Q01804 (OTUD4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
OTU domain-containing protein 4

Alternative name(s):
HIV-1-induced protein HIN-1

Gene names

Name:	OTUD4
Synonyms:	HIN1, KIAA1046

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1113 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Induction	By HIV-1 insertion. Ref.5
Sequence similarities	Contains 1 OTU domain.
Sequence caution	The sequence AAI18573.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAI18654.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence ABD72605.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAA82998.2 differs from that shown. Reason: Intron retention. The sequence BAB71229.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAA48313.1 differs from that shown. Reason: Contaminating sequence. Originates from a chimeric transcript in HIV-1-infected cells. The premature stop may be due to intron retention.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q01804-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q01804-2)

The sequence of this isoform differs from the canonical sequence as follows:
     211-1113: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q01804-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.
     211-1113: Missing.

Isoform 3 (identifier: Q01804-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1113	1113	OTU domain-containing protein 4		PRO_0000083979
Regions
	Domain	34 – 155	122	OTU
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine Ref.4
	Modified residue	438	1	Phosphotyrosine By similarity
	Modified residue	442	1	Phosphoserine Ref.13 Ref.14
	Modified residue	459	1	Phosphotyrosine Ref.10
	Modified residue	892	1	Phosphoserine Ref.15 Ref.17
	Modified residue	899	1	Phosphoserine Ref.15
	Modified residue	1005	1	Phosphoserine Ref.12 Ref.13 Ref.14 Ref.17
	Modified residue	1010	1	Phosphoserine By similarity
	Modified residue	1022	1	Phosphoserine Ref.13 Ref.14 Ref.15
	Modified residue	1023	1	Phosphoserine Ref.13 Ref.14 Ref.15
Natural variations
	Alternative sequence	1 – 65	65	Missing in isoform 3 and isoform 4.		VSP_038830
	Alternative sequence	211 – 1113	903	Missing in isoform 2 and isoform 4.		VSP_021671
	Natural variant	194	1	A → G. Ref.6 Corresponds to variant rs36225458 [ dbSNP | Ensembl ].		VAR_029377
	Natural variant	216	1	A → T. Ref.6		VAR_038848
Experimental info
	Sequence conflict	230	1	E → EQ in BAG63836. Ref.1
	Sequence conflict	230	1	E → EQ in EAX05045. Ref.3
	Sequence conflict	230	1	E → EQ in EAX05046. Ref.3
	Sequence conflict	230	1	E → EQ in AAI18573. Ref.7
	Sequence conflict	230	1	E → EQ in AAI18654. Ref.7
	Sequence conflict	808	1	S → P in BAB71229. Ref.1
	Sequence conflict	914	1	A → S in CAB70748. Ref.9

