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Q01740

- FMO1_HUMAN

UniProt

Q01740 - FMO1_HUMAN

Protein

Dimethylaniline monooxygenase [N-oxide-forming] 1

Gene

FMO1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.

    Catalytic activityi

    N,N-dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.

    Cofactori

    FAD.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 146FADSequence Analysis
    Nucleotide bindingi191 – 1966NADPSequence Analysis

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. monooxygenase activity Source: MGI
    3. N,N-dimethylaniline monooxygenase activity Source: BHF-UCL
    4. NADP binding Source: InterPro

    GO - Biological processi

    1. NADPH oxidation Source: BHF-UCL
    2. organic acid metabolic process Source: BHF-UCL
    3. response to lipopolysaccharide Source: Ensembl
    4. response to osmotic stress Source: Ensembl
    5. small molecule metabolic process Source: Reactome
    6. toxin metabolic process Source: BHF-UCL
    7. xenobiotic metabolic process Source: Reactome

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NADP

    Enzyme and pathway databases

    ReactomeiREACT_13653. FMO oxidizes nucleophiles.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dimethylaniline monooxygenase [N-oxide-forming] 1 (EC:1.14.13.8)
    Alternative name(s):
    Dimethylaniline oxidase 1
    Fetal hepatic flavin-containing monooxygenase 1
    Short name:
    FMO 1
    Gene namesi
    Name:FMO1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:3769. FMO1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: Reactome
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 532531Dimethylaniline monooxygenase [N-oxide-forming] 1PRO_0000147639Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ01740.
    PRIDEiQ01740.

    PTM databases

    PhosphoSiteiQ01740.

    Expressioni

    Tissue specificityi

    Expressed mainly in fetal liver, adult kidney and, to a lesser extent, the intestine.

    Gene expression databases

    ArrayExpressiQ01740.
    BgeeiQ01740.
    CleanExiHS_FMO1.
    GenevestigatoriQ01740.

    Organism-specific databases

    HPAiHPA023680.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000346901.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01740.
    SMRiQ01740. Positions 1-442.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FMO family.Curated

    Keywords - Domaini

    Transmembrane

    Phylogenomic databases

    eggNOGiCOG2072.
    HOGENOMiHOG000076537.
    HOVERGENiHBG002037.
    InParanoidiQ01740.
    KOiK00485.
    OMAiTRFQNML.
    PhylomeDBiQ01740.
    TreeFamiTF105285.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR012143. DiMe-aniline_mOase.
    IPR000960. Flavin_mOase.
    IPR020946. Flavin_mOase-like.
    IPR002253. Flavin_mOase_1.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00743. FMO-like. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000332. FMO. 1 hit.
    PRINTSiPR00370. FMOXYGENASE.
    PR01121. FMOXYGENASE1.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q01740-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAKRVAIVGA GVSGLASIKC CLEEGLEPTC FERSDDLGGL WRFTEHVEEG    50
    RASLYKSVVS NSCKEMSCYS DFPFPEDYPN YVPNSQFLEY LKMYANHFDL 100
    LKHIQFKTKV CSVTKCSDSA VSGQWEVVTM HEEKQESAIF DAVMVCTGFL 150
    TNPYLPLDSF PGINAFKGQY FHSRQYKHPD IFKDKRVLVI GMGNSGTDIA 200
    VEASHLAEKV FLSTTGGGWV ISRIFDSGYP WDMVFMTRFQ NMLRNSLPTP 250
    IVTWLMERKI NNWLNHANYG LIPEDRTQLK EFVLNDELPG RIITGKVFIR 300
    PSIKEVKENS VIFNNTSKEE PIDIIVFATG YTFAFPFLDE SVVKVEDGQA 350
    SLYKYIFPAH LQKPTLAIIG LIKPLGSMIP TGETQARWAV RVLKGVNKLP 400
    PPSVMIEEIN ARKENKPSWF GLCYCKALQS DYITYIDELL TYINAKPNLF 450
    SMLLTDPHLA LTVFFGPCSP YQFRLTGPGK WEGARNAIMT QWDRTFKVIK 500
    ARVVQESPSP FESFLKVFSF LALLVAIFLI FL 532
    Length:532
    Mass (Da):60,311
    Last modified:January 23, 2007 - v3
    Checksum:i627B855F38C2EB6D
    GO
    Isoform 2 (identifier: Q01740-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         45-107: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:469
    Mass (Da):52,813
    Checksum:iFC2C46683FE78025
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti97 – 971H → Q.1 Publication
    Corresponds to variant rs56841822 [ dbSNP | Ensembl ].
    VAR_015358
    Natural varianti223 – 2231R → Q.1 Publication
    Corresponds to variant rs16864310 [ dbSNP | Ensembl ].
    VAR_022204
    Natural varianti227 – 2271S → T.1 Publication
    VAR_022205
    Natural varianti303 – 3031I → T.1 Publication
    Corresponds to variant rs28360418 [ dbSNP | Ensembl ].
    VAR_015359
    Natural varianti303 – 3031I → V.2 Publications
    Corresponds to variant rs16864314 [ dbSNP | Ensembl ].
    VAR_015360
    Natural varianti322 – 3221I → V.1 Publication
    Corresponds to variant rs28360419 [ dbSNP | Ensembl ].
    VAR_022206
    Natural varianti327 – 3271F → L.1 Publication
    Corresponds to variant rs28360420 [ dbSNP | Ensembl ].
    VAR_022207
    Natural varianti373 – 3731K → R.1 Publication
    Corresponds to variant rs28360421 [ dbSNP | Ensembl ].
    VAR_022208
    Natural varianti474 – 4741R → H.1 Publication
    Corresponds to variant rs28360433 [ dbSNP | Ensembl ].
    VAR_022209

