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Q01727

- MSHR_MOUSE

UniProt

Q01727 - MSHR_MOUSE

Protein

Melanocyte-stimulating hormone receptor

Gene

Mc1r

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

    GO - Molecular functioni

    1. melanocortin receptor activity Source: BHF-UCL
    2. melanocyte-stimulating hormone receptor activity Source: MGI
    3. protein binding Source: MGI

    GO - Biological processi

    1. intracellular signal transduction Source: BHF-UCL
    2. melanin biosynthetic process Source: MGI
    3. negative regulation of tumor necrosis factor production Source: Ensembl
    4. pigmentation Source: MGI
    5. positive regulation of cAMP biosynthetic process Source: Ensembl
    6. positive regulation of protein kinase A signaling Source: BHF-UCL
    7. positive regulation of protein kinase B signaling Source: BHF-UCL
    8. positive regulation of protein kinase C signaling Source: BHF-UCL
    9. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    10. sensory perception of pain Source: MGI
    11. UV-damage excision repair Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Melanocyte-stimulating hormone receptor
    Short name:
    MSH-R
    Alternative name(s):
    Melanocortin receptor 1
    Short name:
    MC1-R
    Gene namesi
    Name:Mc1r
    Synonyms:Msh-r
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:99456. Mc1r.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. microtubule cytoskeleton Source: Ensembl
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 315315Melanocyte-stimulating hormone receptorPRO_0000069834Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi17 – 171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi27 – 271N-linked (GlcNAc...)Sequence Analysis
    Lipidationi313 – 3131S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiQ01727.

    PTM databases

    PhosphoSiteiQ01727.

    Expressioni

    Tissue specificityi

    Melanocytes and corticoadrenal tissue.

    Gene expression databases

    BgeeiQ01727.
    CleanExiMM_MC1R.
    GenevestigatoriQ01727.

    Interactioni

    Subunit structurei

    Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production.By similarity

    Protein-protein interaction databases

    BioGridi201338. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01727.
    SMRiQ01727. Positions 42-311.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3535ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini62 – 709CytoplasmicSequence Analysis
    Topological domaini92 – 11625ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini139 – 16123CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini182 – 1898ExtracellularSequence Analysis
    Topological domaini210 – 23829CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini265 – 27713ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini299 – 31517CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 6126Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei71 – 9121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei117 – 13822Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei162 – 18120Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei190 – 20920Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei239 – 26426Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei278 – 29821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG295510.
    GeneTreeiENSGT00750000117286.
    HOGENOMiHOG000246927.
    HOVERGENiHBG108148.
    InParanoidiQ75NA3.
    KOiK04199.
    OMAiAIWAASI.
    OrthoDBiEOG75MVX0.
    TreeFamiTF332646.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001671. Melcrt_ACTH_rcpt.
    IPR000761. MSH_rcpt.
    [Graphical view]
    PANTHERiPTHR22750:SF2. PTHR22750:SF2. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00534. MCRFAMILY.
    PR00536. MELNOCYTESHR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q01727-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTQEPQKSL LGSLNSNATS HLGLATNQSE PWCLYVSIPD GLFLSLGLVS    50
    LVENVLVVIA ITKNRNLHSP MYYFICCLAL SDLMVSVSIV LETTIILLLE 100
    AGILVARVAL VQQLDNLIDV LICGSMVSSL CFLGIIAIDR YISIFYALRY 150
    HSIVTLPRAR RAVVGIWMVS IVSSTLFITY YKHTAVLLCL VTFFLAMLAL 200
    MAILYAHMFT RACQHAQGIA QLHKRRRSIR QGFCLKGAAT LTILLGIFFL 250
    CWGPFFLHLL LIVLCPQHPT CSCIFKNFNL FLLLIVLSST VDPLIYAFRS 300
    QELRMTLKEV LLCSW 315
    Length:315
    Mass (Da):35,226
    Last modified:July 27, 2011 - v2
    Checksum:i9240C7D02B336235
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti101 – 1011A → V in CAA46589. (PubMed:1325670)Curated
    Sequence conflicti216 – 2161A → V in CAA46589. (PubMed:1325670)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X65635 mRNA. Translation: CAA46589.1.
    AB177607 Genomic DNA. Translation: BAD16659.1.
    AB177608 Genomic DNA. Translation: BAD16660.1.
    AB306322 Genomic DNA. Translation: BAG85190.1.
    CH466525 Genomic DNA. Translation: EDL11741.1.
    BC119294 mRNA. Translation: AAI19295.1.
    BC119296 mRNA. Translation: AAI19297.1.
    CCDSiCCDS22756.1.
    PIRiS25581.
    RefSeqiNP_032585.2. NM_008559.2.
    UniGeneiMm.324942.

    Genome annotation databases

    EnsembliENSMUST00000098324; ENSMUSP00000095929; ENSMUSG00000074037.
    GeneIDi17199.
    KEGGimmu:17199.
    UCSCiuc009nvs.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X65635 mRNA. Translation: CAA46589.1 .
    AB177607 Genomic DNA. Translation: BAD16659.1 .
    AB177608 Genomic DNA. Translation: BAD16660.1 .
    AB306322 Genomic DNA. Translation: BAG85190.1 .
    CH466525 Genomic DNA. Translation: EDL11741.1 .
    BC119294 mRNA. Translation: AAI19295.1 .
    BC119296 mRNA. Translation: AAI19297.1 .
    CCDSi CCDS22756.1.
    PIRi S25581.
    RefSeqi NP_032585.2. NM_008559.2.
    UniGenei Mm.324942.

    3D structure databases

    ProteinModelPortali Q01727.
    SMRi Q01727. Positions 42-311.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201338. 1 interaction.

    Chemistry

    BindingDBi Q01727.
    ChEMBLi CHEMBL4077.
    GuidetoPHARMACOLOGYi 282.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q01727.

    Proteomic databases

    PRIDEi Q01727.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000098324 ; ENSMUSP00000095929 ; ENSMUSG00000074037 .
    GeneIDi 17199.
    KEGGi mmu:17199.
    UCSCi uc009nvs.2. mouse.

    Organism-specific databases

    CTDi 4157.
    MGIi MGI:99456. Mc1r.

    Phylogenomic databases

    eggNOGi NOG295510.
    GeneTreei ENSGT00750000117286.
    HOGENOMi HOG000246927.
    HOVERGENi HBG108148.
    InParanoidi Q75NA3.
    KOi K04199.
    OMAi AIWAASI.
    OrthoDBi EOG75MVX0.
    TreeFami TF332646.

    Miscellaneous databases

    NextBioi 291574.
    PROi Q01727.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q01727.
    CleanExi MM_MC1R.
    Genevestigatori Q01727.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001671. Melcrt_ACTH_rcpt.
    IPR000761. MSH_rcpt.
    [Graphical view ]
    PANTHERi PTHR22750:SF2. PTHR22750:SF2. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00534. MCRFAMILY.
    PR00536. MELNOCYTESHR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The cloning of a family of genes that encode the melanocortin receptors."
      Mountjoy K.G., Robbins L.S., Mortrud M., Cone R.D.
      Science 257:1248-1251(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Skin.
    2. "A nucleotide substitution responsible for the tawny coat color mutation carried by the MSKR inbred strain of mice."
      Wada A., Kunieda T., Nishimura M., Kakizoe-Ishida Y., Watanabe N., Ohkawa K., Tsudzuki M.
      J. Hered. 96:145-149(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: MSM/Ms.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiMSHR_MOUSE
    AccessioniPrimary (citable) accession number: Q01727
    Secondary accession number(s): Q75NA3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3