Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Aspartate aminotransferase, mitochondrial

Gene

AAT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol (By similarity).By similarity

Miscellaneous

In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.
Present with 2910 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.1 Publication

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei52Aspartate; via amide nitrogenBy similarity1
Binding sitei155AspartateBy similarity1
Binding sitei216AspartateBy similarity1
Binding sitei423AspartateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • 2-oxoglutarate metabolic process Source: UniProtKB
  • aspartate catabolic process Source: GO_Central
  • aspartate metabolic process Source: UniProtKB
  • biosynthetic process Source: InterPro
  • chronological cell aging Source: SGD
  • glutamate metabolic process Source: UniProtKB
  • replicative cell aging Source: SGD

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciYEAST:YKL106W-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate aminotransferase, mitochondrial (EC:2.6.1.1)
Alternative name(s):
Transaminase A
Gene namesi
Name:AAT1
Ordered Locus Names:YKL106W
ORF Names:YKL461
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL106W
SGDiS000001589 AAT1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000001213? – 451Aspartate aminotransferase, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei286N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

MaxQBiQ01802
PaxDbiQ01802
PRIDEiQ01802

PTM databases

iPTMnetiQ01802

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi34028, 116 interactors
DIPiDIP-4608N
IntActiQ01802, 4 interactors
STRINGi4932.YKL106W

Structurei

3D structure databases

ProteinModelPortaliQ01802
SMRiQ01802
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000185898
InParanoidiQ01802
KOiK14455
OMAiRVGACTI
OrthoDBiEOG092C2B7X

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR000796 Asp_trans
IPR004838 NHTrfase_class1_PyrdxlP-BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11879 PTHR11879, 1 hit
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
PRINTSiPR00799 TRANSAMINASE
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00105 AA_TRANSFER_CLASS_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01802-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRTRLTNCS LWRPYYTSSL SRVPRAPPDK VLGLSEHFKK VKNVNKIDLT
60 70 80 90 100
VGIYKDGWGK VTTFPSVAKA QKLIESHLEL NKNLSYLPIT GSKEFQENVM
110 120 130 140 150
KFLFKESCPQ FGPFYLAHDR ISFVQTLSGT GALAVAAKFL ALFISRDIWI
160 170 180 190 200
PDPSWANHKN IFQNNGFENI YRYSYYKDGQ IDIDGWIEQL KTFAYNNQQE
210 220 230 240 250
NNKNPPCIIL HACCHNPTGL DPTKEQWEKI IDTIYELKMV PIVDMAYQGL
260 270 280 290 300
ESGNLLKDAY LLRLCLNVNK YPNWSNGIFL CQSFAKNMGL YGERVGSLSV
310 320 330 340 350
ITPATANNGK FNPLQQKNSL QQNIDSQLKK IVRGMYSSPP GYGSRVVNVV
360 370 380 390 400
LSDFKLKQQW FKDVDFMVQR LHHVRQEMFD RLGWPDLVNF AQQHGMFYYT
410 420 430 440 450
RFSPKQVEIL RNNYFVYLTG DGRLSLSGVN DSNVDYLCES LEAVSKMDKL

A
Length:451
Mass (Da):51,795
Last modified:December 6, 2005 - v2
Checksum:i758A90434CDBAA7A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41V → A in CAA48188 (PubMed:1482685).Curated1
Sequence conflicti414Y → S in CAA48188 (PubMed:1482685).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68052 Genomic DNA Translation: CAA48188.1
X71133 Genomic DNA Translation: CAA50451.1
Z28106 Genomic DNA Translation: CAA81946.1
BK006944 Genomic DNA Translation: DAA09052.1
PIRiS37933
RefSeqiNP_012816.1, NM_001179672.1

Genome annotation databases

EnsemblFungiiYKL106W; YKL106W; YKL106W
GeneIDi853755
KEGGisce:YKL106W

Similar proteinsi

Entry informationi

Entry nameiAATM_YEAST
AccessioniPrimary (citable) accession number: Q01802
Secondary accession number(s): D6VXI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: December 6, 2005
Last modified: April 25, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health