Q01790 (HUNB_SCICO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein hunchback

Gene names

Name:

hb

Organism

Sciara coprophila (Fungus gnat)

Taxonomic identifier

38358 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Bibionomorpha › Sciaroidea › Sciaridae › Bradysia

Protein attributes

Sequence length	50 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Gap class segmentation protein that controls development of head structures.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the hunchback C2H2-type zinc-finger protein family. Contains 3 C2H2-type zinc fingers.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Developmental protein Gap protein
Gene Ontology (GO)
Biological_process	segmentation Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›50	›50	Protein hunchback		PRO_0000046981
Regions
	Zinc finger	‹1 – 5	›5	C2H2-type 1
	Zinc finger	11 – 33	23	C2H2-type 2
	Zinc finger	39 – ›50	›12	C2H2-type 3
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	50	1

Sequences

	Sequence		Length	Mass (Da)
	Q01790 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: 83741B3F5456C017	FASTA	50	5,881
	10 20 30 40 50 HILKHNGSKP IRCPECNYTC VNRSMLTSHM KSHSNTYPYR CLDCNYATKY

References

[1]	"Evolutionary conservation pattern of zinc-finger domains of Drosophila segmentation genes." Sommer R.J., Retzlaff M., Goerlich K., Sander K., Tautz D. Proc. Natl. Acad. Sci. U.S.A. 89:10782-10786(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	L01612 Genomic DNA. Translation: AAA29815.1.
3D structure databases
ProteinModelPortal	Q01790.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.30.160.60. 1 hit.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
SMART	SM00355. ZnF_C2H2. 1 hit. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 1 hit. PS50157. ZINC_FINGER_C2H2_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HUNB_SCICO

Accession

Primary (citable) accession number: Q01790

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	April 3, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)