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei45 – 10763Missing in isoform 2. 1 PublicationVSP_054543Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64082 mRNA. Translation: AAA52457.1.
    AY879266 Genomic DNA. Translation: AAW56076.1.
    AK290113 mRNA. Translation: BAF82802.1.
    AK296198 mRNA. Translation: BAH12280.1.
    AL021026 Genomic DNA. No translation available.
    AL445673, AL031274 Genomic DNA. Translation: CAI21383.1.
    AL031274, AL445673 Genomic DNA. Translation: CAI22846.1.
    CH471067 Genomic DNA. Translation: EAW90892.1.
    BC047129 mRNA. Translation: AAH47129.1.
    CCDSiCCDS1294.1. [Q01740-1]
    CCDS60351.1. [Q01740-2]
    PIRiA40876.
    RefSeqiNP_001269621.1. NM_001282692.1.
    NP_001269622.1. NM_001282693.1. [Q01740-1]
    NP_001269623.1. NM_001282694.1. [Q01740-2]
    NP_002012.1. NM_002021.2. [Q01740-1]
    UniGeneiHs.1424.

    Genome annotation databases

    EnsembliENST00000354841; ENSP00000346901; ENSG00000010932. [Q01740-1]
    ENST00000367750; ENSP00000356724; ENSG00000010932. [Q01740-1]
    ENST00000402921; ENSP00000385543; ENSG00000010932. [Q01740-2]
    GeneIDi2326.
    KEGGihsa:2326.
    UCSCiuc001ghl.3. human. [Q01740-1]

    Polymorphism databases

    DMDMi399505.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64082 mRNA. Translation: AAA52457.1 .
    AY879266 Genomic DNA. Translation: AAW56076.1 .
    AK290113 mRNA. Translation: BAF82802.1 .
    AK296198 mRNA. Translation: BAH12280.1 .
    AL021026 Genomic DNA. No translation available.
    AL445673 , AL031274 Genomic DNA. Translation: CAI21383.1 .
    AL031274 , AL445673 Genomic DNA. Translation: CAI22846.1 .
    CH471067 Genomic DNA. Translation: EAW90892.1 .
    BC047129 mRNA. Translation: AAH47129.1 .
    CCDSi CCDS1294.1. [Q01740-1 ]
    CCDS60351.1. [Q01740-2 ]
    PIRi A40876.
    RefSeqi NP_001269621.1. NM_001282692.1.
    NP_001269622.1. NM_001282693.1. [Q01740-1 ]
    NP_001269623.1. NM_001282694.1. [Q01740-2 ]
    NP_002012.1. NM_002021.2. [Q01740-1 ]
    UniGenei Hs.1424.

    3D structure databases

    ProteinModelPortali Q01740.
    SMRi Q01740. Positions 1-442.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000346901.

    PTM databases

    PhosphoSitei Q01740.

    Polymorphism databases

    DMDMi 399505.

    Proteomic databases

    PaxDbi Q01740.
    PRIDEi Q01740.

    Protocols and materials databases

    DNASUi 2326.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000354841 ; ENSP00000346901 ; ENSG00000010932 . [Q01740-1 ]
    ENST00000367750 ; ENSP00000356724 ; ENSG00000010932 . [Q01740-1 ]
    ENST00000402921 ; ENSP00000385543 ; ENSG00000010932 . [Q01740-2 ]
    GeneIDi 2326.
    KEGGi hsa:2326.
    UCSCi uc001ghl.3. human. [Q01740-1 ]

    Organism-specific databases

    CTDi 2326.
    GeneCardsi GC01P171217.
    H-InvDB HIX0028548.
    HGNCi HGNC:3769. FMO1.
    HPAi HPA023680.
    MIMi 136130. gene.
    neXtProti NX_Q01740.
    PharmGKBi PA165.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2072.
    HOGENOMi HOG000076537.
    HOVERGENi HBG002037.
    InParanoidi Q01740.
    KOi K00485.
    OMAi TRFQNML.
    PhylomeDBi Q01740.
    TreeFami TF105285.

    Enzyme and pathway databases

    Reactomei REACT_13653. FMO oxidizes nucleophiles.

    Miscellaneous databases

    GeneWikii Flavin_containing_monooxygenase_1.
    GenomeRNAii 2326.
    NextBioi 35479295.
    PROi Q01740.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q01740.
    Bgeei Q01740.
    CleanExi HS_FMO1.
    Genevestigatori Q01740.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR012143. DiMe-aniline_mOase.
    IPR000960. Flavin_mOase.
    IPR020946. Flavin_mOase-like.
    IPR002253. Flavin_mOase_1.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00743. FMO-like. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000332. FMO. 1 hit.
    PRINTSi PR00370. FMOXYGENASE.
    PR01121. FMOXYGENASE1.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, primary sequence, and chromosomal mapping of a human flavin-containing monooxygenase (FMO1)."
      Dolphin C.T., Shephard E.A., Povey S., Palmer C.N.A., Ziegler D.M., Ayesh R., Smith R.L., Phillips I.R.
      J. Biol. Chem. 266:12379-12385(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Liver.
    2. NIEHS SNPs program
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLN-223; THR-227; VAL-303; VAL-322; LEU-327; ARG-373 AND HIS-474.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Thalamus.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Colon.
    7. "Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans."
      Furnes B., Feng J., Sommer S.S., Schlenk D.
      Drug Metab. Dispos. 31:187-193(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS GLN-97; THR-303 AND VAL-303.

    Entry informationi

    Entry nameiFMO1_HUMAN
    AccessioniPrimary (citable) accession number: Q01740
    Secondary accession number(s): A8K248
    , B7Z3P4, Q5QPT2, Q9UJC2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 133 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3