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Q01804 (OTUD4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
OTU domain-containing protein 4

EC=3.4.19.12
Alternative name(s):
HIV-1-induced protein HIN-1
Gene names
Name:OTUD4
Synonyms:HIN1, KIAA1046
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1114 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Deubiquitinating enzyme that specifically hydrolyzes 'Lys-48'-linked polyubiquitin. Ref.21

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). Ref.21

Induction

By HIV-1 insertion. Ref.4

Sequence similarities

Contains 1 OTU domain.

Sequence caution

The sequence AAH57242.2 differs from that shown. Reason: Sequence of unknown origin in the N-terminal part.

The sequence BAA82998.2 differs from that shown. Reason: Intron retention.

The sequence BAB71229.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q01804-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: Gene prediction based on similarity to orthologs and partial EST data.
Isoform 2 (identifier: Q01804-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.
     231-231: Missing.
Note: No experimental confirmation available. Gene prediction based on EST data.
Isoform 3 (identifier: Q01804-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.
Isoform 4 (identifier: Q01804-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.
     211-1114: Missing.
Note: Predicted from a chimeric transcript isolated from HIV-1-infected cells. The premature stop may be due to intron retention.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11141114OTU domain-containing protein 4
PRO_0000083979

Regions

Domain34 – 155122OTU
Region39 – 457Cys-loop By similarity
Region94 – 10411Variable-loop By similarity
Region143 – 1486His-loop By similarity

Sites

Active site421 By similarity
Active site451Nucleophile By similarity
Active site1481 By similarity

Amino acid modifications

Modified residue11N-acetylmethionine Ref.7 Ref.19 Ref.20
Modified residue4391Phosphotyrosine By similarity
Modified residue4431Phosphoserine Ref.13 Ref.15
Modified residue4601Phosphotyrosine Ref.10
Modified residue8931Phosphoserine Ref.16 Ref.18
Modified residue9001Phosphoserine Ref.16
Modified residue10061Phosphoserine Ref.12 Ref.13 Ref.15 Ref.18
Modified residue10111Phosphoserine By similarity
Modified residue10231Phosphoserine Ref.13 Ref.15 Ref.16
Modified residue10241Phosphoserine Ref.13 Ref.15 Ref.16

Natural variations

Alternative sequence1 – 6565Missing in isoform 2, isoform 3 and isoform 4.
VSP_038830
Alternative sequence211 – 1114904Missing in isoform 4.
VSP_021671
Alternative sequence2311Missing in isoform 2.
VSP_053825
Natural variant1941A → G. Ref.5
Corresponds to variant rs36225458 [ dbSNP | Ensembl ].
VAR_029377
Natural variant2161A → T. Ref.5
VAR_038848
Natural variant3981G → V Could be associated with cerebellar ataxia and hypogonadotropic hypogonadism. Ref.22
VAR_070050

Experimental info

Sequence conflict8091S → P in BAB71229. Ref.1
Sequence conflict9151A → S in CAB70748. Ref.9

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 19, 2014. Version 4.
Checksum: AD8DF5FEAB8CBE32

FASTA1,114124,045
        10         20         30         40         50         60 
MEAAVGVPDG GDQGGAGPRE DATPMDAYLR KLGLYRKLVA KDGSCLFRAV AEQVLHSQSR 

        70         80         90        100        110        120 
HVEVRMACIH YLRENREKFE AFIEGSFEEY LKRLENPQEW VGQVEISALS LMYRKDFIIY 

       130        140        150        160        170        180 
REPNVSPSQV TENNFPEKVL LCFSNGNHYD IVYPIKYKES SAMCQSLLYE LLYEKVFKTD 

       190        200        210        220        230        240 
VSKIVMELDT LEVADEDNSE ISDSEDDSCK SKTAAAAADV NGFKPLSGNE QLKNNGNSTS 

       250        260        270        280        290        300 
LPLSRKVLKS LNPAVYRNVE YEIWLKSKQA QQKRDYSIAA GLQYEVGDKC QVRLDHNGKF 

