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Protein

Dimethylaniline monooxygenase [N-oxide-forming] 1

Gene

FMO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.

Catalytic activityi

N,N-dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.

Cofactori

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 14FADSequence analysis6
Nucleotide bindingi191 – 196NADPSequence analysis6

GO - Molecular functioni

  • flavin adenine dinucleotide binding Source: InterPro
  • monooxygenase activity Source: MGI
  • N,N-dimethylaniline monooxygenase activity Source: BHF-UCL
  • NADP binding Source: InterPro

GO - Biological processi

  • drug metabolic process Source: Ensembl
  • NADPH oxidation Source: BHF-UCL
  • organic acid metabolic process Source: BHF-UCL
  • response to lipopolysaccharide Source: Ensembl
  • response to osmotic stress Source: Ensembl
  • toxin metabolic process Source: BHF-UCL
  • xenobiotic metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciZFISH:HS00295-MONOMER.
BRENDAi1.14.13.8. 2681.
ReactomeiR-HSA-217271. FMO oxidises nucleophiles.
SABIO-RKQ01740.

Names & Taxonomyi

Protein namesi
Recommended name:
Dimethylaniline monooxygenase [N-oxide-forming] 1 (EC:1.14.13.8)
Alternative name(s):
Dimethylaniline oxidase 1
Fetal hepatic flavin-containing monooxygenase 1
Short name:
FMO 1
Gene namesi
Name:FMO1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:3769. FMO1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi2326.
OpenTargetsiENSG00000010932.
PharmGKBiPA165.

Chemistry databases

ChEMBLiCHEMBL3430872.
DrugBankiDB00185. Cevimeline.
DB00501. Cimetidine.
DB04871. Lorcaserin.
DB00675. Tamoxifen.
DB05294. Vandetanib.
DB00582. Voriconazole.

Polymorphism and mutation databases

DMDMi399505.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001476392 – 532Dimethylaniline monooxygenase [N-oxide-forming] 1Add BLAST531

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ01740.
PeptideAtlasiQ01740.
PRIDEiQ01740.

PTM databases

iPTMnetiQ01740.
PhosphoSitePlusiQ01740.

Expressioni

Tissue specificityi

Expressed mainly in fetal liver, adult kidney and, to a lesser extent, the intestine.

Gene expression databases

BgeeiENSG00000010932.
CleanExiHS_FMO1.
ExpressionAtlasiQ01740. baseline and differential.
GenevisibleiQ01740. HS.

Organism-specific databases

HPAiHPA023680.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000346901.

Structurei

3D structure databases

ProteinModelPortaliQ01740.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FMO family.Curated

Keywords - Domaini

Transmembrane

Phylogenomic databases

eggNOGiKOG1399. Eukaryota.
COG2072. LUCA.
GeneTreeiENSGT00760000119232.
HOGENOMiHOG000076537.
HOVERGENiHBG002037.
InParanoidiQ01740.
KOiK00485.
OMAiPSVMIEE.
OrthoDBiEOG091G0465.
PhylomeDBiQ01740.
TreeFamiTF105285.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR012143. DiMe-aniline_mOase.
IPR023753. FAD/NAD-binding_dom.
IPR000960. Flavin_mOase.
IPR020946. Flavin_mOase-like.
IPR002253. Flavin_mOase_1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00743. FMO-like. 1 hit.
[Graphical view]
PIRSFiPIRSF000332. FMO. 1 hit.
PRINTSiPR00370. FMOXYGENASE.
PR01121. FMOXYGENASE1.
SUPFAMiSSF51905. SSF51905. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q01740-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKRVAIVGA GVSGLASIKC CLEEGLEPTC FERSDDLGGL WRFTEHVEEG
60 70 80 90 100
RASLYKSVVS NSCKEMSCYS DFPFPEDYPN YVPNSQFLEY LKMYANHFDL
110 120 130 140 150
LKHIQFKTKV CSVTKCSDSA VSGQWEVVTM HEEKQESAIF DAVMVCTGFL
160 170 180 190 200
TNPYLPLDSF PGINAFKGQY FHSRQYKHPD IFKDKRVLVI GMGNSGTDIA
210 220 230 240 250
VEASHLAEKV FLSTTGGGWV ISRIFDSGYP WDMVFMTRFQ NMLRNSLPTP
260 270 280 290 300
IVTWLMERKI NNWLNHANYG LIPEDRTQLK EFVLNDELPG RIITGKVFIR
310 320 330 340 350
PSIKEVKENS VIFNNTSKEE PIDIIVFATG YTFAFPFLDE SVVKVEDGQA
360 370 380 390 400
SLYKYIFPAH LQKPTLAIIG LIKPLGSMIP TGETQARWAV RVLKGVNKLP
410 420 430 440 450
PPSVMIEEIN ARKENKPSWF GLCYCKALQS DYITYIDELL TYINAKPNLF
460 470 480 490 500
SMLLTDPHLA LTVFFGPCSP YQFRLTGPGK WEGARNAIMT QWDRTFKVIK
510 520 530
ARVVQESPSP FESFLKVFSF LALLVAIFLI FL
Length:532
Mass (Da):60,311
Last modified:January 23, 2007 - v3
Checksum:i627B855F38C2EB6D
GO
Isoform 2 (identifier: Q01740-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     45-107: Missing.

