SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q01727

- MSHR_MOUSE

UniProt

Q01727 - MSHR_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Melanocyte-stimulating hormone receptor
Gene
Mc1r, Msh-r
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

GO - Molecular functioni

  1. melanocortin receptor activity Source: BHF-UCL
  2. melanocyte-stimulating hormone receptor activity Source: MGI
  3. protein binding Source: MGI

GO - Biological processi

  1. UV-damage excision repair Source: Ensembl
  2. intracellular signal transduction Source: BHF-UCL
  3. melanin biosynthetic process Source: MGI
  4. negative regulation of tumor necrosis factor production Source: Ensembl
  5. pigmentation Source: MGI
  6. positive regulation of cAMP biosynthetic process Source: Ensembl
  7. positive regulation of protein kinase A signaling Source: BHF-UCL
  8. positive regulation of protein kinase B signaling Source: BHF-UCL
  9. positive regulation of protein kinase C signaling Source: BHF-UCL
  10. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  11. sensory perception of pain Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Melanocyte-stimulating hormone receptor
Short name:
MSH-R
Alternative name(s):
Melanocortin receptor 1
Short name:
MC1-R
Gene namesi
Name:Mc1r
Synonyms:Msh-r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:99456. Mc1r.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535Extracellular Reviewed prediction
Add
BLAST
Transmembranei36 – 6126Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini62 – 709Cytoplasmic Reviewed prediction
Transmembranei71 – 9121Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini92 – 11625Extracellular Reviewed prediction
Add
BLAST
Transmembranei117 – 13822Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini139 – 16123Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei162 – 18120Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini182 – 1898Extracellular Reviewed prediction
Transmembranei190 – 20920Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini210 – 23829Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei239 – 26426Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini265 – 27713Extracellular Reviewed prediction
Add
BLAST
Transmembranei278 – 29821Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini299 – 31517Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. microtubule cytoskeleton Source: Ensembl
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Melanocyte-stimulating hormone receptor
PRO_0000069834Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi17 – 171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi27 – 271N-linked (GlcNAc...) Reviewed prediction
Lipidationi313 – 3131S-palmitoyl cysteine Reviewed prediction

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiQ01727.

PTM databases

PhosphoSiteiQ01727.

Expressioni

Tissue specificityi

Melanocytes and corticoadrenal tissue.

Gene expression databases

BgeeiQ01727.
CleanExiMM_MC1R.
GenevestigatoriQ01727.

Interactioni

Subunit structurei

Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production By similarity.

Protein-protein interaction databases

BioGridi201338. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ01727.
SMRiQ01727. Positions 42-311.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG295510.
GeneTreeiENSGT00750000117286.
HOGENOMiHOG000246927.
HOVERGENiHBG108148.
InParanoidiQ75NA3.
KOiK04199.
OMAiAIWAASI.
OrthoDBiEOG75MVX0.
TreeFamiTF332646.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001671. Melcrt_ACTH_rcpt.
IPR000761. MSH_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF2. PTHR22750:SF2. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00536. MELNOCYTESHR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01727-1 [UniParc]FASTAAdd to Basket

« Hide

MSTQEPQKSL LGSLNSNATS HLGLATNQSE PWCLYVSIPD GLFLSLGLVS    50
LVENVLVVIA ITKNRNLHSP MYYFICCLAL SDLMVSVSIV LETTIILLLE 100
AGILVARVAL VQQLDNLIDV LICGSMVSSL CFLGIIAIDR YISIFYALRY 150
HSIVTLPRAR RAVVGIWMVS IVSSTLFITY YKHTAVLLCL VTFFLAMLAL 200
MAILYAHMFT RACQHAQGIA QLHKRRRSIR QGFCLKGAAT LTILLGIFFL 250
CWGPFFLHLL LIVLCPQHPT CSCIFKNFNL FLLLIVLSST VDPLIYAFRS 300
QELRMTLKEV LLCSW 315
Length:315
Mass (Da):35,226
Last modified:July 27, 2011 - v2
Checksum:i9240C7D02B336235
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti101 – 1011A → V in CAA46589. 1 Publication
Sequence conflicti216 – 2161A → V in CAA46589. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X65635 mRNA. Translation: CAA46589.1.
AB177607 Genomic DNA. Translation: BAD16659.1.
AB177608 Genomic DNA. Translation: BAD16660.1.
AB306322 Genomic DNA. Translation: BAG85190.1.
CH466525 Genomic DNA. Translation: EDL11741.1.
BC119294 mRNA. Translation: AAI19295.1.
BC119296 mRNA. Translation: AAI19297.1.
CCDSiCCDS22756.1.
PIRiS25581.
RefSeqiNP_032585.2. NM_008559.2.
UniGeneiMm.324942.

Genome annotation databases

EnsembliENSMUST00000098324; ENSMUSP00000095929; ENSMUSG00000074037.
GeneIDi17199.
KEGGimmu:17199.
UCSCiuc009nvs.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X65635 mRNA. Translation: CAA46589.1 .
AB177607 Genomic DNA. Translation: BAD16659.1 .
AB177608 Genomic DNA. Translation: BAD16660.1 .
AB306322 Genomic DNA. Translation: BAG85190.1 .
CH466525 Genomic DNA. Translation: EDL11741.1 .
BC119294 mRNA. Translation: AAI19295.1 .
BC119296 mRNA. Translation: AAI19297.1 .
CCDSi CCDS22756.1.
PIRi S25581.
RefSeqi NP_032585.2. NM_008559.2.
UniGenei Mm.324942.

3D structure databases

ProteinModelPortali Q01727.
SMRi Q01727. Positions 42-311.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201338. 1 interaction.

Chemistry

BindingDBi Q01727.
ChEMBLi CHEMBL4077.
GuidetoPHARMACOLOGYi 282.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q01727.

Proteomic databases

PRIDEi Q01727.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000098324 ; ENSMUSP00000095929 ; ENSMUSG00000074037 .
GeneIDi 17199.
KEGGi mmu:17199.
UCSCi uc009nvs.2. mouse.

Organism-specific databases

CTDi 4157.
MGIi MGI:99456. Mc1r.

Phylogenomic databases

eggNOGi NOG295510.
GeneTreei ENSGT00750000117286.
HOGENOMi HOG000246927.
HOVERGENi HBG108148.
InParanoidi Q75NA3.
KOi K04199.
OMAi AIWAASI.
OrthoDBi EOG75MVX0.
TreeFami TF332646.

Miscellaneous databases

NextBioi 291574.
PROi Q01727.
SOURCEi Search...

Gene expression databases

Bgeei Q01727.
CleanExi MM_MC1R.
Genevestigatori Q01727.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001671. Melcrt_ACTH_rcpt.
IPR000761. MSH_rcpt.
[Graphical view ]
PANTHERi PTHR22750:SF2. PTHR22750:SF2. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00536. MELNOCYTESHR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The cloning of a family of genes that encode the melanocortin receptors."
    Mountjoy K.G., Robbins L.S., Mortrud M., Cone R.D.
    Science 257:1248-1251(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skin.
  2. "A nucleotide substitution responsible for the tawny coat color mutation carried by the MSKR inbred strain of mice."
    Wada A., Kunieda T., Nishimura M., Kakizoe-Ishida Y., Watanabe N., Ohkawa K., Tsudzuki M.
    J. Hered. 96:145-149(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: MSM/Ms.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiMSHR_MOUSE
AccessioniPrimary (citable) accession number: Q01727
Secondary accession number(s): Q75NA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi