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Protein

Melanocyte-stimulating hormone receptor

Gene

Mc1r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

GO - Molecular functioni

  • melanocortin receptor activity Source: BHF-UCL
  • melanocyte-stimulating hormone receptor activity Source: MGI
  • ubiquitin protein ligase binding Source: MGI

GO - Biological processi

  • intracellular signal transduction Source: BHF-UCL
  • melanin biosynthetic process Source: MGI
  • negative regulation of tumor necrosis factor production Source: MGI
  • pigmentation Source: MGI
  • positive regulation of cAMP biosynthetic process Source: MGI
  • positive regulation of protein kinase A signaling Source: BHF-UCL
  • positive regulation of protein kinase B signaling Source: BHF-UCL
  • positive regulation of protein kinase C signaling Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • sensory perception of pain Source: MGI
  • UV-damage excision repair Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Melanocyte-stimulating hormone receptor
Short name:
MSH-R
Alternative name(s):
Melanocortin receptor 1
Short name:
MC1-R
Gene namesi
Name:Mc1r
Synonyms:Msh-r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:99456. Mc1r.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35ExtracellularSequence analysisAdd BLAST35
Transmembranei36 – 61Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini62 – 70CytoplasmicSequence analysis9
Transmembranei71 – 91Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini92 – 116ExtracellularSequence analysisAdd BLAST25
Transmembranei117 – 138Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini139 – 161CytoplasmicSequence analysisAdd BLAST23
Transmembranei162 – 181Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini182 – 189ExtracellularSequence analysis8
Transmembranei190 – 209Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini210 – 238CytoplasmicSequence analysisAdd BLAST29
Transmembranei239 – 264Helical; Name=6Sequence analysisAdd BLAST26
Topological domaini265 – 277ExtracellularSequence analysisAdd BLAST13
Transmembranei278 – 298Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini299 – 315CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4077.
GuidetoPHARMACOLOGYi282.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000698341 – 315Melanocyte-stimulating hormone receptorAdd BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi17N-linked (GlcNAc...)Sequence analysis1
Glycosylationi27N-linked (GlcNAc...)Sequence analysis1
Lipidationi313S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ01727.
PRIDEiQ01727.

PTM databases

PhosphoSitePlusiQ01727.

Expressioni

Tissue specificityi

Melanocytes and corticoadrenal tissue.

Gene expression databases

BgeeiENSMUSG00000074037.
CleanExiMM_MC1R.
ExpressionAtlasiQ01727. baseline and differential.
GenevisibleiQ01727. MM.

Interactioni

Subunit structurei

Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201338. 1 interactor.
STRINGi10090.ENSMUSP00000095929.

Chemistry databases

BindingDBiQ01727.

Structurei

3D structure databases

ProteinModelPortaliQ01727.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00770000120529.
HOGENOMiHOG000246927.
HOVERGENiHBG108148.
InParanoidiQ01727.
KOiK04199.
OMAiANQTGPR.
OrthoDBiEOG091G0BVW.
TreeFamiTF332646.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001671. Melcrt_ACTH_rcpt.
IPR000761. MSH_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF2. PTHR22750:SF2. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00536. MELNOCYTESHR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01727-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTQEPQKSL LGSLNSNATS HLGLATNQSE PWCLYVSIPD GLFLSLGLVS
60 70 80 90 100
LVENVLVVIA ITKNRNLHSP MYYFICCLAL SDLMVSVSIV LETTIILLLE
110 120 130 140 150
AGILVARVAL VQQLDNLIDV LICGSMVSSL CFLGIIAIDR YISIFYALRY
160 170 180 190 200
HSIVTLPRAR RAVVGIWMVS IVSSTLFITY YKHTAVLLCL VTFFLAMLAL
210 220 230 240 250
MAILYAHMFT RACQHAQGIA QLHKRRRSIR QGFCLKGAAT LTILLGIFFL
260 270 280 290 300
CWGPFFLHLL LIVLCPQHPT CSCIFKNFNL FLLLIVLSST VDPLIYAFRS
310
QELRMTLKEV LLCSW
Length:315
Mass (Da):35,226
Last modified:July 27, 2011 - v2
Checksum:i9240C7D02B336235
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti101A → V in CAA46589 (PubMed:1325670).Curated1
Sequence conflicti216A → V in CAA46589 (PubMed:1325670).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65635 mRNA. Translation: CAA46589.1.
AB177607 Genomic DNA. Translation: BAD16659.1.
AB177608 Genomic DNA. Translation: BAD16660.1.
AB306322 Genomic DNA. Translation: BAG85190.1.
CH466525 Genomic DNA. Translation: EDL11741.1.
BC119294 mRNA. Translation: AAI19295.1.
BC119296 mRNA. Translation: AAI19297.1.
CCDSiCCDS22756.1.
PIRiS25581.
RefSeqiNP_032585.2. NM_008559.2.
UniGeneiMm.324942.

Genome annotation databases

EnsembliENSMUST00000098324; ENSMUSP00000095929; ENSMUSG00000074037.
GeneIDi17199.
KEGGimmu:17199.
UCSCiuc009nvs.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65635 mRNA. Translation: CAA46589.1.
AB177607 Genomic DNA. Translation: BAD16659.1.
AB177608 Genomic DNA. Translation: BAD16660.1.
AB306322 Genomic DNA. Translation: BAG85190.1.
CH466525 Genomic DNA. Translation: EDL11741.1.
BC119294 mRNA. Translation: AAI19295.1.
BC119296 mRNA. Translation: AAI19297.1.
CCDSiCCDS22756.1.
PIRiS25581.
RefSeqiNP_032585.2. NM_008559.2.
UniGeneiMm.324942.

3D structure databases

ProteinModelPortaliQ01727.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201338. 1 interactor.
STRINGi10090.ENSMUSP00000095929.

Chemistry databases

BindingDBiQ01727.
ChEMBLiCHEMBL4077.
GuidetoPHARMACOLOGYi282.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ01727.

Proteomic databases

PaxDbiQ01727.
PRIDEiQ01727.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098324; ENSMUSP00000095929; ENSMUSG00000074037.
GeneIDi17199.
KEGGimmu:17199.
UCSCiuc009nvs.2. mouse.

Organism-specific databases

CTDi4157.
MGIiMGI:99456. Mc1r.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00770000120529.
HOGENOMiHOG000246927.
HOVERGENiHBG108148.
InParanoidiQ01727.
KOiK04199.
OMAiANQTGPR.
OrthoDBiEOG091G0BVW.
TreeFamiTF332646.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiQ01727.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000074037.
CleanExiMM_MC1R.
ExpressionAtlasiQ01727. baseline and differential.
GenevisibleiQ01727. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001671. Melcrt_ACTH_rcpt.
IPR000761. MSH_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF2. PTHR22750:SF2. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00536. MELNOCYTESHR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSHR_MOUSE
AccessioniPrimary (citable) accession number: Q01727
Secondary accession number(s): Q75NA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.