Note: No experimental confirmation available.
Show »
Length:469
Mass (Da):52,813
Checksum:iFC2C46683FE78025
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01535897H → Q.1 PublicationCorresponds to variant rs56841822dbSNPEnsembl.1
Natural variantiVAR_022204223R → Q.1 PublicationCorresponds to variant rs16864310dbSNPEnsembl.1
Natural variantiVAR_022205227S → T.1 Publication1
Natural variantiVAR_015359303I → T.1 PublicationCorresponds to variant rs28360418dbSNPEnsembl.1
Natural variantiVAR_015360303I → V.2 PublicationsCorresponds to variant rs16864314dbSNPEnsembl.1
Natural variantiVAR_022206322I → V.1 PublicationCorresponds to variant rs28360419dbSNPEnsembl.1
Natural variantiVAR_022207327F → L.1 PublicationCorresponds to variant rs28360420dbSNPEnsembl.1
Natural variantiVAR_022208373K → R.1 PublicationCorresponds to variant rs28360421dbSNPEnsembl.1
Natural variantiVAR_022209474R → H.1 PublicationCorresponds to variant rs28360433dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05454345 – 107Missing in isoform 2. 1 PublicationAdd BLAST63

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64082 mRNA. Translation: AAA52457.1.
AY879266 Genomic DNA. Translation: AAW56076.1.
AK290113 mRNA. Translation: BAF82802.1.
AK296198 mRNA. Translation: BAH12280.1.
AL021026 Genomic DNA. No translation available.
AL445673, AL031274 Genomic DNA. Translation: CAI21383.1.
AL031274, AL445673 Genomic DNA. Translation: CAI22846.1.
CH471067 Genomic DNA. Translation: EAW90892.1.
BC047129 mRNA. Translation: AAH47129.1.
CCDSiCCDS1294.1. [Q01740-1]
CCDS60351.1. [Q01740-2]
PIRiA40876.
RefSeqiNP_001269621.1. NM_001282692.1.
NP_001269622.1. NM_001282693.1. [Q01740-1]
NP_001269623.1. NM_001282694.1. [Q01740-2]
NP_002012.1. NM_002021.2. [Q01740-1]
UniGeneiHs.1424.