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 10, 2010. Version 3. Checksum: 055C446566550749	FASTA	1,113	123,916
	10 20 30 40 50 60 MEAAVGVPDG GDQGGAGPRE DATPMDAYLR KLGLYRKLVA KDGSCLFRAV AEQVLHSQSR 70 80 90 100 110 120 HVEVRMACIH YLRENREKFE AFIEGSFEEY LKRLENPQEW VGQVEISALS LMYRKDFIIY 130 140 150 160 170 180 REPNVSPSQV TENNFPEKVL LCFSNGNHYD IVYPIKYKES SAMCQSLLYE LLYEKVFKTD 190 200 210 220 230 240 VSKIVMELDT LEVADEDNSE ISDSEDDSCK SKTAAAAADV NGFKPLSGNE LKNNGNSTSL 250 260 270 280 290 300 PLSRKVLKSL NPAVYRNVEY EIWLKSKQAQ QKRDYSIAAG LQYEVGDKCQ VRLDHNGKFL 310 320 330 340 350 360 NADVQGIHSE NGPVLVEELG KKHTSKNLKA PPPESWNTVS GKKMKKPSTS GQNFHSDVDY 370 380 390 400 410 420 RGPKNPSKPI KAPSALPPRL QHPSGVRQHA FSSHSSGSQS QKFSSEHKNL SRTPSQIIRK 430 440 450 460 470 480 PDRERVEDFD HTSRESNYFG LSPEERREKQ AIEESRLLYE IQNRDEQAFP ALSSSSVNQS 490 500 510 520 530 540 ASQSSNPCVQ RKSSHVGDRK GSRRRMDTEE RKDKDSIHGH SQLDKRPEPS TLENITDDKY 550 560 570 580 590 600 ATVSSPSKSK KLECPSPAEQ KPAEHVSLSN PAPLLVSPEV HLTPAVPSLP ATVPAWPSEP 610 620 630 640 650 660 TTFGPTGVPA PIPVLSVTQT LTTGPDSAVS QAHLTPSPVP VSIQAVNQPL MPLPQTLSLY 670 680 690 700 710 720 QDPLYPGFPC NEKGDRAIVP PYSLCQTGED LPKDKNILRF FFNLGVKAYS CPMWAPHSYL 730 740 750 760 770 780 YPLHQAYLAA CRMYPKVPVP VYPHNPWFQE APAAQNESDC TCTDAHFPMQ TEASVNGQMP 790 800 810 820 830 840 QPEIGPPTFS SPLVIPPSQV SESHGQLSYQ ADLESETPGQ LLHADYEESL SGKNMFPQPS 850 860 870 880 890 900 FGPNPFLGPV PIAPPFFPHV WYGYPFQGFI ENPVMRQNIV LPSDEKGELD LSLENLDLSK 910 920 930 940 950 960 DCGSVSTVDE FPEARGEHVH SLPEASVSSK PDEGRTEQSS QTRKADTALA SIPPVAEGKA 970 980 990 1000 1010 1020 HPPTQILNRE RETVPVELEP KRTIQSLKEK TEKVKDPKTA ADVVSPGANS VDSRVQRPKE 1030 1040 1050 1060 1070 1080 ESSEDENEVS NILRSGRSKQ FYNQTYGSRK YKSDWGYSGR GGYQHVRSEE SWKGQPSRSR 1090 1100 1110 DEGYQYHRNV RGRPFRGDRR RSGMGDGHRG QHT
	Isoform 2 [UniParc]. Checksum: AE1B7CAC54E8D072	FASTA	210	23,999
	10 20 30 40 50 60 MEAAVGVPDG GDQGGAGPRE DATPMDAYLR KLGLYRKLVA KDGSCLFRAV AEQVLHSQSR 70 80 90 100 110 120 HVEVRMACIH YLRENREKFE AFIEGSFEEY LKRLENPQEW VGQVEISALS LMYRKDFIIY 130 140 150 160 170 180 REPNVSPSQV TENNFPEKVL LCFSNGNHYD IVYPIKYKES SAMCQSLLYE LLYEKVFKTD 190 200 210 VSKIVMELDT LEVADEDNSE ISDSEDDSCK
	Isoform 4 [UniParc]. Checksum: BEF79BFC3DB34EF1	FASTA	145	17,036
	10 20 30 40 50 60 MACIHYLREN REKFEAFIEG SFEEYLKRLE NPQEWVGQVE ISALSLMYRK DFIIYREPNV 70 80 90 100 110 120 SPSQVTENNF PEKVLLCFSN GNHYDIVYPI KYKESSAMCQ SLLYELLYEK VFKTDVSKIV 130 140 MELDTLEVAD EDNSEISDSE DDSCK
	Isoform 3 [UniParc]. Checksum: 5266BAE77822228E	FASTA	1,048	116,953
	10 20 30 40 50 60 MACIHYLREN REKFEAFIEG SFEEYLKRLE NPQEWVGQVE ISALSLMYRK DFIIYREPNV 70 80 90 100 110 120 SPSQVTENNF PEKVLLCFSN GNHYDIVYPI KYKESSAMCQ SLLYELLYEK VFKTDVSKIV 130 140 150 160 170 180 MELDTLEVAD EDNSEISDSE DDSCKSKTAA AAADVNGFKP LSGNELKNNG NSTSLPLSRK 190 200 210 220 230 240 VLKSLNPAVY RNVEYEIWLK SKQAQQKRDY SIAAGLQYEV GDKCQVRLDH NGKFLNADVQ 250 260 270 280 290 300 GIHSENGPVL VEELGKKHTS KNLKAPPPES WNTVSGKKMK KPSTSGQNFH SDVDYRGPKN 310 320 330 340 350 360 PSKPIKAPSA LPPRLQHPSG VRQHAFSSHS SGSQSQKFSS EHKNLSRTPS QIIRKPDRER 370 380 390 400 410 420 VEDFDHTSRE SNYFGLSPEE RREKQAIEES RLLYEIQNRD EQAFPALSSS SVNQSASQSS 430 440 450 460 470 480 NPCVQRKSSH VGDRKGSRRR MDTEERKDKD SIHGHSQLDK RPEPSTLENI TDDKYATVSS 490 500 510 520 530 540 PSKSKKLECP SPAEQKPAEH VSLSNPAPLL VSPEVHLTPA VPSLPATVPA WPSEPTTFGP 550 560 570 580 590 600 TGVPAPIPVL SVTQTLTTGP DSAVSQAHLT PSPVPVSIQA VNQPLMPLPQ TLSLYQDPLY 610 620 630 640 650 660 PGFPCNEKGD RAIVPPYSLC QTGEDLPKDK NILRFFFNLG VKAYSCPMWA PHSYLYPLHQ 670 680 690 700 710 720 AYLAACRMYP KVPVPVYPHN PWFQEAPAAQ NESDCTCTDA HFPMQTEASV NGQMPQPEIG 730 740 750 760 770 780 PPTFSSPLVI PPSQVSESHG QLSYQADLES ETPGQLLHAD YEESLSGKNM FPQPSFGPNP 790 800 810 820 830 840 FLGPVPIAPP FFPHVWYGYP FQGFIENPVM RQNIVLPSDE KGELDLSLEN LDLSKDCGSV 850 860 870 880 890 900 STVDEFPEAR GEHVHSLPEA SVSSKPDEGR TEQSSQTRKA DTALASIPPV AEGKAHPPTQ 910 920 930 940 950 960 ILNRERETVP VELEPKRTIQ SLKEKTEKVK DPKTAADVVS PGANSVDSRV QRPKEESSED 970 980 990 1000 1010 1020 ENEVSNILRS GRSKQFYNQT YGSRKYKSDW GYSGRGGYQH VRSEESWKGQ PSRSRDEGYQ 1030 1040 YHRNVRGRPF RGDRRRSGMG DGHRGQHT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 284-987 (ISOFORMS 1/3). Tissue: Testis and Tongue.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Bienvenut W.V., Heiserich L., Boulahbel H., Gottlieb E., Matallanas D., Cooper W.N., Kolch W. Submitted (JUL-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 1-19; 49-60; 213-145; 249-265; 413-419; 435-446; 457-464; 700-707; 916-935; 944-969 AND 999-1014, ACETYLATION AT MET-1, MASS SPECTROMETRY. Tissue: Colon carcinoma and Mammary carcinoma.
[5]	"HIV-1 promotor insertion revealed by selective detection of chimeric provirus-host gene transcripts." Raineri I., Senn H.-P. Nucleic Acids Res. 20:6261-6266(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 53-1113 (ISOFORM 2), INDUCTION.
[6]	SeattleSNPs variation discovery resource Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 54-1113, VARIANTS GLY-194 AND THR-216.
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 56-1113 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 604-1113 (ISOFORMS 1/3). Tissue: Brain.
[8]	"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 708-1113. Tissue: Brain.
[9]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 814-1113. Tissue: Testis.
[10]	"Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry." Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C. Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-459, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[11]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[12]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1005, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-442; SER-1005; SER-1022 AND SER-1023, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-442; SER-1005; SER-1022 AND SER-1023, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[15]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-892; SER-899; SER-1022 AND SER-1023, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[16]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[17]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-892 AND SER-1005, MASS SPECTROMETRY.

