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Protein

Melanocyte-stimulating hormone receptor

Gene

Mc1r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

GO - Molecular functioni

  • hormone binding Source: Ensembl
  • melanocortin receptor activity Source: BHF-UCL
  • melanocyte-stimulating hormone receptor activity Source: MGI
  • ubiquitin protein ligase binding Source: MGI

GO - Biological processi

  • intracellular signal transduction Source: BHF-UCL
  • melanin biosynthetic process Source: MGI
  • negative regulation of tumor necrosis factor production Source: MGI
  • pigmentation Source: MGI
  • positive regulation of cAMP biosynthetic process Source: MGI
  • positive regulation of feeding behavior Source: Ensembl
  • positive regulation of protein kinase A signaling Source: BHF-UCL
  • positive regulation of protein kinase B signaling Source: BHF-UCL
  • positive regulation of protein kinase C signaling Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • sensory perception of pain Source: MGI
  • UV-damage excision repair Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_313192. G alpha (s) signalling events.
REACT_319210. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Melanocyte-stimulating hormone receptor
Short name:
MSH-R
Alternative name(s):
Melanocortin receptor 1
Short name:
MC1-R
Gene namesi
Name:Mc1r
Synonyms:Msh-r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:99456. Mc1r.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535ExtracellularSequence AnalysisAdd
BLAST
Transmembranei36 – 6126Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini62 – 709CytoplasmicSequence Analysis
Transmembranei71 – 9121Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini92 – 11625ExtracellularSequence AnalysisAdd
BLAST
Transmembranei117 – 13822Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini139 – 16123CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei162 – 18120Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini182 – 1898ExtracellularSequence Analysis
Transmembranei190 – 20920Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini210 – 23829CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei239 – 26426Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini265 – 27713ExtracellularSequence AnalysisAdd
BLAST
Transmembranei278 – 29821Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini299 – 31517CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: GOC
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Melanocyte-stimulating hormone receptorPRO_0000069834Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi27 – 271N-linked (GlcNAc...)Sequence Analysis
Lipidationi313 – 3131S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiQ01727.

PTM databases

PhosphoSiteiQ01727.

Expressioni

Tissue specificityi

Melanocytes and corticoadrenal tissue.

Gene expression databases

BgeeiQ01727.
CleanExiMM_MC1R.
ExpressionAtlasiQ01727. baseline and differential.
GenevisibleiQ01727. MM.

Interactioni

Subunit structurei

Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production.By similarity

Protein-protein interaction databases

BioGridi201338. 1 interaction.
STRINGi10090.ENSMUSP00000095929.

Structurei

3D structure databases

ProteinModelPortaliQ01727.
SMRiQ01727. Positions 42-311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG295510.
GeneTreeiENSGT00770000120529.
HOGENOMiHOG000246927.
HOVERGENiHBG108148.
InParanoidiQ01727.
KOiK04199.
OMAiAIWAASI.
OrthoDBiEOG75MVX0.
TreeFamiTF332646.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001671. Melcrt_ACTH_rcpt.
IPR000761. MSH_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF2. PTHR22750:SF2. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00536. MELNOCYTESHR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01727-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTQEPQKSL LGSLNSNATS HLGLATNQSE PWCLYVSIPD GLFLSLGLVS
60 70 80 90 100
LVENVLVVIA ITKNRNLHSP MYYFICCLAL SDLMVSVSIV LETTIILLLE
110 120 130 140 150
AGILVARVAL VQQLDNLIDV LICGSMVSSL CFLGIIAIDR YISIFYALRY
160 170 180 190 200
HSIVTLPRAR RAVVGIWMVS IVSSTLFITY YKHTAVLLCL VTFFLAMLAL
210 220 230 240 250
MAILYAHMFT RACQHAQGIA QLHKRRRSIR QGFCLKGAAT LTILLGIFFL
260 270 280 290 300
CWGPFFLHLL LIVLCPQHPT CSCIFKNFNL FLLLIVLSST VDPLIYAFRS
310
QELRMTLKEV LLCSW
Length:315
Mass (Da):35,226
Last modified:July 27, 2011 - v2
Checksum:i9240C7D02B336235
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti101 – 1011A → V in CAA46589 (PubMed:1325670).Curated
Sequence conflicti216 – 2161A → V in CAA46589 (PubMed:1325670).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65635 mRNA. Translation: CAA46589.1.
AB177607 Genomic DNA. Translation: BAD16659.1.
AB177608 Genomic DNA. Translation: BAD16660.1.
AB306322 Genomic DNA. Translation: BAG85190.1.
CH466525 Genomic DNA. Translation: EDL11741.1.
BC119294 mRNA. Translation: AAI19295.1.
BC119296 mRNA. Translation: AAI19297.1.
CCDSiCCDS22756.1.
PIRiS25581.
RefSeqiNP_032585.2. NM_008559.2.
UniGeneiMm.324942.

