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Protein

Melanocyte-stimulating hormone receptor

Gene

MC1R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

GO - Molecular functioni

  • G-protein coupled peptide receptor activity Source: BHF-UCL
  • melanocortin receptor activity Source: ProtInc
  • melanocyte-stimulating hormone receptor activity Source: BHF-UCL
  • ubiquitin protein ligase binding Source: UniProtKB

GO - Biological processi

  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
  • intracellular signal transduction Source: BHF-UCL
  • melanin biosynthetic process Source: Ensembl
  • multicellular organism development Source: ProtInc
  • negative regulation of tumor necrosis factor production Source: BHF-UCL
  • pigmentation Source: BHF-UCL
  • positive regulation of cAMP biosynthetic process Source: BHF-UCL
  • positive regulation of protein kinase A signaling Source: BHF-UCL
  • positive regulation of protein kinase B signaling Source: BHF-UCL
  • positive regulation of protein kinase C signaling Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • sensory perception of pain Source: Ensembl
  • UV-damage excision repair Source: BHF-UCL
  • UV protection Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:G66-32018-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Melanocyte-stimulating hormone receptor
Short name:
MSH-R
Alternative name(s):
Melanocortin receptor 1
Short name:
MC1-R
Gene namesi
Name:MC1R
Synonyms:MSHR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:6929. MC1R.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37ExtracellularSequence analysisAdd BLAST37
Transmembranei38 – 63Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini64 – 72CytoplasmicSequence analysis9
Transmembranei73 – 93Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini94 – 118ExtracellularSequence analysisAdd BLAST25
Transmembranei119 – 140Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini141 – 163CytoplasmicSequence analysisAdd BLAST23
Transmembranei164 – 183Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini184 – 191ExtracellularSequence analysis8
Transmembranei192 – 211Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini212 – 240CytoplasmicSequence analysisAdd BLAST29
Transmembranei241 – 266Helical; Name=6Sequence analysisAdd BLAST26
Topological domaini267 – 279ExtracellularSequence analysisAdd BLAST13
Transmembranei280 – 300Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini301 – 317CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • intracellular Source: GOC
  • plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Melanoma, cutaneous malignant 5 (CMM5)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites.
See also OMIM:613099
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05901838V → M in CMM5; moderate decrease in coupling to the cAMP pathway; reduced cell surface expression as a consequence of retention in the endoplasmic reticulum. 1 PublicationCorresponds to variant rs200050206dbSNPEnsembl.1
Natural variantiVAR_05901941S → F in CMM5; complete absence of functional coupling to the cAMP pathway; reduced cell surface expression as a consequence of retention in the endoplasmic reticulum. 2 Publications1
Natural variantiVAR_05902051V → A in CMM5; moderate decrease in coupling to the cAMP pathway; reduced cell surface expression as a consequence of retention in the endoplasmic reticulum. 1 PublicationCorresponds to variant rs766080391dbSNPEnsembl.1
Natural variantiVAR_059022128M → T in CMM5; complete absence of functional coupling to the cAMP pathway; trafficked to the cell surface but unable to bind agonist efficiently. 2 PublicationsCorresponds to variant rs374235260dbSNPEnsembl.1
Natural variantiVAR_059025289C → R in CMM5; complete absence of functional coupling to the cAMP pathway; trafficked to the cell surface but unable to bind agonist efficiently. 1 PublicationCorresponds to variant rs369542041dbSNPEnsembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi65K → R: Only minor effect on internalization rate and protein half-life; when associated with R-226; R-238 and R-310. 1 Publication1
Mutagenesisi226K → R: Only minor effect on internalization rate and protein half-life; when associated with R-65; R-238 and R-310. 1 Publication1
Mutagenesisi238K → R: Only minor effect on internalization rate and protein half-life; when associated with R-65; R-226 and R-310. 1 Publication1
Mutagenesisi310K → R: Only minor effect on internalization rate and protein half-life; when associated with R-65; R-226 and R-238. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi4157.
MalaCardsiMC1R.
MIMi266300. phenotype.
613098. phenotype.
613099. phenotype.
OpenTargetsiENSG00000258839.
Orphaneti618. Familial melanoma.
626. Large congenital melanocytic nevus.
79432. Oculocutaneous albinism type 2.
PharmGKBiPA30673.

