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Q01804

- OTUD4_HUMAN

UniProt

Q01804 - OTUD4_HUMAN

Protein

OTU domain-containing protein 4

Gene

OTUD4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 4 (19 Mar 2014)
      Previous versions | rss
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    Functioni

    Deubiquitinating enzyme that specifically hydrolyzes 'Lys-48'-linked polyubiquitin.1 Publication

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei42 – 421By similarity
    Active sitei45 – 451NucleophileBy similarity
    Active sitei148 – 1481By similarity

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. ubiquitin-specific protease activity Source: UniProtKB

    GO - Biological processi

    1. protein K48-linked deubiquitination Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    OTU domain-containing protein 4 (EC:3.4.19.12)
    Alternative name(s):
    HIV-1-induced protein HIN-1
    Gene namesi
    Name:OTUD4
    Synonyms:HIN1, KIAA1046
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:24949. OTUD4.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671216.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11141114OTU domain-containing protein 4PRO_0000083979Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine3 Publications
    Modified residuei439 – 4391PhosphotyrosineBy similarity
    Modified residuei443 – 4431Phosphoserine2 Publications
    Modified residuei460 – 4601Phosphotyrosine1 Publication
    Modified residuei893 – 8931Phosphoserine2 Publications
    Modified residuei900 – 9001Phosphoserine1 Publication
    Modified residuei1006 – 10061Phosphoserine4 Publications
    Modified residuei1011 – 10111PhosphoserineBy similarity
    Modified residuei1023 – 10231Phosphoserine3 Publications
    Modified residuei1024 – 10241Phosphoserine3 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ01804.
    PaxDbiQ01804.
    PRIDEiQ01804.

    PTM databases

    PhosphoSiteiQ01804.

    Expressioni

    Inductioni

    By HIV-1 insertion.1 Publication

    Gene expression databases

    ArrayExpressiQ01804.
    BgeeiQ01804.
    CleanExiHS_OTUD4.
    GenevestigatoriQ01804.

    Organism-specific databases

    HPAiHPA036623.

    Interactioni

    Protein-protein interaction databases

    BioGridi120112. 31 interactions.
    IntActiQ01804. 26 interactions.
    MINTiMINT-3024530.
    STRINGi9606.ENSP00000409279.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01804.
    SMRiQ01804. Positions 29-155.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 155122OTUPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni39 – 457Cys-loopBy similarity
    Regioni94 – 10411Variable-loopBy similarityAdd
    BLAST
    Regioni143 – 1486His-loopBy similarity

    Sequence similaritiesi

    Contains 1 OTU domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG81083.
    HOVERGENiHBG082091.
    InParanoidiQ01804.
    KOiK13718.
    OrthoDBiEOG7H791H.
    PhylomeDBiQ01804.
    TreeFamiTF326812.

    Family and domain databases

    InterProiIPR003323. OTU.
    [Graphical view]
    PfamiPF02338. OTU. 1 hit.
    [Graphical view]
    PROSITEiPS50802. OTU. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q01804-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEAAVGVPDG GDQGGAGPRE DATPMDAYLR KLGLYRKLVA KDGSCLFRAV     50
    AEQVLHSQSR HVEVRMACIH YLRENREKFE AFIEGSFEEY LKRLENPQEW 100
    VGQVEISALS LMYRKDFIIY REPNVSPSQV TENNFPEKVL LCFSNGNHYD 150
    IVYPIKYKES SAMCQSLLYE LLYEKVFKTD VSKIVMELDT LEVADEDNSE 200
    ISDSEDDSCK SKTAAAAADV NGFKPLSGNE QLKNNGNSTS LPLSRKVLKS 250
    LNPAVYRNVE YEIWLKSKQA QQKRDYSIAA GLQYEVGDKC QVRLDHNGKF 300
    LNADVQGIHS ENGPVLVEEL GKKHTSKNLK APPPESWNTV SGKKMKKPST 350
    SGQNFHSDVD YRGPKNPSKP IKAPSALPPR LQHPSGVRQH AFSSHSSGSQ 400
    SQKFSSEHKN LSRTPSQIIR KPDRERVEDF DHTSRESNYF GLSPEERREK 450
    QAIEESRLLY EIQNRDEQAF PALSSSSVNQ SASQSSNPCV QRKSSHVGDR 500
    KGSRRRMDTE ERKDKDSIHG HSQLDKRPEP STLENITDDK YATVSSPSKS 550
    KKLECPSPAE QKPAEHVSLS NPAPLLVSPE VHLTPAVPSL PATVPAWPSE 600
    PTTFGPTGVP APIPVLSVTQ TLTTGPDSAV SQAHLTPSPV PVSIQAVNQP 650
    LMPLPQTLSL YQDPLYPGFP CNEKGDRAIV PPYSLCQTGE DLPKDKNILR 700
    FFFNLGVKAY SCPMWAPHSY LYPLHQAYLA ACRMYPKVPV PVYPHNPWFQ 750
    EAPAAQNESD CTCTDAHFPM QTEASVNGQM PQPEIGPPTF SSPLVIPPSQ 800
    VSESHGQLSY QADLESETPG QLLHADYEES LSGKNMFPQP SFGPNPFLGP 850
    VPIAPPFFPH VWYGYPFQGF IENPVMRQNI VLPSDEKGEL DLSLENLDLS 900
    KDCGSVSTVD EFPEARGEHV HSLPEASVSS KPDEGRTEQS SQTRKADTAL 950
    ASIPPVAEGK AHPPTQILNR ERETVPVELE PKRTIQSLKE KTEKVKDPKT 1000
    AADVVSPGAN SVDSRVQRPK EESSEDENEV SNILRSGRSK QFYNQTYGSR 1050
    KYKSDWGYSG RGGYQHVRSE ESWKGQPSRS RDEGYQYHRN VRGRPFRGDR 1100
    RRSGMGDGHR GQHT 1114

