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Q01804

- OTUD4_HUMAN

UniProt

Q01804 - OTUD4_HUMAN

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Protein
OTU domain-containing protein 4
Gene
OTUD4, HIN1, KIAA1046
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Deubiquitinating enzyme that specifically hydrolyzes 'Lys-48'-linked polyubiquitin.1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei42 – 421 By similarity
Active sitei45 – 451Nucleophile By similarity
Active sitei148 – 1481 By similarity

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. protein K48-linked deubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
OTU domain-containing protein 4 (EC:3.4.19.12)
Alternative name(s):
HIV-1-induced protein HIN-1
Gene namesi
Name:OTUD4
Synonyms:HIN1, KIAA1046
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:24949. OTUD4.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671216.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11141114OTU domain-containing protein 4
PRO_0000083979Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine3 Publications
Modified residuei439 – 4391Phosphotyrosine By similarity
Modified residuei443 – 4431Phosphoserine2 Publications
Modified residuei460 – 4601Phosphotyrosine1 Publication
Modified residuei893 – 8931Phosphoserine2 Publications
Modified residuei900 – 9001Phosphoserine1 Publication
Modified residuei1006 – 10061Phosphoserine4 Publications
Modified residuei1011 – 10111Phosphoserine By similarity
Modified residuei1023 – 10231Phosphoserine3 Publications
Modified residuei1024 – 10241Phosphoserine3 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ01804.
PaxDbiQ01804.
PRIDEiQ01804.

PTM databases

PhosphoSiteiQ01804.

Expressioni

Inductioni

By HIV-1 insertion.1 Publication

Gene expression databases

ArrayExpressiQ01804.
BgeeiQ01804.
CleanExiHS_OTUD4.
GenevestigatoriQ01804.

Organism-specific databases

HPAiHPA036623.

Interactioni

Protein-protein interaction databases

BioGridi120112. 31 interactions.
IntActiQ01804. 26 interactions.
MINTiMINT-3024530.
STRINGi9606.ENSP00000409279.

Structurei

3D structure databases

ProteinModelPortaliQ01804.
SMRiQ01804. Positions 29-155.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 155122OTU
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni39 – 457Cys-loop By similarity
Regioni94 – 10411Variable-loop By similarity
Add
BLAST
Regioni143 – 1486His-loop By similarity

Sequence similaritiesi

Contains 1 OTU domain.

Phylogenomic databases

eggNOGiNOG81083.
HOVERGENiHBG082091.
InParanoidiQ01804.
KOiK13718.
OrthoDBiEOG7H791H.
PhylomeDBiQ01804.
TreeFamiTF326812.

Family and domain databases

InterProiIPR003323. OTU.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q01804-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEAAVGVPDG GDQGGAGPRE DATPMDAYLR KLGLYRKLVA KDGSCLFRAV     50
AEQVLHSQSR HVEVRMACIH YLRENREKFE AFIEGSFEEY LKRLENPQEW 100
VGQVEISALS LMYRKDFIIY REPNVSPSQV TENNFPEKVL LCFSNGNHYD 150
IVYPIKYKES SAMCQSLLYE LLYEKVFKTD VSKIVMELDT LEVADEDNSE 200
ISDSEDDSCK SKTAAAAADV NGFKPLSGNE QLKNNGNSTS LPLSRKVLKS 250
LNPAVYRNVE YEIWLKSKQA QQKRDYSIAA GLQYEVGDKC QVRLDHNGKF 300
LNADVQGIHS ENGPVLVEEL GKKHTSKNLK APPPESWNTV SGKKMKKPST 350
SGQNFHSDVD YRGPKNPSKP IKAPSALPPR LQHPSGVRQH AFSSHSSGSQ 400
SQKFSSEHKN LSRTPSQIIR KPDRERVEDF DHTSRESNYF GLSPEERREK 450
QAIEESRLLY EIQNRDEQAF PALSSSSVNQ SASQSSNPCV QRKSSHVGDR 500
KGSRRRMDTE ERKDKDSIHG HSQLDKRPEP STLENITDDK YATVSSPSKS 550
KKLECPSPAE QKPAEHVSLS NPAPLLVSPE VHLTPAVPSL PATVPAWPSE 600
PTTFGPTGVP APIPVLSVTQ TLTTGPDSAV SQAHLTPSPV PVSIQAVNQP 650
LMPLPQTLSL YQDPLYPGFP CNEKGDRAIV PPYSLCQTGE DLPKDKNILR 700
FFFNLGVKAY SCPMWAPHSY LYPLHQAYLA ACRMYPKVPV PVYPHNPWFQ 750
EAPAAQNESD CTCTDAHFPM QTEASVNGQM PQPEIGPPTF SSPLVIPPSQ 800
VSESHGQLSY QADLESETPG QLLHADYEES LSGKNMFPQP SFGPNPFLGP 850
VPIAPPFFPH VWYGYPFQGF IENPVMRQNI VLPSDEKGEL DLSLENLDLS 900
KDCGSVSTVD EFPEARGEHV HSLPEASVSS KPDEGRTEQS SQTRKADTAL 950
ASIPPVAEGK AHPPTQILNR ERETVPVELE PKRTIQSLKE KTEKVKDPKT 1000
AADVVSPGAN SVDSRVQRPK EESSEDENEV SNILRSGRSK QFYNQTYGSR 1050
KYKSDWGYSG RGGYQHVRSE ESWKGQPSRS RDEGYQYHRN VRGRPFRGDR 1100
RRSGMGDGHR GQHT 1114

