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Q01722

- GCR2_YEAST

UniProt

Q01722 - GCR2_YEAST

Protein

Glycolytic genes transcriptional activator GCR2

Gene

GCR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    Transcriptional activator required for the expression of glycolytic genes. Enhances the CT box-dependent transcriptional activation of a RAP1-GCR1 complex. Required for GCR1 phosphorylation.3 Publications

    GO - Molecular functioni

    1. RNA polymerase II activating transcription factor binding Source: SGD
    2. RNA polymerase II transcription factor binding transcription factor activity Source: SGD

    GO - Biological processi

    1. positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter Source: SGD
    2. positive regulation of transcription from RNA polymerase II promoter Source: SGD
    3. regulation of glycolytic by positive regulation of transcription from RNA polymerase II promoter Source: SGD
    4. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33208-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycolytic genes transcriptional activator GCR2
    Gene namesi
    Name:GCR2
    Ordered Locus Names:YNL199C
    ORF Names:N1374
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIV

    Organism-specific databases

    CYGDiYNL199c.
    SGDiS000005143. GCR2.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nuclear envelope Source: SGD
    2. nucleus Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 534534Glycolytic genes transcriptional activator GCR2PRO_0000087446Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei151 – 1511Phosphoserine1 Publication
    Modified residuei406 – 4061Phosphoserine1 Publication
    Modified residuei409 – 4091Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ01722.
    PaxDbiQ01722.

    Expressioni

    Gene expression databases

    GenevestigatoriQ01722.

    Interactioni

    Subunit structurei

    Homodimer via the leucine-zipper domain. Forms a complex with a GCR1 homodimer.

    Protein-protein interaction databases

    BioGridi35635. 291 interactions.
    DIPiDIP-732N.
    IntActiQ01722. 14 interactions.
    MINTiMINT-400852.
    STRINGi4932.YNL199C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01722.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni497 – 53438Leucine-zipperAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi281 – 2888Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi255 – 28329Asn-richAdd
    BLAST

    Phylogenomic databases

    eggNOGiNOG42464.
    HOGENOMiHOG000000851.
    OMAiANSSEIW.
    OrthoDBiEOG7X3R3G.

    Sequencei

    Sequence statusi: Complete.

    Q01722-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHHQTKLDVF IIRAYNLLSN ESVISGASLQ SVTNSPQTTT NTPSGMVNGA    50
    VGTGIANPTG LMGSDSTPNI DEIITSTGSN ALTKTNSDSA NGTPNGNSSS 100
    TSAISNASNP ATTGNNASSS ATSNGIYTQA QYSQLFAKIS KLYNATLSSG 150
    SIDDRSTSPK SAIELYQRFQ QMIKELELSF DASPYAKYFR RLDGRLWQIK 200
    TDSELENDEL WRLVSMSIFT VFDPQTGQIL TQGRRKGNSL NTSTKGSPSD 250
    LQGINNGNNN GNNGNIGNGS NIKNYGNKNM PNNRTKKRGT RVAKNAKNGK 300
    NNKNSNKERN GITDTSAFSN TTISNPGTNM LFDPSLSQQL QKRLQTLSQD 350
    VNSRSLTGYY TQPTSPGSGG FEFGLSHADL NPNASSNTMG YNTMSNNGSH 400
    SWKRRSLGSL DVNTLDDEAV EELLQLTNTS KRQRPMTTAA EGALINDGPD 450
    TNLNANNTQM KVDLNPSNSM GPIDTEAVIR PLKEAYDAII SEKGQRIVQL 500
    ERELELQRQE TQWLRKMLIE DMGCVRSMLR DLQR 534
    Length:534
    Mass (Da):58,062
    Last modified:October 1, 1993 - v1
    Checksum:i958D4A9393255B1B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10104 Genomic DNA. Translation: BAA00985.1.
    X78898 Genomic DNA. Translation: CAA55509.1.
    Z71475 Genomic DNA. Translation: CAA96097.1.
    BK006947 Genomic DNA. Translation: DAA10355.1.
    PIRiS31300.
    RefSeqiNP_014200.1. NM_001183037.1.

    Genome annotation databases

    EnsemblFungiiYNL199C; YNL199C; YNL199C.
    GeneIDi855522.
    KEGGisce:YNL199C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10104 Genomic DNA. Translation: BAA00985.1 .
    X78898 Genomic DNA. Translation: CAA55509.1 .
    Z71475 Genomic DNA. Translation: CAA96097.1 .
    BK006947 Genomic DNA. Translation: DAA10355.1 .
    PIRi S31300.
    RefSeqi NP_014200.1. NM_001183037.1.

    3D structure databases

    ProteinModelPortali Q01722.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35635. 291 interactions.
    DIPi DIP-732N.
    IntActi Q01722. 14 interactions.
    MINTi MINT-400852.
    STRINGi 4932.YNL199C.

    Proteomic databases

    MaxQBi Q01722.
    PaxDbi Q01722.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YNL199C ; YNL199C ; YNL199C .
    GeneIDi 855522.
    KEGGi sce:YNL199C.

    Organism-specific databases

    CYGDi YNL199c.
    SGDi S000005143. GCR2.

    Phylogenomic databases

    eggNOGi NOG42464.
    HOGENOMi HOG000000851.
    OMAi ANSSEIW.
    OrthoDBi EOG7X3R3G.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33208-MONOMER.

    Miscellaneous databases

    NextBioi 979556.

    Gene expression databases

    Genevestigatori Q01722.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Role of GCR2 in transcriptional activation of yeast glycolytic genes."
      Uemura H., Jigami Y.
      Mol. Cell. Biol. 12:3834-3842(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INTERACTION WITH GCR1.
    2. "A 21.7 kb DNA segment on the left arm of yeast chromosome XIV carries WHI3, GCR2, SPX18, SPX19, an homologue to the heat shock gene SSB1 and 8 new open reading frames of unknown function."
      Jonniaux J.-L., Coster F., Purnelle B., Goffeau A.
      Yeast 10:1639-1645(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 96604 / S288c / FY1679.
    3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
      Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
      , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
      Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. "Specialized Rap1p/Gcr1p transcriptional activation through Gcr1p DNA contacts requires Gcr2p, as does hyperphosphorylation of Gcr1p."
      Zeng X., Deminoff S.J., Santangelo G.M.
      Genetics 147:493-505(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "Rap1p requires Gcr1p and Gcr2p homodimers to activate ribosomal protein and glycolytic genes, respectively."
      Deminoff S.J., Santangelo G.M.
      Genetics 158:133-143(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, HOMODIMERIZATION.
    7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-406 AND SER-409, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiGCR2_YEAST
    AccessioniPrimary (citable) accession number: Q01722
    Secondary accession number(s): D6W0Y9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome XIV
      Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

    External Data

    Dasty 3