    Note: Gene prediction based on similarity to orthologs and partial EST data.

    Length:1,114
    Mass (Da):124,045
    Last modified:March 19, 2014 - v4
    Checksum:iAD8DF5FEAB8CBE32
    GO
    Isoform 2 (identifier: Q01804-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-65: Missing.
         231-231: Missing.

    Note: No experimental confirmation available. Gene prediction based on EST data.

    Show »
    Length:1,048
    Mass (Da):116,953
    Checksum:i5266BAE77822228E
    GO
    Isoform 3 (identifier: Q01804-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-65: Missing.

    Show »
    Length:1,049
    Mass (Da):117,082
    Checksum:i1DCACF002992C917
    GO
    Isoform 4 (identifier: Q01804-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-65: Missing.
         211-1114: Missing.

    Note: Predicted from a chimeric transcript isolated from HIV-1-infected cells. The premature stop may be due to intron retention.

    Show »
    Length:145
    Mass (Da):17,036
    Checksum:iBEF79BFC3DB34EF1
    GO

    Sequence cautioni

    The sequence AAH57242.2 differs from that shown. Reason: Sequence of unknown origin in the N-terminal part.
    The sequence BAA82998.2 differs from that shown. Reason: Intron retention.
    The sequence BAB71229.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti809 – 8091S → P in BAB71229. (PubMed:14702039)Curated
    Sequence conflicti915 – 9151A → S in CAB70748. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti194 – 1941A → G.1 Publication
    Corresponds to variant rs36225458 [ dbSNP | Ensembl ].
    VAR_029377
    Natural varianti216 – 2161A → T.1 Publication
    VAR_038848
    Natural varianti398 – 3981G → V Could be associated with cerebellar ataxia and hypogonadotropic hypogonadism. 1 Publication
    VAR_070050

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6565Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsVSP_038830Add
    BLAST
    Alternative sequencei211 – 1114904Missing in isoform 4. 1 PublicationVSP_021671Add
    BLAST
    Alternative sequencei231 – 2311Missing in isoform 2. CuratedVSP_053825

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056597 mRNA. Translation: BAB71229.1. Different initiation.
    AK302581 mRNA. Translation: BAG63836.1.
    AC096757 Genomic DNA. No translation available.
    CH471056 Genomic DNA. Translation: EAX05045.1.
    CH471056 Genomic DNA. Translation: EAX05046.1.
    X68242 mRNA. Translation: CAA48313.1.
    DQ427109 Genomic DNA. Translation: ABD72605.1.
    BC057242 mRNA. Translation: AAH57242.2. Sequence problems.
    BC118572 mRNA. Translation: AAI18573.1.
    BC118653 mRNA. Translation: AAI18654.1.
    AB028969 mRNA. Translation: BAA82998.2. Sequence problems.
    AL137460 mRNA. Translation: CAB70748.1.
    CCDSiCCDS3764.1. [Q01804-4]
    CCDS47139.1. [Q01804-3]
    PIRiS30247.
    T46403.
    RefSeqiNP_001096123.1. NM_001102653.1. [Q01804-3]
    NP_059963.1. NM_017493.6. [Q01804-4]
    XP_005263136.1. XM_005263079.2. [Q01804-1]
    UniGeneiHs.270851.

