Q01754 (VP6_ROTGI) Reviewed, UniProtKB/Swiss-Prot
Last modified October 16, 2013. Version 38. History...
Names and origin
|Protein names||Recommended name:|
Intermediate capsid protein VP6
|Organism||Rotavirus B (isolate Rat/United States/IDIR/1984) (RV-B) (Rotavirus B (isolate infectious diarrhea of infant rats))|
|Taxonomic identifier||28877 [NCBI]|
|Taxonomic lineage||Viruses › dsRNA viruses › Reoviridae › Sedoreovirinae › Rotavirus ›|
|Virus host||Homo sapiens (Human) [TaxID: 9606]|
Rattus norvegicus (Rat) [TaxID: 10116]
|Sequence length||391 AA.|
|Protein existence||Evidence at transcript level|
General annotation (Comments)
Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP By similarity.
Homotrimer By similarity. Interacts with VP2 By similarity.
Virion By similarity. Note: Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging Potential.
Belongs to the rotavirus VP6 family.
Sequence annotation (Features)
|||"Molecular cloning, sequence analysis, in vitro expression, and immunoprecipitation of the major inner capsid protein of the IDIR strain of group B rotavirus (GBR)."|
Eiden J.J., Nataro J., Vonderfecht S., Petric M.
Virology 188:580-589(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
|M84456 mRNA. Translation: AAA47348.1.|
|PIR||VPXRIB. A42540. |
3D structure databases
Protocols and materials databases
Family and domain databases
|InterPro||IPR020245. Rotavirus_B_VP6. |
|ProDom||PD042229. Rotavirus_B_VP6. 1 hit. |
[Graphical view] [Entries sharing at least one domain]
|Accession||Primary (citable) accession number: Q01754|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Viral Protein Annotation Program|
Index of protein domains and families