SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q01812

- GRIK4_RAT

UniProt

Q01812 - GRIK4_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Glutamate receptor ionotropic, kainate 4
Gene
Grik4
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > glutamate >> AMPA.

GO - Molecular functioni

  1. extracellular-glutamate-gated ion channel activity Source: RefGenome
  2. ionotropic glutamate receptor activity Source: RGD
  3. kainate selective glutamate receptor activity Source: RefGenome

GO - Biological processi

  1. ion transmembrane transport Source: RefGenome
  2. ion transport Source: RGD
  3. ionotropic glutamate receptor signaling pathway Source: RefGenome
  4. response to corticosteroid Source: RGD
  5. synaptic transmission Source: RGD
  6. synaptic transmission, glutamatergic Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, kainate 4
Short name:
GluK4
Alternative name(s):
Glutamate receptor KA-1
Short name:
KA1
Gene namesi
Name:Grik4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi2734. Grik4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 545525Extracellular Reviewed prediction
Add
BLAST
Transmembranei546 – 56621Helical; Reviewed prediction
Add
BLAST
Topological domaini567 – 62357Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei624 – 64421Helical; Reviewed prediction
Add
BLAST
Topological domaini645 – 804160Extracellular Reviewed prediction
Add
BLAST
Transmembranei805 – 82521Helical; Reviewed prediction
Add
BLAST
Topological domaini826 – 956131Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. axon Source: RGD
  2. cell junction Source: UniProtKB-KW
  3. dendrite Source: RGD
  4. ionotropic glutamate receptor complex Source: RGD
  5. kainate selective glutamate receptor complex Source: RefGenome
  6. nucleus Source: RGD
  7. perikaryon Source: RGD
  8. postsynaptic membrane Source: RefGenome
  9. presynaptic membrane Source: RefGenome
  10. terminal bouton Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 956936Glutamate receptor ionotropic, kainate 4
PRO_0000011551Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi158 – 1581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi220 – 2201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi272 – 2721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi286 – 2861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi323 – 3231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi408 – 4081N-linked (GlcNAc...) Reviewed prediction
Glycosylationi415 – 4151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi479 – 4791N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ01812.
PRIDEiQ01812.

Expressioni

Tissue specificityi

Strong expression in hippocampal CA3 pyramidal cells. Low expression in hippocampal dentate granule cells, in layers II, V and VI of the cortex, and in cerebellar Purkinje cells. No expression in the striatum, reticular thalamus, hypothalamus or amygdaloid complex.

Developmental stagei

Expressed at embryonic day 15 in brain and spinal cord. At embryonic day 19 expression accumulates in the hippocampal formation. Prominent expression in the subicular cortex at postnatal days P1, P8 and P15 but then markedly reduced in the adult.

Gene expression databases

GenevestigatoriQ01812.

Interactioni

Subunit structurei

Forms a heteromeric channel with GRIK1 or GRIK3 By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047794.

Structurei

3D structure databases

ProteinModelPortaliQ01812.
SMRiQ01812. Positions 407-527, 652-786.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi862 – 8654Poly-Arg

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG316680.
GeneTreeiENSGT00740000114953.
HOGENOMiHOG000234371.
HOVERGENiHBG051839.
InParanoidiQ01812.
KOiK05204.
OrthoDBiEOG71G9W6.
PhylomeDBiQ01812.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01812-1 [UniParc]FASTAAdd to Basket

