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Protein

Cytochrome P450 1A2

Gene

CYP1A2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A2 (EC:1.14.14.1)
Alternative name(s):
CYPIA2
Gene namesi
Name:CYP1A2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000051657‹1 – 258Cytochrome P450 1A2Add BLAST›258

Proteomic databases

PRIDEiQ01741

Expressioni

Inductioni

By 3-methylcholanthrene (3MC) and estradiol-17-beta.

Structurei

3D structure databases

ProteinModelPortaliQ01741
SMRiQ01741
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG106944
InParanoidiQ01741
PhylomeDBiQ01741

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
SUPFAMiSSF48264 SSF48264, 1 hit

Sequencei

Sequence statusi: Fragment.

Q01741-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
KFLQIAVEEH YQSFDKNNIR DVTDSLWRSK KTKPRGAADP NEKIINLVND
60 70 80 90 100
IFGAGFDTVT TALSWSLMYL VTQPHSQKKI QESELDTAIG RERRSWLSER
110 120 130 140 150
SMLPYKEAFI LETVPTWQFV PFTIPHSTTR DTTLNGFHIP KECCVFVNQW
160 170 180 190 200
QVNHEAELWE DPFVFRTERF LTDDSTAIDK TLSEKVMGKQ VGLAWKSALG
210 220 230 240 250
TRQWEVSFYL STLTPNWSSA PGGESKKDRV RPIYGLSMKH KRCEHFQVKK

RFSMKSSN
Length:258
Mass (Da):29,914
Last modified:February 1, 1994 - v1
Checksum:iD20F5EAC4DEE52DB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64537 mRNA Translation: AAA62735.1
PIRiJT0575
UniGeneiGga.48615
Gga.61

Similar proteinsi

Entry informationi

Entry nameiCP1A2_CHICK
AccessioniPrimary (citable) accession number: Q01741
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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