Reviewed,
UniProtKB/Swiss-Prot Q01740 (FMO1_HUMAN)
Last modified
November 25, 2008.
Version 75.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Dimethylaniline monooxygenase [N-oxide-forming] 1 EC=1.14.13.8 Alternative name(s): Fetal hepatic flavin-containing monooxygenase 1 Short name=FMO 1 Dimethylaniline oxidase 1 | ||
| Gene names |
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| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 532 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines. |
| Catalytic activity | N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)O. |
| Cofactor | FAD. |
| Subcellular location | |
| Tissue specificity | Expressed mainly in fetal liver, adult kindney and to a lesser extent, the intestine. |
| Sequence similarities | Belongs to the FMO family. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Endoplasmic reticulum Membrane Microsome |
| Coding sequence diversity | Polymorphism |
| Domain | Transmembrane |
| Ligand | FAD Flavoprotein NADP |
| Molecular function | Monooxygenase Oxidoreductase |
| PTM | Acetylation |
Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW intrinsic to endoplasmic reticulum membraneInferred from electronic annotation. Source: InterPro microsomeInferred from electronic annotation. Source: InterPro |
| Molecular function | FAD binding Inferred from electronic annotation. Source: InterPro NADP bindingInferred from electronic annotation. Source: InterPro flavin-containing monooxygenase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 532 | 531 | Dimethylaniline monooxygenase [N-oxide-forming] 1 | PRO_0000147639 | |||||
Regions | |||||||||
| Nucleotide binding | 9 – 14 | 6 | FAD Potential | ||||||
| Nucleotide binding | 191 – 196 | 6 | NADP Potential | ||||||
Amino acid modifications | |||||||||
| Modified residue | 2 | 1 | N-acetylalanine By similarity | ||||||
Natural variations | |||||||||
| Natural variant | 97 | 1 | H → Q | VAR_015358 | |||||
| Natural variant | 223 | 1 | R → Q | VAR_022204 | |||||
| Natural variant | 227 | 1 | S → T | VAR_022205 | |||||
| Natural variant | 303 | 1 | I → T: dbSNP rs28360418. | VAR_015359 | |||||
| Natural variant | 303 | 1 | I → V: dbSNP rs16864314. | VAR_015360 | |||||
| Natural variant | 322 | 1 | I → V | VAR_022206 | |||||
| Natural variant | 327 | 1 | F → L | VAR_022207 | |||||
| Natural variant | 373 | 1 | K → R | VAR_022208 | |||||
| Natural variant | 474 | 1 | R → H | VAR_022209 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning, primary sequence, and chromosomal mapping of a human flavin-containing monooxygenase (FMO1)." Dolphin C.T., Shephard E.A., Povey S., Palmer C.N.A., Ziegler D.M., Ayesh R., Smith R.L., Phillips I.R. J. Biol. Chem. 266:12379-12385(1991) [PubMed: 1712018] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver. |
| [2] | "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)." Livingston R.J., Rieder M.J., Chung M.-W., Downing T.K., Olson A.N., Nguyen C.P., Gildersleeve H., Cassidy C.M., Johnson E.J., Swanson J.E., McFarland I., Yool B., Park C., Nickerson D.A. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLN-223; THR-227; VAL-303; VAL-322; LEU-327; ARG-373 AND HIS-474. |
| [3] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon. |
| [5] | "Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans." Furnes B., Feng J., Sommer S.S., Schlenk D. Drug Metab. Dispos. 31:187-193(2003) [PubMed: 12527699] [Abstract] Cited for: VARIANTS GLN-97; THR-303 AND VAL-303. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| M64082 mRNA. Translation: AAA52457.1. AY879266 Genomic DNA. Translation: AAW56076.1. AL445673, AL031274 Genomic DNA. Translation: CAI21383.1. AL031274, AL445673 Genomic DNA. Translation: CAI22846.1. BC047129 mRNA. Translation: AAH47129.1. | |
| PIR | A40876. |
| RefSeq | NP_002012.1. |
| UniGene | Hs.1424 |
3D structure databases | |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q01740. |
Polymorphism databases | |
| NIEHS-SNPs | Search... |
Genome annotation databases | |
| Ensembl | ENSG00000010932. Homo sapiens. [Contig view] |
| GeneID | 2326. |
| KEGG | hsa:2326. |
Organism-specific databases | |
| H-InvDB | HIX0028548. |
| HGNC | HGNC:3769. FMO1. |
| MIM | 136130. gene. |
| PharmGKB | PA165. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | Q01740. |
| HOVERGEN | Q01740. |
Gene expression databases | |
| ArrayExpress | Q01740. |
| CleanEx | HS_FMO1. |
Family and domain databases | |
| InterPro | IPR012143. dManiline_mOase. IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR000960. Flavin_mOase. IPR002253. Flavin_mOase_1. [Graphical view] |
| Pfam | PF00743. FMO-like. 1 hit. [Graphical view] |
| PIRSF | PIRSF000332. FMO. 1 hit. |
| PRINTS | PR00368. FADPNR. PR00370. FMOXYGENASE. PR01121. FMOXYGENASE1. |
| ProDom | PD000139. FAD_pyr_redox. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 9439. |
| SOURCE | Search... |
Entry information
| Entry name | FMO1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q01740 Secondary accession number(s): Q5QPT2, Q9UJC2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