       310        320        330        340        350        360 
LNADVQGIHS ENGPVLVEEL GKKHTSKNLK APPPESWNTV SGKKMKKPST SGQNFHSDVD 

       370        380        390        400        410        420 
YRGPKNPSKP IKAPSALPPR LQHPSGVRQH AFSSHSSGSQ SQKFSSEHKN LSRTPSQIIR 

       430        440        450        460        470        480 
KPDRERVEDF DHTSRESNYF GLSPEERREK QAIEESRLLY EIQNRDEQAF PALSSSSVNQ 

       490        500        510        520        530        540 
SASQSSNPCV QRKSSHVGDR KGSRRRMDTE ERKDKDSIHG HSQLDKRPEP STLENITDDK 

       550        560        570        580        590        600 
YATVSSPSKS KKLECPSPAE QKPAEHVSLS NPAPLLVSPE VHLTPAVPSL PATVPAWPSE 

       610        620        630        640        650        660 
PTTFGPTGVP APIPVLSVTQ TLTTGPDSAV SQAHLTPSPV PVSIQAVNQP LMPLPQTLSL 

       670        680        690        700        710        720 
YQDPLYPGFP CNEKGDRAIV PPYSLCQTGE DLPKDKNILR FFFNLGVKAY SCPMWAPHSY 

       730        740        750        760        770        780 
LYPLHQAYLA ACRMYPKVPV PVYPHNPWFQ EAPAAQNESD CTCTDAHFPM QTEASVNGQM 

       790        800        810        820        830        840 
PQPEIGPPTF SSPLVIPPSQ VSESHGQLSY QADLESETPG QLLHADYEES LSGKNMFPQP 

       850        860        870        880        890        900 
SFGPNPFLGP VPIAPPFFPH VWYGYPFQGF IENPVMRQNI VLPSDEKGEL DLSLENLDLS 

       910        920        930        940        950        960 
KDCGSVSTVD EFPEARGEHV HSLPEASVSS KPDEGRTEQS SQTRKADTAL ASIPPVAEGK 

       970        980        990       1000       1010       1020 
AHPPTQILNR ERETVPVELE PKRTIQSLKE KTEKVKDPKT AADVVSPGAN SVDSRVQRPK 

      1030       1040       1050       1060       1070       1080 
EESSEDENEV SNILRSGRSK QFYNQTYGSR KYKSDWGYSG RGGYQHVRSE ESWKGQPSRS 

      1090       1100       1110 
RDEGYQYHRN VRGRPFRGDR RRSGMGDGHR GQHT 

« Hide

Isoform 2 [UniParc].

Checksum: 5266BAE77822228E
Show »

FASTA1,048116,953
Isoform 3 [UniParc].

Checksum: 1DCACF002992C917
Show »

FASTA1,049117,082
Isoform 4 [UniParc].

Checksum: BEF79BFC3DB34EF1
Show »

