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Q01718

- ACTHR_HUMAN

UniProt

Q01718 - ACTHR_HUMAN

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Protein

Adrenocorticotropic hormone receptor

Gene

MC2R

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP).2 Publications

GO - Molecular functioni

  1. corticotropin receptor activity Source: ProtInc
  2. melanocortin receptor activity Source: ProtInc

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ProtInc
  2. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
  3. neuropeptide signaling pathway Source: GOC
  4. placenta development Source: Ensembl
  5. positive regulation of cAMP biosynthetic process Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19327. G alpha (s) signalling events.

Protein family/group databases

TCDBi9.A.14.2.4. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Adrenocorticotropic hormone receptor
Short name:
ACTH receptor
Short name:
ACTH-R
Alternative name(s):
Adrenocorticotropin receptor
Melanocortin receptor 2
Short name:
MC2-R
Gene namesi
Name:MC2R
Synonyms:ACTHR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:6930. MC2R.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Glucocorticoid deficiency 1 (GCCD1) [MIM:202200]: A rare, potentially lethal, autosomal recessive disorder characterized by resistance to ACTH action on the adrenal cortex, adrenal insufficiency and an inability of the adrenal cortex to produce cortisol. It usually presents in the neonatal period or in early childhood with episodes of hypoglycemia and other symptoms related to cortisol deficiency, including failure to thrive, recurrent illnesses or infections, convulsions, and shock. In a small number of patients hypoglycemia can be sufficiently severe and persistent that it leads to serious long-term neurological damage or death. The diagnosis is readily confirmed with a low plasma cortisol measurement in the presence of an elevated ACTH level, and normal aldosterone and plasma renin measurements.5 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti74 – 741S → I in GCCD1; complete loss of activity. 2 Publications
VAR_003510
Natural varianti103 – 1031D → N in GCCD1. 1 Publication
VAR_010702
Natural varianti107 – 1071D → N in GCCD1. 1 Publication
VAR_015095
Natural varianti120 – 1201S → R in GCCD1. 1 Publication
VAR_003511
Natural varianti128 – 1281R → C in GCCD1.
VAR_003512
Natural varianti137 – 1371R → W in GCCD1; partial loss of ACTIVITY. 2 Publications
VAR_010703
Natural varianti146 – 1461R → H in GCCD1.
VAR_003513
Natural varianti251 – 2511C → F in GCCD1. 1 Publication
VAR_015096
Natural varianti254 – 2541Y → C in GCCD1; complete loss of activity. 1 Publication
Corresponds to variant rs28940892 [ dbSNP | Ensembl ].
VAR_015295

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi202200. phenotype.
Orphaneti361. Familial glucocorticoid deficiency.
PharmGKBiPA30674.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Adrenocorticotropic hormone receptorPRO_0000069054Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi12 – 121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence Analysis
Lipidationi293 – 2931S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiQ01718.

PTM databases

PhosphoSiteiQ01718.

Expressioni

Tissue specificityi

Melanocytes and corticoadrenal tissue.

Gene expression databases

BgeeiQ01718.
CleanExiHS_MC2R.
ExpressionAtlasiQ01718. baseline and differential.
GenevestigatoriQ01718.

Interactioni

Subunit structurei

Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).3 Publications

Protein-protein interaction databases

BioGridi110328. 3 interactions.
DIPiDIP-29949N.
IntActiQ01718. 1 interaction.
STRINGi9606.ENSP00000333821.

