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Q01682 (PPA2_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thiamine-repressible acid phosphatase pho4

EC=3.1.3.2
Gene names
Name:pho4
ORF Names:SPBC428.03c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length463 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May dephosphorylate thiamine phosphates.

Catalytic activity

A phosphate monoester + H2O = an alcohol + phosphate.

Subcellular location

Secretedcell wall.

Induction

Repressed by thiamine.

Sequence similarities

Belongs to the histidine acid phosphatase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Ref.1
Chain19 – 463445Thiamine-repressible acid phosphatase pho4
PRO_0000023952

Sites

Active site691Nucleophile By similarity
Active site3411Proton donor By similarity

Amino acid modifications

Glycosylation981N-linked (GlcNAc...) Potential
Glycosylation1041N-linked (GlcNAc...) Potential
Glycosylation1861N-linked (GlcNAc...) Potential
Glycosylation2211N-linked (GlcNAc...) Potential
Glycosylation2511N-linked (GlcNAc...) Potential
Glycosylation3281N-linked (GlcNAc...) Potential
Glycosylation4331N-linked (GlcNAc...) Potential
Glycosylation4391N-linked (GlcNAc...) Potential
Glycosylation4581N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q01682 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: F48EAFF8BB6B234A

FASTA46352,119
        10         20         30         40         50         60 
MKLSGISLWL LAASIVHAGK SQFEAFENEF YFKDHLGTIS VYHEPYFNGP TTSFPESCAI 

        70         80         90        100        110        120 
KQVHLLQRHG SRNPTGDDTA TDVSSAQYID IFQNKLLNGS IPVNFSYPEN PLYFVKHWTP 

       130        140        150        160        170        180 
VIKAENADQL SSSGRIELFD LGRQVFERYY ELFDTDVYDI NTAAQERVVD SAEWFSYGMF 

       190        200        210        220        230        240 
GDDMQNKTNF IVLPEDDSAG ANSLAMYYSC PVYEDNNIDE NTTEAAHTSW RNVFLKPIAN 

       250        260        270        280        290        300 
RLNKYFDSGY NLTVSDVRSL YYICVYEIAL RDNSDFCSLF TPSEFLNFEY DSDLDYAYWG 

       310        320        330        340        350        360 
GPASEWASTL GGAYVNNLAN NLRKGVNNAS DRKVFLAFTH DSQIIPVEAA LGFFPDITPE 

       370        380        390        400        410        420 
HPLPTDKNIF TYSLKTSSFV PFAGNLITEL FLCSDNKYYV RHLVNQQVYP LTDCGYGPSG 

       430        440        450        460 
ASDGLCELSA YLNSSVRVNS TSNGIANFNS QCQAHSTNVT VYY 

« Hide

References

« Hide 'large scale' references
[1]"The structural gene coding for thiamin-repressible acid phosphatase in Schizosaccharomyces pombe."
Yang J., Schweingruber M.E.
Curr. Genet. 18:269-272(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 19-30.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[3]"Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library."
Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y.
Genes Cells 5:169-190(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-71.
Strain: ATCC 38364 / 968.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X56939 Genomic DNA. Translation: CAA40258.1.
CU329671 Genomic DNA. Translation: CAA22278.1.
AB027777 Genomic DNA. Translation: BAA87081.1.
PIRS14119.
RefSeqNP_595181.1. NM_001021089.2.

3D structure databases

ProteinModelPortalQ01682.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid277132. 12 interactions.
MINTMINT-4693366.
STRING4896.SPBC428.03c-1.

Proteomic databases

MaxQBQ01682.
PaxDbQ01682.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC428.03c.1; SPBC428.03c.1:pep; SPBC428.03c.
GeneID2540606.
KEGGspo:SPBC428.03c.

Organism-specific databases

PomBaseSPBC428.03c.

Phylogenomic databases

eggNOGNOG260296.
HOGENOMHOG000115655.
KOK01078.
OMACETHATK.
OrthoDBEOG7TQV9N.
PhylomeDBQ01682.

Family and domain databases

Gene3D3.40.50.1240. 1 hit.
InterProIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
IPR016274. Histidine_acid_Pase_euk.
[Graphical view]
PfamPF00328. His_Phos_2. 1 hit.
[Graphical view]
PIRSFPIRSF000894. Acid_phosphatase. 1 hit.
SUPFAMSSF53254. SSF53254. 1 hit.
PROSITEPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20801731.

Entry information

Entry namePPA2_SCHPO
AccessionPrimary (citable) accession number: Q01682
Secondary accession number(s): Q9UU70
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: June 11, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names