Chemistry databases

ChEMBLiCHEMBL3795.
GuidetoPHARMACOLOGYi282.

Polymorphism and mutation databases

BioMutaiMC1R.
DMDMi12644376.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000698181 – 317Melanocyte-stimulating hormone receptorAdd BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...)Sequence analysis1
Lipidationi315S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ01726.
PeptideAtlasiQ01726.
PRIDEiQ01726.

PTM databases

iPTMnetiQ01726.
PhosphoSitePlusiQ01726.

Expressioni

Tissue specificityi

Melanocytes and corticoadrenal tissue.

Gene expression databases

BgeeiENSG00000258839.
ExpressionAtlasiQ01726. baseline and differential.
GenevisibleiQ01726. HS.

Interactioni

Subunit structurei

Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production.1 Publication

GO - Molecular functioni

  • ubiquitin protein ligase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi110327. 11 interactors.
DIPiDIP-48789N.
IntActiQ01726. 2 interactors.
STRINGi9606.ENSP00000451605.

Chemistry databases

BindingDBiQ01726.

Structurei

3D structure databases

ProteinModelPortaliQ01726.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00770000120529.
HOVERGENiHBG108148.
InParanoidiQ01726.
KOiK04199.
TreeFamiTF332646.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001671. Melcrt_ACTH_rcpt.
IPR000761. MSH_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF2. PTHR22750:SF2. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00536. MELNOCYTESHR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01726-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVQGSQRRL LGSLNSTPTA IPQLGLAANQ TGARCLEVSI SDGLFLSLGL
60 70 80 90 100
VSLVENALVV ATIAKNRNLH SPMYCFICCL ALSDLLVSGS NVLETAVILL
110 120 130 140 150
LEAGALVARA AVLQQLDNVI DVITCSSMLS SLCFLGAIAV DRYISIFYAL
160 170 180 190 200
RYHSIVTLPR ARRAVAAIWV ASVVFSTLFI AYYDHVAVLL CLVVFFLAML
210 220 230 240 250
VLMAVLYVHM LARACQHAQG IARLHKRQRP VHQGFGLKGA VTLTILLGIF
260 270 280 290 300
FLCWGPFFLH LTLIVLCPEH PTCGCIFKNF NLFLALIICN AIIDPLIYAF
310
HSQELRRTLK EVLTCSW
Length:317
Mass (Da):34,706
Last modified:December 1, 2000 - v2
Checksum:iCB67405A562C29B2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90S → T (PubMed:1325670).Curated1
Sequence conflicti90S → T (PubMed:8463333).Curated1
Sequence conflicti164A → R (PubMed:1516719).Curated1
Sequence conflicti222A → T in AAQ62976 (Ref. 9) Curated1

