMEG NDRYEGFCVD
460 470 480 490 500
MLKELAEILR FNYKIRLVGD GVYGVPEANG TWTGMVGELI ARKADLAVAG
510 520 530 540 550
LTITAEREKV IDFSKPFMTL GISILYRVHM GRRPGYFSSL DPFSPGVWLF
560 570 580 590 600
MLLAYLAVSC VLFLVARLTP YEWYSPHPCA QGRCNLLVNQ YSLGNSLWFP
610 620 630 640 650
VGGFMQQGST IAPRALSTRC VSGVWWAFTL IIISSYTANL AAFLTVQRME
660 670 680 690 700
VPIESVDDLA DQTAIEYGTI HGGSSMTFFQ NSRYQTYQRM WNYMYSKQPS
710 720 730 740 750
VFVKSTEEGI ARVLNSNYAF LLESTMNEYY RQRNCNLTQI GGLLDTKGYG
760 770 780 790 800
IGMPVGSVFR DEFDLAILQL QENNRLEILK RKWWEGGKCP KEEDHRAKGL
810 820 830 840 850
GMENIGGIFV VLICGLIVAI FMAMLEFLWT LRHSEASEVS VCQEMMTELR
860 870 880 890 900
SIILCQDNIH PRRRRSGGLP PQPPVLEERR PRGTATLSNG KLCGAGEPDQ
910 920 930 940 950
LAQRLAQEAA LVARGCTHIR VCPECRRFQG LRARPSPARS EESLEWDKTT

NSSEPE
Length:956
Mass (Da):107,223
Last modified:November 1, 1996 - v1
Checksum:i970C9D72C8D74700
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti539 – 5391S → F in AAA17830 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59996 mRNA. Translation: CAA42615.1.
U08257 mRNA. Translation: AAA17830.1.
PIRiJS0685.
RefSeqiNP_036704.1. NM_012572.1.
UniGeneiRn.10049.

Genome annotation databases

GeneIDi24406.
KEGGirno:24406.
UCSCiRGD:2734. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59996 mRNA. Translation: CAA42615.1.
U08257 mRNA. Translation: AAA17830.1.
PIRiJS0685.
RefSeqiNP_036704.1. NM_012572.1.
UniGeneiRn.10049.

3D structure databases

ProteinModelPortaliQ01812.
SMRiQ01812. Positions 407-527, 652-786.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047794.

Chemistry

BindingDBiQ01812.
ChEMBLiCHEMBL2094119.
GuidetoPHARMACOLOGYi453.

Proteomic databases

PaxDbiQ01812.
PRIDEiQ01812.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24406.
KEGGirno:24406.
UCSCiRGD:2734. rat.

Organism-specific databases

CTDi2900.
RGDi2734. Grik4.

Phylogenomic databases

eggNOGiNOG316680.
HOGENOMiHOG000234371.
HOVERGENiHBG051839.
InParanoidiQ01812.
KOiK05204.
OrthoDBiEOG71G9W6.
PhylomeDBiQ01812.

Enzyme and pathway databases

ReactomeiREACT_347698. Activation of Ca-permeable Kainate Receptor.

Miscellaneous databases

NextBioi603213.
PROiQ01812.

Gene expression databases

GenevestigatoriQ01812.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Cloning of a putative high-affinity kainate receptor expressed predominantly in hippocampal CA3 cells."
    Werner P., Voigt M., Keinaenen K., Wisden W., Seeburg P.H.
    Nature 351:742-744(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. Boulter J., Pecht G.
    Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiGRIK4_RAT
AccessioniPrimary (citable) accession number: Q01812
Secondary accession number(s): Q62642
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 27, 2015
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.