Q01752 (AAD_PHACH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Aryl-alcohol dehydrogenase [NADP+] Short name=AAD EC=1.1.1.91
Organism	Phanerochaete chrysosporium (White-rot fungus) (Sporotrichum pruinosum)
Taxonomic identifier	5306 [NCBI]
Taxonomic lineage	Eukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Homobasidiomycetes › Corticiales › Corticiaceae › Phanerochaete

Protein attributes

Sequence length	385 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	An aromatic alcohol + NADP+ = an aromatic aldehyde + NADPH.
Post-translational modification	The N-terminus is blocked.
Sequence similarities	Belongs to the aldo/keto reductase 2 family.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	aromatic compound catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aryl-alcohol dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 385	385	Aryl-alcohol dehydrogenase [NADP+]		PRO_0000070364
Regions
	Nucleotide binding	238 – 248	11	NADP By similarity
Sites
	Active site	76	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q01752 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 7D5D6E00690B9A20	FASTA	385	43,563
	10 20 30 40 50 60 MNIWAPAPEP PTKLGRHRQL APGCGLHVSP IQLGAMSIGD KWHPYGMGTM DKEASFKLLD 70 80 90 100 110 120 AFYNAGGNFI DTANVYQDET SEEFIGEWME ARGNRDQMVV ATKYSLVYKR GASFEEIPQK 130 140 150 160 170 180 TQYVGNSLKS MHISVHDSLR KLRTSYIDIF YVHFWDYTCT IEEVMNGLHN LVAQGKVLYL 190 200 210 220 230 240 GVSDTPAWVV SKANNYARMA GKTPFVIYEG EWNITMRDME RDIIPMCIHE GMAIAPWNVL 250 260 270 280 290 300 CAGKIRTDAE EERRLKSGEG GRTLLQFDGW LRNETERKVS KALEKVAEEI GAKSITSVAI 310 320 330 340 350 360 AYLMQKFPYV FPIVGGRKVE HLYANLEALD ISLSPEQMQF LNDTVPFNKG FPYLLFGDGS 370 380 DYNIVHKAAG HYDKWPAQQA IRPQK

References

[1]

"Aryl-alcohol dehydrogenase from the white-rot fungus Phanerochaete chrysosporium. Gene cloning, sequence analysis, expression, and purification of the recombinant enzyme." Reiser J., Muheim A., Hardegger M., Frank G., Fiechter A. J. Biol. Chem. 269:28152-28159(1994) [PubMed: 7961751] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE. Strain: ATCC 24725 / DSM 6909 / CBS 481.73 / BCRC 36200 / NRRL 6361 / VKM F-1767.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L08964 mRNA. Translation: AAA61931.1.
PIR	A55449.
3D structure databases
ProteinModelPortal	Q01752.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
PhylomeDB	Q01752.
Family and domain databases
InterPro	IPR001395. Aldo/ket_red. IPR023210. NADP_OxRdtase_dom. [Graphical view]
Gene3D	G3DSA:3.20.20.100. Aldo/ket_red. 1 hit.
PANTHER	PTHR11732. Aldo/ket_red. 1 hit.
Pfam	PF00248. Aldo_ket_red. 1 hit. [Graphical view]
SUPFAM	SSF51430. Aldo/ket_red. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AAD_PHACH

Accession

Primary (citable) accession number: Q01752

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	September 21, 2011
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program