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Q01741

- CP1A2_CHICK

UniProt

Q01741 - CP1A2_CHICK

Protein

Cytochrome P450 1A2

Gene

CYP1A2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A2 (EC:1.14.14.1)
    Alternative name(s):
    CYPIA2
    Gene namesi
    Name:CYP1A2
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 258›258Cytochrome P450 1A2PRO_0000051657Add
    BLAST

    Proteomic databases

    PRIDEiQ01741.

    Expressioni

    Inductioni

    By 3-methylcholanthrene (3MC) and estradiol-17-beta.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01741.
    SMRiQ01741. Positions 2-253.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG106944.
    PhylomeDBiQ01741.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    SUPFAMiSSF48264. SSF48264. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    Q01741-1 [UniParc]FASTAAdd to Basket

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    KFLQIAVEEH YQSFDKNNIR DVTDSLWRSK KTKPRGAADP NEKIINLVND    50
    IFGAGFDTVT TALSWSLMYL VTQPHSQKKI QESELDTAIG RERRSWLSER 100
    SMLPYKEAFI LETVPTWQFV PFTIPHSTTR DTTLNGFHIP KECCVFVNQW 150
    QVNHEAELWE DPFVFRTERF LTDDSTAIDK TLSEKVMGKQ VGLAWKSALG 200
    TRQWEVSFYL STLTPNWSSA PGGESKKDRV RPIYGLSMKH KRCEHFQVKK 250
    RFSMKSSN 258
    Length:258
    Mass (Da):29,914
    Last modified:February 1, 1994 - v1
    Checksum:iD20F5EAC4DEE52DB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64537 mRNA. Translation: AAA62735.1.
    PIRiJT0575.
    UniGeneiGga.61.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64537 mRNA. Translation: AAA62735.1 .
    PIRi JT0575.
    UniGenei Gga.61.

    3D structure databases

    ProteinModelPortali Q01741.
    SMRi Q01741. Positions 2-253.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q01741.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG106944.
    PhylomeDBi Q01741.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Estradiol-17 beta induces polyaromatic hydrocarbon-inducible cytochrome P-450 in chicken liver."
      Murti J.R., Adiga P.R., Padmanaban G.
      Biochem. Biophys. Res. Commun. 175:928-935(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCP1A2_CHICK
    AccessioniPrimary (citable) accession number: Q01741
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3