Genome annotation databases

EnsembliENST00000354841; ENSP00000346901; ENSG00000010932. [Q01740-1]
ENST00000367750; ENSP00000356724; ENSG00000010932. [Q01740-1]
ENST00000402921; ENSP00000385543; ENSG00000010932. [Q01740-2]
ENST00000617670; ENSP00000481732; ENSG00000010932. [Q01740-1]
GeneIDi2326.
KEGGihsa:2326.
UCSCiuc001ghl.5. human. [Q01740-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64082 mRNA. Translation: AAA52457.1.
AY879266 Genomic DNA. Translation: AAW56076.1.
AK290113 mRNA. Translation: BAF82802.1.
AK296198 mRNA. Translation: BAH12280.1.
AL021026 Genomic DNA. No translation available.
AL445673, AL031274 Genomic DNA. Translation: CAI21383.1.
AL031274, AL445673 Genomic DNA. Translation: CAI22846.1.
CH471067 Genomic DNA. Translation: EAW90892.1.
BC047129 mRNA. Translation: AAH47129.1.
CCDSiCCDS1294.1. [Q01740-1]
CCDS60351.1. [Q01740-2]
PIRiA40876.
RefSeqiNP_001269621.1. NM_001282692.1.
NP_001269622.1. NM_001282693.1. [Q01740-1]
NP_001269623.1. NM_001282694.1. [Q01740-2]
NP_002012.1. NM_002021.2. [Q01740-1]
UniGeneiHs.1424.

3D structure databases

ProteinModelPortaliQ01740.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000346901.

Chemistry databases

ChEMBLiCHEMBL3430872.
DrugBankiDB00185. Cevimeline.
DB00501. Cimetidine.
DB04871. Lorcaserin.
DB00675. Tamoxifen.
DB05294. Vandetanib.
DB00582. Voriconazole.

PTM databases

iPTMnetiQ01740.
PhosphoSitePlusiQ01740.

Polymorphism and mutation databases

DMDMi399505.

Proteomic databases

PaxDbiQ01740.
PeptideAtlasiQ01740.
PRIDEiQ01740.

Protocols and materials databases

DNASUi2326.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354841; ENSP00000346901; ENSG00000010932. [Q01740-1]
ENST00000367750; ENSP00000356724; ENSG00000010932. [Q01740-1]
ENST00000402921; ENSP00000385543; ENSG00000010932. [Q01740-2]
ENST00000617670; ENSP00000481732; ENSG00000010932. [Q01740-1]
GeneIDi2326.
KEGGihsa:2326.
UCSCiuc001ghl.5. human. [Q01740-1]

Organism-specific databases

CTDi2326.
DisGeNETi2326.
GeneCardsiFMO1.
H-InvDBHIX0028548.
HGNCiHGNC:3769. FMO1.
HPAiHPA023680.
MIMi136130. gene.
neXtProtiNX_Q01740.
OpenTargetsiENSG00000010932.
PharmGKBiPA165.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1399. Eukaryota.
COG2072. LUCA.
GeneTreeiENSGT00760000119232.
HOGENOMiHOG000076537.
HOVERGENiHBG002037.
InParanoidiQ01740.
KOiK00485.
OMAiPSVMIEE.
OrthoDBiEOG091G0465.
PhylomeDBiQ01740.
TreeFamiTF105285.

Enzyme and pathway databases

BioCyciZFISH:HS00295-MONOMER.
BRENDAi1.14.13.8. 2681.
ReactomeiR-HSA-217271. FMO oxidises nucleophiles.
SABIO-RKQ01740.

Miscellaneous databases

GeneWikiiFlavin_containing_monooxygenase_1.
GenomeRNAii2326.
PROiQ01740.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000010932.
CleanExiHS_FMO1.
ExpressionAtlasiQ01740. baseline and differential.
GenevisibleiQ01740. HS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR012143. DiMe-aniline_mOase.
IPR023753. FAD/NAD-binding_dom.
IPR000960. Flavin_mOase.
IPR020946. Flavin_mOase-like.
IPR002253. Flavin_mOase_1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00743. FMO-like. 1 hit.
[Graphical view]
PIRSFiPIRSF000332. FMO. 1 hit.
PRINTSiPR00370. FMOXYGENASE.
PR01121. FMOXYGENASE1.
SUPFAMiSSF51905. SSF51905. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiFMO1_HUMAN
AccessioniPrimary (citable) accession number: Q01740
Secondary accession number(s): A8K248
, B7Z3P4, Q5QPT2, Q9UJC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 153 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.