    Genome annotation databases

    EnsembliENST00000447906; ENSP00000395487; ENSG00000164164. [Q01804-1]
    ENST00000454497; ENSP00000409279; ENSG00000164164. [Q01804-3]
    ENST00000509620; ENSP00000424192; ENSG00000164164. [Q01804-4]
    GeneIDi54726.
    KEGGihsa:54726.
    UCSCiuc021xsl.1. human. [Q01804-4]

    Polymorphism databases

    DMDMi302393819.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056597 mRNA. Translation: BAB71229.1 . Different initiation.
    AK302581 mRNA. Translation: BAG63836.1 .
    AC096757 Genomic DNA. No translation available.
    CH471056 Genomic DNA. Translation: EAX05045.1 .
    CH471056 Genomic DNA. Translation: EAX05046.1 .
    X68242 mRNA. Translation: CAA48313.1 .
    DQ427109 Genomic DNA. Translation: ABD72605.1 .
    BC057242 mRNA. Translation: AAH57242.2 . Sequence problems.
    BC118572 mRNA. Translation: AAI18573.1 .
    BC118653 mRNA. Translation: AAI18654.1 .
    AB028969 mRNA. Translation: BAA82998.2 . Sequence problems.
    AL137460 mRNA. Translation: CAB70748.1 .
    CCDSi CCDS3764.1. [Q01804-4 ]
    CCDS47139.1. [Q01804-3 ]
    PIRi S30247.
    T46403.
    RefSeqi NP_001096123.1. NM_001102653.1. [Q01804-3 ]
    NP_059963.1. NM_017493.6. [Q01804-4 ]
    XP_005263136.1. XM_005263079.2. [Q01804-1 ]
    UniGenei Hs.270851.

    3D structure databases

    ProteinModelPortali Q01804.
    SMRi Q01804. Positions 29-155.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120112. 31 interactions.
    IntActi Q01804. 26 interactions.
    MINTi MINT-3024530.
    STRINGi 9606.ENSP00000409279.

    PTM databases

    PhosphoSitei Q01804.

    Polymorphism databases

    DMDMi 302393819.

    Proteomic databases

    MaxQBi Q01804.
    PaxDbi Q01804.
    PRIDEi Q01804.

    Protocols and materials databases

    DNASUi 54726.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000447906 ; ENSP00000395487 ; ENSG00000164164 . [Q01804-1 ]
    ENST00000454497 ; ENSP00000409279 ; ENSG00000164164 . [Q01804-3 ]
    ENST00000509620 ; ENSP00000424192 ; ENSG00000164164 . [Q01804-4 ]
    GeneIDi 54726.
    KEGGi hsa:54726.
    UCSCi uc021xsl.1. human. [Q01804-4 ]

    Organism-specific databases

    CTDi 54726.
    GeneCardsi GC04M146054.
    HGNCi HGNC:24949. OTUD4.
    HPAi HPA036623.
    MIMi 611744. gene.
    neXtProti NX_Q01804.
    PharmGKBi PA142671216.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG81083.
    HOVERGENi HBG082091.
    InParanoidi Q01804.
    KOi K13718.
    OrthoDBi EOG7H791H.
    PhylomeDBi Q01804.
    TreeFami TF326812.

    Miscellaneous databases

    GeneWikii OTUD4.
    GenomeRNAii 54726.
    NextBioi 57297.
    PROi Q01804.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q01804.
    Bgeei Q01804.
    CleanExi HS_OTUD4.
    Genevestigatori Q01804.

    Family and domain databases

    InterProi IPR003323. OTU.
    [Graphical view ]
    Pfami PF02338. OTU. 1 hit.
    [Graphical view ]
    PROSITEi PS50802. OTU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Testis and Tongue.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "HIV-1 promotor insertion revealed by selective detection of chimeric provirus-host gene transcripts."
      Raineri I., Senn H.-P.
      Nucleic Acids Res. 20:6261-6266(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), INDUCTION.
    5. SeattleSNPs variation discovery resource
      Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 2), VARIANTS GLY-194 AND THR-216.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Brain.
    7. Cited for: PROTEIN SEQUENCE OF 1-19; 49-60; 250-266; 414-420; 436-447; 458-465; 701-708; 917-936; 945-970 AND 1000-1015, ACETYLATION AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Colon carcinoma and Mammary carcinoma.
    8. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 709-1114 (ISOFORMS 1/2/3).
      Tissue: Brain.
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 815-1114 (ISOFORMS 1/2/3).
      Tissue: Testis.
    10. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
      Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
      Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-460, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1006, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-443; SER-1006; SER-1023 AND SER-1024, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-443; SER-1006; SER-1023 AND SER-1024, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-893; SER-900; SER-1023 AND SER-1024, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-893 AND SER-1006, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    20. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    21. "OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis."
      Mevissen T.E., Hospenthal M.K., Geurink P.P., Elliott P.R., Akutsu M., Arnaudo N., Ekkebus R., Kulathu Y., Wauer T., El Oualid F., Freund S.M., Ovaa H., Komander D.
      Cell 154:169-184(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY.
    22. Cited for: VARIANT VAL-398.

    Entry informationi

    Entry nameiOTUD4_HUMAN
    AccessioniPrimary (citable) accession number: Q01804
    Secondary accession number(s): B4DYS4
    , Q147U2, Q1ZYK1, Q6PG39, Q96MQ5, Q9NT94, Q9UPV6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: March 19, 2014
    Last modified: October 1, 2014
    This is version 111 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3