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Q01679

- LAC1_PHLRA

UniProt

Q01679 - LAC1_PHLRA

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Protein
Laccase
Gene
LAC
Organism
Phlebia radiata (White-rot fungus)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Most probably plays an important role in lignin degradation.

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Binds 4 copper ions per monomer By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi85 – 851Copper 1; type 2 By similarity
Metal bindingi87 – 871Copper 2; type 3 By similarity
Metal bindingi130 – 1301Copper 2; type 3 By similarity
Metal bindingi132 – 1321Copper 3; type 3 By similarity
Metal bindingi418 – 4181Copper 4; type 1 By similarity
Metal bindingi421 – 4211Copper 1; type 2 By similarity
Metal bindingi423 – 4231Copper 3; type 3 By similarity
Metal bindingi473 – 4731Copper 3; type 3 By similarity
Metal bindingi474 – 4741Copper 4; type 1 By similarity
Metal bindingi475 – 4751Copper 2; type 3 By similarity
Metal bindingi479 – 4791Copper 4; type 1 By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. lignin catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase
Diphenol oxidase
Ligninolytic phenoloxidase
Urishiol oxidase
Gene namesi
Name:LAC
OrganismiPhlebia radiata (White-rot fungus)
Taxonomic identifieri5308 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesCorticialesCorticiaceaePhlebia

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121
Add
BLAST
Chaini22 – 520499Laccase
PRO_0000002928Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi75 – 751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi352 – 3521N-linked (GlcNAc...) Reviewed prediction
Glycosylationi402 – 4021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi457 – 4571N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ01679.
SMRiQ01679. Positions 22-520.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 148127Plastocyanin-like 1
Add
BLAST
Domaini160 – 304145Plastocyanin-like 2
Add
BLAST
Domaini373 – 496124Plastocyanin-like 3
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01679-1 [UniParc]FASTAAdd to Basket

« Hide

MHTFLRSTAL VVAGLSARAL ASIGPVTDFH IVNAAVSPDG FSRQAVLAEG    50
VFPGPLIAGN KGDNFQINVI DELTNATMLK TTTIHWHGFF QHGTNWADGP 100
AFINQCPIAS GDSFLYNFQV PDQAGTFWYH SHLSTQYCDG LRGPFVVYDP 150
ADPYLDQYDV DDDSTVITLA DWYHTAARLG SPFPAADTTL INGLGRCGEA 200
GCPVSDLAVI SVTKGKRYRF RLVSISCDSF FTFSIDGHSL NVIEVDATNH 250
QPLTVDELTI YAGQRYSFIL TADQDVDNYW IRANPGIGIT TGFAGGINSA 300
ILRYDGADVV EPTTTQATSP VVLSESNLAP LTNAAAPGLP EVGGVDLALN 350
FNLTFDGPSL KFQINGVTFV PPTVPVLLQI LSGAQSAADL LPSGSVYALP 400
SNATIELSLP AGALGGPHPF HLHGHTFSVV RPAGSTTYNY VNPVQRDVVS 450
IGNTGDNVTI RFDTNNPGPW FLHCHIDWHL EAGFAVVFAE DIPDVASINP 500
VPQDWSNLCP IYNALDASDH 520
Length:520
Mass (Da):55,704
Last modified:May 10, 2004 - v2
Checksum:iB566CE3CA2791D36
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52134 Genomic DNA. Translation: CAA36379.2.
PIRiS18746.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52134 Genomic DNA. Translation: CAA36379.2 .
PIRi S18746.

3D structure databases

ProteinModelPortali Q01679.
SMRi Q01679. Positions 22-520.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.40.420. 3 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 3 hits.
PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and structural analysis of the laccase gene from the lignin-degrading fungus Phlebia radiata."
    Saloheimo M., Niku-Paavola M.L., Knowles J.K.
    J. Gen. Microbiol. 137:1537-1544(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
    Strain: ATCC 64658 / 79.
  2. Saloheimo M.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO C-TERMINUS.

Entry informationi

Entry nameiLAC1_PHLRA
AccessioniPrimary (citable) accession number: Q01679
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: May 10, 2004
Last modified: February 19, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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