Web resources

SeattleSNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK056597 mRNA. Translation: BAB71229.1. Different initiation. AK302581 mRNA. Translation: BAG63836.1. AC096757 Genomic DNA. No translation available. CH471056 Genomic DNA. Translation: EAX05045.1. CH471056 Genomic DNA. Translation: EAX05046.1. X68242 mRNA. Translation: CAA48313.1. Sequence problems. DQ427109 Genomic DNA. Translation: ABD72605.1. Sequence problems. BC057242 mRNA. Translation: AAH57242.2. BC118572 mRNA. Translation: AAI18573.1. Different initiation. BC118653 mRNA. Translation: AAI18654.1. Different initiation. AB028969 mRNA. Translation: BAA82998.2. Sequence problems. AL137460 mRNA. Translation: CAB70748.1.
IPI	IPI00009780. IPI00399254. IPI00969056. IPI00969366.
PIR	S30247. T46403.
RefSeq	NP_001096123.1. NM_001102653.1. NP_059963.1. NM_017493.6.
UniGene	Hs.270851.
3D structure databases
ProteinModelPortal	Q01804.
SMR	Q01804. Positions 31-152.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q01804. 25 interactions.
STRING	9606.ENSP00000409279.
PTM databases
PhosphoSite	Q01804.
Polymorphism databases
DMDM	302393819.
Proteomic databases
PaxDb	Q01804.
PRIDE	Q01804.
Protocols and materials databases
DNASU	54726.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000296579; ENSP00000296579; ENSG00000164164. ENST00000454497; ENSP00000409279; ENSG00000164164. ENST00000509620; ENSP00000424192; ENSG00000164164.
GeneID	54726.
KEGG	hsa:54726.
UCSC	uc003ika.4. human. uc021xsl.1. human.
Organism-specific databases
CTD	54726.
GeneCards	GC04M146054.
HGNC	HGNC:24949. OTUD4.
HPA	HPA036623.
MIM	611744. gene.
neXtProt	NX_Q01804.
PharmGKB	PA142671216.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG81083.
HOVERGEN	HBG082091.
InParanoid	Q01804.
KO	K13718.
Gene expression databases
ArrayExpress	Q01804.
Bgee	Q01804.
CleanEx	HS_OTUD4.
Genevestigator	Q01804.
GermOnline	ENSG00000164164. Homo sapiens.
Family and domain databases
InterPro	IPR003323. OTU. [Graphical view]
Pfam	PF02338. OTU. 1 hit. [Graphical view]
PROSITE	PS50802. OTU. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	54726.
NextBio	57297.
SOURCE	Search...

Entry information

Entry name

OTUD4_HUMAN

Accession

Primary (citable) accession number: Q01804
Secondary accession number(s): B4DYS4 , Q147U2, Q1ZYK1, Q6PG39, Q96MQ5, Q9NT94, Q9UPV6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	August 10, 2010
Last modified:	May 1, 2013
This is version 97 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.