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Protein

Ras suppressor protein 1

Gene

Rsu1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro.

GO - Biological processi

  • positive regulation of cell-substrate adhesion Source: MGI
  • positive regulation of GTPase activity Source: MGI
  • positive regulation of neural precursor cell proliferation Source: MGI
  • Ras protein signal transduction Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ras suppressor protein 1
Short name:
RSP-1
Short name:
Rsu-1
Gene namesi
Name:Rsu1
Synonyms:Rsp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:103040. Rsu1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 277276Ras suppressor protein 1PRO_0000097500Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ01730.
MaxQBiQ01730.
PaxDbiQ01730.
PeptideAtlasiQ01730.
PRIDEiQ01730.
TopDownProteomicsiQ01730.

PTM databases

iPTMnetiQ01730.
PhosphoSiteiQ01730.

Expressioni

Gene expression databases

CleanExiMM_RSU1.

Interactioni

Protein-protein interaction databases

IntActiQ01730. 1 interaction.
STRINGi10090.ENSMUSP00000028059.

Structurei

3D structure databases

ProteinModelPortaliQ01730.
SMRiQ01730. Positions 6-247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati41 – 6323LRR 1Add
BLAST
Repeati64 – 8522LRR 2Add
BLAST
Repeati87 – 10822LRR 3Add
BLAST
Repeati110 – 13324LRR 4Add
BLAST
Repeati135 – 15622LRR 5Add
BLAST
Repeati158 – 17922LRR 6Add
BLAST
Repeati181 – 20222LRR 7Add
BLAST

Sequence similaritiesi

Contains 7 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0617. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000116557.
HOVERGENiHBG002478.
InParanoidiQ01730.
PhylomeDBiQ01730.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 6 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01730-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKSLKKLVE ESREKNQPEV DMSDRGISSM LDVNGLFSLA HITQLVLSHN
60 70 80 90 100
KLTTVPPNVA ELKNLEVLNF FNNQIEELPT QISSLQKLKH LNLGMNRLNT
110 120 130 140 150
LPRGFGSSRL LEVLELTYNN LNEHSLPGNF FYLTTLRALY LSDNDFEILP
160 170 180 190 200
PDIGKLTKLQ ILSLRDNDLI SLPKEIGELT QLKELHIQGN RLTVLPPELG
210 220 230 240 250
NLDLTGQKQV FKAENNPWVT PIADQFQLGV SHVFEYIRSE TYKYLYGRHM
260 270
QANPEPPKKN NDKSKKISRK PLAAKNK
Length:277
Mass (Da):31,550
Last modified:January 23, 2007 - v3
Checksum:i0D12705A39872F2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63039 mRNA. Translation: CAA44765.1.
CCDSiCCDS15693.1.
PIRiS25770.
UniGeneiMm.905.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63039 mRNA. Translation: CAA44765.1.
CCDSiCCDS15693.1.
PIRiS25770.
UniGeneiMm.905.

3D structure databases

ProteinModelPortaliQ01730.
SMRiQ01730. Positions 6-247.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ01730. 1 interaction.
STRINGi10090.ENSMUSP00000028059.

PTM databases

iPTMnetiQ01730.
PhosphoSiteiQ01730.

Proteomic databases

EPDiQ01730.
MaxQBiQ01730.
PaxDbiQ01730.
PeptideAtlasiQ01730.
PRIDEiQ01730.
TopDownProteomicsiQ01730.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:103040. Rsu1.

Phylogenomic databases

eggNOGiKOG0617. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000116557.
HOVERGENiHBG002478.
InParanoidiQ01730.
PhylomeDBiQ01730.

Miscellaneous databases

ChiTaRSiRsu1. mouse.
PROiQ01730.
SOURCEiSearch...

Gene expression databases

CleanExiMM_RSU1.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 6 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of rsp-1, a novel cDNA capable of suppressing v-Ras transformation."
    Cutler M.L., Bassin R.H., Zanoni L., Talbot N.
    Mol. Cell. Biol. 12:3750-3756(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: NIH Swiss.
    Tissue: Fibroblast.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiRSU1_MOUSE
AccessioniPrimary (citable) accession number: Q01730
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.