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Protein

Glycolytic genes transcriptional activator GCR2

Gene

GCR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator required for the expression of glycolytic genes. Enhances the CT box-dependent transcriptional activation of a RAP1-GCR1 complex. Required for GCR1 phosphorylation.3 Publications

GO - Molecular functioni

  • RNA polymerase II activating transcription factor binding Source: SGD
  • transcription factor activity, RNA polymerase II transcription factor binding Source: SGD

GO - Biological processi

  • negative regulation of transcription by RNA polymerase II Source: SGD
  • positive regulation of antisense RNA transcription Source: SGD
  • positive regulation of ribosomal protein gene transcription by RNA polymerase II Source: SGD
  • positive regulation of transcription by RNA polymerase II Source: SGD
  • regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-33208-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glycolytic genes transcriptional activator GCR2
Gene namesi
Name:GCR2
Ordered Locus Names:YNL199C
ORF Names:N1374
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL199C
SGDiS000005143 GCR2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000874461 – 534Glycolytic genes transcriptional activator GCR2Add BLAST534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei151PhosphoserineCombined sources1
Modified residuei406PhosphoserineCombined sources1
Modified residuei409PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ01722
PaxDbiQ01722
PRIDEiQ01722

PTM databases

iPTMnetiQ01722

Interactioni

Subunit structurei

Homodimer via the leucine-zipper domain. Forms a complex with a GCR1 homodimer.

GO - Molecular functioni

  • RNA polymerase II activating transcription factor binding Source: SGD

Protein-protein interaction databases

BioGridi35635365 interactors.
DIPiDIP-732N
IntActiQ01722 15 interactors.
MINTiQ01722
STRINGi4932.YNL199C

Structurei

3D structure databases

ProteinModelPortaliQ01722
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni497 – 534Leucine-zipperAdd BLAST38

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi281 – 288Nuclear localization signalSequence analysis8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi255 – 283Asn-richAdd BLAST29

Phylogenomic databases

HOGENOMiHOG000000851
InParanoidiQ01722
KOiK21671
OMAiVFIIRAY
OrthoDBiEOG092C2J1M

Sequencei

Sequence statusi: Complete.

Q01722-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHHQTKLDVF IIRAYNLLSN ESVISGASLQ SVTNSPQTTT NTPSGMVNGA
60 70 80 90 100
VGTGIANPTG LMGSDSTPNI DEIITSTGSN ALTKTNSDSA NGTPNGNSSS
110 120 130 140 150
TSAISNASNP ATTGNNASSS ATSNGIYTQA QYSQLFAKIS KLYNATLSSG
160 170 180 190 200
SIDDRSTSPK SAIELYQRFQ QMIKELELSF DASPYAKYFR RLDGRLWQIK
210 220 230 240 250
TDSELENDEL WRLVSMSIFT VFDPQTGQIL TQGRRKGNSL NTSTKGSPSD
260 270 280 290 300
LQGINNGNNN GNNGNIGNGS NIKNYGNKNM PNNRTKKRGT RVAKNAKNGK
310 320 330 340 350
NNKNSNKERN GITDTSAFSN TTISNPGTNM LFDPSLSQQL QKRLQTLSQD
360 370 380 390 400
VNSRSLTGYY TQPTSPGSGG FEFGLSHADL NPNASSNTMG YNTMSNNGSH
410 420 430 440 450
SWKRRSLGSL DVNTLDDEAV EELLQLTNTS KRQRPMTTAA EGALINDGPD
460 470 480 490 500
TNLNANNTQM KVDLNPSNSM GPIDTEAVIR PLKEAYDAII SEKGQRIVQL
510 520 530
ERELELQRQE TQWLRKMLIE DMGCVRSMLR DLQR
Length:534
Mass (Da):58,062
Last modified:October 1, 1993 - v1
Checksum:i958D4A9393255B1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10104 Genomic DNA Translation: BAA00985.1
X78898 Genomic DNA Translation: CAA55509.1
Z71475 Genomic DNA Translation: CAA96097.1
BK006947 Genomic DNA Translation: DAA10355.1
PIRiS31300
RefSeqiNP_014200.1, NM_001183037.1

Genome annotation databases

EnsemblFungiiYNL199C; YNL199C; YNL199C
GeneIDi855522
KEGGisce:YNL199C

Similar proteinsi

Entry informationi

Entry nameiGCR2_YEAST
AccessioniPrimary (citable) accession number: Q01722
Secondary accession number(s): D6W0Y9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: April 25, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome