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Protein

Growth arrest-specific protein 1

Gene

Gas1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells.1 Publication

GO - Biological processi

  • axon guidance Source: MGI
  • camera-type eye development Source: MGI
  • cell cycle arrest Source: MGI
  • cell fate commitment Source: MGI
  • cerebellum morphogenesis Source: MGI
  • developmental growth Source: MGI
  • dorsal/ventral neural tube patterning Source: MGI
  • dorsal/ventral pattern formation Source: MGI
  • embryonic cranial skeleton morphogenesis Source: MGI
  • embryonic digit morphogenesis Source: MGI
  • embryonic morphogenesis Source: MGI
  • embryonic skeletal system development Source: MGI
  • eye morphogenesis Source: MGI
  • middle ear morphogenesis Source: MGI
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of cell growth Source: UniProtKB
  • negative regulation of epithelial cell proliferation Source: MGI
  • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
  • negative regulation of mitotic cell cycle Source: UniProtKB
  • negative regulation of protein processing Source: UniProtKB
  • negative regulation of smoothened signaling pathway Source: MGI
  • odontogenesis Source: UniProtKB
  • outer ear morphogenesis Source: MGI
  • palate development Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of epithelial cell proliferation Source: MGI
  • positive regulation of mesenchymal cell proliferation Source: MGI
  • positive regulation of smoothened signaling pathway Source: MGI
  • programmed cell death Source: MGI
  • regulation of ER to Golgi vesicle-mediated transport Source: UniProtKB
  • regulation of smoothened signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Growth arrest

Names & Taxonomyi

Protein namesi
Recommended name:
Growth arrest-specific protein 1
Short name:
GAS-1
Gene namesi
Name:Gas1
Synonyms:Gas-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:95655. Gas1.

Subcellular locationi

GO - Cellular componenti

  • anchored component of plasma membrane Source: UniProtKB
  • membrane Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 38Sequence analysisAdd BLAST38
ChainiPRO_000002132039 – 315Growth arrest-specific protein 1Add BLAST277
PropeptideiPRO_0000021321316 – 343Removed in mature formSequence analysisAdd BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi114N-linked (GlcNAc...)Sequence analysis1
Lipidationi315GPI-anchor amidated serineSequence analysis1
Glycosylationi321N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ01721.
PaxDbiQ01721.
PeptideAtlasiQ01721.
PRIDEiQ01721.

PTM databases

iPTMnetiQ01721.
PhosphoSitePlusiQ01721.

Expressioni

Gene expression databases

BgeeiENSMUSG00000052957.
CleanExiMM_GAS1.

Interactioni

Protein-protein interaction databases

BioGridi199832. 1 interactor.
DIPiDIP-59801N.
STRINGi10090.ENSMUSP00000064555.

Structurei

3D structure databases

ProteinModelPortaliQ01721.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi281 – 284Poly-Asp4
Compositional biasi293 – 296Poly-Ala4
Compositional biasi310 – 315Poly-Ser6
Compositional biasi331 – 339Poly-Leu9

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW52. Eukaryota.
ENOG4111JS0. LUCA.
HOGENOMiHOG000233688.
HOVERGENiHBG005804.
InParanoidiQ01721.
KOiK06232.
PhylomeDBiQ01721.
TreeFamiTF329660.

Family and domain databases

InterProiIPR016017. GDNF/GAS1.
[Graphical view]
PfamiPF02351. GDNF. 1 hit.
[Graphical view]
SMARTiSM00907. GDNF. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01721-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAALLGGAG ARTGTLPGAL LCLMALLQLL CSAPRGSGLA HGRRLICWQA
60 70 80 90 100
LLQCQGEPDC SYAYSQYAEA CAPVLAQRGG ADAPGPAGAF PASAASSPRW
110 120 130 140 150
RCPSHCISAL IQLNHTRRGP ALEDCDCAQD EHCRSTKRAI EPCLPRTSSV
160 170 180 190 200
GPGAGAGSVM GCTEARRRCD RDSRCNLALS RYLAYCGKLF NGLRCTDECR
210 220 230 240 250
AVIEDMLAVP KAALLNDCVC DGLERPICES VKENMARLCF GPDASNGPGS
260 270 280 290 300
SGSDGGLDDY YDEEYDDEQR AGAAGGEQPL DDDDGLARPG GGAAAAGGRG
310 320 330 340
DLPHGPGRRS SSSGSGGHWA NRSAWTPFAC LLLLLLLLLG SHL
Length:343
Mass (Da):35,694
Last modified:May 16, 2003 - v2
Checksum:iF85D393F248B8895
GO

Sequence cautioni

The sequence CAA46256 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65128 mRNA. Translation: CAA46256.1. Different initiation.
BC058628 mRNA. Translation: AAH58628.1.
PIRiS25771.
RefSeqiNP_032112.1. NM_008086.2.
UniGeneiMm.22701.

Genome annotation databases

GeneIDi14451.
KEGGimmu:14451.
UCSCiuc007qvi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65128 mRNA. Translation: CAA46256.1. Different initiation.
BC058628 mRNA. Translation: AAH58628.1.
PIRiS25771.
RefSeqiNP_032112.1. NM_008086.2.
UniGeneiMm.22701.

3D structure databases

ProteinModelPortaliQ01721.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199832. 1 interactor.
DIPiDIP-59801N.
STRINGi10090.ENSMUSP00000064555.

PTM databases

iPTMnetiQ01721.
PhosphoSitePlusiQ01721.

Proteomic databases

MaxQBiQ01721.
PaxDbiQ01721.
PeptideAtlasiQ01721.
PRIDEiQ01721.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi14451.
KEGGimmu:14451.
UCSCiuc007qvi.2. mouse.

Organism-specific databases

CTDi2619.
MGIiMGI:95655. Gas1.

Phylogenomic databases

eggNOGiENOG410IW52. Eukaryota.
ENOG4111JS0. LUCA.
HOGENOMiHOG000233688.
HOVERGENiHBG005804.
InParanoidiQ01721.
KOiK06232.
PhylomeDBiQ01721.
TreeFamiTF329660.

Miscellaneous databases

PROiQ01721.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052957.
CleanExiMM_GAS1.

Family and domain databases

InterProiIPR016017. GDNF/GAS1.
[Graphical view]
PfamiPF02351. GDNF. 1 hit.
[Graphical view]
SMARTiSM00907. GDNF. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGAS1_MOUSE
AccessioniPrimary (citable) accession number: Q01721
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: May 16, 2003
Last modified: November 2, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.