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Protein

Cytochrome P450 1A2

Gene

CYP1A2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A2 (EC:1.14.14.1)
Alternative name(s):
CYPIA2
Gene namesi
Name:CYP1A2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 258›258Cytochrome P450 1A2PRO_0000051657Add
BLAST

Proteomic databases

PRIDEiQ01741.

Expressioni

Inductioni

By 3-methylcholanthrene (3MC) and estradiol-17-beta.

Structurei

3D structure databases

ProteinModelPortaliQ01741.
SMRiQ01741. Positions 2-253.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG106944.
InParanoidiQ01741.
PhylomeDBiQ01741.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
SUPFAMiSSF48264. SSF48264. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q01741-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
KFLQIAVEEH YQSFDKNNIR DVTDSLWRSK KTKPRGAADP NEKIINLVND
60 70 80 90 100
IFGAGFDTVT TALSWSLMYL VTQPHSQKKI QESELDTAIG RERRSWLSER
110 120 130 140 150
SMLPYKEAFI LETVPTWQFV PFTIPHSTTR DTTLNGFHIP KECCVFVNQW
160 170 180 190 200
QVNHEAELWE DPFVFRTERF LTDDSTAIDK TLSEKVMGKQ VGLAWKSALG
210 220 230 240 250
TRQWEVSFYL STLTPNWSSA PGGESKKDRV RPIYGLSMKH KRCEHFQVKK

RFSMKSSN
Length:258
Mass (Da):29,914
Last modified:January 31, 1994 - v1
Checksum:iD20F5EAC4DEE52DB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64537 mRNA. Translation: AAA62735.1.
PIRiJT0575.
UniGeneiGga.61.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64537 mRNA. Translation: AAA62735.1.
PIRiJT0575.
UniGeneiGga.61.

3D structure databases

ProteinModelPortaliQ01741.
SMRiQ01741. Positions 2-253.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ01741.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG106944.
InParanoidiQ01741.
PhylomeDBiQ01741.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
SUPFAMiSSF48264. SSF48264. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Estradiol-17 beta induces polyaromatic hydrocarbon-inducible cytochrome P-450 in chicken liver."
    Murti J.R., Adiga P.R., Padmanaban G.
    Biochem. Biophys. Res. Commun. 175:928-935(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP1A2_CHICK
AccessioniPrimary (citable) accession number: Q01741
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 1994
Last sequence update: January 31, 1994
Last modified: February 3, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.