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Q01740

- FMO1_HUMAN

UniProt

Q01740 - FMO1_HUMAN

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Protein

Dimethylaniline monooxygenase [N-oxide-forming] 1

Gene
FMO1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.

Catalytic activityi

N,N-dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.

Cofactori

FAD.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 146FAD Reviewed prediction
Nucleotide bindingi191 – 1966NADP Reviewed prediction

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. monooxygenase activity Source: MGI
  3. N,N-dimethylaniline monooxygenase activity Source: BHF-UCL
  4. NADP binding Source: InterPro

GO - Biological processi

  1. NADPH oxidation Source: BHF-UCL
  2. organic acid metabolic process Source: BHF-UCL
  3. response to lipopolysaccharide Source: Ensembl
  4. response to osmotic stress Source: Ensembl
  5. small molecule metabolic process Source: Reactome
  6. toxin metabolic process Source: BHF-UCL
  7. xenobiotic metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

ReactomeiREACT_13653. FMO oxidizes nucleophiles.

Names & Taxonomyi

Protein namesi
Recommended name:
Dimethylaniline monooxygenase [N-oxide-forming] 1 (EC:1.14.13.8)
Alternative name(s):
Dimethylaniline oxidase 1
Fetal hepatic flavin-containing monooxygenase 1
Short name:
FMO 1
Gene namesi
Name:FMO1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:3769. FMO1.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: Reactome
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 532531Dimethylaniline monooxygenase [N-oxide-forming] 1PRO_0000147639Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ01740.
PRIDEiQ01740.

PTM databases

PhosphoSiteiQ01740.

Expressioni

Tissue specificityi

Expressed mainly in fetal liver, adult kidney and, to a lesser extent, the intestine.

Gene expression databases

ArrayExpressiQ01740.
BgeeiQ01740.
CleanExiHS_FMO1.
GenevestigatoriQ01740.

Organism-specific databases

HPAiHPA023680.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000346901.

Structurei

3D structure databases

ProteinModelPortaliQ01740.
SMRiQ01740. Positions 1-442.

Family & Domainsi

Sequence similaritiesi

Belongs to the FMO family.

Keywords - Domaini

Transmembrane

Phylogenomic databases

eggNOGiCOG2072.
HOGENOMiHOG000076537.
HOVERGENiHBG002037.
InParanoidiQ01740.
KOiK00485.
OMAiTRFQNML.
PhylomeDBiQ01740.
TreeFamiTF105285.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR012143. DiMe-aniline_mOase.
IPR000960. Flavin_mOase.
IPR020946. Flavin_mOase-like.
IPR002253. Flavin_mOase_1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00743. FMO-like. 1 hit.
[Graphical view]
PIRSFiPIRSF000332. FMO. 1 hit.
PRINTSiPR00370. FMOXYGENASE.
PR01121. FMOXYGENASE1.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q01740-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAKRVAIVGA GVSGLASIKC CLEEGLEPTC FERSDDLGGL WRFTEHVEEG    50
RASLYKSVVS NSCKEMSCYS DFPFPEDYPN YVPNSQFLEY LKMYANHFDL 100
LKHIQFKTKV CSVTKCSDSA VSGQWEVVTM HEEKQESAIF DAVMVCTGFL 150
TNPYLPLDSF PGINAFKGQY FHSRQYKHPD IFKDKRVLVI GMGNSGTDIA 200
VEASHLAEKV FLSTTGGGWV ISRIFDSGYP WDMVFMTRFQ NMLRNSLPTP 250
IVTWLMERKI NNWLNHANYG LIPEDRTQLK EFVLNDELPG RIITGKVFIR 300
PSIKEVKENS VIFNNTSKEE PIDIIVFATG YTFAFPFLDE SVVKVEDGQA 350
SLYKYIFPAH LQKPTLAIIG LIKPLGSMIP TGETQARWAV RVLKGVNKLP 400
PPSVMIEEIN ARKENKPSWF GLCYCKALQS DYITYIDELL TYINAKPNLF 450
SMLLTDPHLA LTVFFGPCSP YQFRLTGPGK WEGARNAIMT QWDRTFKVIK 500
ARVVQESPSP FESFLKVFSF LALLVAIFLI FL 532
Length:532
Mass (Da):60,311
Last modified:January 23, 2007 - v3
Checksum:i627B855F38C2EB6D
GO
Isoform 2 (identifier: Q01740-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     45-107: Missing.

Note: No experimental confirmation available.

Show »
Length:469
Mass (Da):52,813
Checksum:iFC2C46683FE78025
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti97 – 971H → Q.1 Publication
Corresponds to variant rs56841822 [ dbSNP | Ensembl ].
VAR_015358
Natural varianti223 – 2231R → Q.1 Publication
Corresponds to variant rs16864310 [ dbSNP | Ensembl ].
VAR_022204
Natural varianti227 – 2271S → T.1 Publication
VAR_022205
Natural varianti303 – 3031I → T.1 Publication
Corresponds to variant rs28360418 [ dbSNP | Ensembl ].
VAR_015359
Natural varianti303 – 3031I → V.2 Publications
Corresponds to variant rs16864314 [ dbSNP | Ensembl ].
VAR_015360
Natural varianti322 – 3221I → V.1 Publication
Corresponds to variant rs28360419 [ dbSNP | Ensembl ].
VAR_022206
Natural varianti327 – 3271F → L.1 Publication
Corresponds to variant rs28360420 [ dbSNP | Ensembl ].
VAR_022207
Natural varianti373 – 3731K → R.1 Publication
Corresponds to variant rs28360421 [ dbSNP | Ensembl ].
VAR_022208
Natural varianti474 – 4741R → H.1 Publication
Corresponds to variant rs28360433 [ dbSNP | Ensembl ].
VAR_022209