Polymorphismi

Genetic variants in MC1R define the skin/hair/eye pigmentation variation locus 2 (SHEP2) [MIMi:266300]. Hair, eye and skin pigmentation are among the most visible examples of human phenotypic variation, with a broad normal range that is subject to substantial geographic stratification. In the case of skin, individuals tend to have lighter pigmentation with increasing distance from the equator, with type I skin being the most lightly pigmented and type IV the most dark pigmented. By contrast, the majority of variation in human eye and hair color is found among individuals of European ancestry, with most other human populations fixed for brown eyes and black hair. Partial loss-of-function mutations are associated with fair skin, poor tanning and increased skin cancer risk.
MC1R variants associated with red hair and fair skin, determine female-specific increased analgesia from kappa-opioid receptor agonist [MIMi:613098].1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05901838V → M in CMM5; moderate decrease in coupling to the cAMP pathway; reduced cell surface expression as a consequence of retention in the endoplasmic reticulum. 1 PublicationCorresponds to variant rs200050206dbSNPEnsembl.1
Natural variantiVAR_01361140I → T Associated with fair hair and light skin; partial loss-of-function. 1 PublicationCorresponds to variant rs748138541dbSNPEnsembl.1
Natural variantiVAR_05901941S → F in CMM5; complete absence of functional coupling to the cAMP pathway; reduced cell surface expression as a consequence of retention in the endoplasmic reticulum. 2 Publications1
Natural variantiVAR_05902051V → A in CMM5; moderate decrease in coupling to the cAMP pathway; reduced cell surface expression as a consequence of retention in the endoplasmic reticulum. 1 PublicationCorresponds to variant rs766080391dbSNPEnsembl.1
Natural variantiVAR_01361260V → L Associated with a risk for developing melanoma; unable to stimulate cAMP production as strongly as the wild type receptor in response to alpha-melanocyte-stimulating hormone stimulation. 5 PublicationsCorresponds to variant rs1805005dbSNPEnsembl.1
Natural variantiVAR_00952267R → Q Shows a moderate and not significant decrease of cAMP production to NDP-MSH stimulation; shows a decreased responses to low concentrations of NDP-MSH stimulation. 2 PublicationsCorresponds to variant rs34090186dbSNPEnsembl.1
Natural variantiVAR_00350784D → E May be associated with a risk for developing melanoma; reduced expression at the cell surface. 4 PublicationsCorresponds to variant rs1805006dbSNPEnsembl.1
Natural variantiVAR_04265489G → R.Corresponds to variant rs34540312dbSNPEnsembl.1
Natural variantiVAR_00350892V → M Associated with a risk for developing melanoma; predominantly found in type I skin; shows a moderate and not significant decreased of cAMP production to NDP-MSH stimulation. 7 PublicationsCorresponds to variant rs2228479dbSNPEnsembl.1
Natural variantiVAR_05902193L → R Loss-of-function mutation abolishing agonist binding. 1 Publication1
Natural variantiVAR_04265595T → M.Corresponds to variant rs34158934dbSNPEnsembl.1
Natural variantiVAR_042656104G → S.Corresponds to variant rs2229617dbSNPEnsembl.1
Natural variantiVAR_042657120I → T Shows a moderate and not significant decrease of cAMP production to NDP-MSH stimulation; shows decreased responses to low concentrations of NDP-MSH stimulation. 1 PublicationCorresponds to variant rs33932559dbSNPEnsembl.1
Natural variantiVAR_013613122V → M Associated with fair hair and light skin; partial loss-of-function. 1 PublicationCorresponds to variant rs201192930dbSNPEnsembl.1
Natural variantiVAR_059022128M → T in CMM5; complete absence of functional coupling to the cAMP pathway; trafficked to the cell surface but unable to bind agonist efficiently. 2 PublicationsCorresponds to variant rs374235260dbSNPEnsembl.1
Natural variantiVAR_059023142R → H.2 PublicationsCorresponds to variant rs11547464dbSNPEnsembl.1
