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Protein

Glycolytic genes transcriptional activator GCR2

Gene

GCR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator required for the expression of glycolytic genes. Enhances the CT box-dependent transcriptional activation of a RAP1-GCR1 complex. Required for GCR1 phosphorylation.3 Publications

GO - Molecular functioni

  • RNA polymerase II activating transcription factor binding Source: SGD
  • transcription factor activity, RNA polymerase II transcription factor binding Source: SGD

GO - Biological processi

  • positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter Source: SGD
  • regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-33208-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycolytic genes transcriptional activator GCR2
Gene namesi
Name:GCR2
Ordered Locus Names:YNL199C
ORF Names:N1374
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL199C.
SGDiS000005143. GCR2.

Subcellular locationi

GO - Cellular componenti

  • nuclear envelope Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 534534Glycolytic genes transcriptional activator GCR2PRO_0000087446Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei151 – 1511PhosphoserineCombined sources
Modified residuei406 – 4061PhosphoserineCombined sources
Modified residuei409 – 4091PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ01722.

PTM databases

iPTMnetiQ01722.

Interactioni

Subunit structurei

Homodimer via the leucine-zipper domain. Forms a complex with a GCR1 homodimer.

GO - Molecular functioni

  • RNA polymerase II activating transcription factor binding Source: SGD

Protein-protein interaction databases

BioGridi35635. 292 interactions.
DIPiDIP-732N.
IntActiQ01722. 14 interactions.
MINTiMINT-400852.

Structurei

3D structure databases

ProteinModelPortaliQ01722.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni497 – 53438Leucine-zipperAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi281 – 2888Nuclear localization signalSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi255 – 28329Asn-richAdd
BLAST

Phylogenomic databases

HOGENOMiHOG000000851.
InParanoidiQ01722.
OMAiVFIIRAY.
OrthoDBiEOG092C2J1M.

Sequencei

Sequence statusi: Complete.

Q01722-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHHQTKLDVF IIRAYNLLSN ESVISGASLQ SVTNSPQTTT NTPSGMVNGA
60 70 80 90 100
VGTGIANPTG LMGSDSTPNI DEIITSTGSN ALTKTNSDSA NGTPNGNSSS
110 120 130 140 150
TSAISNASNP ATTGNNASSS ATSNGIYTQA QYSQLFAKIS KLYNATLSSG
160 170 180 190 200
SIDDRSTSPK SAIELYQRFQ QMIKELELSF DASPYAKYFR RLDGRLWQIK
210 220 230 240 250
TDSELENDEL WRLVSMSIFT VFDPQTGQIL TQGRRKGNSL NTSTKGSPSD
260 270 280 290 300
LQGINNGNNN GNNGNIGNGS NIKNYGNKNM PNNRTKKRGT RVAKNAKNGK
310 320 330 340 350
NNKNSNKERN GITDTSAFSN TTISNPGTNM LFDPSLSQQL QKRLQTLSQD
360 370 380 390 400
VNSRSLTGYY TQPTSPGSGG FEFGLSHADL NPNASSNTMG YNTMSNNGSH
410 420 430 440 450
SWKRRSLGSL DVNTLDDEAV EELLQLTNTS KRQRPMTTAA EGALINDGPD
460 470 480 490 500
TNLNANNTQM KVDLNPSNSM GPIDTEAVIR PLKEAYDAII SEKGQRIVQL
510 520 530
ERELELQRQE TQWLRKMLIE DMGCVRSMLR DLQR
Length:534
Mass (Da):58,062
Last modified:October 1, 1993 - v1
Checksum:i958D4A9393255B1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10104 Genomic DNA. Translation: BAA00985.1.
X78898 Genomic DNA. Translation: CAA55509.1.
Z71475 Genomic DNA. Translation: CAA96097.1.
BK006947 Genomic DNA. Translation: DAA10355.1.
PIRiS31300.
RefSeqiNP_014200.1. NM_001183037.1.

Genome annotation databases

EnsemblFungiiYNL199C; YNL199C; YNL199C.
GeneIDi855522.
KEGGisce:YNL199C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10104 Genomic DNA. Translation: BAA00985.1.
X78898 Genomic DNA. Translation: CAA55509.1.
Z71475 Genomic DNA. Translation: CAA96097.1.
BK006947 Genomic DNA. Translation: DAA10355.1.
PIRiS31300.
RefSeqiNP_014200.1. NM_001183037.1.

3D structure databases

ProteinModelPortaliQ01722.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35635. 292 interactions.
DIPiDIP-732N.
IntActiQ01722. 14 interactions.
MINTiMINT-400852.

PTM databases

iPTMnetiQ01722.

Proteomic databases

MaxQBiQ01722.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL199C; YNL199C; YNL199C.
GeneIDi855522.
KEGGisce:YNL199C.

Organism-specific databases

EuPathDBiFungiDB:YNL199C.
SGDiS000005143. GCR2.

Phylogenomic databases

HOGENOMiHOG000000851.
InParanoidiQ01722.
OMAiVFIIRAY.
OrthoDBiEOG092C2J1M.

Enzyme and pathway databases

BioCyciYEAST:G3O-33208-MONOMER.

Miscellaneous databases

PROiQ01722.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiGCR2_YEAST
AccessioniPrimary (citable) accession number: Q01722
Secondary accession number(s): D6W0Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: September 7, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.