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei45 – 10763Missing in isoform 2. VSP_054543Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64082 mRNA. Translation: AAA52457.1.
AY879266 Genomic DNA. Translation: AAW56076.1.
AK290113 mRNA. Translation: BAF82802.1.
AK296198 mRNA. Translation: BAH12280.1.
AL021026 Genomic DNA. No translation available.
AL445673, AL031274 Genomic DNA. Translation: CAI21383.1.
AL031274, AL445673 Genomic DNA. Translation: CAI22846.1.
CH471067 Genomic DNA. Translation: EAW90892.1.
BC047129 mRNA. Translation: AAH47129.1.
CCDSiCCDS1294.1. [Q01740-1]
CCDS60351.1. [Q01740-2]
PIRiA40876.
RefSeqiNP_001269621.1. NM_001282692.1.
NP_001269622.1. NM_001282693.1. [Q01740-1]
NP_001269623.1. NM_001282694.1. [Q01740-2]
NP_002012.1. NM_002021.2. [Q01740-1]
UniGeneiHs.1424.

Genome annotation databases

EnsembliENST00000354841; ENSP00000346901; ENSG00000010932.
ENST00000367750; ENSP00000356724; ENSG00000010932.
ENST00000402921; ENSP00000385543; ENSG00000010932.
GeneIDi2326.
KEGGihsa:2326.
UCSCiuc001ghl.3. human. [Q01740-1]

Polymorphism databases

DMDMi399505.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64082 mRNA. Translation: AAA52457.1 .
AY879266 Genomic DNA. Translation: AAW56076.1 .
AK290113 mRNA. Translation: BAF82802.1 .
AK296198 mRNA. Translation: BAH12280.1 .
AL021026 Genomic DNA. No translation available.
AL445673 , AL031274 Genomic DNA. Translation: CAI21383.1 .
AL031274 , AL445673 Genomic DNA. Translation: CAI22846.1 .
CH471067 Genomic DNA. Translation: EAW90892.1 .
BC047129 mRNA. Translation: AAH47129.1 .
CCDSi CCDS1294.1. [Q01740-1 ]
CCDS60351.1. [Q01740-2 ]
PIRi A40876.
RefSeqi NP_001269621.1. NM_001282692.1.
NP_001269622.1. NM_001282693.1. [Q01740-1 ]
NP_001269623.1. NM_001282694.1. [Q01740-2 ]
NP_002012.1. NM_002021.2. [Q01740-1 ]
UniGenei Hs.1424.

3D structure databases

ProteinModelPortali Q01740.
SMRi Q01740. Positions 1-442.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000346901.

PTM databases

PhosphoSitei Q01740.

Polymorphism databases

DMDMi 399505.

Proteomic databases

PaxDbi Q01740.
PRIDEi Q01740.

Protocols and materials databases

DNASUi 2326.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000354841 ; ENSP00000346901 ; ENSG00000010932 .
ENST00000367750 ; ENSP00000356724 ; ENSG00000010932 .
ENST00000402921 ; ENSP00000385543 ; ENSG00000010932 .
GeneIDi 2326.
KEGGi hsa:2326.
UCSCi uc001ghl.3. human. [Q01740-1 ]

Organism-specific databases

CTDi 2326.
GeneCardsi GC01P171217.
H-InvDB HIX0028548.
HGNCi HGNC:3769. FMO1.
HPAi HPA023680.
MIMi 136130. gene.
neXtProti NX_Q01740.
PharmGKBi PA165.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2072.
HOGENOMi HOG000076537.
HOVERGENi HBG002037.
InParanoidi Q01740.
KOi K00485.
OMAi TRFQNML.
PhylomeDBi Q01740.
TreeFami TF105285.

Enzyme and pathway databases

Reactomei REACT_13653. FMO oxidizes nucleophiles.

Miscellaneous databases

GeneWikii Flavin_containing_monooxygenase_1.
GenomeRNAii 2326.
NextBioi 35479295.
PROi Q01740.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q01740.
Bgeei Q01740.
CleanExi HS_FMO1.
Genevestigatori Q01740.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR012143. DiMe-aniline_mOase.
IPR000960. Flavin_mOase.
IPR020946. Flavin_mOase-like.
IPR002253. Flavin_mOase_1.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00743. FMO-like. 1 hit.
[Graphical view ]
PIRSFi PIRSF000332. FMO. 1 hit.
PRINTSi PR00370. FMOXYGENASE.
PR01121. FMOXYGENASE1.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, primary sequence, and chromosomal mapping of a human flavin-containing monooxygenase (FMO1)."
    Dolphin C.T., Shephard E.A., Povey S., Palmer C.N.A., Ziegler D.M., Ayesh R., Smith R.L., Phillips I.R.
    J. Biol. Chem. 266:12379-12385(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Liver.
  2. NIEHS SNPs program
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLN-223; THR-227; VAL-303; VAL-322; LEU-327; ARG-373 AND HIS-474.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Thalamus.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  7. "Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans."
    Furnes B., Feng J., Sommer S.S., Schlenk D.
    Drug Metab. Dispos. 31:187-193(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS GLN-97; THR-303 AND VAL-303.

Entry informationi

Entry nameiFMO1_HUMAN
AccessioniPrimary (citable) accession number: Q01740
Secondary accession number(s): A8K248
, B7Z3P4, Q5QPT2, Q9UJC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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