FASTA14517,036

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Testis and Tongue.
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"HIV-1 promotor insertion revealed by selective detection of chimeric provirus-host gene transcripts."
Raineri I., Senn H.-P.
Nucleic Acids Res. 20:6261-6266(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), INDUCTION.
[5]SeattleSNPs variation discovery resource
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 2), VARIANTS GLY-194 AND THR-216.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Brain.
[7]Bienvenut W.V., Heiserich L., Boulahbel H., Gottlieb E., Matallanas D., Cooper W.N., Kolch W.
Submitted (JUL-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 1-19; 49-60; 250-266; 414-420; 436-447; 458-465; 701-708; 917-936; 945-970 AND 1000-1015, ACETYLATION AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Colon carcinoma and Mammary carcinoma.
[8]"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 709-1114 (ISOFORMS 1/2/3).
Tissue: Brain.
[9]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 815-1114 (ISOFORMS 1/2/3).
Tissue: Testis.
[10]"Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-460, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[11]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[12]"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1006, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[13]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-443; SER-1006; SER-1023 AND SER-1024, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[14]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-443; SER-1006; SER-1023 AND SER-1024, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[16]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-893; SER-900; SER-1023 AND SER-1024, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[17]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[18]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-893 AND SER-1006, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[19]"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[20]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[21]"OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis."
Mevissen T.E., Hospenthal M.K., Geurink P.P., Elliott P.R., Akutsu M., Arnaudo N., Ekkebus R., Kulathu Y., Wauer T., El Oualid F., Freund S.M., Ovaa H., Komander D.
Cell 154:169-184(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, CATALYTIC ACTIVITY.
[22]"Ataxia, dementia, and hypogonadotropism caused by disordered ubiquitination."
Margolin D.H., Kousi M., Chan Y.M., Lim E.T., Schmahmann J.D., Hadjivassiliou M., Hall J.E., Adam I., Dwyer A., Plummer L., Aldrin S.V., O'Rourke J., Kirby A., Lage K., Milunsky A., Milunsky J.M., Chan J., Hedley-Whyte E.T. expand/collapse author list , Daly M.J., Katsanis N., Seminara S.B.
N. Engl. J. Med. 368:1992-2003(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT VAL-398.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK056597 mRNA. Translation: BAB71229.1. Different initiation.
AK302581 mRNA. Translation: BAG63836.1.
AC096757 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05045.1.
CH471056 Genomic DNA. Translation: EAX05046.1.
X68242 mRNA. Translation: CAA48313.1.
DQ427109 Genomic DNA. Translation: ABD72605.1.
BC057242 mRNA. Translation: AAH57242.2. Sequence problems.
BC118572 mRNA. Translation: AAI18573.1.
BC118653 mRNA. Translation: AAI18654.1.
AB028969 mRNA. Translation: BAA82998.2. Sequence problems.
AL137460 mRNA. Translation: CAB70748.1.
CCDSCCDS3764.1. [Q01804-4]
PIRS30247.
T46403.
RefSeqNP_001096123.1. NM_001102653.1. [Q01804-3]
NP_059963.1. NM_017493.6. [Q01804-4]
XP_005263136.1. XM_005263079.2. [Q01804-1]
UniGeneHs.270851.

3D structure databases

ProteinModelPortalQ01804.
SMRQ01804. Positions 29-155.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120112. 31 interactions.
IntActQ01804. 26 interactions.
MINTMINT-3024530.
STRING9606.ENSP00000409279.

PTM databases

PhosphoSiteQ01804.

Polymorphism databases

DMDM302393819.

Proteomic databases

MaxQBQ01804.
PaxDbQ01804.
PRIDEQ01804.

Protocols and materials databases

DNASU54726.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000296579; ENSP00000296579; ENSG00000164164. [Q01804-4]
ENST00000454497; ENSP00000409279; ENSG00000164164.
ENST00000509620; ENSP00000424192; ENSG00000164164. [Q01804-4]
GeneID54726.
KEGGhsa:54726.
UCSCuc021xsl.1. human. [Q01804-4]

Organism-specific databases

CTD54726.
GeneCardsGC04M146054.
HGNCHGNC:24949. OTUD4.
HPAHPA036623.
MIM611744. gene.
neXtProtNX_Q01804.
PharmGKBPA142671216.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG81083.
HOVERGENHBG082091.
InParanoidQ01804.
KOK13718.
OrthoDBEOG7H791H.
PhylomeDBQ01804.
TreeFamTF326812.

Gene expression databases

ArrayExpressQ01804.
BgeeQ01804.
CleanExHS_OTUD4.
GenevestigatorQ01804.

Family and domain databases

InterProIPR003323. OTU.
[Graphical view]
PfamPF02338. OTU. 1 hit.
[Graphical view]
PROSITEPS50802. OTU. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOTUD4.
GenomeRNAi54726.
NextBio57297.
PROQ01804.
SOURCESearch...

Entry information

Entry nameOTUD4_HUMAN
AccessionPrimary (citable) accession number: Q01804
Secondary accession number(s): B4DYS4 expand/collapse secondary AC list , Q147U2, Q1ZYK1, Q6PG39, Q96MQ5, Q9NT94, Q9UPV6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: March 19, 2014
Last modified: July 9, 2014
This is version 109 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM