Melanocyte-stimulating hormone receptor

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Q01727 (MSHR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 103. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Melanocyte-stimulating hormone receptor
Short name=MSH-R

Alternative name(s):
Melanocortin receptor 1
Short name=MC1-R

Gene names

Name:	Mc1r
Synonyms:	Msh-r

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	315 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
Subunit structure	Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Melanocytes and corticoadrenal tissue.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	UV-damage excision repair Inferred from electronic annotation. Source: Compara intracellular protein kinase cascade Inferred from direct assay PubMed 18292087. Source: BHF-UCL melanin biosynthetic process Inferred from mutant phenotype PubMed 7665913. Source: MGI negative regulation of tumor necrosis factor production Inferred from electronic annotation. Source: Compara pigmentation Inferred from mutant phenotype PubMed 9183385. Source: MGI positive regulation of cAMP biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of protein kinase A signaling cascade Inferred from direct assay PubMed 18292087. Source: BHF-UCL positive regulation of protein kinase B signaling cascade Inferred from direct assay PubMed 18292087. Source: BHF-UCL positive regulation of protein kinase C signaling cascade Inferred from direct assay PubMed 18292087. Source: BHF-UCL positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 18292087. Source: BHF-UCL sensory perception of pain Inferred from mutant phenotype PubMed 12663858. Source: MGI
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW microtubule cytoskeleton Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	melanocyte-stimulating hormone receptor activity Inferred from direct assay PubMed 9454589. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 315

315

Melanocyte-stimulating hormone receptor

PRO_0000069834

Regions

Topological domain

1 – 35

Extracellular Potential

Transmembrane

36 – 61

Helical; Name=1; Potential

Topological domain

62 – 70

Cytoplasmic Potential

Transmembrane

71 – 91

Helical; Name=2; Potential

Topological domain

92 – 116

Extracellular Potential

Transmembrane

117 – 138

Helical; Name=3; Potential

Topological domain

139 – 161

Cytoplasmic Potential

Transmembrane

162 – 181

Helical; Name=4; Potential

Topological domain

182 – 189

Extracellular Potential

Transmembrane

190 – 209

Helical; Name=5; Potential

Topological domain

210 – 238

Cytoplasmic Potential

Transmembrane

239 – 264

Helical; Name=6; Potential

Topological domain

265 – 277

Extracellular Potential

Transmembrane

278 – 298

Helical; Name=7; Potential

Topological domain

299 – 315

Cytoplasmic Potential

Amino acid modifications

Lipidation

313

S-palmitoyl cysteine Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict

101

A → V in CAA46589. Ref.1

Sequence conflict

216

A → V in CAA46589. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q01727 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 9240C7D02B336235
Show »

FASTA

315

35,226

        10         20         30         40         50         60 
MSTQEPQKSL LGSLNSNATS HLGLATNQSE PWCLYVSIPD GLFLSLGLVS LVENVLVVIA 

        70         80         90        100        110        120 
ITKNRNLHSP MYYFICCLAL SDLMVSVSIV LETTIILLLE AGILVARVAL VQQLDNLIDV 

       130        140        150        160        170        180 
LICGSMVSSL CFLGIIAIDR YISIFYALRY HSIVTLPRAR RAVVGIWMVS IVSSTLFITY 

       190        200        210        220        230        240 
YKHTAVLLCL VTFFLAMLAL MAILYAHMFT RACQHAQGIA QLHKRRRSIR QGFCLKGAAT 

       250        260        270        280        290        300 
LTILLGIFFL CWGPFFLHLL LIVLCPQHPT CSCIFKNFNL FLLLIVLSST VDPLIYAFRS 

       310 
QELRMTLKEV LLCSW

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The cloning of a family of genes that encode the melanocortin receptors." Mountjoy K.G., Robbins L.S., Mortrud M., Cone R.D. Science 257:1248-1251(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Skin.
[2]	"A nucleotide substitution responsible for the tawny coat color mutation carried by the MSKR inbred strain of mice." Wada A., Kunieda T., Nishimura M., Kakizoe-Ishida Y., Watanabe N., Ohkawa K., Tsudzuki M. J. Hered. 96:145-149(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: MSM/Ms.
[3]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X65635 mRNA. Translation: CAA46589.1. AB177607 Genomic DNA. Translation: BAD16659.1. AB177608 Genomic DNA. Translation: BAD16660.1. AB306322 Genomic DNA. Translation: BAG85190.1. CH466525 Genomic DNA. Translation: EDL11741.1. BC119294 mRNA. Translation: AAI19295.1. BC119296 mRNA. Translation: AAI19297.1.
IPI	IPI00127252.
PIR	S25581.
RefSeq	NP_032585.2. NM_008559.2.
UniGene	Mm.324942.
3D structure databases
ProteinModelPortal	Q01727.
SMR	Q01727. Positions 42-311.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q01727.
Proteomic databases
PRIDE	Q01727.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000098324; ENSMUSP00000095929; ENSMUSG00000074037.
GeneID	17199.
KEGG	mmu:17199.
Organism-specific databases
CTD	4157.
MGI	MGI:99456. Mc1r.
Phylogenomic databases
eggNOG	NOG295510.
GeneTree	ENSGT00700000104085.
HOGENOM	HOG000246927.
HOVERGEN	HBG108148.
InParanoid	Q75NA3.
KO	K04199.
OMA	AITKNRN.
OrthoDB	EOG4ZPDW6.
Gene expression databases
ArrayExpress	Q01727.
Bgee	Q01727.
CleanEx	MM_MC1R.
Genevestigator	Q01727.
GermOnline	ENSMUSG00000074037. Mus musculus.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR001671. Melcrt_ACTH_rcpt. IPR000761. MSH_rcpt. [Graphical view]
PANTHER	PTHR22750:SF2. PTHR22750:SF2. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00534. MCRFAMILY. PR00536. MELNOCYTESHR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q01727.
ChEMBL	CHEMBL4077.
NextBio	291574.
SOURCE	Search...

Entry information

Entry name

MSHR_MOUSE

Accession

Primary (citable) accession number: Q01727
Secondary accession number(s): Q75NA3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 103 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents