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Q01741 (CP1A2_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 1A2

EC=1.14.14.1
Alternative name(s):
CYPIA2
Gene names
Name:CYP1A2
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length258 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

By 3-methylcholanthrene (3MC) and estradiol-17-beta.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 258›258Cytochrome P450 1A2
PRO_0000051657

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
Q01741 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: D20F5EAC4DEE52DB

FASTA25829,914
        10         20         30         40         50         60 
KFLQIAVEEH YQSFDKNNIR DVTDSLWRSK KTKPRGAADP NEKIINLVND IFGAGFDTVT 

        70         80         90        100        110        120 
TALSWSLMYL VTQPHSQKKI QESELDTAIG RERRSWLSER SMLPYKEAFI LETVPTWQFV 

       130        140        150        160        170        180 
PFTIPHSTTR DTTLNGFHIP KECCVFVNQW QVNHEAELWE DPFVFRTERF LTDDSTAIDK 

       190        200        210        220        230        240 
TLSEKVMGKQ VGLAWKSALG TRQWEVSFYL STLTPNWSSA PGGESKKDRV RPIYGLSMKH 

       250 
KRCEHFQVKK RFSMKSSN 

« Hide

References

[1]"Estradiol-17 beta induces polyaromatic hydrocarbon-inducible cytochrome P-450 in chicken liver."
Murti J.R., Adiga P.R., Padmanaban G.
Biochem. Biophys. Res. Commun. 175:928-935(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M64537 mRNA. Translation: AAA62735.1.
PIRJT0575.
UniGeneGga.61.

3D structure databases

ProteinModelPortalQ01741.
SMRQ01741. Positions 2-253.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ01741.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG106944.
PhylomeDBQ01741.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
SUPFAMSSF48264. SSF48264. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCP1A2_CHICK
AccessionPrimary (citable) accession number: Q01741
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families