Structurei

3D structure databases

ProteinModelPortaliQ01718.
SMRiQ01718. Positions 32-291.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularBy similarityAdd
BLAST
Topological domaini50 – 589CytoplasmicBy similarity
Topological domaini80 – 10425ExtracellularBy similarityAdd
BLAST
Topological domaini127 – 14721CytoplasmicBy similarityAdd
BLAST
Topological domaini169 – 18012ExtracellularBy similarityAdd
BLAST
Topological domaini200 – 21718CytoplasmicBy similarityAdd
BLAST
Topological domaini245 – 25612ExtracellularBy similarityAdd
BLAST
Topological domaini279 – 29719CytoplasmicBy similarityAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4926Helical; Name=1By similarityAdd
BLAST
Transmembranei59 – 7921Helical; Name=2By similarityAdd
BLAST
Transmembranei105 – 12622Helical; Name=3By similarityAdd
BLAST
Transmembranei148 – 16821Helical; Name=4By similarityAdd
BLAST
Transmembranei181 – 19919Helical; Name=5By similarityAdd
BLAST
Transmembranei218 – 24427Helical; Name=6By similarityAdd
BLAST
Transmembranei257 – 27822Helical; Name=7By similarityAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG331926.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000246927.
HOVERGENiHBG108148.
InParanoidiQ01718.
KOiK04200.
OMAiKPRGNFE.
OrthoDBiEOG7327PD.
PhylomeDBiQ01718.
TreeFamiTF332646.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001168. ACTH_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001671. Melcrt_ACTH_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF3. PTHR22750:SF3. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00520. ACTROPHINR.
PR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01718-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKHIINSYEN INNTARNNSD CPRVVLPEEI FFTISIVGVL ENLIVLLAVF
60 70 80 90 100
KNKNLQAPMY FFICSLAISD MLGSLYKILE NILIILRNMG YLKPRGSFET
110 120 130 140 150
TADDIIDSLF VLSLLGSIFS LSVIAADRYI TIFHALRYHS IVTMRRTVVV
160 170 180 190 200
LTVIWTFCTG TGITMVIFSH HVPTVITFTS LFPLMLVFIL CLYVHMFLLA
210 220 230 240 250
RSHTRKISTL PRANMKGAIT LTILLGVFIF CWAPFVLHVL LMTFCPSNPY
260 270 280 290
CACYMSLFQV NGMLIMCNAV IDPFIYAFRS PELRDAFKKM IFCSRYW
Length:297
Mass (Da):33,927
Last modified:July 1, 1993 - v1
Checksum:i66EE31961ABB8773
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti27 – 271P → R.
Corresponds to variant rs28926178 [ dbSNP | Ensembl ].
VAR_003509
Natural varianti74 – 741S → I in GCCD1; complete loss of activity. 2 Publications
VAR_003510
Natural varianti103 – 1031D → N in GCCD1. 1 Publication
VAR_010702
Natural varianti107 – 1071D → N in GCCD1. 1 Publication
VAR_015095
Natural varianti120 – 1201S → R in GCCD1. 1 Publication
VAR_003511
Natural varianti128 – 1281R → C in GCCD1.
VAR_003512
Natural varianti137 – 1371R → P Found in a glucocorticoid deficiency patient carrying also mutation I-74. 1 Publication
VAR_064986
Natural varianti137 – 1371R → W in GCCD1; partial loss of ACTIVITY. 2 Publications
VAR_010703
Natural varianti146 – 1461R → H in GCCD1.
VAR_003513
Natural varianti251 – 2511C → F in GCCD1. 1 Publication
VAR_015096
Natural varianti254 – 2541Y → C in GCCD1; complete loss of activity. 1 Publication
Corresponds to variant rs28940892 [ dbSNP | Ensembl ].
VAR_015295
Natural varianti278 – 2781F → C.
Corresponds to variant rs28926182 [ dbSNP | Ensembl ].
VAR_049369

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X65633 Genomic DNA. Translation: CAA46587.1.
AB065915 Genomic DNA. Translation: BAC06130.1.
AK289381 mRNA. Translation: BAF82070.1.
AK315319 mRNA. Translation: BAG37722.1.
CH471113 Genomic DNA. Translation: EAX01503.1.
BC069074 mRNA. Translation: AAH69074.1.
BC094710 mRNA. Translation: AAH94710.1.
BC104169 mRNA. Translation: AAI04170.1.
BC104170 mRNA. Translation: AAI04171.1.
AY225229 Genomic DNA. Translation: AAO67714.1.
CCDSiCCDS11869.1.
PIRiC43265.
RefSeqiNP_000520.1. NM_000529.2.
NP_001278840.1. NM_001291911.1.
UniGeneiHs.248144.

Genome annotation databases

EnsembliENST00000327606; ENSP00000333821; ENSG00000185231.
GeneIDi4158.
KEGGihsa:4158.
UCSCiuc002ksp.1. human.

Polymorphism databases

DMDMi399002.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X65633 Genomic DNA. Translation: CAA46587.1 .
AB065915 Genomic DNA. Translation: BAC06130.1 .
AK289381 mRNA. Translation: BAF82070.1 .
AK315319 mRNA. Translation: BAG37722.1 .
CH471113 Genomic DNA. Translation: EAX01503.1 .
BC069074 mRNA. Translation: AAH69074.1 .
BC094710 mRNA. Translation: AAH94710.1 .
BC104169 mRNA. Translation: AAI04170.1 .
BC104170 mRNA. Translation: AAI04171.1 .
AY225229 Genomic DNA. Translation: AAO67714.1 .
CCDSi CCDS11869.1.
PIRi C43265.
RefSeqi NP_000520.1. NM_000529.2.
NP_001278840.1. NM_001291911.1.
UniGenei Hs.248144.

3D structure databases

ProteinModelPortali Q01718.
SMRi Q01718. Positions 32-291.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110328. 3 interactions.
DIPi DIP-29949N.
IntActi Q01718. 1 interaction.
STRINGi 9606.ENSP00000333821.

Chemistry

BindingDBi Q01718.
ChEMBLi CHEMBL1965.
DrugBanki DB01285. Corticotropin.
DB01284. Cosyntropin.
GuidetoPHARMACOLOGYi 283.

Protein family/group databases

TCDBi 9.A.14.2.4. the g-protein-coupled receptor (gpcr) family.
GPCRDBi Search...

PTM databases

PhosphoSitei Q01718.