Note: Gene prediction based on similarity to orthologs and partial EST data.

Length:1,114
Mass (Da):124,045
Last modified:March 19, 2014 - v4
Checksum:iAD8DF5FEAB8CBE32
GO
Isoform 2 (identifier: Q01804-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.
     231-231: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.

Show »
Length:1,048
Mass (Da):116,953
Checksum:i5266BAE77822228E
GO
Isoform 3 (identifier: Q01804-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.

Show »
Length:1,049
Mass (Da):117,082
Checksum:i1DCACF002992C917
GO
Isoform 4 (identifier: Q01804-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.
     211-1114: Missing.

Note: Predicted from a chimeric transcript isolated from HIV-1-infected cells. The premature stop may be due to intron retention.

Show »
Length:145
Mass (Da):17,036
Checksum:iBEF79BFC3DB34EF1
GO

Sequence cautioni

The sequence AAH57242.2 differs from that shown. Reason: Sequence of unknown origin in the N-terminal part.
The sequence BAA82998.2 differs from that shown. Reason: Intron retention.
The sequence BAB71229.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti194 – 1941A → G.1 Publication
Corresponds to variant rs36225458 [ dbSNP | Ensembl ].
VAR_029377
Natural varianti216 – 2161A → T.1 Publication
VAR_038848
Natural varianti398 – 3981G → V Could be associated with cerebellar ataxia and hypogonadotropic hypogonadism. 1 Publication
VAR_070050

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6565Missing in isoform 2, isoform 3 and isoform 4.
VSP_038830Add
BLAST
Alternative sequencei211 – 1114904Missing in isoform 4.
VSP_021671Add
BLAST
Alternative sequencei231 – 2311Missing in isoform 2.
VSP_053825

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti809 – 8091S → P in BAB71229. 1 Publication
Sequence conflicti915 – 9151A → S in CAB70748. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK056597 mRNA. Translation: BAB71229.1. Different initiation.
AK302581 mRNA. Translation: BAG63836.1.
AC096757 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05045.1.
CH471056 Genomic DNA. Translation: EAX05046.1.
X68242 mRNA. Translation: CAA48313.1.
DQ427109 Genomic DNA. Translation: ABD72605.1.
BC057242 mRNA. Translation: AAH57242.2. Sequence problems.
BC118572 mRNA. Translation: AAI18573.1.
BC118653 mRNA. Translation: AAI18654.1.
AB028969 mRNA. Translation: BAA82998.2. Sequence problems.
AL137460 mRNA. Translation: CAB70748.1.
CCDSiCCDS3764.1. [Q01804-4]
CCDS47139.1. [Q01804-3]
PIRiS30247.
T46403.
RefSeqiNP_001096123.1. NM_001102653.1. [Q01804-3]
NP_059963.1. NM_017493.6. [Q01804-4]
XP_005263136.1. XM_005263079.2. [Q01804-1]
UniGeneiHs.270851.