Genome annotation databases

EnsembliENSMUST00000098324; ENSMUSP00000095929; ENSMUSG00000074037.
GeneIDi17199.
KEGGimmu:17199.
UCSCiuc009nvs.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65635 mRNA. Translation: CAA46589.1.
AB177607 Genomic DNA. Translation: BAD16659.1.
AB177608 Genomic DNA. Translation: BAD16660.1.
AB306322 Genomic DNA. Translation: BAG85190.1.
CH466525 Genomic DNA. Translation: EDL11741.1.
BC119294 mRNA. Translation: AAI19295.1.
BC119296 mRNA. Translation: AAI19297.1.
CCDSiCCDS22756.1.
PIRiS25581.
RefSeqiNP_032585.2. NM_008559.2.
UniGeneiMm.324942.

3D structure databases

ProteinModelPortaliQ01727.
SMRiQ01727. Positions 42-311.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201338. 1 interaction.
STRINGi10090.ENSMUSP00000095929.

Chemistry

BindingDBiQ01727.
ChEMBLiCHEMBL4077.
GuidetoPHARMACOLOGYi282.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ01727.

Proteomic databases

PRIDEiQ01727.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098324; ENSMUSP00000095929; ENSMUSG00000074037.
GeneIDi17199.
KEGGimmu:17199.
UCSCiuc009nvs.2. mouse.

Organism-specific databases

CTDi4157.
MGIiMGI:99456. Mc1r.

Phylogenomic databases

eggNOGiNOG295510.
GeneTreeiENSGT00770000120529.
HOGENOMiHOG000246927.
HOVERGENiHBG108148.
InParanoidiQ01727.
KOiK04199.
OMAiAIWAASI.
OrthoDBiEOG75MVX0.
TreeFamiTF332646.

Enzyme and pathway databases

ReactomeiREACT_313192. G alpha (s) signalling events.
REACT_319210. Peptide ligand-binding receptors.

Miscellaneous databases

NextBioi291574.
PROiQ01727.
SOURCEiSearch...

Gene expression databases

BgeeiQ01727.
CleanExiMM_MC1R.
ExpressionAtlasiQ01727. baseline and differential.
GenevisibleiQ01727. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001671. Melcrt_ACTH_rcpt.
IPR000761. MSH_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF2. PTHR22750:SF2. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00536. MELNOCYTESHR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The cloning of a family of genes that encode the melanocortin receptors."
    Mountjoy K.G., Robbins L.S., Mortrud M., Cone R.D.
    Science 257:1248-1251(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skin.
  2. "A nucleotide substitution responsible for the tawny coat color mutation carried by the MSKR inbred strain of mice."
    Wada A., Kunieda T., Nishimura M., Kakizoe-Ishida Y., Watanabe N., Ohkawa K., Tsudzuki M.
    J. Hered. 96:145-149(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: MSM/Ms.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiMSHR_MOUSE
AccessioniPrimary (citable) accession number: Q01727
Secondary accession number(s): Q75NA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 27, 2011
Last modified: June 24, 2015
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.