Polymorphism databases

DMDMi 399002.

Proteomic databases

PRIDEi Q01718.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000327606 ; ENSP00000333821 ; ENSG00000185231 .
GeneIDi 4158.
KEGGi hsa:4158.
UCSCi uc002ksp.1. human.

Organism-specific databases

CTDi 4158.
GeneCardsi GC18M013874.
HGNCi HGNC:6930. MC2R.
MIMi 202200. phenotype.
607397. gene.
neXtProti NX_Q01718.
Orphaneti 361. Familial glucocorticoid deficiency.
PharmGKBi PA30674.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG331926.
GeneTreei ENSGT00760000118804.
HOGENOMi HOG000246927.
HOVERGENi HBG108148.
InParanoidi Q01718.
KOi K04200.
OMAi KPRGNFE.
OrthoDBi EOG7327PD.
PhylomeDBi Q01718.
TreeFami TF332646.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_19327. G alpha (s) signalling events.

Miscellaneous databases

GeneWikii ACTH_receptor.
GenomeRNAii 4158.
NextBioi 16382.
PROi Q01718.
SOURCEi Search...

Gene expression databases

Bgeei Q01718.
CleanExi HS_MC2R.
ExpressionAtlasi Q01718. baseline and differential.
Genevestigatori Q01718.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001168. ACTH_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001671. Melcrt_ACTH_rcpt.
[Graphical view ]
PANTHERi PTHR22750:SF3. PTHR22750:SF3. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00520. ACTROPHINR.
PR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The cloning of a family of genes that encode the melanocortin receptors."
    Mountjoy K.G., Robbins L.S., Mortrud M., Cone R.D.
    Science 257:1248-1251(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Skin.
  2. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adrenal gland.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "Molecular cloning of a novel melanocortin receptor."
    Gantz I., Konda Y., Tashiro T., Shimoto Y., Miwa H., Munzert G., Watson S.J., Delvalle J., Yamada T.
    J. Biol. Chem. 268:8246-8250(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-293.
  8. "Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2."
    Metherell L.A., Chapple J.P., Cooray S., David A., Becker C., Rueschendorf F., Naville D., Begeot M., Khoo B., Nuernberg P., Huebner A., Cheetham M.E., Clark A.J.L.
    Nat. Genet. 37:166-170(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MRAP.
  9. Cited for: FUNCTION, INTERACTION WITH MRAP AND MRAP2.
  10. "Regulation of G protein-coupled receptor signaling: specific dominant-negative effects of melanocortin 2 receptor accessory protein 2."
    Sebag J.A., Hinkle P.M.
    Sci. Signal. 3:RA28-RA28(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH MRAP AND MRAP2.
  11. "Molecular insights into inherited ACTH resistance syndromes."
    Clark A.J.L., Weber A.
    Trends Endocrinol. Metab. 5:209-214(1994)
    Cited for: REVIEW ON GCCD1 VARIANTS.
  12. "Familial glucocorticoid deficiency associated with point mutation in the adrenocorticotropin receptor."
    Clark A.J.L., McLoughlin L., Grossman A.
    Lancet 341:461-462(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GCCD1 ILE-74.
  13. "Hereditary isolated glucocorticoid deficiency is associated with abnormalities of the adrenocorticotropin receptor gene."
    Tsigos C., Arai K., Hung W., Chrousos G.P.
    J. Clin. Invest. 92:2458-2461(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GCCD1 ARG-120.
  14. "Demonstration by transfection studies that mutations in the adrenocorticotropin receptor gene are one cause of the hereditary syndrome of glucocorticoid deficiency."
    Naville D., Barjhoux L., Jaillard C., Faury D., Despert F., Esteva B., Durand P., Saez J.M., Begeot M.
    J. Clin. Endocrinol. Metab. 81:1442-1448(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS GCCD1 ASN-107 AND PHE-251.
  15. "Novel mutations of the ACTH receptor gene in a female adult patient with adrenal unresponsiveness to ACTH."
    Ishii T., Ogata T., Sasaki G., Sato S., Kinoshita E.I., Matsuo N.
    Clin. Endocrinol. (Oxf.) 53:389-392(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS GCCD1 ASN-103 AND TRP-137.
  16. "Clinical, genetic, and functional characterization of adrenocorticotropin receptor mutations using a novel receptor assay."
    Fluck C.E., Martens J.W.M., Conte F.A., Miller W.L.
    J. Clin. Endocrinol. Metab. 87:4318-4323(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS GCCD1 ILE-74; TRP-137 AND CYS-254.
  17. "Novel human pathological mutations. Gene symbol: MC2R. Disease: Glucocorticoid deficiency."
    Mueller O.T., Coovadia A.
    Hum. Genet. 127:112-112(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT PRO-137.

Entry informationi

Entry nameiACTHR_HUMAN
AccessioniPrimary (citable) accession number: Q01718
Secondary accession number(s): A8K016, Q3MI45, Q504X6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 29, 2014
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3