« Hide

MPRVSAPLVL LPAWLLMVAC SPHSLRIAAI LDDPMECSRG ERLSITLAKN    50
RINRAPERLG KAKVEVDIFE LLRDSEYETA ETMCQILPKG VVAVLGPSSS 100
PASSSIISNI CGEKEVPHFK VAPEEFVRFQ LQRFTTLNLH PSNTDISVAV 150
AGILNFFNCT TACLICAKAE CLLNLEKLLR QFLISKDTLS VRMLDDTRDP 200
TPLLKEIRDD KTATIIIHAN ASMSHTILLK AAELGMVSAY YTYIFTNLEF 250
SLQRMDSLVD DRVNILGFSI FNQSHAFFQE FSQSLNQSWQ ENCDHVPFTG 300
PALSSALLFD AVYAVVTAVQ ELNRSQEIGV KPLSCGSAQI WQHGTSLMNY 350
LRMVELEGLT GHIEFNSKGQ RSNYALKILQ FTRNGFRQIG QWHVAEGLSM 400
DSRLYASNIS DSLFNTTLVV TTILENPYLM LKGNHQDMEG NDRYEGFCVD 450
MLKELAEILR FNYKIRLVGD GVYGVPEANG TWTGMVGELI ARKADLAVAG 500
LTITAEREKV IDFSKPFMTL GISILYRVHM GRRPGYFSSL DPFSPGVWLF 550
MLLAYLAVSC VLFLVARLTP YEWYSPHPCA QGRCNLLVNQ YSLGNSLWFP 600
VGGFMQQGST IAPRALSTRC VSGVWWAFTL IIISSYTANL AAFLTVQRME 650
VPIESVDDLA DQTAIEYGTI HGGSSMTFFQ NSRYQTYQRM WNYMYSKQPS 700
VFVKSTEEGI ARVLNSNYAF LLESTMNEYY RQRNCNLTQI GGLLDTKGYG 750
IGMPVGSVFR DEFDLAILQL QENNRLEILK RKWWEGGKCP KEEDHRAKGL 800
GMENIGGIFV VLICGLIVAI FMAMLEFLWT LRHSEASEVS VCQEMMTELR 850
SIILCQDNIH PRRRRSGGLP PQPPVLEERR PRGTATLSNG KLCGAGEPDQ 900
LAQRLAQEAA LVARGCTHIR VCPECRRFQG LRARPSPARS EESLEWDKTT 950
NSSEPE 956
Length:956
Mass (Da):107,223
Last modified:November 1, 1996 - v1
Checksum:i970C9D72C8D74700
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti539 – 5391S → F in AAA17830. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59996 mRNA. Translation: CAA42615.1.
U08257 mRNA. Translation: AAA17830.1.
PIRiJS0685.
RefSeqiNP_036704.1. NM_012572.1.
XP_006242917.1. XM_006242855.1.
UniGeneiRn.10049.

Genome annotation databases

EnsembliENSRNOT00000048347; ENSRNOP00000047794; ENSRNOG00000030910.
GeneIDi24406.
KEGGirno:24406.
UCSCiRGD:2734. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59996 mRNA. Translation: CAA42615.1 .
U08257 mRNA. Translation: AAA17830.1 .
PIRi JS0685.
RefSeqi NP_036704.1. NM_012572.1.
XP_006242917.1. XM_006242855.1.
UniGenei Rn.10049.

3D structure databases

ProteinModelPortali Q01812.
SMRi Q01812. Positions 407-527, 652-786.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000047794.

Chemistry

BindingDBi Q01812.
ChEMBLi CHEMBL3044.
GuidetoPHARMACOLOGYi 453.

Proteomic databases

PaxDbi Q01812.
PRIDEi Q01812.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000048347 ; ENSRNOP00000047794 ; ENSRNOG00000030910 .
GeneIDi 24406.
KEGGi rno:24406.
UCSCi RGD:2734. rat.

Organism-specific databases

CTDi 2900.
RGDi 2734. Grik4.

Phylogenomic databases

eggNOGi NOG316680.
GeneTreei ENSGT00740000114953.
HOGENOMi HOG000234371.
HOVERGENi HBG051839.
InParanoidi Q01812.
KOi K05204.
OrthoDBi EOG71G9W6.
PhylomeDBi Q01812.

Miscellaneous databases

NextBioi 603213.
PROi Q01812.

Gene expression databases

Genevestigatori Q01812.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view ]
Pfami PF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view ]
PRINTSi PR00177. NMDARECEPTOR.
SMARTi SM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view ]
SUPFAMi SSF53822. SSF53822. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning of a putative high-affinity kainate receptor expressed predominantly in hippocampal CA3 cells."
    Werner P., Voigt M., Keinaenen K., Wisden W., Seeburg P.H.
    Nature 351:742-744(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. Boulter J., Pecht G.
    Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiGRIK4_RAT
AccessioniPrimary (citable) accession number: Q01812
Secondary accession number(s): Q62642
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi