Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q01754

- VP6_ROTGI

UniProt

Q01754 - VP6_ROTGI

Protein

Intermediate capsid protein VP6

Gene
N/A
Organism
Rotavirus B (isolate Rat/United States/IDIR/1984) (RV-B) (Rotavirus B (isolate infectious diarrhea of infant rats))
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP By similarity.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Intermediate capsid protein VP6
    OrganismiRotavirus B (isolate Rat/United States/IDIR/1984) (RV-B) (Rotavirus B (isolate infectious diarrhea of infant rats))
    Taxonomic identifieri28877 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    Rattus norvegicus (Rat) [TaxID: 10116]

    Subcellular locationi

    Virion By similarity
    Note: Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging Potential.Curated

    GO - Cellular componenti

    1. viral intermediate capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Intermediate capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 391391Intermediate capsid protein VP6PRO_0000149567Add
    BLAST

    Interactioni

    Subunit structurei

    Homotrimer. Interacts with VP2.By similarity

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi259 – 2624Poly-Asp

    Sequence similaritiesi

    Belongs to the rotavirus VP6 family.Curated

    Family and domain databases

    InterProiIPR020245. Rotavirus_B_VP6.
    [Graphical view]
    ProDomiPD042229. Rotavirus_B_VP6. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Q01754-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLIETVNAC VGLQKRVLKL APNTNLNTAG QSVLNDYNAL ASRVNGRTYA    50
    LLDQTAVYTP YTVNAPIISL AVRISTDDYD DMRSGIDSIL DILAAAIRTE 100
    GSRPTRVIER RVIEPNVKQL VEDLKLKSLT SEISIANMAA VDTALIQPEI 150
    IETENPLFAD IIEQVIHRPN ASMTGGNIRA TLGRWSGNKG IVTCMSGMDS 200
    EHRFTVDFKT RTCGIINVVY APTAGVIMIP MPTGRNREGH LIDVSAEMMA 250
    ENFAIDFMDD DDIIQTETGV GVFSFPMCNR IRFRINPWDM QKHNDNLWTV 300
    NLANWPQGTS PRQPAISFLF ETRRTFTEGD YQHLSRCAPK VQYMMDTIFP 350
    ETAFTNRPVV DWNVQSLLTS SSQKTWCQKI AMLIAAYAAK I 391
    Length:391
    Mass (Da):43,646
    Last modified:April 1, 1993 - v1
    Checksum:iC50C75F115F4BCD3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M84456 mRNA. Translation: AAA47348.1.
    PIRiA42540. VPXRIB.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M84456 mRNA. Translation: AAA47348.1 .
    PIRi A42540. VPXRIB.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR020245. Rotavirus_B_VP6.
    [Graphical view ]
    ProDomi PD042229. Rotavirus_B_VP6. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, sequence analysis, in vitro expression, and immunoprecipitation of the major inner capsid protein of the IDIR strain of group B rotavirus (GBR)."
      Eiden J.J., Nataro J., Vonderfecht S., Petric M.
      Virology 188:580-589(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiVP6_ROTGI
    AccessioniPrimary (citable) accession number: Q01754
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3