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Q01727 (MSHR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Melanocyte-stimulating hormone receptor

Short name=MSH-R
Alternative name(s):
Melanocortin receptor 1
Short name=MC1-R
Gene names
Name:Mc1r
Synonyms:Msh-r
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

Subunit structure

Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Melanocytes and corticoadrenal tissue.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processUV-damage excision repair

Inferred from electronic annotation. Source: Ensembl

intracellular signal transduction

Inferred from direct assay PubMed 18292087. Source: BHF-UCL

melanin biosynthetic process

Inferred from mutant phenotype PubMed 7665913. Source: MGI

negative regulation of tumor necrosis factor production

Inferred from electronic annotation. Source: Ensembl

pigmentation

Inferred from mutant phenotype PubMed 9183385. Source: MGI

positive regulation of cAMP biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein kinase A signaling

Inferred from direct assay PubMed 18292087. Source: BHF-UCL

positive regulation of protein kinase B signaling

Inferred from direct assay PubMed 18292087. Source: BHF-UCL

positive regulation of protein kinase C signaling

Inferred from direct assay PubMed 18292087. Source: BHF-UCL

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 18292087. Source: BHF-UCL

sensory perception of pain

Inferred from mutant phenotype PubMed 12663858. Source: MGI

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

microtubule cytoskeleton

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmelanocortin receptor activity

Inferred from direct assay PubMed 18292087. Source: BHF-UCL

melanocyte-stimulating hormone receptor activity

Inferred from direct assay PubMed 9454589. Source: MGI

protein binding

Inferred from physical interaction PubMed 9454589. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315Melanocyte-stimulating hormone receptor
PRO_0000069834

Regions

Topological domain1 – 3535Extracellular Potential
Transmembrane36 – 6126Helical; Name=1; Potential
Topological domain62 – 709Cytoplasmic Potential
Transmembrane71 – 9121Helical; Name=2; Potential
Topological domain92 – 11625Extracellular Potential
Transmembrane117 – 13822Helical; Name=3; Potential
Topological domain139 – 16123Cytoplasmic Potential
Transmembrane162 – 18120Helical; Name=4; Potential
Topological domain182 – 1898Extracellular Potential
Transmembrane190 – 20920Helical; Name=5; Potential
Topological domain210 – 23829Cytoplasmic Potential
Transmembrane239 – 26426Helical; Name=6; Potential
Topological domain265 – 27713Extracellular Potential
Transmembrane278 – 29821Helical; Name=7; Potential
Topological domain299 – 31517Cytoplasmic Potential

Amino acid modifications

Lipidation3131S-palmitoyl cysteine Potential
Glycosylation171N-linked (GlcNAc...) Potential
Glycosylation271N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1011A → V in CAA46589. Ref.1
Sequence conflict2161A → V in CAA46589. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q01727 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 9240C7D02B336235

FASTA31535,226
        10         20         30         40         50         60 
MSTQEPQKSL LGSLNSNATS HLGLATNQSE PWCLYVSIPD GLFLSLGLVS LVENVLVVIA 

        70         80         90        100        110        120 
ITKNRNLHSP MYYFICCLAL SDLMVSVSIV LETTIILLLE AGILVARVAL VQQLDNLIDV 

       130        140        150        160        170        180 
LICGSMVSSL CFLGIIAIDR YISIFYALRY HSIVTLPRAR RAVVGIWMVS IVSSTLFITY 

       190        200        210        220        230        240 
YKHTAVLLCL VTFFLAMLAL MAILYAHMFT RACQHAQGIA QLHKRRRSIR QGFCLKGAAT 

       250        260        270        280        290        300 
LTILLGIFFL CWGPFFLHLL LIVLCPQHPT CSCIFKNFNL FLLLIVLSST VDPLIYAFRS 

       310 
QELRMTLKEV LLCSW 

« Hide

References

« Hide 'large scale' references
[1]"The cloning of a family of genes that encode the melanocortin receptors."
Mountjoy K.G., Robbins L.S., Mortrud M., Cone R.D.
Science 257:1248-1251(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Skin.
[2]"A nucleotide substitution responsible for the tawny coat color mutation carried by the MSKR inbred strain of mice."
Wada A., Kunieda T., Nishimura M., Kakizoe-Ishida Y., Watanabe N., Ohkawa K., Tsudzuki M.
J. Hered. 96:145-149(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: MSM/Ms.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X65635 mRNA. Translation: CAA46589.1.
AB177607 Genomic DNA. Translation: BAD16659.1.
AB177608 Genomic DNA. Translation: BAD16660.1.
AB306322 Genomic DNA. Translation: BAG85190.1.
CH466525 Genomic DNA. Translation: EDL11741.1.
BC119294 mRNA. Translation: AAI19295.1.
BC119296 mRNA. Translation: AAI19297.1.
CCDSCCDS22756.1.
PIRS25581.
RefSeqNP_032585.2. NM_008559.2.
UniGeneMm.324942.

3D structure databases

ProteinModelPortalQ01727.
SMRQ01727. Positions 42-311.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid201338. 1 interaction.

Chemistry

BindingDBQ01727.
ChEMBLCHEMBL4077.
GuidetoPHARMACOLOGY282.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ01727.

Proteomic databases

PRIDEQ01727.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000098324; ENSMUSP00000095929; ENSMUSG00000074037.
GeneID17199.
KEGGmmu:17199.
UCSCuc009nvs.2. mouse.

Organism-specific databases

CTD4157.
MGIMGI:99456. Mc1r.

Phylogenomic databases

eggNOGNOG295510.
GeneTreeENSGT00750000117286.
HOGENOMHOG000246927.
HOVERGENHBG108148.
InParanoidQ75NA3.
KOK04199.
OMAAIWAASI.
OrthoDBEOG75MVX0.
TreeFamTF332646.

Gene expression databases

BgeeQ01727.
CleanExMM_MC1R.
GenevestigatorQ01727.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001671. Melcrt_ACTH_rcpt.
IPR000761. MSH_rcpt.
[Graphical view]
PANTHERPTHR22750:SF2. PTHR22750:SF2. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00536. MELNOCYTESHR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio291574.
PROQ01727.
SOURCESearch...

Entry information

Entry nameMSHR_MOUSE
AccessionPrimary (citable) accession number: Q01727
Secondary accession number(s): Q75NA3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries