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Protein

Intermediate capsid protein VP6

Gene
N/A
Organism
Rotavirus B (isolate Rat/United States/IDIR/1984) (RV-B) (Rotavirus B (isolate infectious diarrhea of infant rats))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Intermediate capsid protein VP6
OrganismiRotavirus B (isolate Rat/United States/IDIR/1984) (RV-B) (Rotavirus B (isolate infectious diarrhea of infant rats))
Taxonomic identifieri28877 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Rattus norvegicus (Rat) [TaxID: 10116]

Subcellular locationi

Virion By similarity
Note: Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging (Potential).Curated

GO - Cellular componenti

  1. viral intermediate capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Intermediate capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391Intermediate capsid protein VP6PRO_0000149567Add
BLAST

Interactioni

Subunit structurei

Homotrimer. Interacts with VP2.By similarity

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi259 – 2624Poly-Asp

Sequence similaritiesi

Belongs to the rotavirus VP6 family.Curated

Family and domain databases

InterProiIPR020245. Rotavirus_B_VP6.
[Graphical view]
ProDomiPD042229. Rotavirus_B_VP6. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q01754-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLIETVNAC VGLQKRVLKL APNTNLNTAG QSVLNDYNAL ASRVNGRTYA
60 70 80 90 100
LLDQTAVYTP YTVNAPIISL AVRISTDDYD DMRSGIDSIL DILAAAIRTE
110 120 130 140 150
GSRPTRVIER RVIEPNVKQL VEDLKLKSLT SEISIANMAA VDTALIQPEI
160 170 180 190 200
IETENPLFAD IIEQVIHRPN ASMTGGNIRA TLGRWSGNKG IVTCMSGMDS
210 220 230 240 250
EHRFTVDFKT RTCGIINVVY APTAGVIMIP MPTGRNREGH LIDVSAEMMA
260 270 280 290 300
ENFAIDFMDD DDIIQTETGV GVFSFPMCNR IRFRINPWDM QKHNDNLWTV
310 320 330 340 350
NLANWPQGTS PRQPAISFLF ETRRTFTEGD YQHLSRCAPK VQYMMDTIFP
360 370 380 390
ETAFTNRPVV DWNVQSLLTS SSQKTWCQKI AMLIAAYAAK I
Length:391
Mass (Da):43,646
Last modified:April 1, 1993 - v1
Checksum:iC50C75F115F4BCD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84456 mRNA. Translation: AAA47348.1.
PIRiA42540. VPXRIB.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84456 mRNA. Translation: AAA47348.1.
PIRiA42540. VPXRIB.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR020245. Rotavirus_B_VP6.
[Graphical view]
ProDomiPD042229. Rotavirus_B_VP6. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning, sequence analysis, in vitro expression, and immunoprecipitation of the major inner capsid protein of the IDIR strain of group B rotavirus (GBR)."
    Eiden J.J., Nataro J., Vonderfecht S., Petric M.
    Virology 188:580-589(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiVP6_ROTGI
AccessioniPrimary (citable) accession number: Q01754
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 1, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.