Genome annotation databases

EnsembliENST00000296579; ENSP00000296579; ENSG00000164164. [Q01804-4]
ENST00000454497; ENSP00000409279; ENSG00000164164.
ENST00000509620; ENSP00000424192; ENSG00000164164. [Q01804-4]
GeneIDi54726.
KEGGihsa:54726.
UCSCiuc021xsl.1. human. [Q01804-4]

Polymorphism databases

DMDMi302393819.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK056597 mRNA. Translation: BAB71229.1 . Different initiation.
AK302581 mRNA. Translation: BAG63836.1 .
AC096757 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05045.1 .
CH471056 Genomic DNA. Translation: EAX05046.1 .
X68242 mRNA. Translation: CAA48313.1 .
DQ427109 Genomic DNA. Translation: ABD72605.1 .
BC057242 mRNA. Translation: AAH57242.2 . Sequence problems.
BC118572 mRNA. Translation: AAI18573.1 .
BC118653 mRNA. Translation: AAI18654.1 .
AB028969 mRNA. Translation: BAA82998.2 . Sequence problems.
AL137460 mRNA. Translation: CAB70748.1 .
CCDSi CCDS3764.1. [Q01804-4 ]
CCDS47139.1. [Q01804-3 ]
PIRi S30247.
T46403.
RefSeqi NP_001096123.1. NM_001102653.1. [Q01804-3 ]
NP_059963.1. NM_017493.6. [Q01804-4 ]
XP_005263136.1. XM_005263079.2. [Q01804-1 ]
UniGenei Hs.270851.

3D structure databases

ProteinModelPortali Q01804.
SMRi Q01804. Positions 29-155.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120112. 31 interactions.
IntActi Q01804. 26 interactions.
MINTi MINT-3024530.
STRINGi 9606.ENSP00000409279.

PTM databases

PhosphoSitei Q01804.

Polymorphism databases

DMDMi 302393819.

Proteomic databases

MaxQBi Q01804.
PaxDbi Q01804.
PRIDEi Q01804.

Protocols and materials databases

DNASUi 54726.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296579 ; ENSP00000296579 ; ENSG00000164164 . [Q01804-4 ]
ENST00000454497 ; ENSP00000409279 ; ENSG00000164164 .
ENST00000509620 ; ENSP00000424192 ; ENSG00000164164 . [Q01804-4 ]
GeneIDi 54726.
KEGGi hsa:54726.
UCSCi uc021xsl.1. human. [Q01804-4 ]

Organism-specific databases

CTDi 54726.
GeneCardsi GC04M146054.
HGNCi HGNC:24949. OTUD4.
HPAi HPA036623.
MIMi 611744. gene.
neXtProti NX_Q01804.
PharmGKBi PA142671216.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG81083.
HOVERGENi HBG082091.
InParanoidi Q01804.
KOi K13718.
OrthoDBi EOG7H791H.
PhylomeDBi Q01804.
TreeFami TF326812.

Miscellaneous databases

GeneWikii OTUD4.
GenomeRNAii 54726.
NextBioi 57297.
PROi Q01804.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q01804.
Bgeei Q01804.
CleanExi HS_OTUD4.
Genevestigatori Q01804.

Family and domain databases

InterProi IPR003323. OTU.
[Graphical view ]
Pfami PF02338. OTU. 1 hit.
[Graphical view ]
PROSITEi PS50802. OTU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Testis and Tongue.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "HIV-1 promotor insertion revealed by selective detection of chimeric provirus-host gene transcripts."
    Raineri I., Senn H.-P.
    Nucleic Acids Res. 20:6261-6266(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), INDUCTION.
  5. SeattleSNPs variation discovery resource
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 2), VARIANTS GLY-194 AND THR-216.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  7. Cited for: PROTEIN SEQUENCE OF 1-19; 49-60; 250-266; 414-420; 436-447; 458-465; 701-708; 917-936; 945-970 AND 1000-1015, ACETYLATION AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Colon carcinoma and Mammary carcinoma.
  8. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 709-1114 (ISOFORMS 1/2/3).
    Tissue: Brain.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 815-1114 (ISOFORMS 1/2/3).
    Tissue: Testis.
  10. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
    Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
    Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-460, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1006, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-443; SER-1006; SER-1023 AND SER-1024, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-443; SER-1006; SER-1023 AND SER-1024, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-893; SER-900; SER-1023 AND SER-1024, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-893 AND SER-1006, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  20. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  21. "OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis."
    Mevissen T.E., Hospenthal M.K., Geurink P.P., Elliott P.R., Akutsu M., Arnaudo N., Ekkebus R., Kulathu Y., Wauer T., El Oualid F., Freund S.M., Ovaa H., Komander D.
    Cell 154:169-184(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY.
  22. Cited for: VARIANT VAL-398.

Entry informationi

Entry nameiOTUD4_HUMAN
AccessioniPrimary (citable) accession number: Q01804
Secondary accession number(s): B4DYS4
, Q147U2, Q1ZYK1, Q6PG39, Q96MQ5, Q9NT94, Q9UPV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: March 19, 2014
Last modified: September 3, 2014
This is version 110 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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