Natural variantiVAR_042658147Missing Associated with UV induced susceptibility to skin damage; unresponsive to NDP-MSH stimulation. 1 Publication1
Natural variantiVAR_008522151R → C Associated with red hair and light skin of type I; binds to alpha-MSH but cannot be stimulated to produce cAMP; reduced expression at the cell surface. 9 PublicationsCorresponds to variant rs1805007dbSNPEnsembl.1
Natural variantiVAR_013614155I → T Associated with a risk for developing melanoma; reduced expression at the cell surface. 4 PublicationsCorresponds to variant rs1110400dbSNPEnsembl.1
Natural variantiVAR_013615156V → L.1 PublicationCorresponds to variant rs3212365dbSNPEnsembl.1
Natural variantiVAR_042659157T → I Associated with UV induced susceptibility to skin damage; shows a dramatically decreased cAMP production to NDP-MSH stimulation. 1 PublicationCorresponds to variant rs104894524dbSNPEnsembl.1
Natural variantiVAR_042660159P → T Associated with UV induced susceptibility to skin damage; shows a strong decreased cAMP production to NDP-MSH stimulation. 1 PublicationCorresponds to variant rs104894523dbSNPEnsembl.1
Natural variantiVAR_008523160R → W Associated with a risk for developing melanoma; unable to stimulate cAMP production as strongly as the wild type receptor in response to alpha-melanocyte-stimulating hormone stimulation; reduced expression at the cell surface. 6 PublicationsCorresponds to variant rs1805008dbSNPEnsembl.1
Natural variantiVAR_013632162R → P.1 Publication1
Natural variantiVAR_009523163R → Q Associated with a risk for developing melanoma; shows a moderate and not significant decrease of cAMP production to NDP-MSH stimulation; shows a not significant decrease in cAMP production at any concentrations of NDP-MSH stimulation. 4 PublicationsCorresponds to variant rs885479dbSNPEnsembl.1
Natural variantiVAR_042661166A → G Shows a moderate and not significant decrease of cAMP production to NDP-MSH stimulation; shows a not significant decrease in cAMP production at any concentrations of NDP-MSH stimulation. 1 PublicationCorresponds to variant rs35040147dbSNPEnsembl.1
Natural variantiVAR_042662171A → S.Corresponds to variant rs35784916dbSNPEnsembl.1
Natural variantiVAR_013616196F → L.1 PublicationCorresponds to variant rs3212366dbSNPEnsembl.1
Natural variantiVAR_059024281N → S Functionally silent polymorphism; does not affect receptor surface expression, agonist binding and agonist-induced signaling. 2 PublicationsCorresponds to variant rs141177570dbSNPEnsembl.1
Natural variantiVAR_059025289C → R in CMM5; complete absence of functional coupling to the cAMP pathway; trafficked to the cell surface but unable to bind agonist efficiently. 1 PublicationCorresponds to variant rs369542041dbSNPEnsembl.1
Natural variantiVAR_008524294D → H Associated with a risk for developing melanoma; unable to stimulate cAMP production as strongly as the wild type receptor in response to alpha-melanocyte-stimulating hormone stimulation. 4 PublicationsCorresponds to variant rs1805009dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65634 Genomic DNA. Translation: CAA46588.1.
X67594 mRNA. Translation: CAA47865.1.
AF153431 Genomic DNA. Translation: AAD41349.1.
AF153432 Genomic DNA. Translation: AAD41350.1.
AF153433 Genomic DNA. Translation: AAD41351.1.
AF153434 Genomic DNA. Translation: AAD41352.1.
AF153435 Genomic DNA. Translation: AAD41353.1.
AF153436 Genomic DNA. Translation: AAD41354.1.
AF153437 Genomic DNA. Translation: AAD41355.1.
AF326275 Genomic DNA. Translation: AAK01121.1.
AF263461 Genomic DNA. Translation: AAK58525.1.
AY046528 Genomic DNA. Translation: AAL05887.1.
AY046529 Genomic DNA. Translation: AAL05888.1.
AB241548 Genomic DNA. Translation: BAE94314.1.
AY363626 Genomic DNA. Translation: AAQ62976.1.
AY225228 Genomic DNA. Translation: AAO67713.1.
AF514787 Genomic DNA. Translation: AAM44861.1.
BC007856 mRNA. Translation: AAH07856.1.
BC080622 mRNA. Translation: AAH80622.1.
CCDSiCCDS56011.1.
PIRiS29204.
RefSeqiNP_002377.4. NM_002386.3.
UniGeneiHs.513829.
Hs.734194.

