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Protein

Thiamine-repressible acid phosphatase pho4

Gene

pho4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May dephosphorylate thiamine phosphates.

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei69NucleophileBy similarity1
Active sitei341Proton donorBy similarity1

GO - Molecular functioni

  • acid phosphatase activity Source: PomBase
  • thiamine phosphate phosphatase activity Source: PomBase

GO - Biological processi

  • thiamine biosynthetic process Source: PomBase

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine-repressible acid phosphatase pho4 (EC:3.1.3.2)
Gene namesi
Name:pho4
ORF Names:SPBC428.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC428.03c
PomBaseiSPBC428.03c pho4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000002395219 – 463Thiamine-repressible acid phosphatase pho4Add BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi186N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi221N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi251N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi328N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi433N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi439N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi458N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ01682
PaxDbiQ01682
PRIDEiQ01682

Expressioni

Inductioni

Repressed by thiamine.

Interactioni

Protein-protein interaction databases

BioGridi277132, 13 interactors
STRINGi4896.SPBC428.03c.1

Structurei

3D structure databases

ProteinModelPortaliQ01682
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidine acid phosphatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000115655
InParanoidiQ01682
KOiK01078
OMAiKLYQRYY
OrthoDBiEOG092C2L5B
PhylomeDBiQ01682

Family and domain databases

CDDicd07061 HP_HAP_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
InterProiView protein in InterPro
IPR033379 Acid_Pase_AS
IPR000560 His_Pase_clade-2
IPR029033 His_PPase_superfam
IPR016274 Histidine_acid_Pase_euk
PfamiView protein in Pfam
PF00328 His_Phos_2, 1 hit
PIRSFiPIRSF000894 Acid_phosphatase, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit
PROSITEiView protein in PROSITE
PS00616 HIS_ACID_PHOSPHAT_1, 1 hit
PS00778 HIS_ACID_PHOSPHAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01682-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLSGISLWL LAASIVHAGK SQFEAFENEF YFKDHLGTIS VYHEPYFNGP
60 70 80 90 100
TTSFPESCAI KQVHLLQRHG SRNPTGDDTA TDVSSAQYID IFQNKLLNGS
110 120 130 140 150
IPVNFSYPEN PLYFVKHWTP VIKAENADQL SSSGRIELFD LGRQVFERYY
160 170 180 190 200
ELFDTDVYDI NTAAQERVVD SAEWFSYGMF GDDMQNKTNF IVLPEDDSAG
210 220 230 240 250
ANSLAMYYSC PVYEDNNIDE NTTEAAHTSW RNVFLKPIAN RLNKYFDSGY
260 270 280 290 300
NLTVSDVRSL YYICVYEIAL RDNSDFCSLF TPSEFLNFEY DSDLDYAYWG
310 320 330 340 350
GPASEWASTL GGAYVNNLAN NLRKGVNNAS DRKVFLAFTH DSQIIPVEAA
360 370 380 390 400
LGFFPDITPE HPLPTDKNIF TYSLKTSSFV PFAGNLITEL FLCSDNKYYV
410 420 430 440 450
RHLVNQQVYP LTDCGYGPSG ASDGLCELSA YLNSSVRVNS TSNGIANFNS
460
QCQAHSTNVT VYY
Length:463
Mass (Da):52,119
Last modified:July 1, 1993 - v1
Checksum:iF48EAFF8BB6B234A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56939 Genomic DNA Translation: CAA40258.1
CU329671 Genomic DNA Translation: CAA22278.1
AB027777 Genomic DNA Translation: BAA87081.1
PIRiS14119
RefSeqiNP_595181.1, NM_001021089.2

Genome annotation databases

EnsemblFungiiSPBC428.03c.1; SPBC428.03c.1:pep; SPBC428.03c
GeneIDi2540606
KEGGispo:SPBC428.03c

Similar proteinsi

Entry informationi

Entry nameiPPA2_SCHPO
AccessioniPrimary (citable) accession number: Q01682
Secondary accession number(s): Q9UU70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: March 28, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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