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Protein

Gonadotropin-releasing hormone receptor

Gene

Gnrhr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375281 Hormone ligand-binding receptors
R-MMU-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Gonadotropin-releasing hormone receptor
Short name:
GnRH receptor
Short name:
GnRH-R
Gene namesi
Name:Gnrhr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:95790 Gnrhr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 58Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini59 – 77CytoplasmicSequence analysisAdd BLAST19
Transmembranei78 – 97Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini98 – 115ExtracellularSequence analysisAdd BLAST18
Transmembranei116 – 137Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini138 – 164CytoplasmicSequence analysisAdd BLAST27
Transmembranei165 – 184Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini185 – 211ExtracellularSequence analysisAdd BLAST27
Transmembranei212 – 231Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini232 – 280CytoplasmicSequence analysisAdd BLAST49
Transmembranei281 – 299Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini300 – 305ExtracellularSequence analysis6
Transmembranei306 – 325Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini326 – 327CytoplasmicSequence analysis2

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3232679
GuidetoPHARMACOLOGYi256

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694891 – 327Gonadotropin-releasing hormone receptorAdd BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi18N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi114 ↔ 195PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ01776
PRIDEiQ01776

PTM databases

iPTMnetiQ01776
PhosphoSitePlusiQ01776

Expressioni

Tissue specificityi

Pituitary gland.

Gene expression databases

BgeeiENSMUSG00000029255
CleanExiMM_GNRHR
ExpressionAtlasiQ01776 baseline and differential
GenevisibleiQ01776 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031172

Chemistry databases

BindingDBiQ01776

Structurei

3D structure databases

ProteinModelPortaliQ01776
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119156
HOGENOMiHOG000251590
HOVERGENiHBG009082
InParanoidiQ01776
KOiK04280
OMAiKGYFQCV
OrthoDBiEOG091G0ZDG
PhylomeDBiQ01776
TreeFamiTF106499

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001658 GphnRH_fam_rcpt
IPR027982 GphnRH_rcpt
PANTHERiPTHR24241:SF22 PTHR24241:SF22, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00529 GNADOTRPHINR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q01776-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANNASLEQD PNHCSAINNS IPLIQGKLPT LTVSGKIRVT VTFFLFLLST
60 70 80 90 100
AFNASFLLKL QKWTQKRKKG KKLSRMKVLL KHLTLANLLE TLIVMPLDGM
110 120 130 140 150
WNITVQWYAG EFLCKVLSYL KLFSMYAPAF MMVVISLDRS LAITQPLAVQ
160 170 180 190 200
SNSKLEQSMI SLAWILSIVF AGPQLYIFRM IYLADGSGPT VFSQCVTHCS
210 220 230 240 250
FPQWWHQAFY NFFTFGCLFI IPLLIMLICN AKIIFALTRV LHQDPRKLQL
260 270 280 290 300
NQSKNNIPRA RLRTLKMTVA FATSFVVCWT PYYVLGIWYW FDPEMLNRVS
310 320
EPVNHFFFLF AFLNPCFDPL IYGYFSL
Length:327
Mass (Da):37,684
Last modified:July 1, 1993 - v1
Checksum:iFDDC7B985306FC9F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti76M → I in AAA37716 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01119 mRNA Translation: AAB59636.1
M93108 mRNA No translation available.
L33789, L33778, L33788 Genomic DNA Translation: AAA37716.1
CCDSiCCDS19379.1
PIRiA44013
RefSeqiNP_034453.1, NM_010323.2
UniGeneiMm.26791

Genome annotation databases

EnsembliENSMUST00000031172; ENSMUSP00000031172; ENSMUSG00000029255
GeneIDi14715
KEGGimmu:14715
UCSCiuc008xxl.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGNRHR_MOUSE
AccessioniPrimary (citable) accession number: Q01776
Secondary accession number(s): Q61611
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: March 28, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health