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Q01741

- CP1A2_CHICK

UniProt

Q01741 - CP1A2_CHICK

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Protein

Cytochrome P450 1A2

Gene
CYP1A2
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A2 (EC:1.14.14.1)
Alternative name(s):
CYPIA2
Gene namesi
Name:CYP1A2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 258›258Cytochrome P450 1A2PRO_0000051657Add
BLAST

Proteomic databases

PRIDEiQ01741.

Expressioni

Inductioni

By 3-methylcholanthrene (3MC) and estradiol-17-beta.

Structurei

3D structure databases

ProteinModelPortaliQ01741.
SMRiQ01741. Positions 2-253.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

HOVERGENiHBG106944.
PhylomeDBiQ01741.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
SUPFAMiSSF48264. SSF48264. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q01741-1 [UniParc]FASTAAdd to Basket

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KFLQIAVEEH YQSFDKNNIR DVTDSLWRSK KTKPRGAADP NEKIINLVND    50
IFGAGFDTVT TALSWSLMYL VTQPHSQKKI QESELDTAIG RERRSWLSER 100
SMLPYKEAFI LETVPTWQFV PFTIPHSTTR DTTLNGFHIP KECCVFVNQW 150
QVNHEAELWE DPFVFRTERF LTDDSTAIDK TLSEKVMGKQ VGLAWKSALG 200
TRQWEVSFYL STLTPNWSSA PGGESKKDRV RPIYGLSMKH KRCEHFQVKK 250
RFSMKSSN 258
Length:258
Mass (Da):29,914
Last modified:February 1, 1994 - v1
Checksum:iD20F5EAC4DEE52DB
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64537 mRNA. Translation: AAA62735.1.
PIRiJT0575.
UniGeneiGga.61.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64537 mRNA. Translation: AAA62735.1 .
PIRi JT0575.
UniGenei Gga.61.

3D structure databases

ProteinModelPortali Q01741.
SMRi Q01741. Positions 2-253.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q01741.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG106944.
PhylomeDBi Q01741.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
SUPFAMi SSF48264. SSF48264. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Estradiol-17 beta induces polyaromatic hydrocarbon-inducible cytochrome P-450 in chicken liver."
    Murti J.R., Adiga P.R., Padmanaban G.
    Biochem. Biophys. Res. Commun. 175:928-935(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP1A2_CHICK
AccessioniPrimary (citable) accession number: Q01741
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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