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Protein

Melanocyte-stimulating hormone receptor

Gene

Mc1r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

GO - Molecular functioni

  • melanocortin receptor activity Source: BHF-UCL
  • melanocyte-stimulating hormone receptor activity Source: MGI
  • ubiquitin protein ligase binding Source: MGI

GO - Biological processi

  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  • intracellular signal transduction Source: BHF-UCL
  • melanin biosynthetic process Source: MGI
  • negative regulation of tumor necrosis factor production Source: MGI
  • pigmentation Source: MGI
  • positive regulation of protein kinase A signaling Source: BHF-UCL
  • positive regulation of protein kinase B signaling Source: BHF-UCL
  • positive regulation of protein kinase C signaling Source: BHF-UCL
  • positive regulation of transcription by RNA polymerase II Source: BHF-UCL
  • sensory perception of pain Source: MGI
  • UV-damage excision repair Source: MGI

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Melanocyte-stimulating hormone receptor
Short name:
MSH-R
Alternative name(s):
Melanocortin receptor 1
Short name:
MC1-R
Gene namesi
Name:Mc1r
Synonyms:Msh-r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:99456 Mc1r

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35ExtracellularSequence analysisAdd BLAST35
Transmembranei36 – 61Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini62 – 70CytoplasmicSequence analysis9
Transmembranei71 – 91Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini92 – 116ExtracellularSequence analysisAdd BLAST25
Transmembranei117 – 138Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini139 – 161CytoplasmicSequence analysisAdd BLAST23
Transmembranei162 – 181Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini182 – 189ExtracellularSequence analysis8
Transmembranei190 – 209Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini210 – 238CytoplasmicSequence analysisAdd BLAST29
Transmembranei239 – 264Helical; Name=6Sequence analysisAdd BLAST26
Topological domaini265 – 277ExtracellularSequence analysisAdd BLAST13
Transmembranei278 – 298Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini299 – 315CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4077
GuidetoPHARMACOLOGYi282

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000698341 – 315Melanocyte-stimulating hormone receptorAdd BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi17N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi27N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi313S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ01727
PRIDEiQ01727

PTM databases

PhosphoSitePlusiQ01727

Expressioni

Tissue specificityi

Melanocytes and corticoadrenal tissue.

Gene expression databases

BgeeiENSMUSG00000074037
CleanExiMM_MC1R
ExpressionAtlasiQ01727 baseline and differential
GenevisibleiQ01727 MM

Interactioni

Subunit structurei

Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201338, 1 interactor
STRINGi10090.ENSMUSP00000095929

Chemistry databases

BindingDBiQ01727

Structurei

3D structure databases

ProteinModelPortaliQ01727
SMRiQ01727
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00770000120529
HOGENOMiHOG000246927
HOVERGENiHBG108148
InParanoidiQ01727
KOiK04199
OMAiLCTIAAD
OrthoDBiEOG091G0BVW
TreeFamiTF332646

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001671 Melcrt_ACTH_rcpt
IPR000761 MSH_rcpt
PANTHERiPTHR22750:SF2 PTHR22750:SF2, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00534 MCRFAMILY
PR00536 MELNOCYTESHR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q01727-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTQEPQKSL LGSLNSNATS HLGLATNQSE PWCLYVSIPD GLFLSLGLVS
60 70 80 90 100
LVENVLVVIA ITKNRNLHSP MYYFICCLAL SDLMVSVSIV LETTIILLLE
110 120 130 140 150
AGILVARVAL VQQLDNLIDV LICGSMVSSL CFLGIIAIDR YISIFYALRY
160 170 180 190 200
HSIVTLPRAR RAVVGIWMVS IVSSTLFITY YKHTAVLLCL VTFFLAMLAL
210 220 230 240 250
MAILYAHMFT RACQHAQGIA QLHKRRRSIR QGFCLKGAAT LTILLGIFFL
260 270 280 290 300
CWGPFFLHLL LIVLCPQHPT CSCIFKNFNL FLLLIVLSST VDPLIYAFRS
310
QELRMTLKEV LLCSW
Length:315
Mass (Da):35,226
Last modified:July 27, 2011 - v2
Checksum:i9240C7D02B336235
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti101A → V in CAA46589 (PubMed:1325670).Curated1
Sequence conflicti216A → V in CAA46589 (PubMed:1325670).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65635 mRNA Translation: CAA46589.1
AB177607 Genomic DNA Translation: BAD16659.1
AB177608 Genomic DNA Translation: BAD16660.1
AB306322 Genomic DNA Translation: BAG85190.1
CH466525 Genomic DNA Translation: EDL11741.1
BC119294 mRNA Translation: AAI19295.1
BC119296 mRNA Translation: AAI19297.1
CCDSiCCDS22756.1
PIRiS25581
RefSeqiNP_032585.2, NM_008559.2
UniGeneiMm.324942

Genome annotation databases

EnsembliENSMUST00000098324; ENSMUSP00000095929; ENSMUSG00000074037
GeneIDi17199
KEGGimmu:17199
UCSCiuc009nvs.2 mouse

Similar proteinsi

Entry informationi

Entry nameiMSHR_MOUSE
AccessioniPrimary (citable) accession number: Q01727
Secondary accession number(s): Q75NA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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