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Protein

Gonadotropin-releasing hormone receptor

Gene

Gnrhr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375281. Hormone ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Gonadotropin-releasing hormone receptor
Short name:
GnRH receptor
Short name:
GnRH-R
Gene namesi
Name:Gnrhr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:95790. Gnrhr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 58Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini59 – 77CytoplasmicSequence analysisAdd BLAST19
Transmembranei78 – 97Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini98 – 115ExtracellularSequence analysisAdd BLAST18
Transmembranei116 – 137Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini138 – 164CytoplasmicSequence analysisAdd BLAST27
Transmembranei165 – 184Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini185 – 211ExtracellularSequence analysisAdd BLAST27
Transmembranei212 – 231Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini232 – 280CytoplasmicSequence analysisAdd BLAST49
Transmembranei281 – 299Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini300 – 305ExtracellularSequence analysis6
Transmembranei306 – 325Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini326 – 327CytoplasmicSequence analysis2

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3232679.
GuidetoPHARMACOLOGYi256.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694891 – 327Gonadotropin-releasing hormone receptorAdd BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Glycosylationi18N-linked (GlcNAc...)Sequence analysis1
Glycosylationi102N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi114 ↔ 195PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ01776.
PRIDEiQ01776.

Expressioni

Tissue specificityi

Pituitary gland.

Gene expression databases

BgeeiENSMUSG00000029255.
CleanExiMM_GNRHR.
ExpressionAtlasiQ01776. baseline and differential.
GenevisibleiQ01776. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031172.

Chemistry databases

BindingDBiQ01776.

Structurei

3D structure databases

ProteinModelPortaliQ01776.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000251590.
HOVERGENiHBG009082.
InParanoidiQ01776.
KOiK04280.
OMAiVAWIMAG.
OrthoDBiEOG091G0ZDG.
PhylomeDBiQ01776.
TreeFamiTF106499.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001658. GphnRH_fam_rcpt.
IPR027982. GphnRH_rcpt.
[Graphical view]
PANTHERiPTHR24241:SF22. PTHR24241:SF22. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00529. GNADOTRPHINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01776-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANNASLEQD PNHCSAINNS IPLIQGKLPT LTVSGKIRVT VTFFLFLLST
60 70 80 90 100
AFNASFLLKL QKWTQKRKKG KKLSRMKVLL KHLTLANLLE TLIVMPLDGM
110 120 130 140 150
WNITVQWYAG EFLCKVLSYL KLFSMYAPAF MMVVISLDRS LAITQPLAVQ
160 170 180 190 200
SNSKLEQSMI SLAWILSIVF AGPQLYIFRM IYLADGSGPT VFSQCVTHCS
210 220 230 240 250
FPQWWHQAFY NFFTFGCLFI IPLLIMLICN AKIIFALTRV LHQDPRKLQL
260 270 280 290 300
NQSKNNIPRA RLRTLKMTVA FATSFVVCWT PYYVLGIWYW FDPEMLNRVS
310 320
EPVNHFFFLF AFLNPCFDPL IYGYFSL
Length:327
Mass (Da):37,684
Last modified:July 1, 1993 - v1
Checksum:iFDDC7B985306FC9F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti76M → I in AAA37716 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01119 mRNA. Translation: AAB59636.1.
M93108 mRNA. No translation available.
L33789, L33778, L33788 Genomic DNA. Translation: AAA37716.1.
CCDSiCCDS19379.1.
PIRiA44013.
RefSeqiNP_034453.1. NM_010323.2.
UniGeneiMm.26791.

Genome annotation databases

EnsembliENSMUST00000031172; ENSMUSP00000031172; ENSMUSG00000029255.
GeneIDi14715.
KEGGimmu:14715.
UCSCiuc008xxl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01119 mRNA. Translation: AAB59636.1.
M93108 mRNA. No translation available.
L33789, L33778, L33788 Genomic DNA. Translation: AAA37716.1.
CCDSiCCDS19379.1.
PIRiA44013.
RefSeqiNP_034453.1. NM_010323.2.
UniGeneiMm.26791.

3D structure databases

ProteinModelPortaliQ01776.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031172.

Chemistry databases

BindingDBiQ01776.
ChEMBLiCHEMBL3232679.
GuidetoPHARMACOLOGYi256.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ01776.
PRIDEiQ01776.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031172; ENSMUSP00000031172; ENSMUSG00000029255.
GeneIDi14715.
KEGGimmu:14715.
UCSCiuc008xxl.1. mouse.

Organism-specific databases

CTDi2798.
MGIiMGI:95790. Gnrhr.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000251590.
HOVERGENiHBG009082.
InParanoidiQ01776.
KOiK04280.
OMAiVAWIMAG.
OrthoDBiEOG091G0ZDG.
PhylomeDBiQ01776.
TreeFamiTF106499.

Enzyme and pathway databases

ReactomeiR-MMU-375281. Hormone ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiQ01776.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029255.
CleanExiMM_GNRHR.
ExpressionAtlasiQ01776. baseline and differential.
GenevisibleiQ01776. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001658. GphnRH_fam_rcpt.
IPR027982. GphnRH_rcpt.
[Graphical view]
PANTHERiPTHR24241:SF22. PTHR24241:SF22. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00529. GNADOTRPHINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGNRHR_MOUSE
AccessioniPrimary (citable) accession number: Q01776
Secondary accession number(s): Q61611
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 2, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.