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Q01722

- GCR2_YEAST

UniProt

Q01722 - GCR2_YEAST

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Protein
Glycolytic genes transcriptional activator GCR2
Gene
GCR2, YNL199C, N1374
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional activator required for the expression of glycolytic genes. Enhances the CT box-dependent transcriptional activation of a RAP1-GCR1 complex. Required for GCR1 phosphorylation.3 Publications

GO - Molecular functioni

  1. RNA polymerase II activating transcription factor binding Source: SGD
  2. RNA polymerase II transcription factor binding transcription factor activity Source: SGD
Complete GO annotation...

GO - Biological processi

  1. positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter Source: SGD
  2. positive regulation of transcription from RNA polymerase II promoter Source: SGD
  3. regulation of glycolytic by positive regulation of transcription from RNA polymerase II promoter Source: SGD
  4. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-33208-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycolytic genes transcriptional activator GCR2
Gene namesi
Name:GCR2
Ordered Locus Names:YNL199C
ORF Names:N1374
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL199c.
SGDiS000005143. GCR2.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nuclear envelope Source: SGD
  2. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 534534Glycolytic genes transcriptional activator GCR2
PRO_0000087446Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei151 – 1511Phosphoserine1 Publication
Modified residuei406 – 4061Phosphoserine1 Publication
Modified residuei409 – 4091Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ01722.
PaxDbiQ01722.

Expressioni

Gene expression databases

GenevestigatoriQ01722.

Interactioni

Subunit structurei

Homodimer via the leucine-zipper domain. Forms a complex with a GCR1 homodimer.1 Publication

Protein-protein interaction databases

BioGridi35635. 291 interactions.
DIPiDIP-732N.
IntActiQ01722. 14 interactions.
MINTiMINT-400852.
STRINGi4932.YNL199C.

Structurei

3D structure databases

ProteinModelPortaliQ01722.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni497 – 53438Leucine-zipper
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi281 – 2888Nuclear localization signal Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi255 – 28329Asn-rich
Add
BLAST

Phylogenomic databases

eggNOGiNOG42464.
HOGENOMiHOG000000851.
OMAiANSSEIW.
OrthoDBiEOG7X3R3G.

Sequencei

Sequence statusi: Complete.

Q01722-1 [UniParc]FASTAAdd to Basket

« Hide

MHHQTKLDVF IIRAYNLLSN ESVISGASLQ SVTNSPQTTT NTPSGMVNGA    50
VGTGIANPTG LMGSDSTPNI DEIITSTGSN ALTKTNSDSA NGTPNGNSSS 100
TSAISNASNP ATTGNNASSS ATSNGIYTQA QYSQLFAKIS KLYNATLSSG 150
SIDDRSTSPK SAIELYQRFQ QMIKELELSF DASPYAKYFR RLDGRLWQIK 200
TDSELENDEL WRLVSMSIFT VFDPQTGQIL TQGRRKGNSL NTSTKGSPSD 250
LQGINNGNNN GNNGNIGNGS NIKNYGNKNM PNNRTKKRGT RVAKNAKNGK 300
NNKNSNKERN GITDTSAFSN TTISNPGTNM LFDPSLSQQL QKRLQTLSQD 350
VNSRSLTGYY TQPTSPGSGG FEFGLSHADL NPNASSNTMG YNTMSNNGSH 400
SWKRRSLGSL DVNTLDDEAV EELLQLTNTS KRQRPMTTAA EGALINDGPD 450
TNLNANNTQM KVDLNPSNSM GPIDTEAVIR PLKEAYDAII SEKGQRIVQL 500
ERELELQRQE TQWLRKMLIE DMGCVRSMLR DLQR 534
Length:534
Mass (Da):58,062
Last modified:October 1, 1993 - v1
Checksum:i958D4A9393255B1B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10104 Genomic DNA. Translation: BAA00985.1.
X78898 Genomic DNA. Translation: CAA55509.1.
Z71475 Genomic DNA. Translation: CAA96097.1.
BK006947 Genomic DNA. Translation: DAA10355.1.
PIRiS31300.
RefSeqiNP_014200.1. NM_001183037.1.

Genome annotation databases

EnsemblFungiiYNL199C; YNL199C; YNL199C.
GeneIDi855522.
KEGGisce:YNL199C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10104 Genomic DNA. Translation: BAA00985.1 .
X78898 Genomic DNA. Translation: CAA55509.1 .
Z71475 Genomic DNA. Translation: CAA96097.1 .
BK006947 Genomic DNA. Translation: DAA10355.1 .
PIRi S31300.
RefSeqi NP_014200.1. NM_001183037.1.

3D structure databases

ProteinModelPortali Q01722.
ModBasei Search...

Protein-protein interaction databases

BioGridi 35635. 291 interactions.
DIPi DIP-732N.
IntActi Q01722. 14 interactions.
MINTi MINT-400852.
STRINGi 4932.YNL199C.

Proteomic databases

MaxQBi Q01722.
PaxDbi Q01722.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNL199C ; YNL199C ; YNL199C .
GeneIDi 855522.
KEGGi sce:YNL199C.

Organism-specific databases

CYGDi YNL199c.
SGDi S000005143. GCR2.

Phylogenomic databases

eggNOGi NOG42464.
HOGENOMi HOG000000851.
OMAi ANSSEIW.
OrthoDBi EOG7X3R3G.

Enzyme and pathway databases

BioCyci YEAST:G3O-33208-MONOMER.

Miscellaneous databases

NextBioi 979556.

Gene expression databases

Genevestigatori Q01722.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Role of GCR2 in transcriptional activation of yeast glycolytic genes."
    Uemura H., Jigami Y.
    Mol. Cell. Biol. 12:3834-3842(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INTERACTION WITH GCR1.
  2. "A 21.7 kb DNA segment on the left arm of yeast chromosome XIV carries WHI3, GCR2, SPX18, SPX19, an homologue to the heat shock gene SSB1 and 8 new open reading frames of unknown function."
    Jonniaux J.-L., Coster F., Purnelle B., Goffeau A.
    Yeast 10:1639-1645(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "Specialized Rap1p/Gcr1p transcriptional activation through Gcr1p DNA contacts requires Gcr2p, as does hyperphosphorylation of Gcr1p."
    Zeng X., Deminoff S.J., Santangelo G.M.
    Genetics 147:493-505(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Rap1p requires Gcr1p and Gcr2p homodimers to activate ribosomal protein and glycolytic genes, respectively."
    Deminoff S.J., Santangelo G.M.
    Genetics 158:133-143(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, HOMODIMERIZATION.
  7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-406 AND SER-409, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGCR2_YEAST
AccessioniPrimary (citable) accession number: Q01722
Secondary accession number(s): D6W0Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: June 11, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3

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