Genome annotation databases

EnsembliENST00000555147; ENSP00000451605; ENSG00000258839.
GeneIDi4157.
KEGGihsa:4157.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65634 Genomic DNA. Translation: CAA46588.1.
X67594 mRNA. Translation: CAA47865.1.
AF153431 Genomic DNA. Translation: AAD41349.1.
AF153432 Genomic DNA. Translation: AAD41350.1.
AF153433 Genomic DNA. Translation: AAD41351.1.
AF153434 Genomic DNA. Translation: AAD41352.1.
AF153435 Genomic DNA. Translation: AAD41353.1.
AF153436 Genomic DNA. Translation: AAD41354.1.
AF153437 Genomic DNA. Translation: AAD41355.1.
AF326275 Genomic DNA. Translation: AAK01121.1.
AF263461 Genomic DNA. Translation: AAK58525.1.
AY046528 Genomic DNA. Translation: AAL05887.1.
AY046529 Genomic DNA. Translation: AAL05888.1.
AB241548 Genomic DNA. Translation: BAE94314.1.
AY363626 Genomic DNA. Translation: AAQ62976.1.
AY225228 Genomic DNA. Translation: AAO67713.1.
AF514787 Genomic DNA. Translation: AAM44861.1.
BC007856 mRNA. Translation: AAH07856.1.
BC080622 mRNA. Translation: AAH80622.1.
CCDSiCCDS56011.1.
PIRiS29204.
RefSeqiNP_002377.4. NM_002386.3.
UniGeneiHs.513829.
Hs.734194.

3D structure databases

ProteinModelPortaliQ01726.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110327. 11 interactors.
DIPiDIP-48789N.
IntActiQ01726. 2 interactors.
STRINGi9606.ENSP00000451605.

Chemistry databases

BindingDBiQ01726.
ChEMBLiCHEMBL3795.
GuidetoPHARMACOLOGYi282.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ01726.
PhosphoSitePlusiQ01726.

Polymorphism and mutation databases

BioMutaiMC1R.
DMDMi12644376.

Proteomic databases

PaxDbiQ01726.
PeptideAtlasiQ01726.
PRIDEiQ01726.

Protocols and materials databases

DNASUi4157.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000555147; ENSP00000451605; ENSG00000258839.
GeneIDi4157.
KEGGihsa:4157.

Organism-specific databases

CTDi4157.
DisGeNETi4157.
GeneCardsiMC1R.
HGNCiHGNC:6929. MC1R.
MalaCardsiMC1R.
MIMi155555. gene.
266300. phenotype.
613098. phenotype.
613099. phenotype.
neXtProtiNX_Q01726.
OpenTargetsiENSG00000258839.
Orphaneti618. Familial melanoma.
626. Large congenital melanocytic nevus.
79432. Oculocutaneous albinism type 2.
PharmGKBiPA30673.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00770000120529.
HOVERGENiHBG108148.
InParanoidiQ01726.
KOiK04199.
TreeFamiTF332646.

Enzyme and pathway databases

BioCyciZFISH:G66-32018-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418555. G alpha (s) signalling events.

Miscellaneous databases

ChiTaRSiMC1R. human.
GeneWikiiMelanocortin_1_receptor.
GenomeRNAii4157.
PROiQ01726.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000258839.
ExpressionAtlasiQ01726. baseline and differential.
GenevisibleiQ01726. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001671. Melcrt_ACTH_rcpt.
IPR000761. MSH_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF2. PTHR22750:SF2. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00536. MELNOCYTESHR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSHR_HUMAN
AccessioniPrimary (citable) accession number: Q01726
Secondary accession number(s): Q66K38
, Q6UR93, Q8WWX6, Q8WWX7, Q96I33, Q96RU4, Q9UBF7, Q9UN58, Q9UN59, Q9UN60, Q9UN61, Q9UN62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: December 1, 2000
Last modified: November 2, 2016
This is version 179 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.